항고혈압약물 사용 실태조사

주은희,서세민,이용복,고익배 전남대학교 약품개발연구소 1996 약품개발연구지 Vol.4 No.1

Recently the frequency of hypertension and its complication became increased. The use of antihypertensive drug was surveyed in order to take the basic materials about the treatment of hypertension. This study was accomplished with the prescription sheets and chart profiles of the two hundred hypertensive patients of the internal medical department in Chonnam National University Hospital during 6 months from Jan. 1988 to June 1988. Fifteen percent of hypertensive patients had family history. On analysis of hypertension-related complication, 40% occupied cardiovascular diseases such as angina pectoris, myocardial infarction and congestive heart failure. Carl analysis of the combination of antihypertensive drug, 60% occupied the combination of diuretic, β-blocker,(sympatholytic) and Ca-antagonist. The use of sympatholytic except for α, β-blocker was trending toward decrease, but the use of Ca-antagonist toward increase.

전남대학교병원 입원환자 약제 알러지에 관한 연구

주은희,서세민,이용복,고익배 한국병원약사회 1995 병원약사회지 Vol.12 No.2

This study was accomplished to take the available informations about drug allergy, its prevention and therapy. Drug allergy was surveyed with the inpatients in Chonnam national University Hospital during 14 days from Oct. 5 to Oct. 18, 1989. The medical doctors of the ward of the clinical department wrote the drug allergy survey card and our team members reviewed the chart profiles to perform exactly. The drug allergic patients occupied 3.2% of total 657 inpatients. The longer the hospitalization period, the higher the ratio of the occurrence of drug allergy. On the allergy-induced drug, cephalosporins occupied 10 cases, penicillins 7 cases, NSAIDS 3 cases and the miscellaneous drugs 8 cases. On the route of drug administration in the case of drug allergy, parenteral route occupied 16 cases and oral route 5 cases. The symptom of drug allergy included skin eruption(16 cases), palpitation(6 cases), drug fever(4 cases), itching sense(3 cases), flushing face(1 case) and syncope(1 case). The major test of drug allergy was skin test. On the onset time of drug allergy after starting drug therapy, 3 cases occurred immediately, 4 cases after 1 day-2 days, 5 cases during 2 days-1 week and 5 cases after 2 weeks.

백출 Extract 의 혈압강하작용

고석태,서세민 한국약제학회 1976 Journal of Pharmaceutical Investigation Vol.6 No.2

1. In the rabbit and the dog, the blood pressure response to water extract and methanol extract obtained from Atractylodes rhizoma alba was investigated. 2. Water extract and methanol extract, when administered into the rabbit and the dog by the route of vein, produced fall of the blood pressure. 3. The depressor response of the rabbit to water extract and methanol extract was not affected by Avicel^ⓡ, propranolol and atropine. 4. The depressor response by water extract and methanol extract in the rabbit was not affected by guanethidine, but water extract and methanol extract produced elevation of blood pressure in this rabbit. 5. Pretreatment of rabbit with chlorisendamine or phenoxybenzamine weakened the depressor response to water extract and methanol extract, and the both extracts produced secondary elevation of blood pressure in this rabbit. 6. The pressor response of the chlorisondamine-treated rabbit to water extract and methanol extract was not affected by atropine. 7. Water extract decreased the pressor action of tyramine and depressor action of pilocarpine and isoproterenol, but did not affect the blood pressure response of nor einephrine, angiotensin and dimethylpehnyl piperazinium iodide (DMPP).

항고혈압약물 사용 실태조사

주은희,서세민,이용복,고익배 한국병원약사회 1995 병원약사회지 Vol.12 No.2

Recently the frequency of hypertension and its complication became increased. The use of antihypertensive drug was surveyed in order to take the basic materials about the treatment of hypertension. This study was accomplished with the prescription sheets and chart profiles of the two hundred hypertensive patients of the internal medical department in Chonnam national University Hospital during 6 months from Jan. 1988 to June 1988. Fifteen percent of hypertensive patients had family history. On analysis of hypertension-related complication, 40% occupied cardiovascular diseases such as angina pectoris, myocardial infarction and congestive heart failure. On analysis of the combination of antihypertensive drug, 60% occupied the combination of diuretic, β-blocker, (sympatholytic) and Ca-antagonist. The use of sympatholytic except for α, β-blocker was trending toward decrease, but the use of Ca-antagonist toward increase.

전남대학교병원 입원환자 약제 알러지에 관한 연구

주은희,서세민,이용복,고익배 전남대학교 약품개발연구소 1996 약품개발연구지 Vol.4 No.1

This study was accomplished to take the available informations about drug allergy, its prevention and therapy. Drug allergy was surveyed with the inpatients in Chonnam National University Hospital during 14 days from Oct, 5 to Oct. 18, 1989. The medical doctors of the ward of the clinical department wrote the drug allergy survey card and our team members reviewed the chart profiles to perform exactly. The drug allergic patients occupied 3.2% of total 657 inpatients. The longer the hospitalization period, the higher the ratio of the occurrence of drug allergy. On the allergy-induced drug, cephalosporins occupied 10 cases, penicillins 7 cases, NSAIDS 3 cases and the miscellaneous drugs 8 cases. On the route of drug administration in the case of drug allergy, parenteral route occupied 16 cases and oral route 5 cases. The symptom of drug allergy included skin eruption(16 cases), palpitaion(6 cases), drug fever(4 cases), itching sense(3 cases), flushing face(1 case) and syncope(1 case). The major test of drug allergy was skin test. On the onset time of drug allergy after starting drug therapy, 3 cases occurred immediately, 4 cases after 1 day-2 days, 5 cases during 2 days-1 week and 5 cases after 2 weeks.

전남대학교병원 응급실을 통한 급성중독 실태조사

이용복,주은희,서세민,고익배,김미숙,정영녀 전남대학교 약품개발연구소 1996 약품개발연구지 Vol.4 No.1

This study was aimed to take the available informations about the acute poisoning, its prevention and therapy. This survey was accomplished with acute intoxicated patients in the ER(emergency room) of Chonnam National University Hospital during 42 months from Jan.1986 to June 1989. The intoxicated patients occupied 5.8% of total ER patients (47007 cases). The average of intoxicated patients per day in ER was 2.13. On sex analysis, males occupied 49.3% and females 50.7%. On the motive of poisoning, intoxication by accident occupied 42.1%, by suicide attempt 39.4%, and by the others 18.5%. Poisoning substances included CO poisoning(23.9%), agricultural agents (22.8%), drugs(15.4%), chemicals(14.6), bites, rodenticides and food poisoning. The mortality of intoxicated patients was 8% (216 cases) and the major death-inducing substance was paraquat(39.8%). To decrease and prevent these acute poisonings, we suggest, first, that agricultural agents and psychotropic drugs must be carefully controlled by authorities, second, the informations on the acute poisoning continuously collected, third, poison control center established as soon as possible.

종합병원 외래환자 다제병용에 관한 실태조사

주은희,조행남,서세민,이용복,고익배 한국병원약사회 1997 병원약사회지 Vol.14 No.2

This study was accomplished to obtain the basic materials about polypharmacy-related drug interaction and side effect. The polypharmacy in relation to the route of drug administration, dosage form, clinical department and age was surveyed with the 1,632 outpatients in Chonnam University Hospital at one day of January, March and May in 1991. On the route of drug administration, internal medicine occupied 81.2%, the combination of internal medicine & external medicine 7.3%, external medicine 3.9%, injection 3.8% and the combination of internal medicine & injection 3.4%. On drug dosage form, internal medicine occupied 92.1%, injection 7.6% and external medicine 11.6%. The case to use 4 drugs occupied the highest value of 26.2% and the case to use 1 drug 8.4%. The highest number of used drug was 14 and 90% of the patients used less than 6 drugs. The average number of used drug per patient was 4.2. The average number of used drug in ophthalmological department was the lowest value of 2.4, in surgical department 4.4, in internal medical department 4.7 and in neurological department the highest value of 5.7. The average number of used drug in infants and pediatrics was 2.8, in 15-20 year old youth 3.6, in 21-60 year old adults 4.3 and in above 61 year old geriatrics 4.7. As age increased, the number of used drug tended to increase.

야콘을 포함한 수종 천연물의 남성호르몬 대사 억제효과 및 전립선비대 증상 개선효과

박정숙,유건동,서세민,한상배,홍진태,한건 대한약학회 2013 약학회지 Vol.57 No.4

We reported previously that the extracts of Yacon tuber and leaf have spermatogenic activity and testosterone level increasing effect in men. The aim of this study was to investigate the mechanism of testosterone level increasing effect of Yacon tuber and leaf extracts. In this study, we found that Yacon leaf extracts and chlorogenic acid, a constituent of Yacon extracts showed significantly inhibition effect of testosterone degradation in rat liver homogenate. We suggest that this could be a part of direct mechanism about increasing effect of testosterone level. Futhermore, we evaluated the inhibition effect of testosterone metabolism of Torilis japonica and Coix lacryma-jobi have been reported as 5α-reductase inhibitor. The inhibition ratio of testosterone metabolism of these were Torilis japonica〉Coix lacryma-jobi〉Yacon. We also evaluated the benign prostatic hyperplasia (BPH) score with the preparation composed of these natural product, Yacon pill. It showed the decreased the BPH score in men. Rats with BPH showed significantly increased dihydrotestosterone (DHT) levels in the serum; however, Yacon pill extracts treated rats showed significant reduction of DHT levels compared with the BPH group. Conclusively, Yacon pill showed the possibility as ameliorable agents of BPH symptoms.

종합병원 입원환자 다제병용에 관한 실태조사

주은희,김희정,서세민,이용복,고익배 한국병원약사회 1995 병원약사회지 Vol.12 No.3

According to the recent tendency of polypharmacy in clinical department, the probability of the occurrence of drug interaction and adverse effect become increased. This study on the polypharmacy was accomplished for the 1760 inpatients in Chonnam National University Hospital at one day of January, April and July in 1990, in order to obtain the available informations for the monitoring of polypharmacy-related drug interaction and side effect, on the route of drug administration, injection occupied 42.5%, the combination of internal medicine and injection 34.6%, thus these two cases 77.1%. On drug dosage form, injection occupied 83.4%, internal medicine 54% and external medicine 7.6%. The case to use 4 drugs occupied the highest value of 11.2% and the case to use 1 drug occupied 8.6%. The highest number of used drug was 28 and 90% of the patients used less than 12 drugs. The average number of used drug per patient was 6.3. The average number of used drug in surgical department was 6, in internal medical department 6.5 and in otorhinolaryngological department the highest value of 7.1. The average number of used drug in infants and pediatrics was 5.2, in 21-50 year old adults 6.2 and in above 71 year old geriatrics 6.9. As age increased, the number of used drug tended to increase. So we should make a thorough investigation of polypharmacy-related drug interaction and side effect, especially to geriatrics.

종합병원 입원환자 다제병용에 관한 실태조사

이용복,주은희,서세민,고익배,김희정 전남대학교 약품개발연구소 1996 약품개발연구지 Vol.4 No.1

According to the recent tendency of polypharmacy in clinical department, the probability of the occurrence of drug interaction and adverse effect became increased. This study on the polypharmacy was accomplished for the 1760 inpatients in Chonnam National University Hospital at one day of January, April and July in 1990, in order to obtain the available informations for the monitoring of polypharmacy-related drug interaction and side effect, On the route of drug administration, injection occupied 42.5%, the combination of internal medicine and injection 34.6%, thus these two cases 77.1%. On drug dosage form, injection occupied 83.4%, internal medicine 54% and external medicine 7.6%. The case to use 4 drugs occupied the highest value of 11.2% and the case to use 1 drug occupied 8.6%. The highest number of used drug was 28 and 90% of the patients used less than 12 drugs. The average number of used drug per patient was 6.3. The average number of used drug in surgical department was 6, in internal medical department 6.5 and in otorhinolaryngological department the highest value of 7.1. The average number of used drug in infants and pediatrics was 5.2, in 21-50 year old adults 6.2 and in above 71 year old geriatrics 6.9. As age increased, the number of used drug tended to increase. So we should make a thorough investigation of polypharmacy-related drug interaction and side effect, especially to geriatrics.