Cholesterol ester transfer protein gene is associated with high-density lipoprotein cholesterol levels in Korean population

설재웅,이종은,이명숙,지선하 한국유전학회 2012 Genes & Genomics Vol.34 No.2

High-density lipoprotein (HDL) cholesterol levels are associated with decreased risk of coronary artery disease. Several genome-wide association studies (GWAS) for HDL cholesterol levels have implicated cholesterol ester transfer protein (CETP)as possibly causal. We tested for the association between single nucleotide polymorphisms (SNPs) in CETP gene and HDL cholesterol levels in Korean population. A total of 979 subjects in Seoul City were genotyped using a genome-wide marker panel for a discovery study. Another 2,277 subjects in Bundang-Gu in Korea were used for a replication study with selected markers. In the discovery phase, the top SNP associated with mean HDL cholesterol levels was rs6499861 in the CETP gene on chromosome 16 (p=1.18×10-6 in the Seoul City sample, p=8.91×10-3 in the Bundang-Gu sample). Another SNP (rs6499863) in the CETP gene was also among the top five SNPs associated with HDL cholesterol levels (p=3.83×10-5 in the Seoul City sample, p=3.29×10-3 in the Bundang-Gu sample). SNP rs1800775 was also associated with HDL cholesterol levels (p=4.86×10-4 in meta-analysis results of 3256 samples). This study clearly demonstrates that genetic variants in CETP influence HDL cholesterol levels in Korean adults.

건강보험공단 청소년 흡연예방교육의 현황과 문제점

설재웅,이상욱,손태용,오희철 한국보건행정학회 2002 보건행정학회지 Vol.12 No.4

The objectives of this study were to look into the present conditions and problems of smoking prevention programs for young people carried out by the Korean health insurance corporation(KHIC) and to provide the basic data for the governmental policy. In order to examine the actual achievements of existing smoking cessation programs, a survey was conducted over 235 KHIC branches. The person responsible for the cessation program from each branch responded to questionnaire sent by mail with regard to smoking cessation programs. The survey shows the shortage of responsible persons. educational subjects were mainly elementary, middle school and high school students. The main educational method was to watch the video of which the content is the knowledge of smoking. but most of these videos were made for adults. Therefore, these videos are not appropriate for the children. 37% of these branches estimated the effectiveness of their program. On the basis of the survey data and analysis of current situations, the following actions are recommended in order to develop a more effective cessation program; first, the establishment of the effective administrative plan, second, the supplementation of the educator and the responsible person, third, the development of text books and videos which are appropriate for the children.

The ABCG2 Polymorphism rs2725220 Is Associated with Hyperuricemia in the Korean Population

설재웅,지선하,양성주,김소리울 한국유전체학회 2014 Genomics & informatics Vol.12 No.4

Elevated serum uric acid levels are associated with a variety of adverse health outcomes, including gout, hypertension,diabetes mellitus, metabolic syndrome, and cardiovascular diseases. Several genome-wide association studies on uric acidlevels have implicated the ATP-binding cassette, subfamily G, member 2 (ABCG2) gene as being possibly causal. Weinvestigated an association between the single-nucleotide polymorphism (SNP) rs2725220 in the ABCG2 gene and uric acidlevels in the Korean population. A total of 991 subjects in Seoul City were used for a replication study with ABCG2 SNPrs2725220. The rs2725220 SNP in the ABCG2 gene was associated with mean uric acid levels (effect per allele 0.25 mg/dL, p < 0.0001). Subjects with the GC/CC genotype had a 1.78-fold (range, 1.22- to 2.62-fold) higher risk of having abnormal uricacid levels (≥7.0 mg/dL) than subjects with the GG genotype. When analyzed by gender, the association with ABCG2 wasstronger in men than in women. The association with ABCG2 was much stronger in male subjects with body mass index (BMI) ≥ 26.4 (odds ratio, 5.09; 95% confidence interval, 2.41 to 10.8) than in male subjects with BMI < 26.4. This study clearlydemonstrates that genetic variations in ABCG2 influence uric acid levels in Korean adults.

농약사용과 암발생과의 관계

설재웅,이상욱,손태용,지선하,남정모,오희철,Sull, Jae-Woong,Yi, Sang-Wook,Sohn, Tae-Yong,Jee, Sun-Ha,Nam, Chung-Mo,Ohrr, Hee-Chul 대한예방의학회 2002 예방의학회지 Vol.35 No.1

Objective : Few studies have examined the relationship between the risk of cancer and exposure to pesticides in Korea or in other East Asian that have until recently used chlorophenoxy herbicides. The aim of this study was to evaluate the relationship between the exposure to pesticides and cancer incidence. Methods : We conducted a prospective cohort study with a follow-up period of 13 years (1985-1998). The subjects included 2,687 male and 3,589 female Kangwha Island residents, Koreans aged fifty-five or more as of March 1985, who received a personal health interview and completed a health examination survey. A Cox proportional hazards models were used to estimate relative risks(RR). Results : At baseline, the mean age of the study participants in 1985 was 66.4 for males and 67.1 for females. During the 13 years follow-up, a total of 300 incidents of cancer in males and 140 in females developed. In males, the total cancer incidence in the highest group was RR, 1.4 (95%. CI=1.0-1.9), p for trend=0.041, for digestive organ cancer Incidence in the highest group, RR, 1.5 (95% CI=1.0-2.3), p for trend=0.057, for stomach cancer, incidence in the highest group, RR, 1.6 (95% CI=0.9-2.8), p for trend=0.094, for gallbladder cancer incidence in the highest group, RR, 9.1 (95% CI=1.1-77.0), p for trend=0.014 were elevated according to the higher frequency of pesticide use per year. In particular, the risk of gallbladder cancer was very high. Although not significant, the risk of liver cancer was higher than in the non-exposed group (in the highest group, RR, 2.0(95% CI=0.7-5.9)). In females, although not significant, breast cancer incidence in the highest exposure group was higher than in the non-exposed group (in the highest group, RR, 4.7 (95% CI=0.5-27.9)). Conclusions : This study demonstrates that Korean farmers who use pesticides, particularly males, have a significantly higher total cancer incidence, particularly from digestive organ cancers such as, stomach, gallbladder, and liver cancer. In particular, the risk of gallbladder cancer was very high.

Glutathione S-Transferase M1 Status and Breast Cancer Risk: A Meta-Analysis

설재웅,오희철,강대룡,남정모 연세대학교의과대학 2004 Yonsei medical journal Vol.45 No.4

It is not yet clear whether Glutathione S-transferase M1 (GSTM1) polymorphisms affect the risk of breast cancer. The aim of this study is to provide a comprehensive meta-analysis of all the available, published case-control studies on the extent of the possible association between GSTM1 polymorphisms and susceptibility to breast cancer. Twenty case-control studies on GSTM1 and breast cancer were identified using both PUBMED and a manual search. Meta-analysis was conducted by the Peto method. Subgroup analyses were undertaken, in order to explore the relationship between effect sizes and the study characteristics. The overall odds ratio (OR) was found to be 1.06 (95% CI, 0.99-1.14). The OR for post-menopausal women with GSTM1 deficiency was determined to be 1.19 (95% CI, 1.05-1.34). In populations with a low frequency of GSTM1 deficiency, a greater increase was observed (OR, 1.20; 95% CI, 1.08-1.34). Furthermore, the highest associations were found in post-menopausal women with a low frequency of GSTM1 deficiency (OR, 1.44; 95% CI, 1.20-1.73). The fact that GSTM1 deficiency is not rare in the general population implies that the attributable risk for breast cancer could be sizable. Further studies focusing on the structure of haplotype blocks of GSTM1 are required in order to find a specific haplotype with a predisposing breast cancer susceptibility allele.

제1회 한·일 전기기술교류회의 참관기

설재웅,Seol, Jae-Ung 대한전기협회 2006 전기저널 Vol.359 No.-

Effects of Obesity and Family History of Diabetes on the Association of CETP rs6499861 with HDL-C Level in Korean Populations

설재웅,김소리울,지선하 한국지질동맥경화학회 2019 지질·동맥경화학회지 Vol.8 No.2

Objectives: The aim of this study was to examine the associations of cholesterol ester transfer protein (CETP) rs6499861 and rs12708980 with high-density lipoprotein cholesterol (HDL-C) considering obesity and family history of diabetes (FHD) in Korean men and women. Methods: We analyzed the association of CETP single nucleotide polymorphisms (SNPs) with HDL-C among individuals selected from a hospital (n=4 294) and the Bundang-gu area in Korea (n=2 304). Results: We found that the CETP SNP rs6499861 was associated with a lower HDL-C level (effect per allele: −2.044 mg/dL, p<0.0001). Individuals with a rs6499861 CG/GG genotype had a 1.45-fold higher risk of an abnormal level of HDL-C (<40 mg/dL) than those with a CC genotype. This genotype-HDL-C association was stronger in women (odds ratio [OR], 1.99; 95% confidence interval [CI], 1.39–2.85) compared with men (OR, 1.33; 95% CI, 1.10–1.61) and in women with a FHD (OR, 4.82; 95% CI, 1.86–12.5; p=0.0012) compared with women without a family history. Relative to individuals with a CC genotype and body mass index (BMI) <25.69 kg/m2, individuals with a CG/GG genotype and BMI ≥25.69 kg/m2 had an OR (95% CI) of 2.61 (1.97–3.47). Conclusions: These findings indicate that CETP variants are linked to HDL-C level in Koreans and that this link is stronger in obese men and in women who have a FHD.

증분컨덕턴스 MPPT제어 기반 계통연계형 태양광발전시스템의 전력품질 평가

薛在雄(Jae-Woong Seol),章在正(Jae-Jung Jang),金東珉(Dong-Min Kim),李丞爀(Seung-Hyuk Lee),金鎭吾(Jin-O Kim) 대한전기학회 2007 전기학회논문지 Vol.56 No.1

During the last years, there has been an increased interest in the new energy such as photovoltaic(PV) system from the viewpoint of environmental pollution. In this regard, this paper estimates the power quality of grid-connected PV system. As the maximum power operating point(MPOP) of photovoltaic(PV) power systems alters with changing atmospheric conditions, the efficiency of maximum power point tracking(MPPT) is important in PV power systems. Moreover, grid-connected PV system occurs some problems such as voltage inequality and harmonics. Therefore, this paper presents the results of a grid-connected PV system modeling that contains incremental conductance MPPT controller by PSCAD/EMTDC simulator and investigates the influence that can occur in the grid-connected PV system from aspect of power quality, i.e. voltage drop, total harmonic distortion (THD) and total demand distortion(TDD). For the case study, the measured data of the PV array in Cheongwadae, Seoul, Korea is used.

계통연계형 태양광발전시스템의 PSCAD/EMTDC 모델링 및 전력품질 평가 (pp.2193-2194)

설재웅(Jae-Woong Seol),장재정(Jae-jung Jang),김진오(Jin-O Kim) 대한전기학회 2006 대한전기학회 학술대회 논문집 Vol.2006 No.7

This paper presents the results of a grid-connected photovoltaic (PV) system modeling that contain incremental conductance MPPT(Maximum Power Point Tracking) controller by PSCAD/EMTDC simulator and investigates the influence that can occur in the grid-connected PV system from aspect of power quality, i.e. voltage drop, total harmonic distortion(THD) and total demand distortion(TDD). The measured data the PV array modeling of PSCAD/EMTDC in Cheongwadae, Seoul, Korea is used in the paper.

가족기반 코호트 연구의 사례와 전망

설재웅(Jae Woong Sull),박수경(Sue Kyung Park),오희철(Heechoul Ohrr),지선하(Sun Ha Jee) 한국역학회 2008 Epidemiology and Health Vol.30 No.1

  가족기반 코호트 연구를 하는 것은 단면연구나 일반인을 대상으로 하는 코호트 연구에 비하여 비용과 시간이 많이 걸리는 단점이 있으나 만성질환의 환경요인과 유전요인을 동시에 연구함에 있어서 많은 장점을 가지므로 연구계획 시 고려할 가치가 있겠다. 그 주된 장점으로는 population structure의 영향을 적게 받는 다는 것, Imprinting의 효과를 볼 수 있다는 것과 연관성(association) 분석 이외에 linkage 분석도 동시에 할 수 있다는 것이다. 따라서 실제로 미국의 프램험 연구와 유럽의 IMAGE project 등에서 가족기반 코호트 연구를 활발히 진행 중이며 genome-wide association 연구를 포함한 성공적인 여러 관련 결과들을 발표하고 있다.   가족 기반 코호트에서 주로 사용되는 연구방법은 linkage 분석과 TDT 분석, 그리고 imprinting effect 분석이다. 이와 관련된 내용은 본 연구에서 간단히 기술하였다. 최근 가족기반 코호트 연구의 방향은 다른 환자-대조군 연구나 일반인구 코호트 유전 연구와 마찬가지로 genome-wide association 연구를 하는 것이다. 미국과 영국을 포함한 여러 나라에서 경쟁적으로 가족기반코호트를 이용한 genome-wide association 연구를 진행하고 있으나 생활습관요인과 유전요인이 상이한 자국민에 대한 연구는 필수적이다. 또한 genome-wide association 연구를 통한 genome-wide imprinting 연구는 국제적으로 초기단계라 할 수 있다. 따라서 국내에서도 국가적인 지원 하에 가족기반 코호트 연구를 시작한다면 국제적으로 경쟁력 있는 연구를 하는 것이 가능하겠다.   Family-based designs are commonly used in genetic association studies to identify and to locate genes that underlie complex diseases. In this paper, we review two examples of genome-wide association studies using family-based cohort studies, including the Framingham Heart Study and International Multi-Center ADHD Genetics Project. We also review statistical methods of family-based designs, including the transmission disequilibrium test (TOT), linkage analysis, and imprinting effect analysis.   In addition, we evaluate the strengths and limitations of the family-based cohort design. Despite the costs and difficulties in carrying out this type of study, a family-based cohort study can play avery important role in genome wide studies. First, the design will be free from biases clue to population heterogeneity or stratification. Moreover, family-based designs provide the opportunity to conduct joint tests of linkage and association. Finally, family-based designs also allow access to epigenetic phenomena like imprinting. The family-based cohort design should be given careful consideration in planning new studies for genome-wide strategies.