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丹參의 methicillin 내성 황색포도구균에 대한 효과
서명원,정승일,신철균,주영승,김홍준,고병섭,Seo, Myung-won,Jeong, Seung-il,Shin, Chol-gyun,Ju, Young-sung,Kim, Hong-jun,Ko, Byoung-seob 대한한방안이비인후피부과학회 2003 한방안이비인후피부과학회지 Vol.16 No.1
Objectives : Gram-positive bacteria have became increasing resistant to antibacterial agents, and hence multi-drug-resistant bacterial pathogens are now a major problem in clinical medicine. There is, therefore, a need for new antibacterial agents. In the course of our screening program for potent antibacterial agent from medicinal plants, the extract of Salvia miltiorrhiza (S. miltiorrhiza) showed antibacterial activity against methcillin resistant Staphylococcus aureus (MRSA) and antibiotic-resistant S. aureus. Methods : S. miltiorrhiza was extracted with 80$\%$ EtOH. The extract was suspended in H2O and fractionated successively with hexane chloroform, ethyl acetate, and n-buthanol. The chloroform fraction, which showed the highest antibacterial activity(MICs, 78㎍/ml) against MRSA, was chromatographed on a silica gel column and recycling prep-LC to give the pure antibacterial component. Results and Conclusions : The second fraction among the chloroform soluble portion of an aqueous EtOH extract of S. miltiorrhiza root showed outstanding antibacterial activity against MRSA and antibiotic-resistant S. aureus compared to the other fraction. An active compound was isolated from the second fraction using silica gel column chromatoraphy and recycling prep-LC. Based on these data together with the IH-, 13C-NMR, mass and mp, the active compounds were identified tanshinone Ⅰ, dehydrotanshinone Ⅰ and cryptotanshinone. Among tanshinones, cryptotanshinone and dihydrotanshinone Ⅰ MICs against MRSA and antibiotics-resistant S. aureus were 12.5, 12.5 and 6.3㎍/ml, respectively.
목질계 바이오매스 에너지화 바이오매스 가스화 정제 기술 소개 및 현황
서명원 ( Myung Won Seo ),김재호 ( Jae Ho Kim ),이시훈 ( See Hoon Lee ) 한국공업화학회 2012 공업화학전망 Vol.15 No.6
지속가능한 바이오매스 자원으로부터 열, 전력을 비롯하여 연료부터 화학원료까지 다양한 제품들을 생산하는 열화학적 전환 공정들이 높은 관심을 받고 있다. 특히 수소, 일산화탄소로 구성된 합성가스를 생산하고 이를 전력, 연료 등을 동시에 생산하는 가스화 공정에 대한 학계, 산업계, 정부의 관심이 매우 높다. 그러나 바이오매스 가스화를 통해 생산된 합성가스는 타르, 황산화물 등의 오염물질들을 함유하고 있어 후속 공정들의 이용을 위하여 정제 공정을 반드시 거쳐야 한다. 본고에서는 바이오매스 가스화 기술에 적용되는 일반적인 정제 과정에 대해서 서술하였으며 세부적으로 불순물 제거 공정, 산성가스 제거 공정, 타르 제거 공정 등의 연구 개발 동향을 살펴보았다.
서명원 ( Myung Won Seo ),정승일 ( Seung Il Jeong ),신철균 ( Chol Gyun Shin ),주영승 ( Young Sung Ju ) 대한본초학회 2003 大韓本草學會誌 Vol.18 No.1
N/A Objectives : The purpose of the study is to enhance the objectivity and availability of the oriental herb medicine by formulating the morphological standard and isolation and structure elucidation of radical scavengers from Chrysanthemum indicum L. These intents are expected to be useful in the examination of several physiochemical and biological reactions, determination of indicator material, and identification of gene with basic sources in the future. Methods : In order to develop the standard formulas and isolation and structure elucidation of radical scavengers from Chrysanthemum indicum L., the experimental examinations of the original herbs have been carried out. The morphological standard was divided into 4 parts as plant · external · internal · powder shape. Three antioxidative compouds were isolated by a bioassay using a 1, 1-diphenyl-2-picrydrazyl(DPPH) free radical. They were identified as luteolin, apigenin and linarin (acacetin-7-O-rutinoside) on the basis of 1H and 13C-NMR and MS data. Results and Conclusions : 1. The plant shape : The color of the slender-hair in its stem is purple-black. The leaf is oval-orbicular shape and has the slender-hair in both sides and its petiole has pseudo-stipule. The entire diameter of flower is 2~2.5cm. The lingulate flower is yellow and the siphonoic flower is deep-yellow color. 2. The external shape of herb: It is a globular-like type, 2~3cm in diameter and brown-yellow to yellow color. The lingulate flower is yellow-white color haved one layer and the siphonoic flower is deep-yellow color. The external layer is oval-velvet and the internal layer is long-oval shape in the bracteole. 3. The internal shape of herb: The change of the petal is relatively large, the upper epidermal cell is irregular oval or sphere shape and the lower epidermal cell is regular sphere shape. The lower epidermal cell has occasionally trichomes or a few air pores. the mesophyll tissue has small thin-walled cells which are relatively dense, and the secretory tissue and reserve substances of the pipe type. The vascular bundle which has reticulate vessel is distributed near to lower epidermis cells. 4. The powder shape of herb: The color of the powder sample is yellow-brown. The fragments of parenchyma, vessel and the calcium oxalate crystal are observed. In the sample of maceration, the epidermal cell of petal is various, the epidermal cell of filament is many side shape. The parenchyma is mostly oval shape which occasionally concludes the calcium oxalate crystal. The vessel has uniforation plate at each edge, which is a spiral vessel, and the type of the pit of lateral wall is alternate shape 5. Isolation and Structure Elucidation of Radical Scavengers: The DPPH radical scavenging activity (RC_50: 13.3㎍) of apigenin was similar to that of α-tocopherol (12.1㎍) and L-ascobic acid (9.8㎍).