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4M 및 HAZOP 기법을 활용한 연구실 위험요소 분석 연구
김태훈 ( T H Kim ),이광원 ( K W Rhie ),서두현 ( D H Seo ),이익모 ( I M Lee ),윤충식 ( C S Yoon ),이윤근 ( Y K Lee ),박정임 ( J I Park ) 한국안전학회(구 한국산업안전학회) 2013 한국안전학회지 Vol.28 No.3
In university laboratories, areas of studies are becoming diverse and complicated according to the development of the industry. New forms of potential risk factors are increasing and they are unlike existing ones. In addition, many students are conducting various experiments in the laboratory. Therefore, they could be exposed to risk more often. Despite these risks, people do not recognize university lab safety activities properly and observe safety precautions. They are exposed to various laboratory accidents continually. In this study, we do not apply the present diagnosis method, checklist, but the safety assessment that is widely used in industry. Then we can find lots of hazard that checklist method could miss. This study will use the 4M and Hazard & Operability to design a new Laboratory safety assessments method.
박유환(Y .H .Park),정춘혜(C .H .Chung),조영신(Y .S .Cho),김동규(D .G .Kim),손현화(H .H .Son),서영선(Y .S .Seo),이미자(M .J .Lee) 대한내과학회 2000 대한내과학회지 Vol.58 No.5
N/A Background : The role of oncogenes and tumor suppressor genes in the pathogenesis of gastric carcinoma has recently received considerable attention. The tumor suppressor gene, p53 locus on chromosome 17p, ceases a mitosis in G1/S check point after DNA demage. Abnormality of the p53 tumor suppressor gene plays an important role in alteration of cells and possibly leads to cancer development. The authors investigated the correlation between expression of p53 and prognosis in advanced gastric carcinoma. Methods : Expression of tumor suppresor gene p53 was investigated immunohistochemically in the primary lesion of 34 patients with advanced gastric carcinoma using paraffin embedded surgical specimens and the relationship of p53 immunopositivity with the clinicopathologic variables(Age, Sex, TNM staging, Lauren classification, Borrmann classification), 5-year survivals and life curves were analyzed. Kaplan and Meier's method is used as a life curve and log crank method is used for the analysis of prognostic factor. Results : Total p53 positive rate was 53% (18 of 34) of all cases. p53 immunopositivity was not associated with other clinicopathologic variables. The 5-year survivals were 44% and 11% for patients with p53 negative and positive gastric carcinomas, respectively. Patents with the expression of p53 has predominantly poor results in comparison of life curve(p<0.05) Conclusion : These findings suggest that p53 gene alteration be associated with poor prognosis of advanced gastric adenocarcinoma(Korean J Med 58:568-574, 2000)