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설혜실,고형석,박인애 대한병리학회 2008 Journal of Pathology and Translational Medicine Vol.42 No.6
Background : Triple-negative breast carcinomas (TNBCs) are associated with high-grade histological tumor and a poor clinical outcome. In this study, we evaluated the histology and immunohistochemical features of DCIS co-existing with TNBC to determine the characteristics of the precursor lesions of TNBC. Methods : Among the 1,610 cases of breast carcinoma, we selected the TNBCs with DCIS (n=196), and compared the pathological and immunohistochemical findings of the DCIS with those of the invasive carcinoma areas. Results : Among the 1,610 breast carcinomas, the TNBCs accounted for 330 cases (20.5%) and there were 196 cases with DCIS. The TN-DCIS cases exhibited high nuclear (94.5%) and histological (94.5%) grades, comedo-necrosis (68.9%) and a small extent of the DCIS-involved area. Immunohistochemically, a p53 expression was present in 48.4% of the TN-DCIS cases and a high Ki-67 index was present in 31.5%. The same TN immunohistochemical profiles as the carcinoma were detected in 109 of the 124 (87.9%) cases, but different profiles were observed in 15 of the 124 (12.1%) cases. The 15 discordant cases were associated with a low histological grade (p=0.037), low p53-positivity (p=0.006) and a low Ki-67 index (p=0.026), as compared to the invasive carcinomas. Conclusions : The results of this study suggest that TN DCIS is a highly probable, but not obligate, precursor lesion of TNBC.
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설혜심(Sul, Hea-sim) 역사학회 2011 역사학보 Vol.0 No.211
In 2009, the author of “Retrospects and Prospects of British History in Korea” declared that there was a huge leap forward in the studies of British History in Korea. Quantitatively and qualitatively, the tendency was maintained for last 2 years: 90 articles and 9 books were published, demonstrating various new subjects and new disciplines. The most visible changes appeared in British History was the influence of transnational perspectives and post-colonialism. In the midst of globalization, the geographical boundaries of studies were expanded, the concept of network and relationship was emphasized, and such subjects as bilateral power, contingency, and immigration/race were actively introduced. Meanwhile, there is also a strong tendency, in the studies of British History, to maintain traditional methods and major subjects: a considerable number of works were published in the ares of political history, social history, intellectual history and the history of thoughts. The very existence of tradition which allows innovation is the most distinctive characteristics British History possesses. The current feature of British History in Korea testifies the existence of an exquisite balance between tradition and innovation. It is, however, extremely difficult to predict the drift of Korea British History. Rather, it will be soon obvious that its fate trembles in balance. The lack of young scholars and disproportional concentration on modern period are urgent problems British History in Korea has to deal with. The future of Korean British History will depend on its capacity of solving these problems.
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월경(越境)의 경험 -메리 워틀리 몬태규(Mary Wortley Montagu)의 여행과 정체성-
설혜심 ( Hea Sim Sul ) 영국사학회 2012 영국연구 Vol.27 No.-
Lady Mary Wortley Montagu (1689-1762) was an extraordinary figure in 18th century England. Born into a true family of aristocrats, she wrote sensational poem and essays, travelled to Turkey as wife to the British ambassador, introduced Ottoman practice of inoculation against smallpox, and later voluntarily exiled for 22 years to the Continent. Her celebrated letter was filled with energy, sophistication and intelligence. 18th century literary critics have scrutinized Montagu`s Turkish Embassy Letters, mostly with the perspectives of Feminism and Orientalism. This article, however, examines not only the Turkish Embassy Letters but also her lifelong correspondence, analyzing Montagu`s own definition of travel. Travel worked like a rite of passage for Montagu and she developed a new identity with the experience of travel--English aristocrat woman abroad. She eventually accepted the new role, hosting a variety of people from her homeland. But she constantly distinguished herself from such other travellers like Grand Tourist. She despised those travellers who had to follow the systemized program or fulfill the purpose of journey. In vogue of secular writings in 18th century literary market, the most popular genre of all was travelogue, Growing interest in the external world and the competition between travel literature brought about a problem of authentication, Montagu was conscious of other travel writers, and tried to secure the authenticity of her own experience and record. Montagu was the first European woman to witness the private lives of Islamic women, such as harem and public bath. With this gender agency, her stratum privilege, intelligence and prolonged sojourn enabled Montagu to claim her travel as a distinctive, superior one. Cultural dislocation fostered a productive relativism for Montagu and consequently allowed her to constitute a new subjectivity. Montagu enjoyed and was proud of her freedom of wondering which did not require a definite objective or destination. Scholars argue that travel became an expression of freedom and an escape from necessity and purpose only in modern times. Montagu, however, is one exceptional example who incarnated herself as a modern traveler in the age of Grand Tour.
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