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RAW 264.7 대식세포에서의 유산균에 의한 Nitric Oxide와 TNF-α의 생성 증가 효과
박소희(So Hee Park),정명준(Myung Jun Chung),김수동(Soo Dong Kim),백대헌(Dae Heoun Baek),강병용(Nam Joo Ha),하남주( Nam Joo Ha) 大韓藥學會 2005 약학회지 Vol.49 No.6
The immune reinforcement of the probiotic lactic acid bacteria Lactobacillus acidophilus, Streptococcus thermophilus and Bifidobacterium bifidum was studied in RAW 264.7 cell line treated with diluted solution (dilution to 25) of the supernatnats of lactic acid bacteria. RAW 264.7 cell line was used as a macrophage model to assess the effects of lactic acid bacteria on the production of nitric oxide (NO) and cytokine tumor necrosis factor (TNF)-α and cell morphological changes. The production of NO and TNF-α were largely affected by lactic acid bacteria in dose-dependent manner in 24 or 48 hr cultures and cell morphological changes were also largely affected by lactic acid bacteria. Especially, Bifidobacterium bifidum differentially stimulated the production of NO and TNF-α. NO production was increased by Bifidobacterium bifidum 25㎕/㎖ more than LPS(20ng/㎖) control, and TNF-α by Bifidobacterium bifidum 6.25㎕/㎖ more than LPS (10ng/㎖) contorl. The in vito approaches employed here should be useful in further characterization of the effects of lactic acid bacteria on systemic immunity.
Bacillus subtilis Natto가 생산하는 Nattokinase의 항혈전 및 피브린 용해능 효능평가
이다령(Da-Lyung Lee),홍성유(Sung-Yu Hong),장양수(Yang-Su Jang),장형욱(Hyung-Wook Jang),맹창재(Chang-Jae Maeng),유철배(Chul-Bae Yoo),백대헌(Dae-Heoun Baek) 한국생물공학회 2012 KSBB Journal Vol.27 No.6
We previously reported that Ultra nattokinase<SUP>ⓡ</SUP> showed high fibrinolytic activity and revealed antithrombotic effect in rat blood plasma based on its ability to suppress collagen-induced platelet aggregation. This research was carried out to verify the clot lysing activity and blood flow enhancing effects of Ultra nattokinase<SUP>ⓡ</SUP> via monitoring and comparing the antithrombotic effects in rat artery between oral administration of Ultra nattokinase<SUP>ⓡ</SUP> and maltodextrin. SD rats were fed with 1.11 mg/kg of Ultra nattokinase<SUP>ⓡ</SUP> for 4 weeks. The effect on arterial thrombosis was then evaluated using an antithrombotic model after induction by FeCl₃. Detected fibrinolytic activity was proportional to the content of Ultra nattokinase<SUP>ⓡ</SUP> and statistical extents of the antithrombotic activity was enhanced strongly twice rather than control group. The PT and the aPTT, however, showed only a small difference between two groups. The results suggest that Ultra nattokinase<SUP>ⓡ</SUP> can effectively treat thromboembolism and enhance blood flow, and that Ultra nattokinase<SUP>ⓡ</SUP> can also prevent venous occlusion by aiding clot lysis.