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수풍순기환 투여가 고지방, 고탄수화물 식이로 유발된 비만형 제2형 당뇨병 동물모델에 미치는 영향
박종설,이병철,두호경,안영민,안세영,Park, Jong-Seol,Lee, Byung-Cheol,Doo, Ho-Kyung,Ahn, Young-Min,Ahn, Se-Young 대한한방내과학회 2009 大韓韓方內科學會誌 Vol.30 No.2
Objective : Obesity is an important cause of diabetes, and lipotoxicity causes insulin resistance. Recently a lot of research is being done on PPAR-${\alpha}$. TNF-${\alpha}$. adiponectin, and leptin, which are important obesity related factors. In this study, we investigated the effects of Supungsunki-hwan on high fat. high carbohydrate diet-induced obese type 2 diabetic mouse models. Methods: Diabetes was induced in ICR male mouse (30${\pm}$5g) with Surwit's high fat, high sucrose diet. Mice were divided into 4 groups(n=10) of Normal. Control. Supungsunkj-hwan group. and acarbose group. The Supungsunki-hwsn group was given 10% Supungsunkj-hwan in their diet. and the acarbose group was given 0.5% acarbose in their diet. After 6 weeks. body weight. food intake, FBS and OGTT. lipid profile and liver enzymes, epididymal fat weight, and gene expression of leptin, adiponectin, TNF-${\alpha}$ and PPAR-${\alpha}$ were measured. Leptin. adiponectin. tumor necrosis factor(TNF)-${\alpha}$ and peroxisome proliferator-activated receptor (PPAR)-${\alpha}$ were evaluated by reverse transcription-polymerase chain reaction. Results : Supungsunkj-hwan increased the gene expression of PPAR-${\alpha}$, which reduces lipotoxicity and insulin resistance. Supungsunkj-hwan also significantly reduced triglyceride. AST. ALT serum levels. and 1 hour oral glucose tolerance levels. Conclusion : These results show that Supungsunkj-hwan improves insulin resistance in the liver and muscles, by reducing triglyceride levels and lipotoxicity through increased PPAR-${\alpha}$ gene expression. This is supported by the fact that Supungsunkj-hwan significantly reduces 1 hour oral glucose tolerance levels. Therefore we suggest that Supungsunkj-hwan would be an effective treatment for obese type 2 diabetic patients.
비유우의 시기적 영양분요구에 대응한 혼파초지조성에 관한 연구
박종설 한국축산학회 1977 한국축산학회지 Vol.19 No.2
This experiment was carried out to find out the most effective combination of gross mixture which could be sufficient the seasonal requirement for the nutreint to milking cow and increase the yields. The testing was done at the grassland of the Korea Newzealand co-operated dairy ranch at Pyeongtaeg, Kyenggi province. After sowed as Table 2, the relation between the seasonal requirement for the nutrient to milking cow- and yields of the green grass and hay was studied. The results obtained were summarized as follows; 1. The green grass yield 2,748㎏ on mixture grassland of orchard grass, ladino clover, and alfalfa in the first year. It the yields from mixture grassland of orchard grass and ladino clover was considered as 100, this was the highest gelds, and mixture grassland of perennial ryegrass, orchard grass, red clover, white clover, Italian ryegrass, and timothy gave the least yields. 2. The mixture grassland of perennial ryegrass, Italian ryegrass, orchard amass, red clover, timothy, and white clover suffered the most summer depression, but the mixture grassland of orchard, grass, ladino clover, and alfalfa yielded much green grass without summer depression. 3. The mixture grassland of perennial ryegrass, Italian ryegrass, orhard grass, red clover, timothy and white clover contained 2.59% of the crude protein. and 2.9% of the crude fiber. The mixture grassland of orchard grass, ladino clover, and alfalfa contained 3.26 of the crude protein. 4. In comparing the seasonal requirement for the nutrient to milking cow to the yields of green grass, hay, and the crude protein, the mixture grassland of orchard grass, ladino clover, and alfalfa gave the highest productivity on July and August, and sufficed the seasonal requirement for the nutrient to milking cow that gave birth on February and March.
Idiopathic Isolated Perigastric Omental Panniculitis
박종설,김서화,윤병욱,오병수,윤동식,홍누리,황인겸,장재훈,김용성 대한상부위장관ㆍ헬리코박터학회 2015 Korean Journal of Helicobacter Upper Gastrointesti Vol.15 No.3
Mesenteric panniculitis (MP) is non-specific inflammation of the adipose tissue that primarily involves the small bowel mesentery. Omental involvement has been rarely reported but we report a case of 25 years old woman with isolated lesser omental panniculitis. This patient was diagnosed by CT findings and recovered completely with conservative treatment. Invasive diagnostic methods or surgical exploration has been used to diagnose MP. However, all six reported cases of omental panniculitis including the current case showed a benign course; therefore, awareness of the CT findings is essential for the best diagnosis and management of omental panniculitis.