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박준언,강기성,이해정 대한화학회 2017 Bulletin of the Korean Chemical Society Vol.38 No.11
The attack of reactive oxygen species (ROS) on unsaturated fatty acids causes peroxidation. The membranes of liver cells are rich in unsaturated fatty acids, which are a target of lipid peroxidation by free radicals. The purpose of the present study was to identify the hepatoprotective potential of Lonicera caerulea and its active compound, cyanidin 3-O-glucoside, on tertiary butyl hydroperoxide (tBHP)-induced oxidative damage in HepG2 cells. L. caerulea extract and its active compound, cyanidin 3-O-glucoside, showed a dose-dependent hepatoprotective effect on tBHP-induced HepG2 cell damage. In addition, L. caerulea and cyanidin 3-O-glucoside inhibited the production of intracellular ROS in tBHP-treated HepG2 cells. The protein expression of phosphorylated-extracellular signal-regulated kinases and Akt, which are responsible for cell protection against ROS, were increased after treatment with cyanidin 3-O-glucoside (50 and 100 μM) in a dose-dependent manner. Therefore, cyanidin 3-O-glucoside is the active compound in L. caerulea, which is responsible for the hepatoprotective effects through the inhibition of ROS and the activation of antioxidant mechanisms.
텍스트 마이닝을 활용한 대학생 문제음주 연구 동향 분석
박준언,윤기혁 국제차세대융합기술학회 2022 차세대융합기술학회논문지 Vol.6 No.6
This study investigated research trends of college students' problem drinking by using text mining. 100 research papers from 2000 to 2021 were collected with the keyword of "college students' problem drinking" from RISS. We aimed to provide preliminary data on college students' problem drinking by identifying latent meaning and patterns of research articles. Results: 140 words were selected for the analysis through preprocessing and stemming from the 100 scholarly literature titles, keywords, and abstracts in Korean and English. The most frequent keyword was 'problem drinking,' and 'college,' 'college students,' 'influence,' 'alcohol,' 'interpersonal relationship, ' 'depression,' etc., were in the following order. TF-I DF indicated 'drinking motivation,' 'self-efficacy,' 'depression,' 'college life,' 'stress,' 'personality,' 'psychsocial,' 'violence,' etc. Topic modeling implied that 'topic 1' was the leading topic out of 8 categories. Finally, we propose future directions based on the results. 본 연구는 빅데이터 분석인 텍스트 마이닝을 활용해 대학생 문제음주 연구 동향을 분석하였다. 분석에 활용한 논문은 100편으로, 학술연구정보서비스(RISS)에서 "대학생 문제음주" 키워드로 2000년부터 2021년까지 선 정하였다. 본 연구의 목적은 대학생 문제음주에 관한 논문의 패턴 및 전체 데이터 속에 잠재된 의미를 파악하여 대학생 문제음주 연구에 활용할 수 있는 기초자료를 제공하고자 함에 목적이 있다. 본 연구의 결과는 첫째, 본 연 구에서 활용된 100개 논문의 국문 또는 영문 제목․주제어․초록에서 수집된 데이터의 형태소분석 및 전처리 과 정을 거쳐 총 140개의 단어를 선정하여 분석하였다. 둘째, 대학생 문제음주 연구 동향에 대한 텍스트 마이닝 결과 가장 높은 빈도의 키워드는 문제음주이고, 그다음으로 대학교, 대학생, 영향, 알코올, 대인관계, 우울 등의 순으로 나타났다. 그리고 TF-IDF의 상위 키워드는 음주 동기, 자기효능감, 우울, 대학 생활, 스트레스, 성격, 심리사회적, 폭력 등의 순으로 나타났다. 셋째, 토픽 모델링에서는 8개의 범주로 유형화하였고, 토픽1이 메인 토픽인 것으로 나 타났다. 연구 결과를 바탕으로 대학생 문제음주 연구에 대한 방향성을 제언하였다.
Comparison of the Wound-Healing Effects of Ginsenosides, their Metabolites, and Aglycones
박준언,Hwan You,이다혜,Wonsang Huh,황귀서,노경태,김기현,함정엽,Noriko Yamabe,김영훈,강기성 대한화학회 2016 Bulletin of the Korean Chemical Society Vol.37 No.1
The effect of ginsenosides, their metabolites, and aglycones on tube formation in human umbilical vein vascular endothelial cells (HUVEC) was investigated to identify ways to potentially enhance wound healing. Of the tested compounds, sapogenins, aglycones of ginsenosides, promoted tube formation, whereas ginsenosides and their metabolites had no effect or inhibitory effects on tube formation. Treatment of HUVEC at concentrations of 6.25 and 12.5 μM 20(S)-protopanaxadiol (PPD) significantly increased tube formation by 34 and 35%, respectively. PPD also had a pronounced effect on the speed of wound closure in mouse dermal wounds.
박준언 이중언어학회 2011 이중언어학 Vol.47 No.-
This paper reviewed the current situation of Korean as a foreign language(KFL) education in terms of major domains: government support system, KFL teaching institutes,curriculum and materials development, KFL education for overseas ethnic-Koreans, KFL education for domestic multicultural families, KFL-related research, testing, etc. Considering the emergent status of KFL education in Korea and abroad, it is strongly advised that both researchers and practitioners maintain close cooperation to establish a theoretically valid and pedagogically well-tested KFL discipline.