固定價格分析을 中心으로한 一般不均衡模型의 延長解釋

서승환 延世大學校 1980 국내석사

감염초기 진단을 위한 고양이와 개의 IgM에 특이적인 단일클론항체 개발 및 적용

서승환 충북대학교 2017 국내석사

Many households around the world including those in Korea and the United States, are living with companion animals, and the ratio of such households is constantly increasing. Among these companion animals, cats and dogs account for the highest percentage of household animals. With the increase of the number of households living with these companion animals, including cats and dogs, the risk of infection with the diseases is also growing. In particular, among cat- or dog-related diseases, there are zoonotic diseases that cause infection in humans. Therefore, it is essential to prevent spread of these diseases by rapidly diagnosing them. IgM is the first antibody that is generated during infection; if IgM is detected in a rapid diagnostic test (RDT) kit, it can faster and more accurately confirm infection and time of the infection. In this study, 6C3E11 and 4E5D7 were developed as monoclonal antibodies (mAbs) specific for cat IgM and dog IgM, respectively, for purpose of diagnosing various diseases related to cats and dogs at the early stage of infection. When comparing these antibodies with commercially available antibodies (GM-20A, GM-40A), the diagnostic efficiency of 6C3E11 was proven to be better than GM-20A, and 4E5D7 showed efficiency similar to that of GM-40A. The newly developed cat IgM or dog IgM specific mAbs can be used to rapidly diagnose various cat- or dog-related diseases at the early stage of infection. 한국과 미국을 포함한 전 세계 많은 가정에서 반려동물과 함께 생활하고 있으며 그 비율 또한 증가하고 있는 추세이다. 이러한 반려동물 중 고양이와 개가 가장 높은 비중을 차지하고 있다. 고양이와 개를 포함한 반려동물과 함께 생활하는 가구가 점차 증가함에 따라 그에 대한 관련 질병의 감염 위험성 역시 높아지고 있다. 특히 고양이 또는 개 관련 질병 중에는 사람에게도 교차 감염을 유발하는 인수공통질병이 존재한다. 따라서 고양이와 개를 포함한 반려동물의 질병 감염여부를 빠르게 진단하여 질병의 확산을 막는 것이 무엇보다 중요하다. IgM은 질병 감염 시 가장 먼저 생성되는 항체로써 이를 진단한다면 질병의 감염 여부 및 감염 시기를 보다 신속하고 정확하게 확인할 수 있다. 본 연구에서는 고양이 및 개와 관련된 다양한 질병을 감염 초기에 진단하기 위한 목적으로, 고양이 IgM과 개 IgM에 특이적인 단일클론항체로써 6C3E11과 4E5D7을 각각 개발하였다. 이들 항체를 이용하여 시중에 판매 중인 항체와 진단효율을 비교한 결과, 6C3E11의 경우, 시중에 판매중인 항체보다 우수한 감도를 보였고 4E5D7의 경우, 비슷한 감도를 나타냈다. 새롭게 개발한 고양이 IgM 또는 개 IgM 특이 단일클론항체를 이용하여 신속진단키트제작 시, 인수공통감염질병을 포함한 다양한 고양이 또는 개 관련 질병들을 감염초기에 신속하게 진단할 수 있을 것이다.

공통수학 수행평가에 대한 적용과 개선방향 연구 : 종합고등학교 인문계학생과 상업계학생의 비교분석을 중심으로

서승환 경희대학교 2001 국내석사

On the basis of the theoretical background of the performance evaluation on which active researches have recently been made as a new alternative in the method of educational evaluations, we have compared and analyzed the actual practices of the performance evaluation, examined its problems, and suggested alternatives for it. The research has been organized around the sample of 133 students in three college-oriented ordinary classes and 86 students in two employment-oriented commerce classes in a comprehensive high school. As the review on the theoretical background of the performance evaluation, in the first place, we examined the definitions of the performance evaluation, the necessity for its introduction, its general characteristics, new theories on instructions, criticism on the multiple choice tests, the patterns of performance evaluation, the necessities for performance evaluation in mathematics, the methods of performance evaluation in mathematics and its grading methods. Subsequently, the basic survey has been made on the ability and interest in mathematics of the students in the sample, on the basis of which the description-based questions of performance evaluation were presented in the three units of sets and propositions, numbers and expressions, equations and inequalities among the areas applicable to the students of ordinary and commerce classes in comprehensive high schools. Through the above survey, the results and reactions thereof have been compared and analyzed for the performance evaluation on the students of ordinary classes, for which the classroom activities were organized mainly for the entrance into the school of higher education, and the students of commerce classes, for which the classroom activities are structured mainly for the career courses. The results of the study may be summarized in two as follows: First, in the basic survey, the preference for common mathematics showed 51.9% in the ordinary classes and 44.1% in the commerce classes, with negligible difference between the two classes. In addition, the degree of understanding of the instructions indicated relatively high levels of 63.2% in the ordinary classes and 79.1% in the commerce classes. The higher level of understanding in the commerce classes may be due to the contents of their lessons which were not related to the entrance examination to higher schools and thus less burdensome to the students. Second, the outcome of the question items for evaluation showed that in the case of the ordinary classes, the achievement was high for the questions of high interest, and high levels of achievement was evident in the verification and the solution with the employment of simple numerical formulas. On the other hand, the levels of interest and achievement did not agree with each other in the commerce classes, which indicated that the students in the commerce class had substantial difficulties in the proof with numerical expressions, while they had the ability to some extent to solve the problems of the verification with the employment of Venn diagrams. The achievement for the questions accessible with the mathematical faculty of thinking in general, however, showed high records both in the ordinary and commerce classes. In line with the conclusions as above, the performance evaluation for the ordinary classes should be targeted to the calculation of complicated expressions or the mathematical concepts, both with a certain level of difficulty, whereas for the commerce classes it should cover the topics easily accessible in actual practices so that the courses can induce the interest and motivations in mathematics. The development and application of various items of questions for these purposes may be the pressing issue deserving the top priority of the attention of the teacher of mathematics.

SI 프로젝트 환경하에서 법적처리와 프로젝트 관리절차에 관한 비교연구

서승환 건국대학교 2006 국내석사

정보시스템 서비스 품질이 사용자 만족에 미치는 영향에 관한 연구 : 사용자 특성에 따른 조절효과를 중심으로

서승환 연세대학교 정보대학원 2007 국내석사

Anti-colitis effect of Lactobacillus sakei K040706 in the dextran sulfate sodium-induced colitis mice model via inhibition of inflammatory responses

서승환 경희대학교 대학원 2017 국내석사

Lactobacillus sakei K040706 (K040706) has been accepted as the most populous lactic acid bacteria (LAB) in over ripened doenjang, known as traditional Korean food. Recently, we reported the immunostimulatory effects of K040706 in macrophages and in a cyclophosphamide-induced mouse model. In this study, we investigated the ameliorative effects of K040706 in a dextran sulfate sodium (DSS)-induced colitis mice. K040706 significantly attenuated DSS-induced disease activity index (DAI), shortening of colon length, and enlargement of spleen. Histological examinations indicated that K040706 suppressed edema, mucosal damage, and the loss of crypts induced by DSS. These results were well correlated with the restoration of tight junction protein expression, such as, claudin1, zonula occludens-1 (ZO-1) and occludin in K040706-treated group. K040706 significantly reduced immune cell infiltration and the expression of intracellular adhesion molecule intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) in colonic tissues. Moreover, K040706 reduced the abnormal secretions and mRNA expressions of pro-inflammatory mediators, such as nitric oxide (NO), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6). K040706 suppressed the activation of nuclear factor-κB (NF-κB) and signal transducer and activator of transcription 3 (STAT3) and the expression of toll-like receptor 4 (TLR4). Importantly, K040706 improved the intestinal microbiota composition. These results suggest that K040706 has an anti-colitic effect by suppression of intestinal inflammatory responses in DSS-induced colitic mice.

활동 스케줄을 고려한 근로자의 활동기반 모형

서승환 圓光大學校 2015 국내박사

정상 유동 장치에서 실린더 행정길이 변화에 따른 유동 특성에 관한 연구

서승환 서울과학기술대학교 산업대학원 2012 국내석사

본 연구는 실린더 행정 길이 변화와 밸브 양정변화에 따라 실린더 내부 유동 특성 변화를 측정하였다. 본 연구를 위한 정상유동 장치에는 충격식 와류 측정기와, 입자영상유속계(particle image velocimetry,PIV)를 사용하였으며, 흡입 밸브 고정 장치를 사용하여 밸브 양정에 변화를 주었고, 실린더 어댑터를 사용하여 실린더내부 행정 길이 변화에 따른 유동변화를 주었다. 일반적으로 흡입유동 측정 위치를 흡입 밸브로부터 1.75B(stroke-bore ratio)에서 실시하는 것이 보통이다. 본 연구에서는 와류 크기를 확인하는 것뿐만 아니라, 실린더 행정 길이 변화에 따라 와류에 미치는 영향을 확인하고자 한다. 와류 측정은 흡입 밸브로부터 1.75B ~ 4.5B 거리까지 실린더 행정 길이를 변화시키며 충격식 와류 측정기로 측정하였다. 그리고 동일한 조건에서 PIV를 사용하여 흡입 유동장을 가시화 하였다. 실린더 행정 길이 변화와 흡입 밸브 양정 변화에 따른 흡입 유량의 변화를 정확하게 확인하기 위하여, 흡입 유량계를 설치하여 동일한 유량에서의 와류 변화를 확인 하였고, 이때 대기압과 실린더 내부의 압력차는 15〃 H2O로 일정하게 유지하게 하였다. 위와 같은 실험 조건하에서 흡입 밸브로부터 발생한 흡입 유동 즉 와류는 실린더 행정길이와 밸브 양정에 따라 증감되었지만, 4.5B 이후에는 안정적인 와류 측정이 이루어짐을 확인하였다. 그리고 연소실 내부 유동 측정 방법 중, 하나인 PIV를 이용하여 실린더 내부 유동 특성을 나타내는 와류와 텀블을 측정하였다.

영덕, 달산지역 화산 파이프의 화산학적 연구

서승환 안동대학교 2015 국내석사

Volcanic pipe in Dalsan area occurs as 1.7km × 1.3km in plan. Rock units in the volcanic pipe can be roughly divided into rhyolitic pyroclastic rocks, andesitic rocks and rhyolitic intrusive rocks. The rhyolitic pyroclastic rocks can be classified into 7 lithofaices: (1) massive tuff breccia, (2) massive ash tuff, (3) massive lapilli tuff, (4) reverse graded lapillistone, (5) normal graded lapilli tuff, (6) accretionary lapilli tuff, (7) lithic breccia. The andesitic rocks are subdivided into 3 lithofaices: (1) andesitic hyaloclastite, (2) porphyritic andesite, (3) peperite. And the rhyolitic intrusive rocks are subdivided into (1) flow-banded rhyolite, (2) porphyritic rhyolite, (3) rhyolitic breccia. The rhyolitic pyroclastic rocks can be associated with lower, middle and upper rock units by eruption mechanisms. The lower rock unit, composed of massive tuff breccia, lithic breccia, was formed by lower wet pyroclastic surges due to phreatomagmatic eruption and rock slides of basement rocks of vent wall. The middle rock unit, composed of massive tuff breccia, reverse graded lapillistone, normal graded lapilli tuff, accretionary lapilli tuff, is made up from lower to higher wet pyroclastic surges by phreatomagmatic eruption due to much influx of groundwater into magma. And the upper rock unit, including massive lapilli tuff and massive tuff breccia, is produced from higher wet pyroclastic surge by phreatomagmatic eruption. The area began with intermediate volcanism elapsing a volcanic quiescence, andesitic lavas effused from cental vent and ring fractures, formed hyaloclastites from quench fragmentation in contact with surface water in crater lake and peperites by chaotic mixing with quench debris at the base under water. And lavas far away from water and magma feeding through conduit could be remained as massive andesites. Afterward, the area began with rhyolitic volcanism again. rising magma along southwestern ring fracture formed rhyolitic breccia owing to contact with groundwater. Intruding magma along cental vent formed flow-banded and porphyritic rhyolites because of no contact with groundwater. Therefore, It can be seen that rhyolitic pyroclastic rocks were formed in the vent, andesitic rocks were produced in the crater and rhyolitic intrusive rocks were formed by the intrusion in the conduit. As results, it could be thought that lithofacies in the volcanic pipe are variously formed by extent of contact of magma and external water, which controlled by location of their magma and lava.

생물전환을 이용한 참당귀의 지표물질의 증가에 따른 항산화활성연구 : Enhancement of indicator substances and antioxidant activities of Angelica gigas Nakai by bioconversion Technology

서승환 안동대학교 2016 국내석사

본 연구는 생물전환을 이용하여 발효한 참당귀 (Angelica gigas Nakai)의 뿌 리를 사용하였으며, 참당귀의 산업화 재료로서 가능성의 확인을 위하여 수행 되었다. 생물전환 중 발효에 사용된 균주는 유산균 속인 Lactobacillus brevis, Lactobacillus acidophillus, 와 Lactobacillus plantarum을 사용하였다. 고성능 액체 크로마토그래피 (HPLC) 분석결과 발효한 당귀에서 decursin 과 nodakenin의 함량이 증가하는 것으로 확인되었으며, 특히 발효한 건조 참당귀 에서 decursin의 함량이 L. brevis 61.354±0.019, L. acidophillus 55.639±0.516, L. plantarum 70.316±0.057 mg/g으로 높게 나타났다. 항산화활성 평가에 사용 된 실험에는 DPPH free radical 소거능, SOD like activity, 총 페놀 함량, 총 플라보노이드 함량 및 ORAC활성을 측정 하였다. 그 결과 DPPH free radical 소거능에서는 발효당귀와 대조구 당귀와는 약간 높거나 비슷하였으며, SOD like activity에서도 DPPH free radical 소거능과 유사한 결과를 보여주었다.또한 총 페놀 함량에서는 L. acidophillus으로 발효한 건조당귀가 33.67%으로 가장 높았다. ORAC assay 결과, 생당귀의 TAC 값 446.80 μM TE/g 보다 높 은 활성을 나타낸 시료는 L. acidophillus 생당귀 (524.10 μM TE/g) 및 L. plantarum 생당귀 (494.77 μM TE/g)이였다. HPLC 분석과 ORAC assay 결 과, 건조당귀의 발효는 decursin의 함량과 ORAC 활성을 증가시키는 것으로 나타났다. 또한 당귀 발효 소재로써는 생당귀가 건조 당귀 보다 바람직한 것 으로 확인되었다.