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BTT0811의 in vitro 3T3 Neutral Red Uptake 시험법을 이용한 광독성 평가
전은영 ( Eun Young Jeon ),정미숙 ( Mi Sook Jung ),서임권 ( Im Kwon Seo ),노효정 ( Hyo Jeong Noh ),정우영 ( Woo Young Jung ),김상석 ( Sang Seok Kim ),배흥모 ( Heung Mo Bae ),전태원 ( Tae Won Jeon ),이상구 ( Sang Goo Lee ),강종구 ( 한국동물실험대체법학회 2013 동물실험대체법학회지 Vol.7 No.1
Phototoxicity is a toxicity reaction induced by UV after applying the chemical to part or entire body. BTT0811 which has co-developed by Biotoxtech Co., Ltd., Korea and Northland, China is recombinant material of thymosin β4. We performed to evaluate the phototoxicity of BTT0811 using in vitro 3T3 neutral red uptake phototoxicity test in OECD guideline. Before evaluating the phototoxicity of this study, we selected two substances for the controls. One of the positive controls was chlorpromazine, already known as a phototoxicity substance, and the other was L-histidine, which has no phototoxicity. Then, we evaluated the phototoxicity of BTT0811 compared with those substances. In results of study, photo irritation factor (PIF) and mean photo effect (MPE) was measured for evaluating phototoxicity. PIF and MPE value of chlorpromazine was more than 6 and 0.15, respectively. Chlorpromazine had phototoxicity resulting from PIF and MPE. On the other hand, L-histidine was measured no PIF value and less than 0.1 of MPE. There was no PIF value of BTT0811 and MPE value of BTT0811 was less than 0.1. Based on the results of this study, BTT0811 did not show any evidence of phototoxicity in BALB/c 3T3 clone A31 cells under the conditions of this study.
연구논문 : BTT0811의 in vitro 3T3 Neutral Red Uptake 시험법을 이용한 광독성 평가
전은영 ( Eun Young Jeon ),정미숙 ( Mi Sook Jung ),서임권 ( Im Kwon Seo ),노효정 ( Hyo Jeong Noh ),정우영 ( Woo Young Jung ),김상석 ( Sang Seok Kim ),배흥모 ( Heung Mo Bae ),전태원 ( Tae Won Jeon ),이상구 ( Sang Goo Lee ),강종구 ( 한국동물실험대체법학회 2013 동물실험대체법학회지 Vol.7 No.1
Phototoxicity is a toxicity reaction induced by UV after applying the chemical to part or entire body. BTT0811 which has co-developed by Biotoxtech Co., Ltd., Korea and Northland, China is recombinant material of thymosin β4. We performed to evaluate the phototoxicity of BTT0811 using in vitro 3T3 neutral red uptake phototoxicity test in OECD guideline. Before evaluating the phototoxicity of this study, we selected two substances for the controls. One of the positive controls was chlorpromazine, already known as a phototoxicity substance, and the other was L-histidine, which has no phototoxicity. Then, we evaluated the phototoxicity of BTT0811 compared with those substances. In results of study, photo irritation factor (PIF) and mean photo effect (MPE) was measured for evaluating phototoxicity. PIF and MPE value of chlorpromazine was more than 6 and 0.15, respectively. Chlorpromazine had phototoxicity resulting from PIF and MPE. On the other hand, L-histidine was measured no PIF value and less than 0.1 of MPE. There was no PIF value of BTT0811 and MPE value of BTT0811 was less than 0.1. Based on the results of this study, BTT0811 did not show any evidence of phototoxicity in BALB/c 3T3 clone A31 cells under the conditions of this study.