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The Effects of Unpredictable Stress on the LHR Expression and Reproductive Functions in Mouse Models
최성영,박진흠,Yuxia Zhu,김영종,박재옥,문창종,신태균,안미정,김석수,박영식,채형복,김태균,김승준 한국임상수의학회 2014 한국임상수의학회지 Vol.31 No.5
The objective of this study was to investigate the effect of chronic unpredictable stress on the reproductivefunction and ovarian luteinizing hormone receptor (LHR) expression. 9-week-old C57BL/6 female mice were randomlydivided into two groups: control group and stressed group. Mice have been stressed twice a day for 35 days with12 different stressors which were randomly selected. The results demonstrate that there is significant increase in theanxiety-related behaviors (P < 0.05), decrease body weight gain rate (P < 0.01) and decrease in the average of littersize in stressed mice compared with control group (P < 0.01). Furthermore, the rate of primary, secondary and earlyantral follicles in stressed mice significantly decreased (P < 0.05), whereas that of atretic follicles significantly increasedcompared with control mice (P < 0.01). The immunohistochemical analysis revealed that reduced LHR expression ingranulosa cells of follicle and luteal cells of corpus luteum in response to chronic unpredictable stress. The westernblot analysis revealed significantly decrease in LHR expression in the stressed mice ovaries compared with the control(P < 0.05). These results suggest that ovarian LHR expression affected by chronic unpredictable stress and the modulatedovarian LHR is responsible for ovarian follicular maldevelopment and reproductive dysfunction.
초기재령 강섬유보강 철근 콘크리트 보의 휨성능에 대한 실험적 연구
하기주,신종학,최민권,이영범,박진흠 대한건축학회 2001 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.21 No.1
Reinforced concrete structures using early age concrete were result in the degradation of flexural performance due to crack, overload, unexpected vibration and impact load. It demands urgently that reinforced concrete structure using early age concrete should be improved the serviceability and flexural performance with the application of new fiber materials. Therefore specimens, designed by the test varibles, such as percent of steel fiber incorporated, were constructed and tested to evaluate and develop the flexural performance of reinforced steel fiber concrete beam. Based on the test results reported in this study, the following conclusions are made. Specimens, designed by the over 0.75% of steel fiber incorporated, were showed the ductile behavior and failed slowly with flexure and flexure-shear. Comparing with the load-displacement relationship of specimen BSS, designed by the recommendations of the Ministry of Construction and Transportation, reinforced steel fiber concrete beam using early age concrete, over 0.75% of steel fiber incorporated, gets enough load carrying capacity and ductility. Increasing the percent of steel fiber incorporated(0.5∼2.0%), the relative fiexural performance of each specimen were increased 19∼60% than that of specimen BSS.