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문맥압 항진증을 동반한 간경변 환자에서 propranolol이 문맥압에 미치는 효과
백순구 ( Baeg Sun Gu ),최윤종 ( Choe Yun Jong ),김광현 ( Kim Gwang Hyeon ),이병준 ( Lee Byeong Jun ),지명관 ( Ji Myeong Gwan ),석기태 ( Seog Gi Tae ),김정민 ( Kim Jeong Min ),김현수 ( Kim Hyeon Su ),이동기 ( Lee Dong Gi ),권상옥 ( 대한내과학회 2003 대한내과학회지 Vol.64 No.6
목적 : Propranolol은 문맥압 항진증을 개선시켜 정맥류 출혈 예방에 효과적이라고 밝혀진 유일한 약물이다. 인종간에 propranolol에 대한 심혈관계의 감수성이 달라 적정 용량 또한 차이가 있는 것으로 알려져 있다. 이에 본 연구는 문맥압 항진증을 동반한 한국인 간경변 환자에서 propranolol이 문맥압에 미치는 효과 및 필요 용량 그리고 약물반응에 영향을 미치는 인자가 있는지 알아보고자 하였다. 방법 : 정맥류 출혈이 있었던 25명의 간 Background : Propranolol is only known drug effective in preventing variceal bleeding by ameliorating portal hypertension. The optimal dose of propranolol is variable due to racial differences of cardiovascular receptor sensitivity. In this prospective st
간성상세포의 수축 및 성장에 대한 Angiotensin 2 수용체 길항제의 억제 효과
백순구 ( Baeg Sun Gu ),조호성 ( Jo Ho Seong ),석기태 ( Seog Gi Tae ),김정민 ( Kim Jeong Min ),이병준 ( Lee Byeong Jun ),최윤종 ( Choe Yun Jong ),김현수 ( Kim Hyeon Su ),이동기 ( Lee Dong Gi ),권상옥 ( Kwon Sang Og ),이건일 ( Lee G 대한소화기학회 2003 대한소화기학회지 Vol.42 No.2
Backgrounds/Aims: This study aimed to investigate the effects of angiotensin II (ANG II) and its receptor antagonist (losartan) on the contraction and growth of HSCs. Methods: HSCs were isolated from Sprague Dawley rat and cultured at various conditions as follows: control, pretreatment of 10(-5) M ANG II, pretreatment of 10(-5) M endothelin, and pretreatment of 10(-5) M ANG II and 10(-6) M losartan. We conducted morphologic analysis with cellular area and length by image analysis system to estimate cell growth in each group. In addition, we measured the change of intracellular calcium currents via electrophysiological methods to evaluate the contractile effect of ANG II and losartan on HSCs. Results: At the fifth day of incubation, the mean cellular area of ANG II-pretreated group and ANG II with losartan-pretreated group were 704.68±22.6 um2 and 332.90±32.6 um2, respectively. This difference was statistically significant (p<0.05). ANG II induced an increase in the intracellular calcium current by 22.0±3.0% compared with basal current level (p<0.05). However, when losartan was pretreated, ANG II did not cause a significant increase in calcium current (3.1±0.8%, p>0.05). Conclusion: ANG II accelerates the contraction and growth of HSCs, while its receptor blocker, losartan, inhibits the contraction and growth of HSCs (Korean J Gastroenterol 2003;42:134-141)
지명관 ( Ji Myeong Gwan ),백순구 ( Baeg Sun Gu ),원찬식 ( Won Chan Sig ),변종원 ( Byeon Jong Won ),김현수 ( Kim Hyeon Su ),이동기 ( Lee Dong Gi ),권상옥 ( Kwon Sang Og ),김영주 ( Kim Yeong Ju ) 대한소화기학회 2003 대한소화기학회 추계학술대회 Vol.2003 No.-
<목적> 간경변환자는 문맥압 항진증과 동맥혈관 저항의 감소에 따른 혈역학적 변화를 갖는다. 본 연구는 간경변환자의 예후에 영향을 미치는 혈역학적 요인에 대해 알아보고자 하였다. <대상 및 방법> 총 103명의 간경변 환자를 대상으로 1999년 12월부터 2003년 6월까지 174주간의 추적연구를 통해 혈역학적 지표로 평균 혈압, 심박동수, 문맥압을 대변하는 간정맥 압력차(hepatic venous pressure gradient), 문맥 혈류량, 비장
대한간학회지 제8차 춘계학술대회 초록집 : 구연 ; 간경변 환자에서 Octreotide 정주가 문맥압에 미치는 영향
박동훈 ( Park Dong Hun ),백순구 ( Baeg Sun Gu ),김문영 ( Kim Mun Yeong ),최윤종 ( Choe Yun Jong ),김현수 ( Kim Hyeon Su ),이동기 ( Lee Dong Gi ),권상옥 ( Kwon Sang Og ),김영주 ( Kim Yeong Ju ) 대한간학회 2002 Clinical and Molecular Hepatology(대한간학회지) Vol.8 No.2(S)
지명관 ( Ji Myeong Gwan ),최윤종 ( Choe Yun Jong ),백순구 ( Baeg Sun Gu ),윤상진 ( Yun Sang Jin ),김현수 ( Kim Hyeon Su ),이동기 ( Lee Dong Gi ),김영주 ( Kim Yeong Ju ) 대한내과학회 2003 대한내과학회지 증례 특집호 65-5 부록3 Vol.0 No.-
We report an uncommon case of pyogenic hepatic abscess with hepatobronchial fistula. A 59 year-old male was admitted because of purulent sputum and cough. Ultrasonography and abdominal computed tomography showed an abscess on the superior segment of right
데옥시콜릭산에 의한 HT-29 대장상피세포의 신호전달 -NF-κB와 Interleukin-8의 역할-
이동기 ( Lee Dong Gi ),박선영 ( Park Seon Yeong ),백순구 ( Baeg Sun Gu ),권상옥 ( Kwon Sang Og ),정준모 ( Jeong Jun Mo ),오억수 ( O Eog Su ),김현수 ( Kim Hyeon Su ) 대한소화기학회 2004 대한소화기학회지 Vol.43 No.3
Background/Aims: Deoxycholic acid (DCA) has been appeared to be an endogenous colon tumor promoter. In this study, we investigated whether DCA induces nuclear factor-kappa B (NF-kB) activation and IL-8 expression, and tauroursodeoxycholic acid (TUDC) inhibits this signaling in HT-29 cells. Methods: After DCA treatments, time courses of NF-kB binding activity were determined by electrophoretic mobility shift assay (EMSA). Also, we performed Western blotting of IkBα to confirm NF-kB activation. Time and concentration courses of DCA-induced secretion of IL-8 were measured with ELISA in supernatants of cultured media from the cells. To evaluate the role of NF-kB, IL-8 levels were assessed after pretreatment with using phosphorothioate-modified anti-sense oligonucleotides (ODN). Moreover, DCA-induced secretions of IL-8 were measured after pretreatment with TUDC. Results: DCA dose-dependently induced prominent NF-kB binding complexes from 30 min to 8 hr and degradation of IkBα. The secretions of IL-8 were increased with DCA (50~200 μM) treatment in a time and dose-dependent manner. Pre-incubation of the cells with TUDC (0.1~10 μM) for 2 hours caused significant decreases in DCA induced IL-8 secretion. However, transient transfection using p50 or p65 AS-ODN showed no effect on IL-8 secretion. Conclusions: DCA may play as a colonic tumor promoter through anti-apoptotic effect of NF-kB activation and IL-8 expression, and DCA-induced NF-kB independent IL-8 expression is inhibited by TUDC. (Korean J Gastroenterol 2004;43:176-185)
이종인 ( Lee Jong In ),이상수 ( Lee Sang Su ),원구태 ( Won Gu Tae ),안강현 ( An Gang Hyeon ),이성우 ( Lee Seong U ),백순구 ( Baeg Sun Gu ),김승률 ( Kim Seung Lyul ),용석중 ( Yong Seog Jung ),신계철 ( Sin Gye Cheol ),정순희 ( Jeong 대한내과학회 1993 대한내과학회지 Vol.44 No.2
N/A Background : Because there aremany different reporting results about the etologies of solitary pulmonary nodules (SPNs), we cannot know the exact incidence of each causative disease. SPNs have a good prognosis relatively even if it is a malignant lesion. In Korea, where there is a high incidence of pulmonary tuberculosis, the differential diagnosis of SPNs should be performed. Methods : Among 351 patients who visited Wonju Chistian Hospital for SPNs in chest x-ray between 1982 and 1989, we evaluated 74 patients in whom the causes of SPNs could be elucidated by sputum AFB study, cytology, histolgic study, chest of solitary pulmonary nodule (SPN) seen at the Wonju Christian Hospital from 1982 to 1989. The followings were obtained. 1) The malignancies of SPN 74cases were 25 cases (33.7%). The primary lung carcinomas were 24 cases : The epidermoid carcinomas of these were 11 cases (45.8%), metastasis I case, tuberculoma 42 cases, and the other 7 cases. 2) The age distribution of benign lesions was from 19 to 73 years old with the mean age of 46 years old, and the age distribution of malignancies was from 17 to 77 years old with the mean age of 57 years old. The 23 cases (92.0%) of malignant nodules were more than 40 years old. The malignant frequency of SPN in a group of age more than 40 years old was 40.3% and in a group of age less than 40 years old, it was 11.7%. The malignant frequency was directly proportional to the increase of age(p<0.05). 3) The 3 cases of SPN were detected accidentally during physical up, all were benign. The 14 cases were detected during the evaluation of other diseases, 12 cases were benign. The 23 cases (40%) of 57 cases were symptomatic. Chest pain, dyspnea, and weight loss frequency in a group of less than 3cm in size was 11.9% and in a group of less than 3cm in size, it was 62.5% (p<0.05). 6) Calcifications were noted in 15 cases of 74 cases on the plain films, all were 7 central types, 7 diffuse types and 1 popcorn type. One of malignant cases had calcification on the chest CT scar. Among the 59 cases with non-calcified nodules, 25 cases were malignant (42.3%). The mean Hounsfield Unit of benign lesions was 182.5U and that of malignancies was 94U, there was a statistical difference between both groups(p<0.01). 7) The 21 cases (50%) of tuberculomas were located at the apicoposterior segment of upper lobe or the superior segment of lower lobe, but the 7 cases (28%) of malignancies were located at above sites. 8) The diagnostic accuracy of sputum study was 9.4% and that of fiberoptic bronchoscopy (FOB) was 33.3%. The diagnostic accuracy of transbronchial lung biopsy (TBLB) and transthoracic needle aspiration biopsy (TTNAB) was 57.4%. The percentage of primary lung cancer among SPNs which are larger than 3cm in size, occurring in the age of older than 40 years old and with no calcifications on radiologic examintion should be suspected as malignancies and diagnosed with sputum study, fiberoptic bronchoscopy, TBLB, and TTNAB.