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음나무 잎 및 수피의 진통소염효과 및 아주반트로 유발된 산화적 스트레스에 대한 효과
박희준,남정환,정현주,김원배,박광균,정원윤,최종원,Park, Hee-Juhn,Nam, Jung-Hwan,Jung, Hyun-Ju,Kim, Won-Bae,Park, Kwang-Kyun,Chung, Won-Yoon,Choi, Jong-Won 한국생약학회 2005 생약학회지 Vol.36 No.4
The leaves (KPL) of Kalopanax pictus (KP) are used as a vegetable or a functional food in Korean society. The stem bark (Kalopanacis Cortex, KPS) has been traditionally used to treat neurotic pain, rheumatoid arthritis and diabetic disease. This research was undertaken to demonstrate that the leaf extract of KP (KPL) has also the antinociceptive and antiinflammatory effects like the extract (KPS) of Kalopanacis Cortex and to compare the activity levels of several extracts obtained from KP. Antinociceptive and antiinflammatory effects were measured against the extracts described as followings; KPL-1 (the MeOH extract obtained from the leaf shoot of KP collected on May), KPL-2 (the MeOH extract from KP collected on June), KPL-3 (the MeOH ectract from KP with no thorns), KPS-1 (MeOH extract from KPS of a Korean habitat), KPS-2 (MeOH extract from KPS of a Chinese habitat). The antimociceptive test undertaken by acetic acid-induced writhing, hot plate-, and tail-flick methods using mice. The anti-inflammatory test was also undertaken by measuring the edema in the carrageenan-induced test. The order of activity potency in the antinociceptive and antiinflammatory assays was commonly shown as followings: KPL-3>KPS>1>KPS-2>KPL-1>KPL-2. This order was also observed in acetic acid-induced vascular permeability test. The antiinflammatory activity in carrageenan-induced assay was also observed as the following order: KPL-3>KPS- 1>PS-2>KPL-1>KPL-2. In addition, adjuvant-induced rats were used for a model to assess the oxidative stress. Treatment of the rat with the extracts reduced serum thiobarbituric acid-reactive substances (TBARS), hydroxy radical(OH) and superoxide dismutase(SOD) activity caused by FCA together together with the inhibition of hepatic TBARS level and lipofuscin content. The above finding suggests that the leaf extract has the antinociceptive and antinflammatory activity. It is also suggested that KPL-3 with more potent activity than other tested extracts could be developed for a new available biomaterial.
함박꽃나무 잎으로 부터 새로운 Aporphine계 Alkaloid 성분의 분리
박희준,Park, Hee-Juhn 한국생약학회 1996 생약학회지 Vol.27 No.2
From the leaves of Magnolia sieboldii a new aporphine-type alkaloid named magnoporphine was isolated. The structure of magnoporphine was all assigned by $^1H-^1H$COSY, $^1H-^{13}C$ COSY and $^1H-^{13}C$ long range NMR. In addition, costunolide, syringin, syringenin $4-O-{\beta}-cellobioside$ and echinacoside was isolated.
박희준,이은,최무영,임태진,차배천,Park, Hee-Juhn,Lee, Eun,Choe, Moo-Young,Rhim, Tae-Jin,Cha, Bae-Cheon 한국생약학회 1996 생약학회지 Vol.27 No.3
Wildbean(Glycine soja Siebold et Zucc.) is known as the orgin of soybean (Glycine max Merr.). Based on the hypothesis that the secondary transformation of chemical compound in wildbean might have occurred during its breed improvement to soybean. this study was carried out to compare the antioxidant activities and chemical composition in wildbean and soybean. The present study demonstrates that 1) Antioxidant activity was much higher in EtOAc, extract of wildbean than in soybean. 2) strong antioxidant activity observed in EtOAc extract of wildbean was due to the presence of (-)-epicatechin, which was not present in the extract of soybean but isolated, for the first time, from the extract of wild bean, and 3) antioxidant activity of the isolated (-)-epicatechin was greater than that of tocopherol, the previously known antioxidant.
자원식물로서 응용을 위한 야광나무 열매의 식물화학적 연구
박희준(Hee Juhn Park),이명선(Myung Sun Lee),양한석(Han Suk Young),최재수(Jae Sue Choi),정원태(Won Tae Jung) 한국생약학회 1994 생약학회지 Vol.24 No.4
Very little utilization of the fruits of Malus baccata(Rosaceae) has been employed for food and medicinal plants except for preparing fruit beverages. But, it was estimated as valuable to investigate the chemical components for the botanical resource of this plant. In this study, it was found that the fruits of this plant contained primary long chain alcohol, β-sitosterol, campesterol, ursolic acid and β-D-glucosides of β-sitosterol and campesterol. However, phloretin(dihydrochalcone) and its 5-O-glucoside(phloridzin) known as plant growth regulators in many Rosaceae plants were not found in this plant material by co-TLC analysis with authentic specimens. Although plant sex hormone, estrone, was often contained in relates of M. baccata, e.g., Prunus spp., Crataegus spp. and Malus spp., this compound was not detected in this fruit by comparison with an authentic material. By RIC chromatography, it was suggested that the Soxhlet extraction by the solvent of ether was excellently useful to extract ursolic acid efficiently.
박희준(Hee-Juhn Park),이승배(Seung-Bae Lee),이은(Eun Lee),차배천(Bae-Chun Cha),최무영(Moo-Young Choi),이승목(Sung Mok Lee),정원태(Won Tae Chung) 한국식품영양과학회 1995 한국식품영양과학회지 Vol.24 No.3
단삼의 혈소판응집 억제 활성물질이 지용부 및 수용부에 분포한다는 각각 다른 보고가 있으나 본 연구에서는 수용부는 혈소판응집억제 활성을 나타내지 않았으며 diterpene quinone 성분의 하나인 cryptotanshinone은 현저한 혈소판응집억제 활성을 나타내었으므로 이의 유효 생리활성물질은 diterpene quinone 색소에 분포할 것으로 추측된다. 뿐만 아니라, cryptotanshinone은 항균작용도 동시에 나타내는 생리활성 물질이었다. 또한, 복잡한 조성을 나타내는 단삼의 지용성 색소 성분의 분석을 위해서 GC-MS 분석을 행한 결과 유용한 분석적 결과를 제시하였다. 즉, 가장 많은 색소 성분은 tanshinone Ⅱ이었으며, 또한 새로운 diterpene quinone 성분의 존재가 시사되었다. The ether extract of Salviae miltiorrhizae Radix(SMR) was fractionated to give five subfractions, so that two subfractions of them were recrystallized to yield each pure diterpene quinone pigment. On the basis of spectral evidence, these two compounds were identified as tanshinone Ⅱ and cryptotanshinone. Cryptotanshinone exhibited both of a potent platelet anti-aggregating activity in vitro and a potent antimicrobial activity. GC-MS analysis of the ether extract showed that tanshinone Ⅱ was contained in the largest proportion of all the diterpene quinones. In addition, GC-MS analysis gave other valuable analytical informations.
박희준(Hee-Juhn Park),권상혁(Sang-Hyuk Kwon),이명선(Myung-Sun Lee),김갑태(Gap-Tae Kim),최무영(Moo-Young Choi),정원태(Won-Tae Jung) 한국식품영양과학회 2000 한국식품영양과학회지 Vol.29 No.6
수증기 증류법으로부터 얻은 배초향(Agastache rugosa, Labiatae)의 정유는 부패균을 포함하는 수종의 미생물에 대하여 현저한 항균활성을 나타내었다. 배초향의 유효성분을 확인하기 위하여 정유성분을 GC-MS로 분석한 결과 GC chromatogram에서 얻은 각 피크의 retention time 및 mass spectral data의 표준물질과의 비교에 의해서 isomenthone, menthone, dihydrocarvone, anethole, vanillin, eugenol, methyleugenol, β-caryophyllene, β-caryophyllene oxide 등의 정유성분이 확인되었다. 이 연구에서 밝혀진 여러 성분들의 항균활성은 잘 알려져 있으므로 이들이 그 유효성분으로 추측된다. 또한 Korean mint로 세계적으로 알려져 있는 배초향의 정유는 식품 방부제로서 적합할 것으로 생각된다. The essential oil obtained by steam distillation from the herbs of Agastache rugosa showed significant antimicrobial activities against putrefactive bacterial strains along with other bacterial strains. For the elucidation of the volatile components, the essential oil was analyzed by GC-MS. Each component was identified by GC or mass spectral analysis. The identified compounds were as follows : isomenthone, menthone, dihydrocarvone, anethole, vanillin, eugenol, methyleugenol, β-caryophyllene, β-caryophyllene oxide. Several abundant components with phenylpropanoid-type structures were maybe contributable to the activity. This essential oil could be suitable for the development of a food presevative.
박희준(Hee Juhn Park),문숙희(Suk Hee Moon),박건영(Kun Young Park),최재수(Jae Sue Choi),정해영(Hae Young Chung),양한석(Han Suk Young),서석수(Suk Soo Suh) 대한약학회 1991 약학회지 Vol.35 No.4
The anti-mutagenic effect of Orostachys japonicus (0J) toward aflatoxin (AFB1) and N-methyl-N''-nitro-N-nitrosoguanidine (MNNG) in the Salmonella assay system was studied. The methanol extract of OJ inhibited the mutagenicity induced by AFBI about 97% when 5% of the extract added to the system. Butanol fraction from the methanol extract was the most effective against AFB1. However, other fractions of hexane, chloroform, and ethylacetate also showed considerable antimutagenic activity against AFB1. Several identified compounds from the fractions of OJ exhibited anti-mutagenic effect. beta-Sitosterol, astragalin and kaempferol-3-rhamnosyl-7-glucoside were selected from the compounds, and these compounds inhibited the mutagenicity dose-dependently. These 3 compounds also decreased the mutagenicity induced by MNNG. From these results, it is suggested that the major compounds such as triterpene, sterol and flavonoid in the OJ were responsible for the inhibition of the AFB1 and MNNG-induced mutagenicities.
박희준(Hee Juhn Park),임상철(Sang Cheol Lim),이명선(Myung sun Lee),양한석(Han Suk Young) 한국생약학회 1994 생약학회지 Vol.25 No.1
From the whole plants of Orostachys japonicus(Crassulaceae), taraxerone, stigmast-4-ene-3-one and ergost-4-ene-3-one were isolated and characterized by spectral data.