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Zoom-in Micro-tomography와 3차원 Fuzzy Distance Transform을 이용한 쥐 대퇴부의 해면골 두께 측정
박정진,조민형,이수열,Park, Jeong-Jin,Cho, Min-Hyoung,Lee, Soo-Yeol 대한의용생체공학회 2006 의공학회지 Vol.27 No.4
Micro computed tomography (micro-CT) has been used for in vivo animal study owing to its noninvasive and high spatial resolution capability. However, the sizes of existing detectors for micro-CT systems are too small to obtain whole-body images of a small animal object with $\sim$10 micron resolution and a part of its bones or other organs should be extracted. So, we have introduced the zoom-in micro-tomography technique which can obtain high-resolution images of a local region of an live animal object without extracting samples. In order to verify our zoom-in technique, we performed in vivo animal bone study. We prepared some SD (Sprague-Dawley) rats for making osteoporosis models. They were divided into control and ovariectomized groups. Again, the ovariectomized group is divided into two groups fed with normal food and with calcium-free food. And we took 3D tomographic images of their femurs with 20 micron resolution using our zoom-in tomography technique and observed the bone changes for 12 weeks. We selected ROI (region of interest) of a femur image and applied 2D FDT (fuzzy distance transform) to measure the trabecular bone thickness. The measured results showed obvious bone changes and big differences between control and ovariectomized groups. However, we found that the reliability of the measurement depended on the selection of ROI in a bone image for thickness calculation. So, we extended the method to 3D FDT technique. We selected 3D VOI (volume of interest) in the obtained 3D tomographic images and applied 3D FDT algorithm. The results showed that the 3D technique could give more accurate and reliable measurement.
소형 동물의 생체 촬영을 위한 고해상도 Micro-CT 시스템의 개발
박정진,이수열,조민형,Park, Jeong-Jin,Lee, Soo-Yeol,Cho, Min-Hyoung 대한의용생체공학회 2007 의공학회지 Vol.28 No.1
Recently, small-animal imaging technology has been rapidly developed for longitudinal screening of laboratory animals such as mice and rats. One of newly developed imaging modalities for small animals is an x-ray micro-CT (computed tomography). We have developed two types of x-ray micro-CT systems for small animal imaging. Both systems use flat-panel x-ray detectors and micro-focus x-ray sources to obtain high spatial resolution of $10{\mu}m$. In spite of the relatively large field-of-view (FOV) of flat-panel detectors, the spatial resolution in the whole-body imaging of rats should be sacrificed down to the order of $100{\mu}m$ due to the limited number of x-ray detector pixels. Though the spatial resolution of cone-beam CTs can be improved by moving an object toward an x-ray source, the FOV should be reduced and the object size is also limited. To overcome the limitation of the object size and resolution, we introduce zoom-in micro-tomography for high-resolution imaging of a local region-of-interest (ROI) inside a large object. For zoom-in imaging, we use two kinds of projection data in combination, one from a full FOV scan of the whole object and the other from a limited FOV scan of the ROI. Both of our micro-CT systems have zoom-in micro-tomography capability. One of both is a micro-CT system with a fixed gantry mounted with an x-ray source and a detector. An imaged object is laid on a rotating table between a source and a detector. The other micro-CT system has a rotating gantry with a fixed object table, which makes whole scans without rotating an object. In this paper, we report the results of in vivo small animal study using the developed micro-CTs.
박정진(Jeong Jin Park),임선희(Seon Hee Lim),김봉룡(Bong Ryong Kim),김형완(Hyoung Wan Kim),김준완(Joon Wan Kim),김태형(Tae Hyong Kim),장유현(Yoo hyun Jang),이계희(Kyu Heui Lee),양대현(Dae Hyun Yang) 대한소화기학회 2001 대한소화기학회지 Vol.38 No.1
Idiopathic portal hypertension (IPH) is a rare disease characterized by overt splenomegaly and portal hypertension in the absence of cirrhosis or vascular obstruction. The most common cause of death in IPH patients is known to be variceal bleeding, which is usually treated with surgical method. Recently, interventional radiologic methods such as transjugular intrahepatic portocaval shunt, ballon-occluded retrograde transvenous obliteration, or partial splenic embolization (PSE), have been tried to control portal hypertension. A 24-year-old man presented with repeated gastrointestinal bleeding due to rupture of esophageal varices, but his liver function tests were completely normal and any possible etiologies of his portal hypertension couldn’t be demonstrated. He was diagnosed as IPH by laparoscopic liver biopsy after PSE, which could control portal hypertension as well. For twelve months after PSE, he hasn’t experienced bleeding again. We report the case of PSE to control portal hypertension in a patient with IPH who presented with variceal bleeding. (Korean J Gastroenterol 2001;38:48-52)
제임스 로즈노(James Rosenau)의 변화 개념으로 본 분단국가의 대(對)정책: 대북정책 수립에 주는 역설
박정진 ( Jeong Jin Park ) 경남대학교 극동문제연구소 2017 한국과 국제정치 Vol.33 No.2
본 연구는 제임스 로즈노의 세계에 대한 `분합(fragmegration)`과 `원근접성(distant proximities)` 개념에서 나타난 변화에 대한 인식을 분단국가의 상대국에 대한 대(對)정책에 응용, 분석하였다. 분단국가 대정책이 통합 성공에 필요한 부분을 성공 사례인 서독의 대동독정책과 한국의 대북정책에 적용하였다. 분석에는 로즈노의 변화에 필요한 개념으로 수평-수직 네트워크, 새로운 형태의 정부, 거버넌스, 정책을 위해 필요한 권위 틀(spheres of authority) 등을 중점적으로 택하였다. 분석 결과, 한국의 대북정책은 6.25 전쟁으로 인해 더 많은 관리가 필요하였다. 그러나 역대 정부의 정책을 살펴볼 때 수평-수직 네트워크보다 대통령 개인의 영향력이 주도적이었으며, 정책의 장기적 관리에 필요한 권위 틀, 거버넌스 구조 구성에 역점을 두기보다 참여 자체에 중점을 두었다. 또한 상대국의 스포일러 정책적 저항에 대한 대립에 집중하여, 통합에 필요한 북한과의 네트워크 구성이 쉽지 않았다. 반면 독일의 경우 상대적으로 유리한 조건에서 잘 짜인 통일 인식을 바탕으로 한 많은 구성원의 참여가 수평-수직 네트워크 구조로 나타났다. 또한 수직 네트워크인 정치권이 정책에 적응해나간 점, 정책의 장기적 관리에 의한 투 트랙 구조로 동독과의 네트워크 확장 등이 통일에 성공한 관리 요인으로 분석되었다. In this study I apply a pre-theory conception of James Rosenau`s concept `fragmegration` and `distant proximities` to analyze what influences change in policy of `parted countries` status toward an enemy state. I analyze two cases of divided nations: West Germany`s policy toward East Germany, a case of successful integration; and South Korea`s policy toward North Korea, a case of ongoing division. The study focuses on horizontal-vertical networks, new forms of governance, the actual governance, and the spheres of authority needed for policy. The results of the analysis are as follows. In the case of Korea, South Korea`s North Korean policy required more management because of the Korean War. However, when examining the past government policies, the influence of the president is more dominant than the horizontal-vertical network, and the emphasis is on participation itself rather than the spheres of authority and governance structure necessary for long-term policy management. In addition, considering the opposition to the policy and resistance of other countries, it was not easy to form a network with North Korea necessary for integration. On the other hand, in the case of Germany, the horizontal-vertical network structure is shown by the participation of many members based on the well-recognized recognition of reunification under relatively favorable conditions. In addition, management succeeded to unify because of the vertical network politics through policy adaptation and network expansion with East Germany through a two-track structure via long-term management of the policy.