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- 저자 : 성유미(Yu-Mi Sung) (검색결과 6 건)
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Tube furnace를 이용한 바이오매스의 스팀 가스화 연구
성연경(Yeon Kyung Sung),최인환(In Hwan Choi),방병열(Byung Ryeul Bang),유미정(Mi Jung Yu),류태우(Tae U Yu),이은도(Uen do Lee) 한국연소학회 2009 KOSCOSYMPOSIUM논문집 Vol.- No.39
In this study, a fundamental study of biomass gasification was conducted in a tube furnace. Syngas compositions and gas yield are monitored as a function of time with different temperature and steam to biomass ratio. Syngas is mainly composed of hydrogen, carbon monoxide and methane. The gasification process can be separated in devolatization and char gasification, and syngas production is highly influenced by the gasification temperature and steam amount. Adding steam enhances the char gasification and hydrogen yield is significantly affected by the steam and gasification temperature.
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상부위장관 출혈이 의심되는 클로자핀과 부스피론의 상호작용
성유미,김수인,연규월,임원정,Sung, Yu-Mi,Kim, Soo-In,Yun, Kyu-Wol,Lim, Weon-Jeong 한국정신신체의학회 2006 정신신체의학 Vol.14 No.1
서론: 치료저항성 환자 치료 시 선택될 수 있는 여러 약물들의 병용 투여에 의해 예측할 수 없는 심각한 부작용을 야기하는 약물 상호작용이 일어날 수 있다. 저자들은 만성 정신분열병 환자에서 클로자핀(clozapine)과 부스피론(buspirone)을 병용 투여한 후 상부위장관 출혈이 의심되는 사례가 있어 보고하고자 한다. 증례: 망상형 정신분열병으로 진단받은 69세 여자 환자로 입원 당시 혈색소가 약간 감소된 것을 제외하고는 신체검사와 검사실 검사 상 다른 특이 소견은 없었다. 불안 증상이 심하여 부스피론 15mg을 올란자핀(olnazapine) 30mg과 같이 투여하였다. 하지만, 병력상 약물에 반응이 좋지 않고 본원 입원 치료에서 치료 반응이 없어 올란자핀을 클로자핀으로 교체하였다 인원 11주째, 클로자핀으로 교체한 지 4주가 지난 후, 환자는 클로자핀 300mg과 부스피론 60mg을 복용하고 있었다. 이 시점에서 약 4일 동안 간헐적으로 복통, 발한, 저혈압, 구토, 발열과 함께 토혈, 흑색변 소견 보였지만, 위내시경과 위장조영촬영에서 상복부위장관 출혈 소견은 발견되지 않았다. 모든 약물을 중단한 후, 상부위장관 출혈 의심 증상은 사라졌다. 이후 클로자핀만 단독으로 투여한 후, 정신병적 증상 호전을 보였고 상부위장관 출혈 소견도 재발하지 않았다. 고찰: 상부위장관 출혈은 클로자핀과 부스피론 각각의 약리학적 작용 및 부작용의 측면에서는 예상할 수 없었던 부작용이었으나, 정신분열병 치료를 위해 투여하고 있던 클로자핀에 추가적으로 항불안 효과가 있는 부스피론을 복합 투여하는 동안 발생하였으며 부스피론을 중단한 이후에는 동일한 부작용이 재발하지 않았다. 따라서, 저자들은 상부위장관 출혈 부작용의 발생 원인을 클로자핀과 부스피론 두 약물의 상호작용에 의한 것으로 보고 참고 문헌에 기초하여 몇 가지 가능한 기전들에 대해 고찰해 보았다. 두 약물의 상호작용에 대한 명백한 기전은 아직 밝혀지지 않았으나 상부위장관 출혈은 잠재적으로 생명에 치명적인 부작용이므로 클로자핀과 부스피론의 병용 투여 시 특별한 주의를 요한다. Introduction: Unexpected serious and lethal drug interactions can be occurred by polypharmacy for treatment-resistant psychiatric disorders. We report a case who has suspected upper gastrointestinal bleeding after the combination of clozapine and buspirone. Case : A 69-year-old woman with DSM-IV schizophrenia who was admitted to our hospital had no previous medical problems. Findings on physical exam, laboratory values, EEG, and a magnetic reso-nance imaging scans were no abnormality, except for slightly low level of hemoglobin at admission. Because of aggravating anxiety symptom, a trial of buspirone was begun from 15mg, in addition to olanzapine 30mg. And then olanzapine was switched to clozapine due to her treatment-refractory his-tory and poor response on this admission. Moreover, At the admission 11 weeks later, after 4 weeks of starting buspirone and clozapine, she was placed on a regimen of clozapine 300mg and buspirone 60mg. At this point, she started to complaint nonspecific abdominal pain for 4 days and then hematemesis, melena and hypotension were developed suddenly with negative findings in gastroduodenoscopy. After stopping all medication, the suspected upper gastrointestinal bleeding was subsided. After the regimen was switched back to clozapine only, psychotic symptoms were improved without the recurrence of the adverse events. Conclusion : We concluded that the upper gastrointestinal bleeding in this case was attributed to the drug interaction with clozapine and buspirone, although the definite mechanism is not clear. The clini-cians should be very cautious to prescribe the combination of clozapine and buspirone due to a possible lethal adverse effect.
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서건휘,유미라,김지윤,성영미,최형진,안송희,정다영,김미나,김민정,이송이,안동진,박찬영,김현희,Suh, Geon-Hwi,Yu, Mi-Ra,Kim, Ji-Yun,Sung, Young-Mi,Choi, Hyoung-Jin,An, Song-Hui,Jeong, Da-Young,Kim, Mi-Na,Kim, Min-Jung,Lee, Song-I,An, Dong-Jin,P 대한물리치료과학회 2012 대한물리치료과학회지 Vol.19 No.3
Purpose : The purpose of present study was to investigate pulmonary function among smokers and non-smokers, and effect on respiratory muscle training in smoker. Methods : Twenty participants were allocated into smokers group(n = 10) and non-smokers group(n = 10). Pulmonary function was measured by spirometry(Pony FX, COSMED Inc., Italy). The smoker group was compared pulmonary function before and after respiratory muscle training. Results : The results were as follows; There was significant difference on PEF, FEV1/FVC%, FEF25~75%, MEF75% and MEF50% among smoker and non-smokers(p<.05). But, there was not significantly difference after intervention in smokers. Conclusion : The present study found that smoker decreased pulmonary function than non-smokers.
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외상성 뇌손상 환자에서 뇌자기공명영상 소견에 따른 정신증상, 신경인지기능 및 삶의 질
김지민,성유미,연규월,김영철,임원정,김수인 大韓神經精神醫學會 2007 신경정신의학 Vol.46 No.3
Objectives : This study was intended to compare psychiatric symptoms, neurocognitive function and quality of life between normal finding group and abnormal finding group on Brain-MRI. We investigated which variables were related to quality of life (QOL) in traumatic brain injury (TBI) patients. Methods : Among thirty nine patients who had mild to moderate TBI, twenty two patients (57%) showed abnormal brain MRI findings correlated with their injury and 17 patients (43%) showed normal or nonspecific brain MRI findings. All patientscompleted Symptom check list-90-revised (SCL-90-R), Beck depression inventory (BDI), State-trait anxiety inventory (STAI), Korean version of the Smith Kline Beecham Quality ofLife scale (KvSBQOL) and Marlowe-Crown Social Desirability Scale (MCSDS). Two psychiatrists assessed the patients using Hamilton rating scale for depression (HAMD), Hamilton anxiety scale (HAMA) and functional assessment scale (FAS). In addition, K-orean Wechsler Adult intelligence Scale (K-WAIS), Rey-Kim Memory Test (R-KMT) and Kims frontal-executive neuropsychological test (KF-ENT) were assessed. Results : On FAS, the mean score was significantly lower in the abnormal finding on B-MRI group than the normal finding group (p=0.014). In the patients with abnormal MRI findings, the QOL scores significantly correlated with several subscales of SCL-90-R (obsessive-compulsive, depression, anxiety, global severity index and positive symptom total), FAS and memory quotient after controlling for MCSDS. However, in the patients with normal MRI findings, QOL scores significantly correlated with BDI and all subscales of SCL-90-R. When all pertinent variables were entered in stepwise regression analysis, depression (p<0.05) and interpersonal sensitivity (p<0.05) subscales of SCL-90-R explained 38.5% and 17.7% of the variance of the QOL score in patients with abnormal MRI findings. As for the patients with normal MRI findings, depression (p<0.05) subscale of SCL-90-R accounted for 54.2% of the variance of the QOL score. Conclusion : TBI patients who have persisting abnormal brain findings suffered from impaired daily functioning. Depression and interpersonal sensitivity explained 55% of the variance of the QOL together, In the patients with normal brain MRI findings, objective depression or anxiety did not correlate with QOL whereas subjective depressive symptom accounted for 54.2% of the variance of the QOL. This study suggests that subjective psychiatric symptoms including depression significantly correlated with the subjective QOL of TBI patients regardless of their brain MRI finding.
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