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서효빈,이수천,권태동,강준용,송영주,류승필 한국운동영양학회 2011 Physical Activity and Nutrition (Phys Act Nutr) Vol.15 No.1
This study purposed to examine the effects of ginger extract and swimming exercise administered to hyperglycemic rats on their insulin resistance, antioxidant ability and apoptosis. For this purpose, we divided 40 15-week-old male SD rats with induced hyperglycemia into control group (CON), exercise group (EX), ginger extract group (GI), and ginger extract + exercise group (GI+EX), and through 8 weeks’ experiment we performed weight, blood glucose, insulin concentration, HOMA-IR, SOD activity, TBARS content and apoptosis of gastrocnemius muscle. Body weight was not significantly different among the groups. Blood glucose changed significantly over time in GI and GI-EX. Insulin concentration decreased significantly over time in GI and GI-EX, and was significantly lower in GI-EX among the groups. HOMA-IR decreased significantly over time in EX, GI and GI-EX, and was significantly lower in GI-EX among the groups. Among time points x groups, significant difference was observed in GI-EX at time points 2, 3 and 5. As to the antioxidant ability of gastrocnemius muscle, SOD activity and TBARS content were not changed by ginger extract and exercise, and apoptosis. No significant difference was observed in apoptotic factors P53 and caspase-3, anti-apoptotic factors Bcl-2 among the groups. Accordingly, the administration of ginger extract and exercise are expected to lower blood glucose and prevent diabetes and hyperglycemia, antioxidant capacity and apoptosis in the additional study is necessary.
서효빈,이인호,전병덕,권태동,류승필 한국운동영양학회 2012 Physical Activity and Nutrition (Phys Act Nutr) Vol.16 No.4
This study was carried out to investigate the effect of Salicornia herbacea L. (SHL) intake and acute exercise on lipids metabolism in streptozotocin (STZ)-induced diabetic rats. Four different groups of 40 STZ-induced diabetic Sprague-Dawley male rats were given a diet of feed mixed with SHL powder for 6 weeks. To adapt to the acute swimming exercise, the exercise group went through a period of swimming induction over one week. Then, they performed the acute swimming exercise the next day. 24 hours after the acute swimming exercise, the rats were sacrificed and samples were collected and analyzed. There was no significant change in body weight as compared to the control group. Stored fat was found to have decreased in the group which was fed a diet supplemented with SHL powder. There was a significant reduction in blood glucose, triglyceride and total-cholesterol in the SHL intake group only. There was no change in L-FABP and CPT-1 protein expression determined to have occurred due to acute exercise, but there was a statistically significant increase in the expression of both proteins determined for the SHL grouip. Moreover, the SHL group with acute exercise exhibited an increase in cytochrome C oxidase. Based on the results above, it seems that SHL powder could help to prevent various diabetic complications. In addition, it seems necessary to prove the effectiveness of SHL as a healthy functional food by carrying out further research on its intake in relation to metabolic syndromes and exercise capabilities.
고지방식이 섭취와 수영운동 수행시 오렉신 호르몬과 백색지방 갈변화에 미치는 영향
서효빈,남주옥,권태동 한국생활환경학회 2019 한국생활환경학회지 Vol.26 No.5
The objective of the present study was to investigate the effects of a high-fat diet and swimming exercise on neuropeptide hormone orexin and browning of white adipose tissue. Accordingly, a high-fat diet was administered and a swimming exercise regimen was applied for 6 weeks to 32 male Sprague-Dawley rats. In the comparison between the groups, body fat mass was significantly lower. The amount of dietary intake was significantly higher in the highfat diet group. Although there were no significant changes in orexin hormone levels in blood. With respect to heat generating factors, the high-fat diet + exercise and high-fat diet group showed significantly higher expression of PGC- 1α and UCP-1 in muscles. The high-fat diet and high-fat diet + exercise groups showed a significantly higher expression of FNDC5 in fat tissues, whereas the high-fat diet group showed significantly higher expression of UCP-1 in fat tissues. The findings of the present study revealed that regular exercise stimulates the hypothalamus of the brain to regulate the function of orexin, a neuropeptide hormone, which promotes the expression of heat generating factors PGC-1α, FNDC5, and UCP-1, However, the future studies might have a positive impact on obesity treatment and improvement.
뇌동맥 조영술을 위한 이오파미돌 250 조영제의 유효성과 안전성: 이오파미돌 300과 비교한 다기관, 무작위배정, 이중맹검 연구
서효빈,한문희,권배주,임소향,정철규,김성현,김재형 대한영상의학회 2007 대한영상의학회지 Vol.57 No.6
Purpose: To evaluate and compare the safety, tolerance and the image quality of cerebral angiography images with the use of the nonionic monomeric contrast agent, iopamidol at 250 mgI/mL or 300 mgI/mL. Materials and Methods: This study was approved by the institutional review board and was performed from December 2005 to March 2006. A total of 90 patients undergoing an elective cerebral angiography were studied during a phase III clinical trial to compare the safety and diagnostic efficacy of iopamidol at 250 mgI/ml and 300 mgI/ml. The overall quality of cerebral angiography images was independently graded into three categories: good, bad and nondiagnostic by two radiologists. Results: The image quality of the cerebral angiography was good in 100% of the patients in both groups. A total of 4.44% of the patients experienced adverse events (4.44% in the iopamidol 250 group and 4.44% in the iopamidol 300 group). No statistically significant differences were observed between the two studied groups for either the proportion of patients with one or more adverse events or the intensity of the adverse events. Conclusion: The safety and efficacy (quality of the radiographic diagnostic visualization) of Iopamidol at 250 and 300 mg I/ml did not reveal any significant differences and thus are comparable. 목적: 비이온성 수용성 요오드 조영제인 이오파미돌(iopamidol) 250 mgI/mL과 이오파미돌 300 mgI/mL을 이용하여 얻어진 뇌동맥혈관조영술에서 영상의 질과 조영제의 안전성을 비교하여 저농도 이오파미돌의 비열등성을 입증하고자 하였다. 대상과 방법: 의학연구윤리심의위원회의의 승인을 받았으며, 환자들에게 임상시험에 참가한다는 동의를 얻었다. 진단을 목적으로 뇌동맥혈관조영술을 필요로 하는 총 90명의 환자를 무작위 배분하여 2005년 12월부터 2006년 3월까지 이중맹검법으로 시험약과 대조약을 이용해 뇌동맥혈관조영술을 시행하였다. 2명의 영상의학과 전문의가 이중맹검법으로 독립적으로 영상의 질을 평가하였고, 조영술 후 28시간까지 대상 환자들을 관찰하여 내약성, 이상반응, 임상병리검사, 활력징후결과를 비교하였다. 결과: 영상의 질은 시험군과 대조군에서 두 영상의학과 전문의 모두‘우수’로 조사되었으며, 평가의 유효율은 두 시험군 모두에서 100%였다. 부작용 발현율은 두 군에서 각각 4.44%(2/45, 2/45)였다. 내약성, 이상반응의 발현율과 그 정도에서 두 군간의 유의한 차이는 없었으며, 기타 투약 후 활력 징후나 신체진찰 결과 특이 변화는 없었다. 모든 결과에서 통계적으로 유의한 차이를 보이지 않았다. 결론: 뇌동맥혈관조영술에 의한 진단이 필요한 뇌혈관 질환자를 대상으로 저농도 이오파미돌을 이용한 검사는 영상의 질이나 약제의 안전성이 300 mgI/mL의 이오파미돌과 다르지 않음을 확인하였다.
서효빈,남주옥,송영주,권태동,여윤기,류승필 한국운동영양학회 2012 Physical Activity and Nutrition (Phys Act Nutr) Vol.16 No.2
This study was conducted to examine the possibility of Salicornia herbacea L. powder as a functional food beneficially affecting carbohydrate metabolism and antioxidant capacity. Twenty-four, 6-week old, maleSprague-Dawleyrats were classified into three groups:normal diet control (CON), high-fat diet control (HFC) and high fat diet + Salicornia herbacea L. (SHF). Related feed was provided to each group for 4 weeks. Weight gain rate increased most in the HFC rats, and the concentration of glucose was significantly high in both the HFC and SHF groups, compared to the CON group. The SHF group showed a significantly high expression rate of Glut 4 (21.36%), compared to the CON and HFC groups. The glycogen content in muscle was significantly high in both the HFC and SHF groups, compared to the CON group. There were significant differences in the malondialdehydecontent in muscles between the groups, with the content in the CON and HFC groups being significantly higher than the SHF group. All the groups showed a similar tendency to each other in the liver tissue as well. Concerning the expression of Cu,Zn-super oxide dismutase andglutathione peroxidaseproteins, the SHF group was significantly higher than the CON and HFC groups. Overall, the experiment result above implies a possibility that an intake of Salicornia herbacea L. powder can regulate weight by decreasing the weight gain rate, further suggesting its effectiveness as a functional food before exercise by increasing the energy storage capacity and antioxidant capacity.
서효빈,전병덕,류승필 한국운동영양학회 2015 Physical Activity and Nutrition (Phys Act Nutr) Vol.19 No.1
Hyobin Seo, Byung-Duk Jeon and Sungpil Ryu. Persimmon vinegar ripening with the mountain-cultivated ginseng ingestion reducesblood lipids and lowers inflammatory cytokines in obese adolescents. JENB., Vol. 19, No. 1, pp.1-10, 2015 [Purpose]This studyinvestigated the effect of the vinegar, which is made of 4-year-old mountain-cultivated ginseng ripened into 4-year-matured persimmonvinegar, on the blood lipids level and inflammatory cytokines concentration in obese female adolescents. [Methods]Subjects ingestedthe vinegar, so-called 'mountain-cultivated ginseng persimmon vinegar (MPV)', without meals every day for 6 weeks with activitiescontrol. Subjects were grouped into control (CON), persimmon vinegar (PV), and MPV with 10 people in each group. Bloodlipids, triglyceride (TG), total-cholesterol (TC), and high density lipoprotein-cholesterol (HDL-C) were analyzed. Also, glutamicoxaloacetic transaminase (GOT) and glutamate pyruvate transaminase (GPT) were analyzed for the hepatotoxicity. Blood cytokines,interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB)were analyzed. [Results]Subjects showed a high reduction in body weight and body fat. Their blood lipid level was effectivelyimproved, and the secretion of inflammatory cytokine was suppressed as well, except for TNF-α. However, the change ratio ofthe cytokines was high in PV and MPV. Such results were similar to those from research subjects who took persimmon vinegaronly (PV), but the effect of the vinegar (MPV) was more remarkable. Besides, this mixture was found to have no effect onthe hepatotoxicity. [Conclusion]The significance of this study is that all the experiments were conducted without controlling researchsubjects' daily lives, and it is suggested that the vinegar may be recommended as a kind of health supplement food to suppressobesity. Especially, since these two products are traditional foods of Korean people, which have been taken for ages, it is expectedthat the fusing of two foods may be better applied to ordinary people who are concerned about obesity. [Key words]Mountain-cultivatedginseng, persimmon vinegar, blood lipids, inflammatory cytokines, obese adolescents
대두단백 섭취와 운동이 혈중지질농도, SOD 및 MDA에 미치는 영향
서효빈(HyoBinSeo),이혜향(HyeHyangLee),이윤경(YounKyungLee),전혜린(HyeRinJeon),전병덕(ByungDukJeon),류승필(SungPilRyu),김영범(YeongBeomKim),윤신중(ShinJoongYoun),이수천(SooChunLee) 한국체육학회 2008 한국체육학회지 Vol.47 No.6
본 연구에서는 대두단백섭취와 운동이 혈중지질, SOD활성과 MDA함량에 미치는 영향에 대해 알아보고자 하였다. 4주령 된 SD계 수컷 28마리를 고지방식이(CON), 고지방식이+운동(EX), 대두단백식이(SP), 대두단백식이+운동(SPE)군으로 나누어 4주간 실험에서 혈중지질개선 및 SOD활성도와 MDA함량에 대한 결과는 대두단백식이와 운동군에서 체중 및 체지방이 유의하게 감소되었고, 혈중지질에서는 TC, HDL-C, LDL-C에서는 유의한 차이는 나타나지 않았으나 TG에서 통계적으로 유의하게 나타났다. SOD활성도와 MDA함량에서는 유의한 차이는 나타나지 않았으나 대두단백식이와 운동군에서 긍정적인 경향을 나타내었다. 따라서 본 연구에서는 대두단백식이와 운동이 비만의 예방에 도움을 줄 것으로 사료되며 혈중지질의 개선과 항산화능은 콩의 생리적기전에 대한 더 많은 연구가 필요 할 것으로 사료된다. This study was investigate that the ingestion of soy protein and exercise training on the blood lipids and activity of SOD and MDA content. Sprague-Dawley 28 males grouped as high fat diet (CON), high fat diet+exercise (EX), Soy protein diet (SP), and Soy protein diet+exercise (SPE), respectively. The body weight and fat were decreased in SPE significantly. There was no significant difference in blood TC, HDL-C, and LDL-C, except TG. There was no significant difference in activity of SOD and MDA content, however, there was positive tendency in SPE. These results suggested that soy protein diet and exercise training have the beneficial effect of lowering blood lipid. However, physiologic mechanisms of bean were not clear.
C2C12 근육모세포와 전기자극에 따른 FNDC5/irisin pathway 기전 연구
서효빈(Seo, Hyo-Bin),전병덕(Jeon, Byung-Duk),권태동(Kwon, Tae-Dong) 한국체육과학회 2023 한국체육과학회지 Vol.32 No.6
The tThe this study, we attempted to investigate the effects of EPS (Electrical Pulse Stimulation) the C2C12 cell line composed of mouse skeletal muscle cells. The experimental group was divided into -Electrical pulses stimulation (CON), Low Electrical pulses stimulation (L-EPS), High Electrical pulses stimulation (H-EPS), electrical impulse was introduced to the differentiated C2C12 myotubes for four days under the condition of high intensity 14V/mm, 50Hz, 1ms, low intensity 0.3 V/mm, 1.0 Hz, and 4.0 ms. Then, the C2C12 cell’s morphological change was analyzed along with changes in the cell length, and western blot analysis was conducted on the protein expressed from the C2C12 cell. The C2C12 cell line, composed of the mouse skeletal muscle cells, was stimulated through EPS after its differentiation. The expression of PPAR-γ was significantly higher in the H-EPS group, and the results of PGC-1α, FNDC5, and irisin showed statistically significant differences between each group, and the L-EPS group treated with electrical stimulation compared to the CON group, the H-EPS group showed significantly higher activity. It is thought that the increase in muscle PGC-1α, FNDC 5, and Irisin, which are browning factors for fat, after electrical stimulation will lead to an increase in UCP-1, PPAR-γ, PRDC 16, and FABP-4 in fat tissue, that is, the intensity of exercise. Accordingly, by presenting positive results in the muscle factor among fat browning factors, based on this, it is possible to establish factors such as increased utilization of energy metabolism, anti-obesity, and metabolic syndrome through research on physiological mechanisms in relation to various exercise intensities and methods.
산양삼 첨가 고지방식이가 골격근의 항세포사멸에 대한 작용 연구
서효빈 ( Hyobin Seo ),김판기 ( Pan Gi Kim ),류승필 ( Sungpil Ryu ) 한국산림과학회 2015 한국산림과학회지 Vol.104 No.3
The purpose of this study was to investigate the anti-apoptosis-related protein expression in skeletal muscle of rats with different amount of mountain ginseng (MG) added high-fat diet fed. Twenty-four Sprague Dawley male rats were divided into the high-fat diet control group (CON), 0.5% of MG added diet group (MG1), and 1.0% of MG added diet group (MG2) with eight rats each. The P53, anti-apoptotic protein, was significantly lower in MG2 than CON and MG1. The bcl-2 and bcl-xl, however, were not significantly different from MG1 but from CON. The caspase-9 and -3, were significantly lower in MG groups than CON. In addition, it was dramatically lower in MG2. These results suggested that MG addition to the high-fat diet suppressed p53 protein expression and enhanced anti-apoptototic protein expression. MG may be a positive effects on health as a medicinal plant.