Chronic Placental Inflammation in Twin Pregnancies

방희진,김정선,배고은,박하영,김연미,최석주,오수영,노정래 대한병리학회 2015 Journal of Pathology and Translational Medicine Vol.49 No.6

Background: Chronic placental inflammation, such as villitis of unknown etiology (VUE) and chronic chorioamnionitis (CCA), is considered a placental manifestation of maternal anti-fetal rejection. The aim of this study is to investigate its frequency in twin pregnancies compared to singleton pregnancies. Methods: Three hundred twin placentas and 1,270 singleton placentas were consecutively collected at a tertiary medical center in Seoul, Republic of Korea from 2009 to 2012. Hematoxylin and eosin sections of tissue samples (full-thickness placental disc and chorioamniotic membranes) were reviewed. Results: Non-basal VUE was more frequent in twin placentas than in singleton placentas (6.0% vs 3.2%, p < .05). In preterm birth, CCA was found less frequently in twin placentas than in singleton placentas (9.6% vs 14.8%, p < .05), reaching its peak at an earlier gestational age in twin placentas (29–32 weeks) than in singleton placentas (33–36 weeks). CCA was more frequent in twin pregnancies with babies of a different sex than with those with the same sex (13.8% vs 6.9%, p = .052). Separate dichorionic diamniotic twin placentas were affected by chronic deciduitis more frequently than singleton placentas (16.9% vs 9.7%, p < .05). Conclusions: The higher frequency of non-basal VUE in twin placentas and of CCA in twin placentas with different fetal sex supports the hypothesis that the underlying pathophysiological mechanism is maternal anti-fetal rejection related to increased fetal antigens in twin pregnancies. The peak of CCA at an earlier gestational age in twin placentas than in singleton placentas suggests that CCA is influenced by placental maturation.

Expression of PEG10 Is Associated with Poor Survival and Tumor Recurrence in Hepatocellular Carcinoma

방희진,하상윤,황수현,박철근 대한암학회 2015 Cancer Research and Treatment Vol.47 No.4

Purpose Paternally expressed gene 10 (PEG10), first identified as an imprinted gene, is paternallyexpressed and maternally silenced. In hepatocellular carcinoma (HCC), PEG10 has beenidentified as a potential target gene located within the amplified 7q21 locus. The purposeof this study was to investigate the expression of PEG10 protein in HCC and evaluate itsprognostic significance. Materials and MethodsPEG10 protein expression was examined by immunohistochemistry in tumor tissues from218 HCC patients undergoing curative resection. Furthermore, the relationships betweenPEG10 expression and clinicopathologic features or postoperative survival of HCC patientswere evaluated. The median follow-up period was 119.8 months for survivors. ResultsPEG10 expression was observed in 148 of the 218 HCCs (67.9%) and was significantlycorrelated with younger age, female, higher Edmondson grade, microvascular invasion,intrahepatic metastasis, higher American Joint Committee on Cancer T-stage, and higher!-fetoprotein level. PEG10 expression was an independent predictor of early recurrence(p=0.013), and it showed an unfavorable influence on recurrence-free survival (p < 0.001). A subgroup analysis showed that among patients with !-fetoprotein " 20 ng/mL (80patients), the PEG10-positive group also showed an unfavorable influence on recurrencefreesurvival (p=0.002). Moreover, a multivariate survival analysis identified PEG10 as anindependent predictor of shorter recurrence-free survival (p=0.005). PEG10 expressionshowed an unfavorable influence on overall survival (p=0.007) but was not an independentpredictor of shorter overall survival (p=0.128). ConclusionPEG10 protein could be a potential biomarker predicting early recurrence and recurrencefreesurvival in HCC patients after curative resection, even in those with normal serum!-fetoprotein levels.

비행시험용 자료융합 필터

정경호,방희진,김흥범 제어로봇시스템학회 2012 제어로봇시스템학회 각 지부별 자료집 Vol.2012 No.12

무기체계 시험평가업무 정량적 관리방안 연구

장용식,방희진,한성희,김재갑,Jang, Yongsik,Bang, Heejin,Han, Sunghee,Kim, Jaekab 한국군사과학기술학회 2016 한국군사과학기술학회지 Vol.19 No.1

In this paper, we suggest a quantitative management scheme to accomplish effective weapon systems test and evaluation service(T&E). The Capability Maturity Model Integration(CMMI) process model has been introduced and applied for that purpose by the 8th directorate, Agency for Defense Development(ADD). Although a CMMI process model was developed focusing on the software development, systematic approaching scheme in the CMMI process model can be utilized for the quantitative management implementation of a weapon systems T&E service. To manage a T&E service quantitatively, at first, organizational performance objectives and sub processes are established, and then each performance indicators and performance base lines are followed.

비행시험용 자료융합 기법 연구

정경호,오세진,방희진,이용재,김흥범 한국항공우주학회 2010 한국항공우주학회 학술발표회 논문집 Vol.2010 No.4

ATAD2 as a Poor Prognostic Marker for Hepatocellular Carcinoma after Curative Resection

황혜원,하상윤,방희진,박철근 대한암학회 2015 Cancer Research and Treatment Vol.47 No.4

Purpose Cancer cells frequently express genes that are specifically or preferentially expressed inmale germ cells under normal conditions. The ATPase family AAA domain-containing 2(ATAD2) is one such and works as an important cofactor for MYC-dependent transcription. In hepatocellular carcinoma (HCC), ATAD2 has been identified as a candidate driver genelocated within the amplified 8q24 locus. However, the prognostic significance of ATAD2protein expression in HCC remains uncertain. Materials and MethodsWe investigated ATAD2 protein expression by immunohistochemistry in tumor tissue from182 HCC patients who underwent curative resection. Associations of ATAD2 expressionwith clinicopathologic variables or prognosis of HCC patients were analyzed. ResultsATAD2 expression was observed in 119 (65.4%) of the 182 HCCs and tended to be independentpredictor of early recurrence (p=0.059). ATAD2 expression showed an unfavorableinfluence on recurrence-free survival (RFS) (p < 0.001). Subgroup analysis among patientswith tumor size ! 5.0 cm (n=109), patients at Barcelona Clinic Liver Cancer stage 0 or A(n=92), and patients with "-fetoprotein ! 20 ng/mL (n=61), the ATAD2-positive groupsunfavorably influenced RFS (p=0.008, p=0.009, and p=0.013, respectively). In addition,ATAD2 expression was an independent predictor of shorter RFS (p=0.002). ATAD2 expressionshowed an unfavorable influence on disease-specific survival (p=0.001), but was notan independent predictor of shorter disease-specific survival (p=0.109). ConclusionATAD2 protein expression may be a potential predictor of RFS in HCC patients after curativeresection and ATAD2 may have prognostic value in patients with early stage HCC or normalserum "-fetoprotein level.

무기체계 시험수행을 위한 국지 기상가시화 시스템 구축

장용식,민준기,방희진,류충호,박종세,정백희 한국기상학회 2018 한국기상학회 학술대회 논문집 Vol.2018 No.10

Aggressive Clinical Deterioration of Recurrent Extramammary Paget’s Disease: A Case Report

김상윤,홍혜선,방희진,윤상은,남은미,이경은 대한내과학회 2017 대한내과학회 추계학술대회 Vol.2017 No.1

증례 : 소화기; 췌관내 유두상 점액종양을 동반한 국소종괴형 자가면역성 췌장염 1예

김효진 ( Hyo Jin Kim ),방희진 ( Hee Jin Bang ),장기택 ( Kee Taek Jang ),김정희 ( Jung Hee Kim ),장은영 ( Eun Young Jang ),최규 ( Kyu Choi ),이광혁 ( Kwang Hyuck Lee ) 대한내과학회 2014 대한내과학회지 Vol.86 No.4

자가면역성 췌장염에 대한 이해가 넓어짐에 따라 대부분의 경우에 수술적 절제 없이 진단되고 있다. 최근에 수술 후진단된 자가면역성 췌장염은 거의 모두 수술 전 검사에서췌장의 일부에만 이상 소견을 보이는 국소형으로 영상 검사에서 췌장암으로 오인되었던 경우이다. 저자들은 췌관내 유두상 점액종양과 그 주위로 국소 종괴를 형성하는 자가면역성 췌장염을 수술 전에 낭성 종양에서 발생한 췌장암으로 진단하고 수술한 증례를 경험하여 췌관내 유두상 점액종양과 병발한 자가면역성 췌장염을 국내 최초로 보고한다. 본증례는 췌장에 국소 종괴형으로 발생한 자가면역성 췌장염이 췌관내 유두상 점액종양 주위로 특히 심한 국소적인 림프형질세포의 침윤 및 섬유화를 일으켜 수술 전 영상 검사에서 낭성 종양을 동반한 췌장암과 감별이 어려운 증례였다. Autoimmune pancreatitis (AIP) has been increasingly recognized in recent years, and most cases are diagnosed without surgery. However, focal-type mass-forming AIP is difficult to differentiate from pancreatic cancer without surgical resection. A 61-year-oldmale patient with a clinical impression of pancreatic cancer underwent surgery. A postoperative pathologic examination showed lo-cally dense lymphoplasma cell infiltration and numerous lymphoid follicles with fibrosis and a low-grade intraductal papillary mu-cinous neoplasm (IPMN). Here, we report the first case of localized mass-forming AIP combined with a low-grade IPMN, which mimicked pancreatic cancer, in Korea. (Korean J Med 2014;86:466-471)

Cytologic Characteristics of Thymic Adenocarcinoma with Enteric Differentiation: A Study of Four Fine-Needle Aspiration Specimens

권아영,한정호,조해연,김석휘,방희진,현지연 대한병리학회 2017 Journal of Pathology and Translational Medicine Vol.51 No.5

Thymic adenocarcinoma is extremely rare. Although its histologic features have been occasionally reported, a lack of description of the cytologic features has hampered the prompt and accurate diagnosis of this condition. Herein, we describe the cytologic findings and histology of four aspiration cytology specimens of thymic adenocarcinoma. The specimens were obtained from primary tumors, metastatic lymph nodes, and pericardial effusions. All four specimens showed three-dimensional glandular clusters with a loss of polarity and nuclear overlapping. One specimen had extensive extracellular mucinous material. Three specimens contained tumor cells with intracytoplasmic vacuoles. While the specimen with extracellular mucin showed relatively mild cytologic atypia, other specimens exhibited more atypical cytologic changes: irregular nuclear membranes, a coarse chromatin pattern, and prominent nucleoli. The cytologic features were correlated with the histologic features in each case of enteric type thymic adenocarcinoma. The differential diagnosis included other thymic carcinomas, yolk sac tumors, and metastatic adenocarcinoma from the lung or colorectum.