http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
필리핀에서 유입된 Dengue hemorrhagic fever
배성진 ( Bae Seong Jin ),정진원 ( Jeong Jin Won ),김진영 ( Kim Jin Yeong ),김남중 ( Kim Nam Jung ),김양수 ( Kim Yang Su ),류지소 ( Lyu Ji So ),우준희 ( U Jun Hui ) 대한내과학회 2003 대한내과학회지 증례 특집호 65-5 부록3 Vol.0 No.-
Dengue Hemorrhagic Fever/dengue shock syndrome (DHF/DSS) is an acute febrile illness characterized by decreased platelet counts and hypovolemic shock due to increased vascular permeability and plasma leakage in patients infected with any one of four serot
배성진(Sung Jin Bae),안원석(Won Suk An),박건욱(Geun Wook Park),박희승(Hee Seung Park),김구(Gu Kim),김동수(Dong Su Kim),김광동(Kwang Dong Kim),정재열(Jae Youl Jung),장광열(Kwang Yul Chang),김선택(Sun Tack Kim),김성은(Seong Eun Kim),김 대한내과학회 1997 대한내과학회지 Vol.52 No.5
N/A Objective .We aimed to compare efficacy of treatment between steroid therapy and steroid-chlorambucil combination therapy in patients with adult-onset idiopathic membranous glomerulonephritis (MN). Methods: A series of 31 biopsy-proved idiopathic MN patients was analyzed retrospectively to estimate effect of treatment with steroid and/or cytotoxic agent. All patients (male 15, female 16, mean age of 37 years old) presented a full-blown nephrotic syndrome (proteinuria >3.0gm/day, serum albumin <3.0mg/dL, edema) at the initiation of treat- ment and were observed for at least 6 months (mean follow up period: 28±23 months). Clinical and laboratory information were obtained at the time of presentation and at last follow up. Each patient was assigned to one of the following protacols. 1) Steroid therapy prednisolone 40 or 60mg/day (single dose) for 16 weeks. 2) Steroid-Chlorambucil combination therapy: for 6 months with three cycles of methylprednisolone pulse therapy (lgm 1V for 3 days), prednisolone 0.5mg/kg/day for 27 days, then chlorambucil 0.2mg/kg/day for 28 days. 3. Cyclophosphamide 2mg/kg/day for 28 days. Results: 1) Final status in total 31 cases irrespective of therapeutic modality were complete remission in 5 (16%) cases, partial remission in 9 (29%) cases, no response in 12 (41%) cases, spontaneous complete re- mission in 1 cases, and spontaneous partial remission in 1 case. 2) After initial steroid therapy (in 25 cases), We observed no response in 17 (68%) case, partial remission in 3 (12%) cases, complete remission in 3 (12%) cases, and spontaneous partial remission in 2 (8%) cases. 3) The combination therapy (steroid and chlorambucil) tried in 10 cases results in 5 (50%) cases of partial remission, 2 (20%) cases of complete remission, 1 (10%) case of spontaneous partial remission, and 2 (20%) cases of no response. 4) During follow up period, renal functional deterioration was absent in any case and final albumin levels were significantly increased (p<0.05). Conclusion: Steroid-chlorambucil combination pro- toco1 is considered to be a more effective treatment with higher rate of overall remission compared to steroid therapy. Idiopathic MN itself seems to have a relatively benign course when considering that renal function was preserved in all cases without progression to chronic renal failure and that a few cases of spontaneous remission could be observed. For the limitation in number of cases and duration of follow up in this study, it needs prospective controlled study of more larger scale with long-term follow up to get a more reliable results.
사구체신염 환자의 생검조직에서 endothelin - 1 의 발현양상
배성진(Sung Jin Bae),안원석(Won Suk An),나서희(Suh Hee Rha),김성은(Seong Eun Kim),김기현(Ki Hyun Kim) 대한내과학회 2002 대한내과학회지 Vol.62 No.5
목적 : Endothelin-1은 강력한 신혈관 수축작용이 있으며, 체내 Na+ 대사에 관여하고, 세포 실험에서는 메산지움 세포의 분화와 수축을 일으키며 세포외 기질 생산을 자극한다고 보고되고 있다. 이에 저자는 사구체신염 환자의 신생검 조직에 endothelin-1에 대한 면역조직화학염색을 시행하여 endothelin-1과 사구체신염의 세포증식성 변화와의 관계를 구명하고자 하였다. 방법 : 대상은 정상 신기능의 성인 사구체 신질환자 64예였다. 초점성 사구체신염과 미만성 메산지움증식성 사구체신염의 병리소견을 보이는 IgA 신병증, 막성증식성 사구체신염, 연구균감염 후 사구체신염과 국소성 및 미만성 증식성 낭창성신염 등은 증식성 사구체신염군으로 하고, 미세변화 신증후군, 막성신병증 및 미소변화 IgA 신병증은 비증식성 사구체신염군으로 분류하였다. 환자들의 신생검 조직을 anti-endothelin-1 serum으로 avidin-biotin-complex 법에 의한 immunoperoxidase 염색을 하여 endothelin-1의 발현 양상을 비교 분석하였다. 결과 : 증식성 사구체신염군의 생검조직에서 비증식성 사구체신염군에 비하여 사구체 모세혈관 내피세포, 간질내 혈관 내피세포 그리고 세뇨관 상피세포에서 각각 endothelin-1 면역반응이 강하였다. 결론 : 이상의 결과로 endothelin-1은 사구체신염의 세포증식과정이나 세포증식 후의 이차적 손상에 중요한 역할을 할 것으로 보인다. Background: Endothelin-1 has been found to be a potent mitogen in cultured mesangial cells. In addition, the urinary hyperexcretion of endothelin-1 was observed in patients with glomerulonephritis. Methods: The author studied endothelin-1 immunoreactivity in 64 kidney biopsies of patients with various glomerular diseases by immunoperoxidase staining utilizing anti-endothelin-1 serum from the rabbit. Results: A group of Ig A nephropathy with glomerular proliferative change (8 focal glomerulonephritis and 7 diffuse mesangial proliferative glemerulonephritis) and a group of other proliferative glomerulonephritis (11 membranoproliferative glomerulonephritis type I, 5 poststreptococcal glomerulonephritis, 8 focal or diffuse proliferative lupus nephritis) have more prominent endothelin-1 protein expression in the glomerular endothelium, the vascular endothelium and the tubular epithelium than non-proliferative glomerular disease group (12 minimal change nephrotic syndrome, 7 membranous nephropathies, 6 IgA nephropathies with minor glomerular abnormality). Conclusion : These results suggest that endothelin-1 has a potential role in the pathophysiology of proliferative glomerualr diseases.(Korean J Med 62:530-536, 2002)
양챵호(Chang Ho Yang),배성진(Sung Jin Bae),박희승(Hee Seung Park),이혁(Lee Hyuck),김병수(Byung Soo Kim),손지원(Ji Won Son),김무현(Moo Hyun Kim),김종성(Jong Seong Kim),도현국(Hyun Kuk Do) 대한내과학회 1996 대한내과학회지 Vol.51 No.2
N/A Objectives: In this study the pulmonary venous flow velocity pattern was analysed in 25 hypertensive patients with and without heart failure to clarify whether the pulmonary venous flow velocity pattern provides compensatory information in the interpretation of the mitral flow velocity pattern. Mothods: 25 patients with hypertension were considered for this study. Eight of the 25 patients with hypertension had symptom of congestive heart failure(group 2). Control group fulfilled the following criteria (1) no history of heart disease or hypertension, (2) no hyperlipidemia, (3) normal EKG, chest X-ray, Doppler echocardiographic recordings were made with the subject in the left lateral position during quiet respiration. The pulmonary venous flow velocity pattern and mitral flow velocity pattern were examined in the apical four-chamber view. The isovolumic relaxation time was examined in the apical five-chamber view. Results : The mitral flow velocity pattern in 17 hypertensive patients without heart failure was charaterized by a decreased in the peak early diastolic filling velocity(E, p>0.05), an increased peak filling velocity at atrial contraction(A, p<0.05) and a decreased E/A ratio (p<0,05). The mitral flow velocity pattern was normalized in 8 patients with heart failure, with no differences in mitral flow velocity pattern as compared with 13 normal subjects. In patients with heart failure, S wave was lower and D wave was higher and the S/D ratio was lower compared with hypertensive patients without heart failure(p>0,05) and D wave was higher and the S/D ratio was lower compared with control subjects(p<0.05). Conclusion: Analysis of the pulmonary venous flow velocity pattern in conjunction with the mitral flow velocity pattern provieds important and more reliable information in the interpretation of the mitral flow velocity pattern in hypertensive patients with and without heart failure
관상동맥 협착 환자에서의 관동맥 혈류 예비능 - Doppler Guidewire Study-
김무현(Moo Hyun Kim),배성진(Sung Jin Bae),양창호(Chang Ho Yang),김상곤(Sang Gon Kim),손지원(Ji Won Son),도현국(Hyun Kuk Dho),김종성(Jong Seong Kim) 대한내과학회 1996 대한내과학회지 Vol.50 No.2
N/A Objectives: Coronary flow reserve(CFR) is the ratio of the maximal hyperemic to basal coronary blood flow velocity hyperemia, which was introduced by Gould et al, as a functional parameter in the coronary artery stenosis. Methods: To evaluate the difference of the CFR between the significant and insignificant coronary artery narrowings, we measured coronary flow velocity in 17 patients(11 nonstenotic group and 6 stenotic patients) by 0.0l4 inch intracoronary Doppler-tipped guidewire after nitroglycerine 200㎍ intracoronary infusion during coronary arteriography. We measured coronary flow velocity in 11 left coronary artery and 6 right coronary artery before and after adenosine intracoronary infusion(LCA 12㎍, RCA 6㎍). Results: 1) Average peak velocity(APV, cm/sec) of steno- tic patients was higher than nonstenotic group(19.8 vs 36.6, p<0.05), but diastolic systolic velocity ratio (DSVR) were not significantly different between both groups. 2) APV after adenosine infusion in stenotic and nonstenotic group were 56.3±16.4, 60±23.4cm/sec, respectively, which are significantly increased compared to the basal state(p<0.01). 3) Mean coronary flow reserve(CFR) in the stenotic group was significantly lower than nonstenotic group(1.98±0.9 vs 3.57±1.0, p<0.01). 4) Systolic and diastolic blood pressure decreased significantly after adenosine intracoronery bolus infusion(p<0.01), but heart rate did not changed significantly(p>0.05). The mean time that came back to the baseline flow velocity after adenosine infusion was 27.1 seconds. Conclusion: Coronary flow reserve decreased significantly in the coronary artery stenosis compared to normal or insignificant stenosis. And adenosine caused significant fall in blood pressure after intracoronary infusion, but did not in heart rate
한경근(Kyung Geun Han),배성진(Sung Jin Bae),김성은(Seong Eun Kim),김기현(Ki Hyun Kim),박정하(Jeong Ha Park),지삼룡(Sam Ryong Ji),임정현(Jeong Hyun Lim),장광열(Goang Yul Jang) 대한신장학회 2000 Kidney Research and Clinical Practice Vol.19 No.3
N/A There are some clinical evidences that hepatitis B virus(HBV) infection may cause IgA nephropathy. To evaluate clinical significances and pathogenetic roles of HBV infection in patients with IgA ne-phropathy, we studied that varius clinical and lab- oratory findings in 172 patients with IgA nephrop-athy as serum hepatitis B surface antigen(HBsAg) positive(19 cases) and negative group(153 cases). The result was as following: 1) The incidence of positive serum HRsAg was 11.0%(19/172 cases) in patients with IgA nephrop- athy and it was higher than that of the randomized age-sex matched general population(4.1%) but has no significance statistically. 2) There was no significant differences in incidence of hypertension, serum levels of IgA, C3, SGOT, SGFf between HBsAg postive and negative group. 3) The cases of nephrotic range proteinuria(3.5g/ day) was more prevalent in HBsAg positive group (31.6%) than that in negative group(7.2%). significantly(p<0.05). 4) The cases of impaired renal function(serum creatinine more than 1.4mg/dL) were more frequent in HBsAg positive group(42.19%) than that in neg-ative group(13.1%) significantly(p<0.05).
박정하(Jung Ha Park),배성진(Sung Jin Bae),배상문(Sang Moon Bae),노명환(Myung Hwan Noh),김재석(Jae Seok Kim),박희승(Hee Seung Park),정원태(Won Tae Jung),김성은(Seong Eun Kim),김기현(Ki Hyun Kim),김영훈(Yeong Hoon Kim) 대한내과학회 1996 대한내과학회지 Vol.50 No.6
N/A Objectives - A series of biopsy-proven 76adult onset minimal change nephrotic syndrome(MCNS) was analyzed to estimate the clinical courses including the rate and the pattern of response to corticosteroids or cytotoxic agents and the characteristics of relapse, Methods: The diagnoses of all cases were made between 1985 and 1994. Mean follow up duration was 2.4±2.0 years. All the patients had the apparent onset of their disease when aged 16or more and presented with a full-blown nephrotic syndrome (proteinuria>3.0gm/day, serum albumin<3.0gm/dl and edema). None had either past history of a nephrotic syndrome or other renal disease. All the cases were classified to five groups (16-25, 26-35, 36-45, 46-55, above 56) according to age and were analyzed. The clinical and laboratory information was obtained on each patient at the time of presentation and at last follow-up. Renal tissues were examined by light, fluorescence and electron micorscopy. The initial prednisolone was used at a dose of 40mg/day p.o. given up to 16weeks and the response to prednisolone therapy was evaluated, then tapered by 10mg every 2weeks. Cyclophosphamide was used at a dose of 2mg/kg/day p.o. given for 8-10weeks(maximal daily dose of 100mg) and the response to cyclophosphamide therapy was also evaluated. When there was no apparent response to cyclophosphamide therapy, the prednisolone regimen same as initial therapy was added consecutively after completion of cyclophosphamide therapy. All cases were reviewed retrospectively and analysed with SPSS/PC' program. Results: 1) The prevalence of young patients(16-25 year group) was higher(37cases, 49%). There was a preponderance of males(2.6:1). 2) The outcomes for sixty-nine patients, who given an initial course of prednisolone were 50cases (73%) in complete remission(CR), 9cases (13%) in a partial remission(PR) and 10cases(14%) remained nephrotic. The 34(68%) of 50cases who achieved complete remission were relapsed. 3) Cyclophosphamide was used in 35patients. The response to cyclophosphamide therapy were 7cases(20%) in CR, 12cases(34%) in PR and 16cases(46%) remained nephrotic till eighth weeks of treatment. A CR was obtained in 63%(10/16) with subsequent use of prednisolone after cyclophosphamide therapy because of poor response to cyclophosphamide. The cumulative CR rate was 60% (21/35) within 28th weeks of treatment. 4) The age of patients had no relationship to the response rate, time to response, relapse rate and number of relapse after prednisolone therapy. 5) At the final follow-up, 52cases(68%) were in CR, 6cases(8%) were in PR and 18cases(24%) were nephrotic, but all cases preserved normal renal function. Conclusion: Adult onset MCNS showed relatively good response with an daily 40mg of prednisolone as initial dose. The response to cyclophosphamide therapy in those who had inadequate response to initial prednisolone therapy or recurrent relapse was 60% of complete remission. Furthermore, the subsequent use of prednisolone after cyclophosphamide therapy is supposed to increase the response rate in case of poor cyclophosphamide response. Finally, as known the disease has a favorable out- come without renal function impairment.