다섯 가지 시계그리기검사 채점법의 알쯔하이머병 선별 유용성 비교

서은현 ( Eun Hyun Seo ),박희형 ( Hee Hyung Park ),이동영 ( Dong Young Lee ),추일한 ( Il Han Choo ),이정희 ( Jung Hie Lee ),정세훈 ( Sae Hoon Chung ),윤종철 ( Jong Chul Youn ),김기웅 ( Ki Woong Kim ),주진형 ( Jin Hyung Jhoo ),김신 한국정신병리진단분류학회 2006 精神病理學 Vol.15 No.1

Objectives: This study aimed to compare the reliability and screening ability for Alzheimer`s disease (AD) of five scoring methods of clock drawing test(CDT). Methods: Consecutively recruited 155 probable AD patients and 155 normal control subjects participated in the study. The clock picture drawn by each subject was scored according to five CDT scoring methods, such as the CERAD, Rouleau, Sunderland, Mendez and Todd method. The inter-rater reliability was compared by calculating Pearson`s correlation coefficients. The screening ability was compared by analyzing the receiver operating characteristic(ROC) curves. Results: The five scoring methods had excellent inter-rater reliability in common. In terms of the screening ability for overall AD, there was no difference among the scoring methods. There was also no inter-method difference in screening ability for very mild AD. In contrast, as for the screening of mild to severe AD, the CERAD method showed significantly better ability than the other four methods. Conclusions: Regardless of their complexity, CDT scoring methods appears to have similar screening ability for overall AD. In screening clinically more evident AD except very mild one, however, the CERAD methods, in spite of its simplicity, can be probably applied more usefully than other CDT scoring methods.

알칼리 용해성 회합 증점제의 합성 및 유성학적 물성에 관한 연구

서은현,이덕연,이종길,김중현 ( Eun Hyun Seo,Doug Youn Lee,Jong Kil Lee,Jung Hyun Kim ) 한국공업화학회 1997 공업화학 Vol.8 No.4

본 연구에서는 associative macromonomer로서 비이온성 vinyl surfactant ester(alkyloxy poly(ethyleneoxy)_n ethyl acrylate)[VSE]를 사용한 유화중합을 통하여 회합형 아크릴 증점제를 합성하고, 유성학적 물성을 고찰하였다. VSE의 소수성 말단기의 탄소수, ethoxylation 정도에 따라 회합형 증점제의 중점효과가 크게 영향을 받았다. VSE의 종류를 고정하고, 공단량체 조성을 달리하여 제조한 아크릴 회합형 증점제의 수용액 점도 변화를 고찰한 결과, VSE의 양이 늘어날수록 증점효과가 증가하였다. 이것은 VSE의 소수성 말단기의 상호작용에 의한 회합 증점 메카니즘에 의해 증점효과가 향상되었기 때문이다. 또한 사슬전이제에 의한 분자량이 감소할수록 hydrodynamic volume이 작아져 증점효과가 감소하였다. Associative acrylic thickeners were prepared by emulsion copolymerization using nonionic vinyl surfactant esters as an associative macromonomer and their rheological properties were investigated. The thickening efficiency was shown to depend on the chain length of terminal hydrophobe and degree of ethoxylation of VSE. For a given VSE, increasing the content of VSE enhanced the efficiency of the resulting polymers as a thickener. It was attributed to the intermolecular association of terminal hydrophobes of assoaative thickener in aqueous solution. The chain transfer agent caused to reduce the molecular weight of associative thickener, resulted in decrease of thickening efficiency.

수용성 아크릴 호제의 합성 및 그 응용에 대한 연구

이덕연,서은현,김중인,김중현 ( Doug Youn Lee,Eun Hyun Seo,Joong In Kim,Jung Hyun Kim ) 한국공업화학회 1996 공업화학 Vol.7 No.3

본 연구에서는 유화중합을 통해 water jet loom용 경사 호제인 비용제형 수용성 아크릴 호제(GSW-7000)를 합성하였다. 이 호제는 아크릴계 호제의 암모늄염 형태로 제조되어 weaving force에 대한 저항력과 water jet loom 사용에 있어 물에 대한 저항력이 우수하였다. 제조한 GSW-7000은 sizing에 적당한 점도를 가지고 있고, 신도와 접착력, 용해성, 침투성 및 호부착성이 우수하였다. 또한 본 호제로 처리된 호부사는 접착강도가 높아 기존 용제형 아크릴 호제에 비하여 sizing시 호제 소모량을 70∼80% 수준으로 저하시켜도 우수한 집속성 및 포합력을 나타내었으며, 호피막이 유연하며 평활성 및 내마모성이 우수하여 호부시 유제 및 대전 방지제를 사용하지 않아도 sizing 및 제직이 가능하였다. Water-based acrylic sizing agent(GSW-7000) was prepared by emulsion copolymerization for sizing polyester yarns. Ammonium salt version of the acrylic sizing agent offered greater abrasion resistance to weaving forces and water resistance for water jet loom. GSW-7000 exhibited proper viscosity for sizing, high penetration ability and excellent adhesion to polyester yarn. It was possible to reduce the size pick-up to 70∼80% of ordinary solvent-based sizing agent due to excellent adhesive strength of GSW-7000.

고혈압 환자에서 불안증상에 영향을 미치는 정신심리학적 요인

문석현,김승곤,양혜정,서은현,윤형준,Moon, Seock Hyeon,Kim, Seung-Gon,Yang, Hae-Jung,Seo, Eun Hyun,Yoon, Hyung-Jun 대한불안의학회 2022 대한불안의학회지 Vol.18 No.1

Objective : The aim of this study was to investigate the prevalence of anxiety symptoms and its association with psychological factors in patients with hypertension. Methods : The Participants included 124 patients with hypertension. Anxiety symptoms were evaluated by the Hospital Anxiety and Depression Scale. Socio-demographics, perceived stress, state-trait anger, life satisfaction, and ego resiliency were assessed. Stepwise multiple regression analyses were carried out to examine the impact of perceived stress, state-trait anger, and life satisfaction on anxiety symptoms. In addition, moderated regression analysis was performed to explore the moderating effect of ego resiliency between perceived stress and anxiety symptoms. Results : A total of 17 subjects (13.7%) were identified as having anxiety symptoms. Higher perceived stress and state-trait anger, and lower life satisfaction were found to be significant correlates of anxiety symptoms. In the final model, higher levels of perceived stress (β=0.378, p<0.001) and trait anger (β=0.320, p<0.001) were related to higher levels of anxiety symptoms, while a higher level of life satisfaction (β=-0.166, p=0.025) was associated with a lower level of anxiety symptoms. Further, ego resiliency buffered the negative effect of perceived stress on anxiety symptoms. Conclusion : This study demonstrated the prevalence of anxiety symptoms and associated psychological factors among patients with hypertension. Our findings suggest that improving life satisfaction and ego-resiliency as well as controlling stress and anger may be important in the management of anxiety symptoms in patients with hypertension.

당뇨병 환자에서 우울 및 불안증상과 자아탄력성, 사회적 갈등 및 지지 사이의 연관성

정회운,김상훈,박상학,김승곤,김정호,서은현,윤형준,Jung, Hoe-Woon,Kim, Sang Hoon,Park, Sang Hag,Kim, Seung-Gon,Kim, Jung Ho,Seo, Eun Hyun,Yoon, Hyung-Jun 대한불안의학회 2020 대한불안의학회지 Vol.16 No.1

Objective : The purpose of this study was to investigate the association of depressive/anxiety symptoms with psychosocial factors including ego resilience, social conflict, and social support as well as hemoglobin A1c in patients with diabetes mellitus (DM). Methods : The subjects were 144 patients with DM. Depressive/anxiety symptoms were evaluated by the Hospital Anxiety and Depression Scale. Sociodemographic factors, hemoglobin A1c, ego resilience, social conflict, and social support were measured. Multiple regression analyses were performed to examine the impact of hemoglobin A1c, ego resilience, social conflict, and social support on depressive/anxiety symptoms. Results : A total of 32.6% and 24.3% of participants were identified with depressive and anxiety symptoms, respectively. Depressive/anxiety symptoms positively correlated with the social conflict score. Conversely, ego resilience and social support negatively correlated with depressive/anxiety symptoms. In the final model of the multiple regression analyses, ego resilience was associated with a lower level of depressive (β=-0.083, p=0.019)/anxiety (β=-0.125, p=0.001) symptoms whereas social conflict was related to a higher level of depressive (β=0.353, p=0.011)/anxiety (β=0.460, p=0.003) symptoms. Also, hemoglobin A1c positively associated with anxiety symptoms (β=0.495, p=0.012) whereas social support negatively related to depressive symptoms (β=-0.464, p=0.004). Conclusion : We found possible risk and protective psychosocial factors of underlying depressive/anxiety symptoms among patients with DM. Our findings suggest that enhancing ego resilience and social support as well as decreasing social conflict would be crucial in the prevention and management of depressive/anxiety symptoms in patients with DM.

MMSE와 SIRQD의 조합을 통한 치매선별 정확도 향상

윤제연 ( Je-yeon Yun ),이동영 ( Dong Young Lee ),서은현 ( Eun Hyun Seo ),윤종철 ( Jong Chul Youn ),우종인 ( Jong In Woo ) 한국정신병리진단분류학회 2011 精神病理學 Vol.20 No.1

목 적 본 연구에서는 간이 인지기능 검사인 Mini-Mental Sta-te Examination(MMSE)와 치매선별용 정보제공자 보고용 설문지인 Seoul Informant Report Questionnaire(SI- RQD)의 조합이 개별 도구에 비해 치매 선별 정확도를 향상시킬 수 있는지를 규명하고자 하였다. 방 법 462명의 치매 환자와 423명의 비치매 노인에게 MM-SE in the Korean version of the Consortium to Esta-blish a Registry for Alzheimer’s Disease(CERAD) assessment packet(MMSE-KC) 검사를 시행하였다. 또한, 각 대상자의 정보제공자에게 SIRQD 설문지를 작성하도록 하였다. 이를 통해 얻어진 MMSE-KC 점수와 SI-RQD 점수를 조합하여 조합 점수로서 단순합 점수와 가중합 점수를 구하였다. MMSE-KC 점수와 SIRQD 점수, 두 점수의 제곱 및 두 점수간의 상호작용을 독립 변수로 하는 로지스틱 회귀분석을 통해 치매 여부를 예측하는 회기모형 I을 구하고 이를 이용하여 가중합 I을 산출하였다. 아울러 회기 모형 I에 포함된 독립변수들과 교육 연수를 함께 고려한 회기모형 II를 구하고 이를 이용하여 가중합 II를 구하였다. Receiver Operating Charac-teristics 곡선하 면적 비교를 통해 MMSE-KC 점수, SI-RQD 점수, 단순합, 가중합 I 및 II 간의 치매 선별 정확도를 비교하였다. 결 과 MMSE-KC 점수의 치매 선별 정확도는 SIRQD 점수에 비해 유의하게 높았다. 단순합의 치매 선별 정확도는 MMSE-KC를 단독 사용하였을 때와 비교하여 통계적으로 유의한 차이를 보이지 않았지만, 로지스틱 회기식을 통해 얻은 조합 점수인 가중합 I과 II는 MMSE-KC 점수 단독 사용시에 비해 유의하게 향상된 치매 선별 정확도를 나타냈다. 결 론 본 연구에서 나타난 이러한 결과들은 기존에 서구 노인을 대상으로 보고된 바와 같이 한국 노인에서도 서로 다른 접근 방식을 취하는 대표적인 두 가지 치매 선별 방식에 의한 점수를 적절한 가중치를 주어 조합함으로써 치매 선별 정확도를 향상시킬 수 있음을 지지한다. 아울러 본 연구 결과는 이러한 조합 시 교육 수준을 함께 고려할 경우 선별 정확도를 더욱 높일 수 있음을 시사한다. Objectives:We aimed to investigate whether the combination of a brief cognitive test, the Mini-Mental State Examination(MMSE), and an informant report-based screening questionnaire for dementia, the Seoul Informant Report Questionnaire(SIRQD), can improve the screening accuracy for dementia compared to each individual instrument. Methods:Four hundred and sixty-two dementia patients and 423 non-demented elderly individuals were included in this study. The MMSE in the Korean version of the Consortium to Establish a Registry for Alzheimer’s Disease Assessment Packet(MMSE-KC) and SIRQD were applied to each subject and his or her reliable informant, respectively. Simple sum(SS) score and two weighted sum(WS) scores, derived from stepwise logistic regression model only including MMSE-KC and SIRQD scores(WS I), or model including both scores and education (WS II), were calculated to combine the contributions of the two instruments to dementia screening. We compared dementia screening accuracy among individual instrument scores and three combination scores by using area under the curve(AUC) of the Receiver Operating Characteristics curves. Results:Both WS I and II showed significantly better dementia screening accuracy than each individual screening instrument score, while SS did not. In addition, WS II demonstrated superior screening accuracy compared to WS I. WS I and WS II predicted dementia clinical diagnosis 62.7% and 64.7%, respectively. Conclusion:The finding from this study indicated that proper combination of brief cognitive test and informant report-based questionnaire can improve the dementia screening accuracy of each individual screening instrument. Moreover, educational level probably contributes to the further improvement of dementia screening ability when added to combination model.

중학교 청소년에서 학교폭력행태와 자살사고와의 연관성

이선정(Sun-Jung Lee),양혜정(Hae-Jung Yang),김승곤(Seung-Gon Kim),윤형준(Hyung-Jun Yoon),서은현(Eun-Hyun Seo) 대한생물치료정신의학회 2022 생물치료정신의학 Vol.28 No.2

Objectives:This study aimed to investigate the prevalence of bullying behavior and its association with suicidal ideation among middle school students. Methods:This was a cross sectional study of a sample including 781 second grade middle school students(438 males and 343 females) in Gwang-ju metropolitan city. Information on bullying involvement, suicidal ideation and depressive/anxiety symptoms were collected using a self-administered questionnaire. Subjects were classified into subgroups of bully, victim, bully or victim, bully-victim, and witnessing. The data were analyzed using binary logistic regression analyses, adjusted for covariates. Results:The prevalence of bullying victimization, bullying perpetration, bullying witnessing and suicidal ideation were 26.5%, 24.5%, 21.6% and 26%, respectively. Suicidal ideation was positively correlated with bullying victimization, bullying perpetration, bullying witnessing. Using binary logistic regression analyses, the odds ratio of bully-victim group compared to non bullying involvement was 2.41, the highest among all groups. Conclusions:Our findings indicate that school bullying, victim, and witnessing are associated with suicidal ideation, especially in bully and victim group. In addition, it is essential to develop prevention strategies and interventions for adolescents involved in any bullying involvement.

청소년에서 인터넷 게임중독에 미치는 인자

양혜정(Hae-Jung Yang),김승곤(Seung-Gon Kim),김상훈(Sang-Hoon Kim),박상학(Sang-Hag Park),윤형준(Hyung-Jun Yoon),서은현(Eun-Hyun Seo) 대한생물치료정신의학회 2020 생물치료정신의학 Vol.26 No.2

Objectives:This study aimed to investigate the prevalence of internet game addiction and its association with environmental characteristics such as parent supervision, gaming hour (time spent on gaming) and attention-deficit hyperactivity disorder (ADHD) symptoms among middle school students. Methods:A total of 596 (416 males and 180 females) first grade middle-school students in Gwang-ju metropolitan city were included in this study. Subjects were asked to complete a self-reported questionnaire, including measures of the Internet Gaming Use-Elicited Symptom Screen (IGUESS), Attention deficit hyperactivity disorder (ADHD) symptom, environmental factor such as parent supervision, and game related factor like game hours. Internet Game addiction and non-addiction group were defined using IGUESS score of 10 as a cut-off. The data were analyzed using hierarchical regression analyses. Results:Internet Game addiction group was fifty-two subjects (8.7%). Male students were significantly higher than female students (OR 25.01). IGUESS score was statistically negatively correlated with parent attachment and parent supervision, while IGUESS score was positively correlated with time spent on gaming per day, the longest time spent on gaming per day and violent game and ADHD score. Among variables, IGUESS score showed the highest correlation with the longest time spent on gaming per day (r=0.373, p<0.01). Using hierarchical regression analyses, the longest time spent on gaming per day was also the highest predicting factor affecting internet game addiction among variables. Conclusion:Our findings indicate that parent supervision, parent attachment and game related characteristics such as gaming per day, the longest time spent on gaming per day and violent game and ADHD were associated with internet game addiction.

두 가지 한글판 간이정신상태평가(Mini-Mental State Examination)의 비교 : MMSE-KC와 K-MMSE

주진형,김기웅,이동영,윤종철,이태주,추일한,고혜정,서은현,우종인 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.1

Objectives : We compared the scores of the MMSE-KC (Korean version of MMSE in the Korean version of CERAD As-sessment Packet) and K-MMSE (Korean MMSE), and analyzed the influences of age, gender, and educational level on the differences between the two. Methods : We administered the MMSE-KC and K-MMSE simultaneously along with geriatric depression scale (GDS-K) to 733 community-dwelling elderly aged 50 or over in three districts of Suwon. The differences between the MMSE-KC scores and K-MMSE scores were examined by repeated measure ANOVA computing the MMSE for intra-individual factor, age, gender, and educational level as inter-individual factor, and GDS-K score as a covariate. Results : The scores of MMSE-KC and K-MMSE were identical only in the 17.8% of the subjects and the difference between the MMSE-KC score and K-MMSE score were significantly influenced by the educational level of the subjects (F (3,173) =8.21, p<0.001). The MMSE-KC score was higher than the K-MMSE score in illiterate subjects, and lower than the K-MMSE score in literate or educated subjects. Although the main effect of the kind of MMSE was not significant in total MMSE scores (F (1,731)=0.91, p>0.1), it was highly significant in 'judgement and writing/reading' subscores (F (1,731)=16.35, P<0.001) and its influences were significantly varied by the educational level of the subjects (F (1,731) =20.82, P<0.001). Conclusion : The MMSE-KC and K-MMSE which were standardized differently are not identical in scores as well as in content, and the difference between the two is greatly influenced by the educational level of the subject. When interpreting or comparing the MMSE scores of the two different versions of Korean MMSE, the comparability of the scores among them observed in this study should be considered.