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주간과다졸림이 동반된 불면증의 임상적, 수면다원검사 관점에서의 탐색
성민재,김재림,최수정,주은연 대한수면연구학회 2022 Journal of sleep medicine Vol.19 No.2
Objectives: Insomnia is a disorder that involves poor sleep quality at nighttime and various symptoms in the daytime. Although it is known to increase cardiovascular risk as well as psychiatric comorbidities such as depression and anxiety, less attention has been paid to daytime sleepiness in patients with insomnia. This study aimed to investigate clinical and polysomnographic characteristics and identify factors influencing excessive daytime sleepiness in patients with insomnia.Methods: Between 2014 and 2022, 1,241 patients with insomnia as the primary symptom who underwent polysomnography were included in the study. Patients with an Epworth sleepiness scale ≥10 were classified as having insomnia accompanied by daytime sleepiness, and sleep-related questionnaire responses and polysomnography findings were utilized for analysis.Results: A total of 327 patients (26.3%) had daytime sleepiness, and a higher prevalence was observed in younger and male individuals. Poor sleep quality, severe depression, and insomnia were identified through the questionnaire. Polysomnography showed longer total sleep times, a higher proportion of stage N3 sleep, and higher sleep efficiency. The variables related to the Epworth sleepiness scale identified in multiple regression analysis were age, the Korean Beck Depression Inventory-II, sleep latency, and the apnea-hypopnea index on polysomnography.Conclusions: Insomnia with excessive daytime sleepiness was more affected by depression than indicated by polysomnography findings. The pathophysiology is presumed to be related to sleep misperception, and further studies are needed to elucidate the discrepancy between excessive daytime sleepiness and polysomnography findings.
1P-123 Donor-Donor Copolymer for Narrow Band Green-Selective Organic Photodiode
성민재,김경환,김윤희,정대성,권순기 한국공업화학회 2017 한국공업화학회 연구논문 초록집 Vol.2017 No.1
A new donor-donor copolymer was synthesized for narrow band green-selective organic photodiode application. Thanks to well-defined intramolecular conjugation and inhibited intermolecular interaction of new polymer compared to its donor-acceptor type analogues, new polymer revealed narrow band green-selective absorption peak at 510 nm with low full width at half-maximum value of 98 nm. In addition, deep ionization energy of new polymer, as confirmed by photophysical analyses, made it less susceptible to oxidational degradation. Green-selective organic photodiodes (OPDs) were fabricated utilizing new polymer as a green absorbing donor material and ZnO as a nonabsorbing acceptor material
성민재,윤희준,박광훈,김란,조장환,정대성,김윤희 한국공업화학회 2015 한국공업화학회 연구논문 초록집 Vol.2015 No.1
Random copolymerization strategy is introduced to increase the solubility of donor-acceptor copolymers so that they can be processed with environmentally benign, halogen-free solvents. Traditionally, it has been believed that the random copolymer with a lower crystalline order should have a significantly lower charge carrier mobility. This report shows that random copolymerization between two highly planar, chargedelocalized repeating units can significantly enhance the solubility while almost preserving the high charge carrier mobility. A comparative study was conducted for a series of random copolymers consisting of diketopyrrolopyrrole-thienothiophene (DPP-TT) and DPP-selenophene-vinylene-selenophene (DPP-SVS) with composition ratios of 10:0, 9:1, 7:3, 5:5, 3:7, 1:9, and 0:10 by using the crystalline order determined from grazing-incident X-ray diffraction measurements and charge carrier mobility determined from field effect transistor measurements. The results showed that the copolymer tends to have a lower degree of intermolecular ordering as the DPP-TT:DPP-SVS composition ratio approaches 5:5 because of the increased segmental randomness in the polymer chain. Nevertheless, the FET mobility did not follow the tendency of crystalline order; instead, it simply followed the order of increasing content of DPP-SVS in the copolymer. This result implies that we can use the random copolymerization strategy to increase the solubility of donor-acceptor copolymers if the two constituent repeating units are structurally planar and the electrons are fully delocalized.
기면병 환자에서 다중수면잠복기검사의 검사-재검사 신뢰도 검증
성민재,최수정,홍승봉,주은연 대한수면연구학회 2020 Journal of sleep medicine Vol.17 No.2
Objectives: The diagnosis of hypersomnia may be changed by the repeated multiple sleep latency test (MSLT). We investigated the long-term reliability of MSLT in the diagnosis of narcolepsy type 1(NT1) and 2 (NT2). Methods: We reviewed the data of patients with NT1 and NT2 who underwent MSLT at least twice between 2008 and 2020. The clinical information and polysomnography/MSLT data were thoroughly assessed, and two sleep experts evaluated the consistency and reliability of diagnosis independently. Results: Eighty patients (38 with NT1 and 42 with NT2 as a final diagnosis) were included in this study. Of the 80 patients, 20 (nine with NT1 and 11 with NT2) underwent the 3rd MSLT. No significant differences were found in the sleep data and Epworth Sleepiness Scale at baseline. During the 2nd MSLT, 18.4% (n=7) patients with NT1 and 47.6% (n=20) patients with NT2 did not satisfy the diagnosis of narcolepsy. At the 3rd MSLT, six out of nine patients with NT1 and seven of 11 patients with NT2 were not suitable for narcolepsy. Two of the initial NT1 (5.2%) and 10 of the initial NT2 (23.8%) patients were found to be normal. Three patients who were confirmed to have NT1 through consecutive MSLTs had significantly shorter sleep latency and more number of sleep-onset rapid eye movements than the other patients. Conclusions: The reliability of MSLT were not robust in the diagnosis of NT1 and NT2 in this long-term follow-up study. The MSLT results should be interpreted with careful consideration based on elaborate preparations.