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마황부자세신탕(麻黃附子細辛湯)의 마우스 단회 경구투여 독성 및 골수세포를 이용한 유전독성 평가
성익재,박미연,전우현,김종대,Sung, Ik-Jae,Park, Mee-Yeon,Cheon, Woo-Hyun,Kim, Jong-Dae 대한동의생리학회 2009 동의생리병리학회지 Vol.23 No.5
The object of this study was to obtain acute information single oral dose toxicity of Mahwangbujaseshin-tang extracts, with mouse bone marrow cell micronucleus test for detecting possible genotoxicity. In order to observe the 50% lethal dose, approximate lethal dosage, maximum tolerance dosage and target organs, test articles were once orally administered to ICR mice at dose levels of 2000, 1000, 50 mg/kg according to the recommendation of KFDA Guidelines. The mortality and changes on body weight, clinical signs and gross observation were monitored during 14 days after dosing according to KFDA Guidelines with organ weights of 12 types of principle organs. In addition, after twice oral treatment of Mahwangbujaseshin-tang extracts 2000, 1000 and 500 mg/kg, we checked the changes on the number of MNPCE. We could not find any mortality, clinical signs, changes in the body weight and gross findings upto 2000 mg/kg treated group. The limited dosages in rodents except for increases of lymphoid organ weights and hypertrophy encounted as results from pharmacological effects of Mahwangbujaseshin-tang extracts, immune modulator effects with some sporadic accidental findings not toxicological signs. No evidence of increases of MNPCE numbers were also detected in all three different dosages of Mahwangbujaseshin-tang extracts treated mice. The results obtained in this study suggest that the LD50 and ALD of Mahwangbujaseshin-tang extracts in mice were considered as over 2000 mg/kg because no mortalities were detected upto 2000 mg/kg that was the highest dose recommended by KFDA and OECD. And the results of mouse bone marrow micronucleus test of Mahwangbujaseshin-tang extracts is negative results.
자동차사고로 발생한 경항통 환자의 추나요법의 효과에 대한 임상적 연구
허수영,지재동,성익재,김규섭,이승우,김현석,김재영,권오곤,Heo, Su-Young,Jee, Jae-Dong,Sung, Ik-Jae,Kim, Gyu-Sub,Lee, Seung-Woo,Kim, Hyun-Seok,Kim, Jae-Young,Kwon, Oh-Gon 척추신경추나의학회 2013 척추신경추나의학회지 Vol.8 No.1
Objectives : The purpose of this study is to investigate the effect of Chuna treatment for neck pain patients caused by traffic accident. Methods : 64 patients were divided into two groups, experimental group and control group, of 32 patients each. Control group was treated with general korean medical treatment three times per week for 2 weeks. Experimental group was treated with Chuna treatment and general korean medical treatment three times per week for 2 weeks. We evaluated the treatment effect of each group with the visual analog scale(VAS) and neck disability index(NDI). Results : 1. In both two groups, VAS were decreased significantly in statistics after treatment. 2. In both two groups, NDI were decreased significantly in statistics after treatment. 3. There were significant reduction of the VAS in experimental group than control group, but, there were not significant reduction of the NDI in experimental group than control group. Conclusions : We suggest that Chuna treatment could be recommended as a useful therapy to neck pain patients caused by traffic accident.
요추 4번의 회전변위와 척추측만증과의 상관성에 관한 연구
김규섭,김재영,민영광,서영태,성익재,이승우,지재동,Kim, Gyu-Sub,Kim, Jae-Young,Min, Young-Kwang,Seo, Young-Tae,Sung, Ik-Jae,Lee, Seung-Woo,Jee, Jae-Dong 척추신경추나의학회 2012 척추신경추나의학회지 Vol.7 No.1
Objectives : The purpose of this study is to find out the relation between 4th lumbar rotational malposition and scoliosis. Methods : We investigated 22 cases of patients who were diagnosed as scoliosis. We used AP & Lateral view X-ray for patients. And we analysed the relation between 4th lumbar rotational malposition and scoliosis. Results : P-value was 0.436 between 4th lumbar rotational amount and lordotic angle, and was 0.758 between 4th lumbar rotational amount and wedge angle(p>0.05). And p-value was 0.022 between 4th lumbar rotational amount and scoliotic apex rotational amount(p<0.05), but was 0.286 between 4th lumbar rotational amount and Cobb's angle(p>0.05). Conclusions : The results suggest that 4th lumbar rotational malposition was statistically correlation with scoliotic apex rotational malposition, was not Cobb's angle, 4th lumbar lordotic & wedge angle.