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흰쥐 대동맥에서 imipramine의 혈관이완 작용기전
강형섭,이상우,백성수,조성건,김진상,Kang, Hyung-sub,Lee, Sang-woo,Baek, Sung-su,Joe, Sung-gun,Kim, Jin-shang 대한수의학회 2003 大韓獸醫學會誌 Vol.43 No.4
Although the antidepressant effects of imipramine (IMI) have been well known in several studies, the effects on cardiovascular system, particularly the vasorelaxant effects, have not known clearly. We hypothesis that IMI-induced vasorelaxation involves NO (nitrie oxide), activation of guanylate cyclase (GC) and $Ca^{2+}$ channel. The possible roles of the endothelium and $Ca^{2+}$ in IMI-induced responses were investigated using isolated rings of rat thoracic aorta and anesthesized rats. In KCl-precontracted rings. IMI produces endothelium-dependent and endothelium-independent relaxations in intact (+E) as well as endothelium-denuded (-E) rat aorta in a concentration-dependent manner. In phenylephrine (PE)-precontracted rings, the IMI-induced relaxation was significantly greater in +E rings. The IMI-induced relaxations were suppressed by nitric oxide synthase (NOS) inhibitors, N(G)-nitro-L-arginine (L-NNA), N(omega)-nitro-L-arginine methyl ester (L-NAME) and aminoguanidine, a non-selective GC inhibitor, methylene blue, $Na^+$ channel blockers, lidocaine and procaine, or $Ca^{2+}$ channel blockers, nifedipine and verapamil, in PE-precontracted +E rings, but not in PE-precontracted -E rings. These relaxations were also suppressed by lidocaine or procaine in -E aortic rings. However, IMI-induced relaxations were not inhibited by a PLC inhibitor 2-nitro-4-carboxyphenyl-n,n-diphenylcarbamate (NCDC), an inositol monophosphatase inhibitor, lithium, indomethacin and dexamethasone in +E and -E rings. In vivo, infusion of IMI elicited significant decrease in arterial blood pressure. After intravenous injection of saponin, NOS inhibitors. MB and nifedipine, infusion of IMI inhibited the IMI-lowered blood pressure markedly. These findings suggest that the endothelium-dependent relaxation induced by IMI is mediated by activation of NO/cGMP signaling cascade or inhibition of $Ca^{2+}$ entry through voltage-gated channel, and this mechanism may contribute to the hypotensive effects of IMI in rats.
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성창훈(Chang Hoon Seong),백성수(Sung Su Baek) 한국스포츠교육학회 2000 한국스포츠교육학회지 Vol.7 No.2
본 연구는 중학생들이 체육수업에서 경험하는 재미의 촉진요인과 저해요인을 분석하였다. 606명의 남녀학생들이 촉진(302명)과 저해요인(304명)을 묻는 개방형 설문지에 각각 반응하였으며, 여기에서 얻어진 770개의 촉진요인과 816개의 저해요인 원자료는 3단계 범주화 방법을 통하여 내용 분석하였다. 분석 결과, 재미를 촉진시키는 요인으로는 과제의 선택성과 자율성(40.6%), 긍정적 수업방식(25.4%), 운동의 심리 ·생리적 효과(14.8%), 교사(7.5%), 경쟁과 시합(3.9%), 실기평가(3.6%)의 6개 일반영역이 도출되었으며, 저해요인은 과제의 선택제한(27.2%), 부정적 수업방식(30.4%), 열악한 교육환경(14.2%), 교사(14.1%), 평가(7.3%), 교실수업(7.0%), 학생요인(2.0%), 잡일하기(1.7%)의 8개 일반영역으로 대분되었다 특히, 하위 분류 영역에서 나타난 체육수업의 재미요인들은 스포츠 연구들에서 제시된 재미요인들과 비교하여 현저한 개념적 차이를 보였다. 나아가 재미 촉진요인과 저해요인의 하위 주제들 간에도 다소의 차이를 보였으며, 촉진과 저해요인에 포함된 각 주제의 반응빈도에 대한 성별에 따른 차이 역시 발견되었다. 이러한 결과는 학생들의 동기와 정서를 보다 잘 이해하고 이에 바탕을 둔 학교 체육프로그램의 내용 선정과 운영 측면에서 논의하였다. This study investigated the promotive and interuptive sources of enjoyment in middle school-based Physical Education(PE). Middle school students(301 boys, 305 girls) responded an open-ened question regarding the factors promotive and interuptive sources of enjoyment in PE. A total of 1586 reponse(770 promotive and 816 interuptive sources) on the open-ened question were content-analyzed. In the 1st subject analysis, the 18 promotive and 15 ineruptive dimensions of enjoyment were emerged, and in the details area of 2nd subject analysis, it was divided into the 11 promotive and 10 interuptive dimensions. It the general area of the final classification, the 7 promotive sources were the task, instruction method, psychological/physiological effect of exercise, to like the teacher, competition and match, skill measure, others etc., and the interuptive sources were classified into task, instruction method, educational environment, teacher, skill measure load, classroom work, student, to do the miscellaneous works, lack of physical education class, others etc. The dimentions generally fit into the students` experience catagories in PE(Goudas & Biddle, 1993). However, some unique sources of enjoyment reflect the nature of middle school PE in korea. Gender difference in the dimention and the level of PE enjoyment were also identified.
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흰쥐 관류 간장에서 L-dopa 및 Dopamine이 Mg^(2+) 유리에 미치는 영향
백성수,강형섭,김진상 한국수의공중보건학회 2002 예방수의학회지 Vol.26 No.3
Magnesium is one of essential minerals for all cells. In mammals it is the second most abundant intracellular cation. Magnesium shows many roles in various physiological processes. Although recent studies demonstrated that adrenergic receptor stimulation evokes marked changes in Mg^(2+) homeostasis, the regulation of Mg^(2+) by dopamine and dopamine precursors is not yet known. The purpose of this study was to identify the mobilization of Mg^(2+) by dopamine and dopamine precursors in the perfused rat livers. Mg^(2+) content was measured by atomic absorbance spectrophotometry. Mg^(2+) efflux was increased by L-dihydroxyphenylalanine (L-dopa) or dopamine but not by L-tyrosine from rat liver. L-dopa-induced Mg^(2+) efflux was inhibited or partial inhibited by β-methyldopa and diethyldithiocarbamate (DEDC), inhibitors of catecholamines converting enzyme. But dopamine-induced Mg^(2+) efflux was not inhibited by DEDC or phenylpropargylamine, inhibitors of dopamine β-hydroxylase. Fluphenazine, dopaminergic antagonist, inhibited dopamine-induced Mg^(2+) efflux. L-dopa-induced Mg^(2+) efflux was also inhibited or partial inhibited by fluphenazine. In addition, the Mg^(2+) efflux by L-dopa or dopamine was completely inhibited by adrenergic antagonists (propranolol and prazosine) or imipramine. These results indicate that the Mg^(2+) efflux from rat liver could be induced by L-dopa and dopamine, and these effects can be mediated by the dopaminergic and/or adrenergic receptor stimulation.
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