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      • KCI등재

        플라스틱 광섬유용 클래드 재료 개발 - PMMA/THV 블렌드의 상용성과 계면 접착력 -

        박은주,박인철,이무성,박민,Park, Eun-Ju,Park, In-Cheol,Lee, Moo-Sung,Park, Min 한국섬유공학회 2008 한국섬유공학회지 Vol.45 No.6

        We investigated the miscibility of poly(methyl methacrylate) (PMMA) and random copolymers of tetrafluoroethylene-hexafluoropropylene-vinylidene fluoride (THV) blends and their interfacial adhesion as part of the development of cladding materials for PMMA based plastic optical fiber. Three different types of THV with different copolymer composition were used as candidates for them. PMMA/THV blends being melt-mixed at $240^{\circ}C$ showed typical immiscible morphology and the glass transition temperatures of the component polymers did not change after mixing. However, tie chains connecting matrix and dispersed phase were identified when THV with high content of vinylidene fluoride, i.e., THV220 was used. In spite of the intrinsic immiscibility of PMMA/THV blends the interfacial adhesion obtained from peel test was above $10^4N/m^2$ at the adhesion temperature of $240^{\circ}C$ and increased with increasing the temperature for THV220. From the melt viscosity data of the polymers it was recommended that the extrusion temperature of THV should be higher than that of PMMA in order to obtain smooth interface between core and cladding layer.

      • KCI등재

        《난경(難經)》 오사론(五邪論)을 적용한 침법(鍼法)이 2K1C 고혈압(高血壓) 백서(白鼠)의 혈압(血壓)에 미치는 영향(影響)

        박은주,나창수,윤여충,조명래,Park, Eun-ju,Na, Chang-su,Yun, Yeu-chung,Cho, Myung-rae 대한침구의학회 2003 대한침구의학회지 Vol.20 No.1

        Objectives : The purpose of this study is to compare Xingjian(LR2) Shaofu(HT8) with Dadun(LR1) Shaofu(HT8) on Blood Pressure in Hypertensive RAT induced by Two Kidney One Clip(2KIC). Methods : This experiments was to investigate the effects of LR2 HT8(originated from ${\ll}$Classic on Difficulty${\gg}$ Shi Ze Xie Qi Zi), LR1 HT8(originated from ${\ll}$Ling Shu${\gg}$ Sheng Ze Xie Zhi) acupuncture on the blood pressure, cardiomegalic index, and plasma levels of atrial natriuretic peptide in hypertensive rat induced by 2K1C. Results: 1. Blood pressure was decreased significantly after third acupuncture of LR2 HT8. 2. Blood pressure was decreased significantly after acupuncture of LR2 HT8, but was increased after LR2 HT8. 3. Cardiomegalic index was not changed after acupuncture of LR2-HT8 and LR1-HT8 4. Plasma levels of atrial natriuretic peptide was increased significantly after acupuncture of LR2 HT8 but LR1 HT8 was not changed.

      • KCI등재

        Erk AND RETINOIC ACID SIGNALING PARTICIPATE IN THE SEGREGATION AND PATTERNING OF FIRST ARCH DERIVED MAXILLA AND MANDIBLE

        박은주,탁혜진,박은하,백정미,이상휘,Park, Eun-Ju,Tak, Hye-Jin,Park, Eun-Ha,Baik, Jeong-Mi,Zhengguo, Piao,Lee, Sang-Hwy Korean Association of Maxillofacial Plastic and Re 2009 Maxillofacial Plastic Reconstructive Surgery Vol.31 No.2

        In vertebrates, the face is mainly formed with neural crest derived neural crest cells by the inherent programs and the interactive environmental factors. Extracellular signaling-regulated kinase (Erk) is one of such programs to regulate the various cellular functions. And retinoic acid (RA) also plays an important role as a regulator in differentiation process at various stages of vertebrate embryogenesis. We wanted to know that the segregation as well as the patterning of maxillary and mandibular structure is greatly influenced by the maxillomandibular cleft (MMC) and the failure of this development may result in the maxillomandibular fusion (syngnathia) or other patterning related disorder. It has been well documented that the epithelium at this cleft region has significant expression of Fibroblast growth factor (Fgf) 8, and it is essential for the patterning of the first arch derived structures. By the morphological, skeletal, cell proliferation and apoptotic, and hybridization analysis, we checked the effects of Erk inhibition and/or RA activation onto MMC and could observe that Erk and RA signaling is individually and synergically involved in the facial patterning in terms of FGF signaling pathway via Barx-l. So RA and Erk signaling work together for the MMC patterning and the segregation of maxilla-mandible by controlling the Fgf-related signaling pathways. And the abnormality in MMC brought by aberrant Fgf signaling may result in the disturbances of maxillary-mandibular segregation.

      • KCI등재
      • KCI등재

        가정의학 임상실습과정에 대한 구조화된 평가

        박은주,이상엽,임선주,윤소정,감비성,백선용,김윤진,우재석,이정규,정동욱,조영혜,이유현,탁영진,Park, Eun Ju,Lee, Sang Yeoup,Im, Sun Ju,Yune, So Jung,Kam, Beesung,Baek, Sun Yong,Kim, Yun-Jin,Woo, Jae Seok,Lee, Jeong-Gyu,Jeong, Dong-Wook,Cho, Yo 연세대학교 의과대학 2017 의학교육논단 Vol.19 No.1

        This study was conducted to analyze the strengths and weaknesses of a 3-week family medicine clerkship program based on the results of an online survey taken by the students (N=127) and a structured interview with a focus group (n=10), aimed to improve the quality of the clerkship program. The online survey contained questions pertaining to goals, schedule, contents, arrangement, atmosphere, environment, evaluation, and satisfaction regarding the clerkship. The focus group interview addressed the schedule and achievements of the program. Scores were reported on a 5-point Likert scale. Most students were highly satisfied with the overall quality of the clerkship. The structured interview results showed that 97.6% of the clerkship program was executed according to the schedule. The focus group reported a perfect score of 5 points on several measures including: accomplishment of the educational goals of the family medicine clerkship, providing many chances to obtain medical histories and perform physical examinations on real patients, experience with various symptoms and diseases, positive attitudes of faculty members when teaching, notification of the guidelines for evaluation beforehand, well-constructed and effective clerkship schedule, and reflection of student feedback. However, the focus group gave low scores on: support for health accidents of students, access to patient information, enough opportunities to practice clinical skills, appropriate rest facilities for students, and fairness of clerkship evaluation process. In conclusion, the structured evaluation performed after the 3-week clerkship program motivated students and helped them ensure an efficient clerkship. This structured evaluation also suggested basic data to make the professor who is subject of the assessment. This study shows that structured assessment is an effective method which can be used to improve the quality of clerkships.

      • KCI등재

        의료기기 기업을 위한 BIA 성분분석에 대한 연구

        박은주,박노국,Park, Eun Ju,Park, Roh Gook 한국벤처창업학회 2014 벤처창업연구 Vol.9 No.6

        본 연구에서는 우리나라 의료기기 기업에서 이용 가능한 생체 저항 분석법의 유용성을 비만뿐만 아니라 심혈관질환의 위험성을 예측하고 관리 가능한지를 파악하기 위해 혈액검사와 비교하여 분석하였다. 특히 BIA 측정치 중 인체부위별 겉둘레와 지방두께와의 상관관계를 분석하였다. 본 연구에서는 우리나라 의료기기 산업에 있어 BIA의 활용과 진단을 기반으로 효율적인 관리와 평가를 위해 이용 가능하도록 제안하는데 목적이 있다. This Study was done to estimate the availability of biological resistance analysis method in medical equipment companies in Korea, and if it is usefull in predicting risk of obesity and cardiovascular disease and managing of it, by means of comparing it with blood tests. Especially, we analyzed the correlation between circumference length and fat thickness of each site of body area, which are ones of among measurement values of the BIA. This study has the purpose to propose the use of BIA as basement of diagnosis for efficient management and assessment in the medical device industry in our country.

      • KCI등재후보

        Effects of Paecilomyces tenuipes Cultivated in Egg Yolk on Lipid Metabolism in Rats on a High Fat-Cholesterol Diet

        박은주,Sang Mong Lee,Nam Sook Park,진병래,Han-Seok Kang,Jee Hyung Jung 한국식품영양과학회 2006 Journal of medicinal food Vol.9 No.2

        We investigated the effects of the fruiting bodies of cultivated Paecilomyces tenuipesgrown on egg yolk (PTE)on lipid and antioxidant metabolisms. Forty 8-week-old male Sprague-Dawley rats were fed a high fat/high cholesterol diet(control) or a high fat/high cholesterol diet with 1%, 3%, or 5% PTE for 5 weeks. PTE was found to significantly lower plasmatotal lipid, total cholesterol, low-density lipoprotein cholesterol, and the atherogenic index, compared with the control. He-patic total lipid and total cholesterol were also significantly lower than in the control group. The hypolipidemic activity ofPTE was increased with increasing concentrations, and plasma lipid peroxidation was significantly lower in the 3% and 5%PTE groups than in the control or 1% PTE group. Plasma total radical trapping antioxidant potential, erythrocytic antioxidantenzyme, and leukocytic DNA damage were not significantly different among the groups. Our results indicate that P. tenuipescultivated on egg yolk can improve lipid profiles and lipid peroxidation in rats fed a high fat/high cholesterol diet.

      • KCI등재

        호스피스 완화의료에서의 초기평가와 돌봄 계획의 수립: 평가도구를 중심으로

        박은주,고수진,천재경,Park, Eun Ju,Koh, Su Jin,Cheon, Jae Kyung 한국호스피스완화의료학회 2019 한국호스피스.완화의료학회지 Vol.22 No.2

        포괄적이고 총체적 돌봄을 제공하는 호스피스 완화의료의 경우 평가도구를 사용하여 문제목록의 객관화하고 돌봄 계획의 구체화하는 것이 필요하다. 초기평가는 입원 당일 혹은 1일 이내에 환자의 증상과 사회적, 영적 문제, 완화의료에 대한 요구가 무엇인지 파악하며 개괄적인 돌봄의 방향을 설정하는 과정이다. 현재 병에 대한 인식과 예후를 파악하는 것부터 연명의료계획서 작성까지 함께 검토한다. 초기평가도구로는 간단하지만 포괄적으로 신체적, 정신적, 사회적, 영적 영역을 아우르는 13개의 간단한 질문으로 구성된 NEST를 추천한다. 초기평가에서 파악된 문제에 대하여 구체적인 평가도구들을 활용하여 돌봄 계획을 수립하며 입원 후 3일이내 시행하는 것이 좋다. 신체적 영역의 경우 기능상태를 포함하여 통증과 비 통증 증상, 삶의 질을 함께 파악할 수 있는 다증상 평가도구가 도움이 될 수 있다. 환자의 증상은 단독으로 의미를 가지는 것이 아니라 복합적인 상호작용으로 발생하며, 그에 따라 포괄적으로 접근해야 하기 때문이다. 정신심리적 영역은 심리적 고통과 불안, 우울을 평가한다. 사회적 영역의 평가는 의사결정, 사회경제적 환경 파악, 가족 평가 및 임종 준비의 단계로 이루어진다. 영적 평가 역시 중요한데 FACIT-Sp나 SHI를 사용할 수 있다. 평가도구를 활용하는 것은 환자의 고통을 경감시키고 삶의 질을 향상시킬 뿐 아니라 의료진이 체계적으로 훈련되는 방안이 될 수 있으며 그 과정 자체가 더 나은 돌봄 제공을 위한 발판이 될 수 있다. For hospice palliative care that provides comprehensive and general care, it is necessary to use assessment tools to objectively list issues and detail care plans. The initial assessment is a process of establishing an overall direction of care by identifying the patient's symptoms, social and spiritual issues and palliative care needs on the admission day or within one day of admission. This process is also used to identify the patients' and families' awareness of the illness, prognosis, treatment options and if the Physician Orders for Life-Sustaining Treatment (POLST) has been drafted. Consisting of 13 simple questions regarding the physical, mental, social, and spiritual domains, the Needs at the End-of-Life Screening Tool (NEST) is recommended as an initial assessment tool. Using specific assessment tools, a care plan is established for the issues identified in the initial assessment within three days of admission. A multidisciplinary assessment tool can be helpful in the physical domain. The psychosocial domain evaluates psychological distress, anxiety and depression. The social domain examines an ability to make decisions, understanding of the socioeconomic circumstance, family relationship, and death preparedness. A spiritual evaluation is also important, for which the Functional Assessment of Chronic Illness Therapy-Spiritual WellBeing Scale (FACIT-Sp) or the Spiritual Health Inventory (SHI) can be used. The use of an assessment tool could not only contribute to pain mitigation a better quality of life for patients, but also provide systematic training for a multidisciplinary team; And the process itself could be a stepping stone for the better care provision.

      • KCI등재

        Effects of Cordyceps militaris Cultivated on Rice on Lipid Metabolism in Rats Fed High Fat-cholesterol Diets

        박은주,Sang Mong Lee,Nam Sook Park 한국식품영양과학회 2006 Preventive Nutrition and Food Science Vol.11 No.2

        Dongchunghacho rice, produced by cultivating Dongchunghacho fungus on rice, could be an effective functional food because it offers added value to rice and thus increases rice consumption. However, the physiological effect of Dongchunghacho rice has not been reported yet although there is increasing consumers demand. Therefore, we investigated the effect of Dongchunghacho rice (unpolished rice cultivated with Cordyceps militaris) on lipid metabolism in hyperlipidemic rats. Forty of 8 wk-old male Sprague-Dawley rats were divided into four groups after a 1 week of adaptation period and fed either a normal diet (66% polished rice diet, NC), high fat (12 g/100 g)-high cholesterol (1 g/100 g) diet with 53% polished rice (HC), or high fat-high cholesterol diets supplemented with 30% of the total rice as either unpolished rice (UR) or Dongchunghacho rice (DR). After 4 weeks, rats fed the Dongchunghacho rice diet with high fat and cholesterol had dramatically lower plasma LDL cholesterol concentrations and atherogenic indexes and higher plasma HDL cholesterol levels compared with the rats consuming polished rice or unpolished rice with high fat and cholesterol diet. Dongchunghacho rice led to less total lipid and total cholesterol accumulation in liver. However, these significant reductions in plasma or hepatic lipid profiles were not closely correlated with fecal total lipid or total cholesterol excretion. The plasma concentration of total cholesterol and triglycerides were not affected by Dongchunghacho rice. This hypolipidemic effect of Dongchunghacho rice seemed to be unrelated to unpolished rice itself, because the plasma and hepatic lipid profiles of UR group were not different from that of the HC group. These results suggest that unpolished rice containing cultivated Cordyceps militaris can improve plasma and hepatic lipid profiles in rats fed with high fat-high cholesterol diet.

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