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박재관,김성종,이삼철,정경락 전북대학교 공학연구원 ( 구 전북대학교 공업기술연구소 ) 2002 工學硏究 Vol.33 No.-
The purpose of this study was making a equation to predict relationship between pressure drop and frontal area in 40% glycerol solution at 37 ℃. Before using whole blood, we estimated pressure drop with experimental equation, and compared the results with experimental results. Also, we tried to make module design that contained the maximum number of hollow fiber membranes in 3㎝diameter tube. We have observed pressure drop of 40% glycerol solution flow rate in each modules that have been changed by the number of the hollow fibers, and studied about the equation related between flow rate and pressure drop, friction factor and Reynolds number. The results showed that the pressure drop which was calculated with the various frontal area was similar to the pressure drop of using the equation obtained from the experimental. Also, the maximum number of hollow fiber is 675, which can be inserted in 3㎝diameter tube when the out side of diameter was 380㎛. It satisfied pressure drop(<15㎜Hg).
혈관 내 폐 보조장치에서 적혈구의 microencapsulation에 의한 산소전달속도의 향상
박재관,김기범,정경락,장경환 전북대학교 공학연구원 ( 구 전북대학교 공업기술연구소 ) 2002 工學硏究 Vol.33 No.-
In this study, we tried to improve oxygen transfer rate and reduce pressure drop on intravascular lung assist device with microencapsulation of red blood cells, because microcapsulation of red cells reduce blood hemolysis. Hemoglobin was purified from outdated human red blood cells used. Phospholipid was purified from egg yolk. The hemosome was prepared by encapsulation of hemoglobin with phospholipid multilayer, using rotary vacuum evaporator. The function of hemosome was tested by measuring oxygen dissociation curve using blood gas analyzer. Oxygen dissociation curve of hemosome showed the same figure as the curve of normal red blood cells. Pressure drop showed lower use of hemosome rather than normal blood, because viscosity of hemosome are lower than that of normal blood. Also, oxygen transfer rate showed lower use of hemosome rather than normal blood at 2 hour, but it showed higher use of hemosome rather than normal blood after 2 hour. Because microencapsulation of normal red blood cells prevent hemolysis of normal red blood cells.
Perfluorocarbon 유화액에 의한 혈관 내 폐 보조장치에서의 압력손실과 산소전달
김기범,박재관,김성종,정인수,정경락 전북대학교 공학연구원 ( 구 전북대학교 공업기술연구소 ) 2002 工學硏究 Vol.33 No.-
The purpose of this study was to evaluate the effects of the perfluorocarbone emulsion in a novel membrane module that satisfied the limiting factor of minimizing the pressure loss in the intravascular blood flow pattern. It observed the mind on the viscosity that to mix with blood in the ratio of 1:4. The device used a bundle consisted of several hundred hollow fiber having the outside diameter of 380㎛. and the axial jacket length of 600 ㎜. The pressure drop of the membrane module device consisting of 300 hollow fibers was observed 10 ㎜Hg at the flow rate 4 ℓ/min and could be get sphere of pressure drop to apply equipment.