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Decursin from Angelica gigas Nakai Inhibits B16F10 Melanoma Growth Through Induction of Apoptosis
김병수,서효빈,김하정,배상문,손혜남,이윤정,류승필,박낭운,남주옥 한국식품영양과학회 2015 Journal of medicinal food Vol.18 No.10
Decursin, a bioactive phytochemical isolated from Angelica gigas Nakai (danggwi), has shown preclinical anticancer efficacy in various cancer models. However, the antitumor effect of decursin in melanoma models remains undefined. The antitumor activities of decursin were investigated in B16F10 cells in vitro and in vivo. In this study, we show that treatment with decursin inhibited cell proliferation in a dose-dependent manner in B16F10 cells, but not in normal cells. Decursin also induced apoptosis in B16F10 cells, as determined by annexin V-staining assay and transferase-mediated nickend labeling (TUNEL) staining assay. Decursin increased the phosphorylation of p38 as well as the expression of Bax while decreasing the phosphorylation of extracellular signaling-regulated kinase (ERK) and the expression of Bcl-2 in B16F10 cells. Moreover, decursin activated caspase-3 in B16F10 cells and xenograft tumor tissue. Together, these findings support further investigations into the potential use of decursin in the treatment of melanoma cells.
김상현,강대환,조병만,양웅석,송근암,조몽,송철수,배상문 대한소화기학회 1999 대한소화기학회지 Vol.33 No.4
Background/Aims: Hepatitis C virus (HCV) infection is known to be prevalent in leprous patients Hepatitis G virus (HGV) is transmitted parenterally as HCV. This study was performed to assess the prevalence of HGV infection in leprous patients and non-leprous family members of leprous patients Methods: This study included 96 leprous patients and 47 non-leprous family members of leprous patients. HCV-antibody was tested by the 3rd generation enzyme linked immunosorbent assay (ELISA). Anti-HCV positive sera were confirmed by the 2nd generation recombinant immunoblot assay (RIBA) and reverse transcription-polymerase chain reaction (RT-PCR) from 5'-UTR. HGV-RNA was detected by RT-PCR from E1 region. Results: The prevalence of HCV infection in the leprous patients (55.2%) and the non-leprous family members (8.5%) was higher than that of genera population of Korea. The prevalence of HGV infection in the leprous patients and their non-leprous family members was 10.4% and 6.4% (95% confidence interval, 5.1-18.3%), rspectively. These values were higher than that of general population (1.4%). The higher prevalence of the HGV infection in the leprous patients was not related with leprosy nor HCV infection. Conclusions: Leprous patients are exposed to high risk of HGV infection as well as HCV infection.
부산 경남지역의 Gas Chromatography 와 Mass Spectrophotometer(GC/MS)를 이용한 담낭담석 분석
김상현,강대환,강영진,양웅석,조몽,송철수,송근암,배상문 대한내과학회 1999 대한내과학회지 Vol.56 No.1
Objectives : The composition of gallstones is very variable depending on many factors such as diet, sex, race, genetic background, and so on. The compositional changes of gallstones have been reported in Korean people. Author studied the compositional characteristics of gallstones in Pusan area to see geographical difference. Material and Methods : Gas chromatography and Mass spectrophotometry was performed on the gallstones obtained from the 34 patients who had been taken cholecystectomy because of acute or chronic cholecystitis. Cholesterol gallstone was defined as the composition of the cholesterol is more than 50%. Results : The cholesterol gallstone was 67.6% (23/34) in the 34 patients. There was sexual difference in the cholesterol gallstone group, which the ratio of male and female was 1:2.3(7/16), while there was no difference in the non-cholesterol stone(5:6). The cholesterol stone consisted with cholesterol, bilirubin, bile acid, and palmitic acid and the propotion of them was 75.6%, 4.6%, 15.0%, and 1.8% respectively. While the proportion of non-cholesterol stone was 30.2%, 26.8%, 37.5%, and 5.5% respectively. Conclusions : The cholesterol stone was major fraction of gallstone of the patients in Pusan area. There was no difference on the compostion of gallstones between those of patients in Pusan area and in the other area of Korea.
박정하(Jung Ha Park),배성진(Sung Jin Bae),배상문(Sang Moon Bae),노명환(Myung Hwan Noh),김재석(Jae Seok Kim),박희승(Hee Seung Park),정원태(Won Tae Jung),김성은(Seong Eun Kim),김기현(Ki Hyun Kim),김영훈(Yeong Hoon Kim) 대한내과학회 1996 대한내과학회지 Vol.50 No.6
N/A Objectives - A series of biopsy-proven 76adult onset minimal change nephrotic syndrome(MCNS) was analyzed to estimate the clinical courses including the rate and the pattern of response to corticosteroids or cytotoxic agents and the characteristics of relapse, Methods: The diagnoses of all cases were made between 1985 and 1994. Mean follow up duration was 2.4±2.0 years. All the patients had the apparent onset of their disease when aged 16or more and presented with a full-blown nephrotic syndrome (proteinuria>3.0gm/day, serum albumin<3.0gm/dl and edema). None had either past history of a nephrotic syndrome or other renal disease. All the cases were classified to five groups (16-25, 26-35, 36-45, 46-55, above 56) according to age and were analyzed. The clinical and laboratory information was obtained on each patient at the time of presentation and at last follow-up. Renal tissues were examined by light, fluorescence and electron micorscopy. The initial prednisolone was used at a dose of 40mg/day p.o. given up to 16weeks and the response to prednisolone therapy was evaluated, then tapered by 10mg every 2weeks. Cyclophosphamide was used at a dose of 2mg/kg/day p.o. given for 8-10weeks(maximal daily dose of 100mg) and the response to cyclophosphamide therapy was also evaluated. When there was no apparent response to cyclophosphamide therapy, the prednisolone regimen same as initial therapy was added consecutively after completion of cyclophosphamide therapy. All cases were reviewed retrospectively and analysed with SPSS/PC' program. Results: 1) The prevalence of young patients(16-25 year group) was higher(37cases, 49%). There was a preponderance of males(2.6:1). 2) The outcomes for sixty-nine patients, who given an initial course of prednisolone were 50cases (73%) in complete remission(CR), 9cases (13%) in a partial remission(PR) and 10cases(14%) remained nephrotic. The 34(68%) of 50cases who achieved complete remission were relapsed. 3) Cyclophosphamide was used in 35patients. The response to cyclophosphamide therapy were 7cases(20%) in CR, 12cases(34%) in PR and 16cases(46%) remained nephrotic till eighth weeks of treatment. A CR was obtained in 63%(10/16) with subsequent use of prednisolone after cyclophosphamide therapy because of poor response to cyclophosphamide. The cumulative CR rate was 60% (21/35) within 28th weeks of treatment. 4) The age of patients had no relationship to the response rate, time to response, relapse rate and number of relapse after prednisolone therapy. 5) At the final follow-up, 52cases(68%) were in CR, 6cases(8%) were in PR and 18cases(24%) were nephrotic, but all cases preserved normal renal function. Conclusion: Adult onset MCNS showed relatively good response with an daily 40mg of prednisolone as initial dose. The response to cyclophosphamide therapy in those who had inadequate response to initial prednisolone therapy or recurrent relapse was 60% of complete remission. Furthermore, the subsequent use of prednisolone after cyclophosphamide therapy is supposed to increase the response rate in case of poor cyclophosphamide response. Finally, as known the disease has a favorable out- come without renal function impairment.