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성원준 ( Won Joon Seong ),오정은 ( Jeong Eun Oh ),이윤희 ( Yoon Hee Lee ),홍대기 ( Dae Gy Hong ),이택후 ( Taek Hoo Lee ),이윤순 ( Yoon Soon Lee ),박일수 ( Il Soo Park ) 대한산부인과학회 2009 Obstetrics & Gynecology Science Vol.52 No.7
목적: 본 연구는 IgA 신병증이 병합된 임신에서 산모와 태아의 예후를 알아보고, 임신의 합병증과 관련된 예후인자를 찾기 위함이다. 연구 방법: 1997년에서 2006년 사이에 본원에서 조직검사상 IgA 신병증으로 진단받은 여성 가운데 14명의 산모에서 발생한 20예의 임신을 대상으로 하였다. 이 중 분만한 17예의 산모를 대상으로 내과, 산부인과 및 신생아 의무기록과 검사 소견을 후향적으로 조사하여 통계 분석하였다. 결과: 20예의 임신 중 자연유산이 3예이었고 17예에서 생존아를 분만하였다. 47%에서 중증 자간전증, 53%에서 저출생체중아가 발생하였고, 59%에서 37주 이전에 조산하였다. 그러나 조산의 대부분은 34주 이후에 발생하였고 신생아는 모두 생존하였다. 임신 전에 비하여 분만 후에 혈압의 유의한 상승이 관찰되었다. 결론: IgA 신병증 환자에서 임신은 금기는 아니지만 자간전증, 조산 및 저출생체중아의 빈도가 증가하므로 고위험 임신에 준한 면밀한 산전관리가 요구된다. Objective: We performed this study to evaluate maternal and fetal outcomes of pregnancies with IgA nephropathy. Methods: We reviewed 20 pregnancies occurred in 14 women who were diagnosed as IgA nephropathy with the method of renal biopsy between 1997 and 2006. We used clinical and laboratory data from medical records and statistic analysis using SPSS 15.0. Results: Of 20 prenancies, there were 17 live births and 3 spontaneous abortions. There was no stillbirth and congenital anomaly. We found severe preeclampsia in 47%, low birth weight in 53% and preterm birth (comprising medical indications) in 59%. But most were late preterm birth and all were alive. Blood pressure was elevated after delivery compared with pre-pregnancy. Conclusion: Although pregnancy is not contraindicated in IgA nephropathy, it is associated with significant complications comprising preeclampsia, preterm birth and low birth weight.
차현화 ( Hyun Hwa Cha ),성원준 ( Won Joon Seong ) 대한주산의학회 2015 Perinatology Vol.26 No.1
본 증례에서는 수술적 처치 없이 자발적으로 복원된 자궁내번증의 증례에 대해 보고한다. 이 증례는 처음에는 자궁내번증이 아닌 자궁무력증으로 진단되어 자궁동맥색전술로 성공적으로 처치되었다. 그러나 경과 관찰 중 시행한 골반 진찰에서 부분 자궁내번증이 발견되었다. 다행히 분만 8주 후 자궁내번증은 자발적으로 복원되었다. We report a case of unrecognized uterine inversion that restored spontaneously without surgical intervention. Initially, the case was diagnosed as uterine atony and not uterine inversion and was managed successfully with uterine artery embolization. However, a partial uterine inversion was detected on a subsequent scheduled pelvic examination. Fortunately, her uterus was completely restored without any surgical intervention on eighth week after delivery.
차현화 ( Hyun-hwa Cha ),성원준 ( Won Joon Seong ) 한국모자보건학회 2021 한국모자보건학회지 Vol.25 No.1
With the continued fight against coronavirus disease 2019 (COVID-19), new guidelines on its management are emerging; however, information on COVID-19 and pregnancy remains limited. Therefore, this study aimed to review the guidelines of the American College of Obstetricians and Gynecologists, Society for Maternal Fetal Medicine, and Royal College Obstetrics and Gynecology and International Society of Ultrasound in Obstetrics and Gynecology.
조산통 혹은 조기양막파수 산모와 임신 중반기 무증상 산모에서 Ureaplasma urealyticum과 Mycoplasma hominis의 검출율
김미주 ( Mi Ju Kim ),최민혜 ( Min Hye Choi ),성원준 ( Won Joon Seong ),구태본 ( Tae Bon Koo ),박일수 ( Il Soo Park ) 대한주산의학회 2008 Perinatology Vol.19 No.4
목적: 본 연구의 목적은 조산 혹은 조기양막파수 산모와 임신 중반기 무증상 산모에서 Ureaplasma urealyticum과 Mycoplasma hominis의 검출률을 알아보고자 하였다. 방법: 2002년 2월부터 2002년 7월까지 조기 진통이나 조기 양막 파수가 있었던 산모(1군) 43명, 임신 18~24주의 무증상 산모(2군) 47명, 그리고 만삭의 산모(3군) 64명으로 총 154명의 산모를 대상으로 본 연구를 진행하였다. 환자들은 입원 당시 혹은 외래에서 자궁경부 swab (Dacron(R))을 시행하여, Ureaplasma urealyticum과 Mycoplasma hominis의 감염 여부를 MYCOFASTR(R) Evolution 2 (International Microbio Signes, France)의 지침에 따라 시행한 후 판정하였다. 결과: 무증상 임신 중기인 2군과 만삭분만 한 3군간에 자궁경부 swab 결과는 큰 차이가 없었다. 조산의 임박군인 1군 내에서 임신 주수에 따른 Ureaplasma urealyticum의 검출률은 임신 주수가 32주 이상인 군(15/20,75%)에서 32주 미만인 군(10/23, 43.4%)보다 유의하게 높았다(p<0.05). 무증상군인 2군에서 임신 중기 Ureaplasma urealyticum과 Mycoplasma hominis 노출군과 비노출군간에 조산률의 의미 있는 차이는 보이지 않았다. 결론: Ureaplasma urealyticum과 Mycoplasma hominis는 조산의 원인이라기 보다는 분만에 가까워지면서 검진율이 증가하므로 자연적인 경관의 숙화에 따른 숙주 방어력의 소실을 비롯한 다른 원인에 대하여 더 연구하여야 하겠다. Purpose: The purpose of this study was to examine the risk of preterm birth in pregnant women with Ureaplasma urealyticum and/or Mycoplasma hominis infection and the prevalence of these organisms in normal pregnancy. Methods: Between February 2002 and July 2002, we included 43 pregnant women prior to 37 weeks of gestation with definite gross leakage of amniotic fluid (n=16) (group 1), 47 healthy women without any obstetric problems between 18 and 24 weeks of gestation (group 2) and 64 women who delivered fullterm fetuses who had taken cervical swabs around 36 weeks gestation (group 3). Cervical swabs (Dacron(R)) were taken on admission in group 1 and at outpatients in group 2 and 3. Detections of U. urealyticum and M. hominis were done using commercial kits (MYCOFAST(R)Evolution 2, International Microbio Signes, France). Results: There was no significant difference between mid-gestation (group 2) and fullterm (group 3) in cervical swab result. In group 1, the detection rate of Ureaplasma uealyticum was higher in impending preterm birth over 32 weeks of gestational age (15/20, 75%) than 32 weeks or less (10/23, 43.4%) (p<0.05). In group 2, there was no significant difference in preterm birth rate between the exposed and the non-exposed to U. urealyticum and/or M. hominis in middle of 2nd trimester. Conclusion: U. urealyticum does not seem to be a predictor of preterm birth, and there seems to be some different mechanism according to gestational age. We couldn`t varify that M. Hominis and U. urealyticum were related to preterm birth, although U. urealyticum was highly detected in impending preterm birth.
손미영 ( Mi Yeung Sohn ),서지민 ( Ji Min Seo ),조현정 ( Hyun Jung Cho ),서장수 ( Jang Soo Suh ),성원준 ( Won Joon Seong ),박일수 ( Il Soo Park ),( Anthony Atala ),유지 ( James J Yoo ),손윤희 ( Yun Hee Shon ) 한국조직공학·재생의학회 2012 조직공학과 재생의학 Vol.9 No.1s
Human stem cells are typically obtained for clinical application of cell therapy by isolating and subculturing adherent cells. The expansion of stem cells depends on the culture conditions and requires medium supplemented with fetal bovine serum (FBS) to generate relevant numbers of cells. However, the presence of FBS is a major obstacle for clinical use of the stem cells. Therefore, we have evaluated the capacity of expansion of amniotic fluid-derived stem cells (AFSCs) in a commercial serum-free medium in comparison with a conventional FBS-containing medium. AFSCs were expanded in two different culture media. Proliferation rate of the cells was higher in serum-free medium than in FBS-containing medium. Stem cells isolated in the both media were morphologically similar, and they were expressed identical surface antigens and mRNA of stem cell markers. AFSCs in the both media were also able to differentiate into the myogenic cells. These results suggest that a commercial serum-free medium (MesemCult-XF Medium) is an optimal medium for expansion of AFSCs. It allows a better cell expansion, preserves cell characteristics, and reduces the culture period. This medium seems suitable for clinical scale expansion of AFSCs.