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오매 추출물에 함유된 Ursolic Acid에 의한 Helicobacter pylori의 Urease 활성억제
박찬엘 ( Chan El Park ),박창호 ( Chang Ho Park ) 한국화학공학회 2013 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.51 No.5
전통식물한약재에 대한 데이터베이스, 한국식물자원에 대한 문헌 및 선행연구 결과에 근거해 선정한 6가지의 식물한약재(연교, 소목, 형개, 황련, 소엽, 오매)의 에탄올(70%) 추출물 중에서 오매 추출물이 Helicobacter pylori의 urease 활성에 가장 강한 억제력을 나타내었다. 극성이 다른 용매를 사용한 회분식 용매추출과 칼럼 크로마토그래피를 이용한 3단계 분리공정을 통하여 오매 추출물에 함유된 유효성분을 분리·정제하였다. NMR 분석에 의해 정제된 오매 추출물에 함유된 활성성분이 ursolic acid로 확인되었다. 본 실험결과는 오매에 함유된 이 성분이 항생제를 대신하여 H. pylori 제거에 활용될 수 있음을 시사하였다. Urease activity of Helicobacter pylori was most strongly inhibited by extract of Mume Fructus among ethanol (70%, v/v) extract of 6 herbal materials selected from our previous work, database on traditional herbal materials, and literature data on Korean plant resources. Active compounds in the extract of Mume Fructus were separated by batch extraction, and further purified by chromatography in a silica gel column and an octadecyl silica gel column using solvents of different polarity. By NMR analysis of the last chromatographic fraction we identified ursolic acid as the active compound of urease inhibition. The result suggests that this component in Mume Fructus can possibly be used for the eradication of H. pylori.
박찬이,전성룡,우경인,장혜란,Chan Yi Park,Seong Lyong Jeon,Kyung In Woo,Hae Ran Chang 대한안과학회 2007 대한안과학회지 Vol.48 No.2
Purpose: To study the frequency and aspects of ptosis in Koreans aged 50 years or older. Methods: In this study, 377 elderly people visiting retirement center were included. Margin-reflex distance 1 (MRD1) and palpebral fissure (PF) were evaluated with an attempt to eliminate eyebrow elevation. Levator function (LF) was measured with Berke`s method. If the measured MRD1 was less than 2 mm, ptosis was diagnosed and its frequency, relation to sex, age, levator function and superior deep sulcus were investigated. Results: There was a correlation between decreasing MRD1, PF and LF with increasing age. Ptosis was observed in 207 subjects (54.9%), and its frequency was augmented as age increased. Although it was not statistically significant, the levator function of those with ptosis (10.0±1.9 mm) was lower than those without ptosis (11.3±1.9 mm). Questionnaires were administered and 196 respondents (51%) said that their eyelid droop had become more pronounced over time. Among these respondents, 33 (16.1%) indicated that their droopy eyelid causes discomfort by blocking their vision. Their MRD1 was 1.2±1.0 mm, which was significantly lower than that of the other 163 respondents (1.8±1.1 mm, P<0.05). Conclusions: Koreans aged 50 years or older showed a very high frequency (54.9%) of ptosis and as age increased, the frequency of ptosis also increased. Surgical correction is recommended when the ptosis causes patient discomfort due to impaired vision.
A comparative study of ADL and IADL of residential home and home for the aged dwelling elderly
박찬의,장정훈,이재형,Park, Chan-Eui,Chang, Chung-Hoon,Lee, Jae-Hyoung The Korean Society of Physical Therapy 2006 대한물리치료학회지 Vol.18 No.4
연구목적: 본 연구는 가정 거주노인과 시설 거주 노인의 일상생활동작(ADL)과 도구적 일상생활동작(IADL)을 비교 분석하여 노인 돌봄에 관여하는 의료 종사자, 특히 물리치료사와 작업치료사의 업무에 도움을 주고자 시행하였다. 방법: 일상생활동작 및 도구적 일상생활동작의 검진은 한국형 일상생활동작 평가서와 도구적 일상생활동작 평가서를 사용하여 거주 형태가 다른 두 노인 집단의 평가 결과를 분석하였다. 결과: 노인들의 일상생활동작과 도구적 일상생활동작의 수행 능력은 부부 동거, 자녀 수, 수입, 현재 앓고 있는 질병 및 나이에 의해 영향을 받고 있는 것으로 나타났다. 또한 일상생활동작 중에는 한 가지 동작이 도구적 일상생활동작은 한 가지 동작을 제외한 모든 동작에서 수행 능력의 차이를 보이고 있다. 부부가 함께 동거하는 노인이 홀로 사는 노인에 비해 전반적으로 일상생활 활동이 원활한 것으로 나타났다. 결론: 한국형 일상생활동작 평가서와 도구적 일상생활동작 평가서가 한국 노인의 일상생활 활동을 평가하는데 보다 사용하기 좋았다. 노인을 돌보는 의료 종사자 특히 물리치료사 및 작업치료사는 노인의 일상생활 활동을 증진시키기 위해 훈련을 시행한다면 일상생활동작 훈련에서는 목욕하기에 중점을 두고 도구적 일상생활동작의 훈련에서는 거의 모든 동작을 훈련 시켜야 할 것을 조언한다. Purpose: The purpose of this study was to investigate the activities of daily living (ADL) and instrumental activities of daily living (IADL) of residential home dwelling elderly and home for the aged dwelling elderly. In attempt to address medical professional caring the elderly, this comparative study examines the factors associated with dependence in the ADL and IADL in two samples of elderly people living in two different environments. Methods: The instrument of ADL and IADL widely used Katz ADL and IADL. Katz ADL and IADL was not a perfect fit for Korean. In concern with cultural factors Won developed K(Korean)-ADL and K-IADL scale reflecting Korean's own language expression and cultural factors in year of 2002. The assessment tool of this study was K-ADL and K-IADL. Differences of ADL and IADL were tested for statistical significance using group t-test and x2 test for comparisons between the residential home dwelling elderly and the home for the aged dwelling elderly. Results: Comparison of assessment for K-ADL and K-IADL in two different dwelling types was significant. Performance of ADL and IADL depend upon their living environment such as social status, number of children, income, present illness as well as age group. This study also showed significant differences of performance in some activities of ADL and IADL between the elderly who live in their own home and live in home for the aged. Comparison of performance of ADL and IADL in different dwelling types revealed that only one item of ADL was significant but only one item of IADL was not significant. It means that IADL is more difficult activities in the home for the aged dwelling elderly than the residential home dwelling elderly. The coupled elderly has more independent in some ADL and IADL activities compared with the single elderly. Conclusion: Using K-ADL and K-IADL is more convenient for Korean elderly. Medical professional consider some factors like dwelling style, social status, existing diseases and disabilities in order to care the elderly and train him/her activities of daily living as well as instrumental activities of daily living. Medical professional, especially physical and occupational therapist emphasize the training items which are bathing of ADL and grooming, housework, preparing meals, laundry, traveling, public transportation, shopping, using telephone and taking medicine of IADL based on the result of this study.