Estrogen Receptor 1 유전자 내 2개의 단일염기 다형성과 한국인 여성 정신분열병 환자의 연합에 관한 연구

박진경,이서경,이상민,박준헌,김지영,조아랑,Park, Jin Kyung,Lee, Seo Kyong,Lee, Sang Min,Park, Jun Heon,Kim, Ji Yeong,Cho, Ah Rang 대한생물정신의학회 2007 생물정신의학 Vol.14 No.4

Objectives : Schizophrenia is equally distributed in both sexes. However, later-onset, milder psychopathology, and better outcome are associated with the females. This reason is thought to be partly due to the estrogen system. Recently, it was suggested that estrogen receptor 1(ESR1) gene polymorphisms might affect the expression of ESR1 and were associated with several psychiatric disorders. Thus, we investigated the association between two single nucleotide polymorphisms(SNPs) in the ESR1 gene and Korean schizophrenic patients in this study. Methods : Genotype, allele, and haplotype frequencies of the two SNPs(rs 2234693 and rs 2228480) were analyzed between 218 Korean controls and 158 Korean schizophrenic patients. Also, age of onset and negative symptom scale scores according to genotypes were analyzed in the patients with schizophrenia. Results : There was a significant difference in allele frequencies of rs 2234693 between the schizophrenic patients and the controls(p=0.03). Genotype distributions(p=0.03) and allele frequencies(p=0.01) of rs 2234693 were significantly different between the female schizophrenic patients and the female controls. The frequency of TC-CC genotypes compared with TT genotype in the female schizophrenic patients was significantly higher than that in the female controls(OR=2.36). The mean age of onset in the schizophrenic patients with TC-CC genotypes was significantly lower than that in the patients with TT genotype. The frequency of rs 2234693C- rs 2228480G haplotype in the female schizophrenic patients was relatively higher than that in the female controls. Conclusions : These results of our study support the possibility that the ESR1 gene polymorphisms might be involved in the susceptibility of females to schizophrenia and play a role in sex difference of schizophrenia.

광주시 C대학 도서관 독서토론클럽의 참여자 인식 평가 연구

박진경,이명규,Park, Jin-Gyeong,Lee, Myoung-Gyu 한국비블리아학회 2015 한국비블리아학회지 Vol.26 No.1

이 연구는 광주광역시 C대학 도서관에서 운영하는 독서토론클럽 참여자의 인식을 조사하고 평가하기 위한 것이다. 이를 위해 참여자의 인구통계학적 특성, 참여기간과 태도에 따른 참여효과 차이, 독서토론클럽의 문제점에 대해 조사하였다. 자료의 수집은 설문조사와 인터뷰를 통해 이루어졌으며, 분석 결과 참여기간이 1년 미만인 참여자보다는 3년 이상인 참여자가, 참여태도가 나쁜 참여자보다는 좋거나 매우 좋은 참여자의 참여효과가 더 높은 것으로 드러났다. 또한, 향후 대학도서관 독서진흥프로그램의 운영에 일조하기 위해 독서토론클럽 문제점을 분석한 결과를 토대로 활성화 방안을 제시하였다. The purpose of this study is the investigation and evaluation of participants' awareness in the Book debate club which is managed by library of C University in Gwangju. For this purpose, the difference of the impact of participation in accordance to the participation duration and attitude, the demographic property of participants, and the problem of Book debate club are investigated. The collection of data is achieved by questionnaires and interviews. In the analyzed result, the period and manner of the participation are very important factors. Also, the activation plan is proposed on the basis of the analyzed result of problems in reading debate club to contribute to the management of future University library's reading promotion program.

콕스 비례위험 모형을 이용한 중소기업의 업종별 생존율 및 생존요인 분석

박진경,오광호,김민수,Park, Jin-Kyung,Oh, Kwang-Ho,Kim, Min-Soo 한국데이터정보과학회 2012 한국데이터정보과학회지 Vol.23 No.2

최근 글로벌 금융위기와 중소기업들의 연이은 도산으로 인해 국내 중소기업들의 구조조정에 대한 논의가 활발히 진행되고 있다. 이에 본 논문에서는 신용보증기금에 등록된 중소기업 자료에 대하여 업종별 생존율 동향을 비교분석하였다. 이때 생존율의 차이는 로그순위 검정과 윌콕슨의 검정통계량을 사용하여 분석하였다. 또한 재무변수들을 이용하여 중소기업의 업종별 콕스 회귀분석을 실시하였다. 그 결과, 도소매업과 서비스업이 경공업과 중공업, 건설업에 비하여 생존율이 높았으며, 건설업의 경우 생존율이 가장 낮음을 알 수 있었다. 또한, 업종별로 유의한 재무변수를 살펴보면, 건설업은 자기자본비율, 유동비율이 커질수록 부도율이 감소하는 반면에 차입금의존도가 커질수록 부도율이 증가하였다. 경공업은 자기자본비율, 총자산 순이익률이 커질수록, 도소매업은 자기자본비율, 유동비율이 커질수록 부도율이 감소하였다. 중공업은 자기자본비율, 총자산 순이익률, 유동비율이 커질수록 부도율이 감소하였지만 결합지표가 커질수록 부도율이 증가하였다. 마지막으로, 서비스업은 유동비율이 커질수록 부도율이 감소하였다. Global crisis expedites the change in the environment of industry and puts small size enterprises in danger of mass bankruptcy. Because of this, domestic small size enterprises is an urgent need of restructuring. Based on the small business data registered in the Credit Guarantee Fund, we estimated the survival probability in the context of the survival analysis. We also analyzed the survival time which are distinguished depending on the types of business in the small business. Financial variables were also conducted using COX regression analysis of small businesses by types of business. In terms of types of business wholesale and retail trade industry and services were relatively high in the survival probability than light, heavy, and the construction industries. Especially the construction industry showed the lowest survival probability. In addition, we found that construction industry, the bigger BIS (bank of international settlements capital ratio) and current ratio are, the smaller default-rate is. But the bigger borrowing bond is, the bigger default-rate is. In the light industry, the bigger BIS and ROA (return on assets) are, the smaller a default-rate is. In the wholesale and retail trade industry, the bigger bis and current ratio are, the smaller a default-rate is. In the heavy industry, the bigger BIS, ROA, current ratio are, the smaller default-rate is. Finally, in the services industry, the bigger current ratio is, the smaller a default-rate is.

Endowment of Duplicated Serial Number for Window-controlled Selective-repeat ARQ

박진경,신우철,하준,최천원,Park, Jin-Kyung,Shin, Woo-Cheol,Ha, Jun,Choi, Cheon-Won Institute of Korean Electrical and Electronics Eng 2003 전기전자학회논문지 Vol.7 No.2

통신 경로 상에 위치한 인접 노드간의 오류 제어를 위해 window-controlled selective repeat ARQ 방식을 고려한다. 이 방식에서 전송될 패킷은 순환적 그리고 순차적으로 순차 번호를 부여받는다. 한편 송신 노드는 이전 window에 소속된 모든 패킷에 대해 긍정적 응답을 받을 때까지 새 window에 소속된 패킷을 전송할 수 없으며, 이러한 전송의 연기로 인해 throughput 및 지연 성능의 저하가 야기된다. 본 논문에서는 지연 성능을 향상시키기 위한 방안으로 프레임 내에서 순차 번호를 중복 사용하는 부수적 방식을 고려한다. 이러한 중복 규칙을 고정형, 임의형, 적응형으로 분류하여 범주별 중복 규칙을 제시하고 각 중복 규칙에 따른 지연 성능을 평가한다. 계량적 분석 결과로부터 순차 번호를 중복 부여하여 (특히 ADR-T2의 도입으로) 평균 패킷 지연 시간을 효과적으로 줄일 수 있음을 관찰한다. 또한 이러한 지연 성능의 개선은 국지적으로 최적인 window 크기를 만족할 수 있는 확률의 증가에 기인함을 규명한다. We consider a window-controlled selective-repeat ARQ scheme for error control between two adjacent nodes lying on a communication path. In this scheme, each packet to be transmitted is endowed with a serial number in a cyclic and sequential fashion. In turn, the transmitting node is not allowed to transmit a packet belonging to a window before every packet in the previous window is positively acknowledged. Such postponement of packet transmission incurs a degradation in throughput and delay performance. In this paper, aiming at improving packet delay performance, we employs a supplement scheme in which a serial number is duplicated within a frame. Classifying duplication rules into fixed, random and adaptive categories, we present candidate rules in each category and evaluate the packet delay performance induced by each duplication rule. From numerical examples, we observe that duplicating serial numbers, especially ADR-T2 effectively reduces mean packet delay for the forward channel characterized by a low packet error rate. We also reveal that such delay enhancement is achieved by a high probability of hitting local optimal window size.

한국인 정신분열병 환자와 Catalase 유전자 다형성의 연합

박진경,이희제,반건호,박종득,정주호,장환일,Park, Jin-Kyung,Lee, Hee-Jae,Bahn, Geon-Ho,Park, Jong-Deuk,Chung, Joo-Ho,Chang, Hwan-Il 대한생물정신의학회 2002 생물정신의학 Vol.9 No.1

본 연구에서는 정신분열병과 antioxidant defense system사이의 관련성을 알아보기 위해 항산화 효소(antioxidant enzyme)중의 하나인 CAT의 유전자 다형성을 한국인 정신분열병 환자군과 대조군 사이에서 비교 분석하였다. 환자군과 대조군의 HinfI 다형성에 따른 CAT유전자형과 대립유전자형의 빈도는 통계적으로 유의한 차이는 없었지만, 여성 정신분열병 환자군과 여성 대조군 사이의 유전자형 빈도에서는 통계적으로 유의한 차이를 나타내었다. 연구결과 CAT유전자가 여성 정신분열병과 관련이 있을 수 있다는 가능성이 제시된다. Objective:There is increasing evidence that free radical-mediated CNS neuronal dysfunction is involved in the pathophysiology of schizophrenia. This study was performed to examine the relationship between antioxidant defense system and schizophrenia by analyzing polymorphism of catalase gene, an antioxidant enzyme. Method:Genotype and allele frequencies in the promoter region in the catalase gene using restriction fragment length polymorphism were studied, comparing 155 Korean controls with 167 Korean schizophrenics. Results:No difference was found between the schizophrenics and the controls in genotype and allele frequencies of HinfI polymorphism in the catalase gene. Significant difference was found between the female schizophrenics and the female controls in the genotype distribution(${\chi}^2$=11.096, df=2, p=0.004). Conclusions:The results do not support an association between polymorphism of catalase gene and schizophrenia. However, this study suggests that HinfI polymorphism in the catalase gene could be associated with female schizophrenics.

폐암에서의 협대역 내시경의 역할

박진경,최창민,Park, Jinkyeong,Choi, Chang Min 대한기관식도과학회 2011 大韓氣管食道科學會誌 Vol.17 No.1

The proliferation of new technologies has significantly enhanced the diagnostic capabilities of flexible bronchoscopy compared with traditional methods. Narrow band imaging (NBI), an optical technique in which filtered light enhances superficial neoplasms based on their neoangiogenic patterns, was developed to screen for central intraepithelial moderate or severe dysplasia, carcinoma in situ (CIS), and microinvasive neoplasia in patients at risk for lung cancer. Because angiogenesis occurs preferentially in dysplastic and neoplastic lesions, NBI may identify early dysplastic lesions better than white light bronchoscopy (WLB) currently in use. NBI bronchoscopy can be used not only to detect precancerous lesions, but also to screen for cancerous lesions. We prospectively evaluated 101 patients with suspected lung cancer between July 2009 and June 2010. All were previously scheduled for flexible bronchoscopy CT scans. Abnormal NBI was defined by Shibuya's descriptors (tortuous, dotted, or spiral and screw patterns). Biopsies of 132 lesions in 92 patients showed that 78 lesions (59.1%) were malignant and 54 (40.9%) were benign. The diagnostic sensitivity of bronchoscopy in detecting malignancy was 96.2% (75/78). When assorted by lesion pattern, the sensitivity and specificity of NBI bronchoscopy in detecting malignancies were 69.2% (54/78) and 96.3% (52/54), respectively, for the spiral and screw pattern and 14.1% (11/78) and 96.3% (52/54), respectively, for the dotted pattern. Unexpectedly, additional cancerous lesions were detected in five patients (2 dotted and 3 spiral and screw). As a screening tool for malignant lesions, NBI bronchoscopy should assess combinations of all three lesion. The dotted and spiral and screw patterns may be helpful in determining which lesions should be biopsied. NBI bronchoscopy may be useful not only for the diagnosis of early-stage lung cancer but also for more accurate local staging of lung cancer.

초기 폐암에서 기관지 초음파 내시경의 임상적 유용성

박진경,황보빈,Park, Jinkyeong,Hwangbo, Bin 대한기관식도과학회 2011 大韓氣管食道科學會誌 Vol.17 No.1

Endobronchial ultrasound (EBUS), which enables visualization of lesions beyond the bronchus, broadens the fields of bronchoscopy. Two types of ultrasound, radial and linear, are used for bronchoscopy. Radial EBUS is performed by inserting an ultrasound mini-probe through the working channel of a flexible bronchoscope. Evaluation of the depth of invasion of early endobronchial lung cancers using radial EBUS is useful in deciding endobronchial treatment. A central tumor limited to within the cartilaginous layer is a good indication for endobronchial photodynamic therapy. EBUS-guide sheath (GS) technique is a sampling method assisted by localization of peripheral lesions using EBUS. The diagnostic yield of EBUS-GS method is higher than that of conventional transbronchial biopsy. High diagnostic values of EBSU-GS method are reported even in small (${\leq}2cm$) peripheral tumors. Linear EBUS is used for endobronchial ultrasound guided transbronchial needle aspiration (EBUS-TBNA). EBUS-TBNA has high diagnostic yields in mediastinal staging of lung cancer even in patients having radiologically early stage lung cancers with normal CT or PET findings in the mediastinum. EBUS is a valuable method in evaluating early endobronchial tumors and peripheral small lung cancers and as well as in mediastinal staging.

산화물이 코팅된 전도성 금속 분말의 제조 및 태양전지 전면 전극으로의 응용

박진경,이영인,Park, Jin Gyeong,Lee, Young-In 한국재료학회 2014 한국재료학회지 Vol.24 No.9

Recently, improvement in the conversion efficiency of silicon-based solar cells has been achieved by decreasing emitter doping concentration, because the lightly doped emitter can effectively prevent the recombination of electrons and holes generated by solar light irradiation. This type of emitter is very thin due to the low doping concentration, thus conductive materials (i.e., silver) used for front electrodes can easily penetrate the emitter during a firing process because of their large diffusivity in silicon. This results in junction leakage currents which might reduce cell efficiencies. In this study, $Al_2O_3$-coated Ag powders were synthesized by an ultrasonic spray pyrolysis method and applied to the conductive materials of the front electrode to control the junction leakage current. The $Al_2O_3$ shell obstructs the Ag diffusion into the emitter during the firing process. The powder is spherical with a core-shell structure and the thickness of the $Al_2O_3$ shell is tens of nanometers. Solar cells were fabricated using pure Ag powders or the $Al_2O_3$-coated Ag powder as front electrode materials, and the conversion efficiency and junction leakage current were compared to investigate the role of the $Al_2O_3$ shell during the firing processes.

교통안전형 보행정책 추진방안 연구

박진경,Park, Jin-Gyeong 대한교통학회 2014 교통 기술과 정책 Vol.11 No.3

생존분석기법을 이용한 건설업과 타 업종간의 부도율 비교 분석

박진경,오광호,김민수,Park, Jin-Kyung,Oh, Kwang-Ho,Kim, Min-Soo 한국데이터정보과학회 2010 한국데이터정보과학회지 Vol.21 No.4

최근의 전 세계적인 경기 침체에 따라 산업계 전반에 관한 연구가 활발히 진행되고 있다. 본 연구에서는 신용보증기금에 등록된 중소기업들의 자료에 대하여 생존 분석을 이용하여 생존율을 추정하였다. 또한 중소기업의 자산규모와 업종에 따라 건설업과 타 업종으로 구분하여 생존율에 관한 동향을 비교분석하였다. 이때 생존율은 생명표에 의해 구하였으며, 업종별 생존율의 차이는 로그순위 검정과 윌콕슨의 검정통계량을 사용하여 분석하였다. 실험 결과 중소기업의 자산규모가 10억 이상이 가장 높았으며, 1억 미만, 1억에서 10억 미만은 비슷한 생존율을 보였다. 업종별로는 도소매업과 서비스업이 경공업과 중공업, 건설업에 비하여 생존율이 높았으며 건설업의 경우 생존율이 가장 낮음을 알 수 있었다. 또한 대부분의 중소기업들은 시간이 지날수록 위험률이 상승하는 추세를 보였다. With the recent recession, studies on the economy are actively being conducted throughout the industry. Based on the Small Business data registered in the Credit Guarantee Fund, we estimated the survival probability in the context of the survival analysis. We also analyzed the survival time for the construction and the other industries which are distinguished depending on the types of business and assets in the Small Business. The survival probability was estimated by using the life-table and the difference between the survival probabilities for the different types of business was described via the method of the Log-rank test and the Wilcoxon test. We found that the small business with over one billion asset has the highest survival probability and that with less than 1000 million asset showed the similar survival probability. In terms of types of business Wholesale and Retail trade industry and Services were relatively high in the survival probability than Light, Heavy, and the construction industries. Especially the construction industry showed the lowest survival probability. Most of the Small Business tend to increase in the hazard rate over time.