문제적 과잉 성 행동자의 휴지기 상태 시 집행 통제 회로의 기능적 연결성 변화

석지우 한국감성과학회 2019 감성과학 Vol.22 No.1

Individuals with Problematic hypersexual behavior (PHB) has shown the in the inability to control sexual impulses and arousal. The previous studies identified these characteristics are related to the structural and functional changes of the brain region responsible for inhibitory functions. However, very little research has been done on functional connectivities among the brain areas during the resting state in Individuals with Problematic hypersexual behavior. Therefore, the purpose of this study is to identify the deficit of the functional connectivity in the executive control network during resting state using functional magnetic resonance imaging devices among Individuals with Problematic hypersexual behavior. For this study, magnetic resonance imaging data were obtained for 16 individuals with PHB and 19 normal controls with similar demographic characteristics. The areas related to the executive control network (LECN, RECN) were selected as the region of interest, and the correlation coefficient with time series signals between these areas was measured to identify the functional connectivity, and between groups analysis was used. The results showed a significant difference in the functional connectivity strength of executive control network between two groups. In other words, there are the decreased functional connectivities between superior/middle frontal gyrus and caudate, and between superior/middle frontal gyrus and superior parietal gyrus/angular gyrus in the individuals with PHB. In addition, these functional connectivities were related to the severity of hypersexual behavior. The results of this study suggest that the inability to control sexual impulses and arousal in individuals with PHB might be related to the reduced functional connectivity of executive control circuits. 문제적 과잉 성 행동은 성 충동과 각성을 통제하지 못하는 것과 관련이 있으며, 억제 기능을 담당하는 뇌 영역의 구조적, 기능적 변화와 관련이 있음이 밝혀졌다. 그러나 아직까지 문제적 과잉 성 행동의 휴지기 상태 시 뇌의 기능적 연결성에 관한 연구는 거의 없다. 따라서 본 연구에서는 자기공명영상장치를 사용하여 휴지기 상태 시 문제적 과잉 성 행동자의 집행 통제 회로(RECN, LECN)의 기능적 연결성의 결함을 규명하고자 하였다. 이를 위해 17명의 문제적 과잉 성 행동자와 인구통계학적 특성이 유사한 20명의 정상대조군을 대상으로 휴지기 상태 시 자기공명영상데이터가 획득하였다. 실행기능 제어 회로(LECN, RECN)와 관련된 영역을 관심 뇌 영역으로 선정하였으며, 이들 영역간 시계열 신호와의 상관계수를 기능 연결성 정도로 가정하고 집단 간 비교 검증을 하였다. 그 결과, 정상대조군과 문제적 과잉 성행동군의 집행 통제회로의 기능적 연결 강도에 유의한 차이가 나타났다. 즉, 정상대조군에 비해 문제적 과잉 성행동군은 상/중전두회와 미상핵, 상/중전두회와 두정회의 기능적 연결성이 저하된 것으로 나타났다. 또한, 이 영역간 기능적 연결강도는 과잉 성 행동 지수와 부적상관이 있는 것으로 나타났다. 본 연구 결과는 문제적 과잉 성행동자들이 성 충동과 각성을 제어하지 못하는 것이 집행 통제회로의 기능적 연결성 저하와 관련이 있음을 시사한다.

성 중독자의 억제기능 뇌 기전 연구

석지우,손진훈 한국감성과학회 2015 춘계학술대회 Vol.2015 No.-

성 중독자들은 성 충동이 유발되었을 때, 다른 상황적인 요인들이 있음에도 성욕을 억제하지 못하는 특징을 보인다(Carnes 2001; Laaser & Earle, 2001). 억제 기능은 여러 하위 영역으로 나누어지며, 그에 따른 다양한 측정치로 측정되고 있다. Dillon과 Pizzagalli(2007)는 억제 기능이 우세한 반응을 억제하는 반응 억제와 간섭을 일으키는 자극을 억제하는 인지 억제로 나누어진다고 보았다. 본 연구에서는 성 중독자가 목표와 관련된 정보에 대해 주의초점을 유지하면서 방해 정보를 억제할 수 있는 능력에 결함을 가지고 있다고 판단하여, go-nogo 과제와 stroop 과제를 이용하여 성 중독군의 억제 기능에 결함이 있는지를 규명하고, 이러한 억제 기능의 결함이 신경기능학적 손상과 관련이 있는지를 알아보고자 하였다.

주요우울장애 여성의 피질 두께와 회백질 용적의 특징

석지우(Ji-Woo Seok),손진훈(Jin-Hun Sohn) 대한인간공학회 2019 大韓人間工學會誌 Vol.38 No.5

Objective: The purpose of this study is to find brain areas shown a difference of the volume and cortical thickness between females with major depressive disorder (MDD) and healthy females. Background: Although neuroimaging studies on the characteristics of MDD have been accumulating, limited studies have used both brain volume and cortical thickness to find the structural alteration in MDD. Integrating measures of structural brain imaging provide profound insights into the neurobiological underpinnings of MDD. Method: Twenty-two females with MDD and 23 age- and sex-matched healthy females participated in this study. A 3T Philips Achieva MRI scanner (Philips Medical Systems, Best, The Netherlands) was used for image acquisition. Gray matter volume and cortical thickness were analyzed using voxel-based morphometry (VBM) and surface-based morphometry (SBM). Results: VBM results indicated that individuals with MDD had significantly reduced gray matter volume in the anterior cingulate gyrus, hippocampus, hippocampal gyrus and precuneus and cerebellum compared to controls. Moreover, gray matter volume in the right anterior cingulate gyrus was negatively correlated with the severity of depression. SBM results demonstrated that compared to healthy controls, individuals with MDD showed reduced cortical thickness in temporal pole, paracentral gyrus, angular gyrus and insula. Conclusion: These findings suggest that structural alterations in the anterior cingulate gyrus are linked to MDD, thereby providing understanding into the neural mechanisms underlying MDD. Application: Alterations in the anterior cingulate cortex may act as neuroimaging markers of MDD, and these findings provide a possibility to developed the diagnosis system for MDD.

알코올 사용 장애자의 현출 네트워크의 기능적 연결성 증가

석지우(Ji-Woo Seok),박미숙(Mi-Sook Park) 대한인간공학회 2019 大韓人間工學會誌 Vol.38 No.6

Objective: The aim of this study is to identify the altered functional connectivities of the salience network during resting state among individual with alcohol use disorder using functional magnetic resonance imaging. Background: Individuals with Alcohol Use Disorder (AUD) has shown significant attention and attraction to alcohol-related stimuli. The previous studies demonstrated the neuropsychological, physiological responses elicited by alcohol-related cue. These researches suggested the altered functional connectivities between brain areas related to incentive salience among AUD patients, but not yet fully explored the functional connectivities in salience network during resting-state among AUD patients in the literatures. Method: In this study, functional magnetic resonance imaging data were acquired for 22 AUD patients and 22 healthy controls with similar demographic characteristics. The functional connectivities between the regions in salience network was chosen as the region of interest (ROI), and the ROI to ROI analysis with time series signals was conducted. After that two-sample t test was performed. Results: In the results, AUD patients exhibited increased functional connectivities in the right anterior insula - left supramarginal gyrus, the right supramarginal gyrus - left rostral prefrontal cortex, right supramarginal gyrus - right rostral prefrontal cortex, and right supramarginal gyrus - left supramarginal gyrus compared to healthy controls. The strengths of functional connectivity in these areas were linked to the severity of AUD measured by Alcohol Use Disorder Identification Test (AUDIT). Conclusion: The results of the study suggest that abnormal incentive salience toward alcohol-related stimuli might be associated with the aberrant functional connectivities in salience network. Application: The aberrant functional connectivities in salience network might apply for discrimination of AUD, and determination the severity of AUD as neuroimaging markers.

Regional Grey and White Matter Changes in the Brain Reward System Among Patients with Alcohol Dependency

박미숙,석지우,김은예,노지혜,손진훈 한국감성과학회 2017 감성과학 Vol.20 No.4

The purpose of the study was to find grey matter (GM) and white matter (WM) volume reduction in the brain reward system among patients with alcohol dependency. This study investigated regional GM and WM in chronic alcoholic patients, focusing primarily on the reward system, including principal components of the mesocorticolimbic reward circuit as well as cortical areas with modulating and oversight functions. Sixteen abstinent long-term chronic alcoholic men and demographically matched 16 healthy control men participated in the study. Morphometric analysis was performed on magnetic resonance brain scans using voxel-based morphometry (VBM)-diffeomorphic Anatomical Registration through Exponentiated Liealgebra (DARTEL). We derived GM and WM volumes from total brain and cortical and subcortical reward-related structures. Morphometric analyses that revealed the total volume of GM and WM was reduced and cerebrospinal fluid (CSF) was increased in the alcohol group compared to control group. The pronounced volume reduction in the reward system was observed in the GM and WM of the nucleus accumbens (NAc), GM of the amygdala, GM and WM of the hippocampus, WM of the thalamus, GM and WM of the insula, GM of the dorsolateral prefrontal cortex (DLPFC), GM of the orbitofrontal cortex (OFC), GM of the cingulate cortex (CC), GM and WM of the parahippocampal gyrus in the alcohol group. We identified volume reductions in WM as well as GM of reward system in the patients with alcohol dependency. These structural deficits in the reward system elucidate underlying impairment in the emotional and cognitive processing in alcoholism.

수치심과 죄책감의 뇌 활성화

노지혜,석지우,박찬아,정재준 한국감성과학회 2016 추계학술대회 Vol.2016 No.-

분노를 유발하는 자서전적 기억 회상에 의한 뇌 활성화 영역의 연결성

음영지,석지우,노지혜,손진훈 한국감성과학회 2016 추계학술대회 Vol.2016 No.-

Altered patterns of brain activity during transient anger among young males with alcohol use disorders: A preliminary study

박미숙,손선주,석지우,김은혜,손진훈 한국감성과학회 2015 감성과학 Vol.18 No.2

The aim of the study was to investigate the neural substrates associated with processing anger among young males with alcohol use disorders (AUDs) using functional magnetic resonance imaging (fMRI). Eighteen individuals with AUD and 15 demographically similar non-abusers participated in the study. Participants were scanned on their brain functioning while they viewed an audio-visual film clip that was previously designed specifically to induce anger emotion, followed by anpsychological assessment. Greater brain activities were detected in the left inferior frontal gyrus (IFG) and dorsal anterior cingulate cortex (dACC) among subjects with AUD compared to the controls during the exposure to anger-provoking stimuli. Despite the same level of subjective anger during anger induction, the greater activations both in the IFG and dACC regions may suggestthat individuals with AUD have a greater propensity to undergo cognitive control and self-regulation while experiencing anger. The aim of the study was to investigate the neural substrates associated with processing anger among young males with alcohol use disorders (AUDs) using functional magnetic resonance imaging (fMRI). Eighteen individuals with AUD and 15 demographically similar non-abusers participated in the study. Participants were scanned on their brain functioning while they viewed an audio-visual film clip that was previously designed specifically to induce anger emotion, followed by anpsychological assessment. Greater brain activities were detected in the left inferior frontal gyrus (IFG) and dorsal anterior cingulate cortex (dACC) among subjects with AUD compared to the controls during the exposure to anger-provoking stimuli. Despite the same level of subjective anger during anger induction, the greater activations both in the IFG and dACC regions may suggestthat individuals with AUD have a greater propensity to undergo cognitive control and self-regulation while experiencing anger. Key words: fMRI; Alcohol use disorders; Anger; Brain activation

복셀 기반의 형태계측을 이용한 알코올 사용 장애의 cingulate와 orbitofrontal cortex의 체적 비교 연구

김은예,박미숙,석지우,손진훈 한국감성과학회 2014 추계학술대회 Vol.2014 No.-

인지처리치료: 외상후 스트레스 장애의 일차 치료

최진희,소형석,황순조,석지우,최하연,이승훈,이은영 한국정신신체의학회 2022 정신신체의학 Vol.30 No.2

Posttraumatic stress disorder (PTSD) is well known to have a limited response to drug treatment. Many recently published clinical care guidelines recommend trauma-focused psychotherapies such as cognitive processing therapy (CPT) and prolonged exposure therapy (PE) as first-line treatment and medication such as serotonin reuptake inhibitors and venlafaxine as second-line treatment. Current review introduces the session composition and contents of CPT and presents various CPT studies that show therapeutic effect for civilian and veterans/military with PTSD. In order for clinicians to help effectively patients with PTSD, it is necessary to learn and actively use evidence-based trauma-focused psychotherapies including CPT and PE. 외상후 스트레스 장애는 다양한 치료들에 대한 치료반응이 좋지 않아, 많은 임상가들에게 큰 도전이 되고 있다. 최근 발간된 여러 임상 진료지침들은 인지처리치료 및 지연노출치료를 포함한 트라우마 초점 정신치료들을 일차 치료로 공통적으로 권고하고 있다. 환자에게 근거에 기반한 치료적 선택지들에 대하여 정보를 제공함으로써 환자와 임상가가 함께 최선의 치료방법을 선택할 수 있도록 하는 것이 중요하며, 이를 위해 인지처리치료의 내용과 근거를 소개하는 것이 본 종설의 목적이다. 인지처리치료의 회기 구성과 내용을 요약하여 소개하고, 외상후 스트레스 장애에 대한 인지처리치료의 효과를 알아본 다양한 연구들을 민간인 집단과 재향군인/현역군인 집단으로 구분하여 제시하였다. 인지처리치료의 탈락율을 낮추고 치료성적을 올리며 치료접근도를 높일 수 있는 방법들 및 외상후 스트레스 장애에 대한 근거중심치료의 활성화를 위한 방안을 토의한다