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Gentamicin의 投與方法에 따른 藥物動態學的 비교에 관한 實驗
朴姸珠,孫基鎬,Sands, Charles D. 한국병원약사회 1986 병원약사회지 Vol.3 No.2
Gentamicin was administered in a single dose of 1㎎/㎏ to a healthy adult on two separate occasions; one time by I. V. bolus and the other by a 30 minute I. V. infusion. Serial blood samples were collected for 24 hours and various pharmacokinetic parameters calculated and compared. Gentamicin pharmacokinetics were best described by a three compartment model. Elimination half-life, Vd, AUC and time to peak concentration were similar for the two systems, but peak serum concentration was significantly different. The method of drug administration can have a profound influence on peak serum concentrations and time to attain peak. proper recommendations to obtain blood samples can be made only with the knowledge of drug pharmacokinetics and infusion method used in a specific institution.
등교를 거부하는 아동의 사례연구 -놀이치료를 중심으로-
박연주 충남대학교 교육연구소 2009 교육연구논총 Vol.30 No.1
본 연구는 아동상담의 한 방법인 놀이치료이론에 관한 문헌고찰 및 선행연구를 통하여 치료목표와 개념을 소개하였고, 실제로 아동상담사례를 놀이치료로 적용하여 분석하였다. 아동중심놀이치료, 정신분석적 놀이치료, 인지-행동놀이치료, 발달놀이치료, 부모놀이치료 이론과 놀이치료과정을 중심으로 살펴보았다. 상담사례는 등교를 거부하는 초등학교 1학년 여자아동으로 불안과 위축으로 학교가기를 싫어하는 내용이다. 24회기의 놀이치료를 실시하였는데 내담아동은 치료자와 함께 놀이를 통해 심리적, 정서적 어려움을 표출하였다. 내담아동은 놀이치료를 통해 불안감과 스트레스가 감소되었으며 자신감과 사회적 기술을 터득하게 되었고 내담 어머니는 상담을 통해 아동에 대해 적절하고 민감하게 반응하였다. 학교부적응 아동에게 놀이치료를 실시하여 학교를 가게 되고 친구와 잘 지내게 되었다. The purpose of study was to investigate the theory of play therapy and the effect of the individual play therapy on a child with school refusal. She was anxious and coward. This study was designed to determine the effectiveness of 24 sessions play therapy. The subject was a 8-year old girl with school refusal. This therapy used child-centered play therapy, psychodynamic play therapy, cognitive-behavioral play therapy, developmental play therapy, filial play therapy approach. Also counseling with the child`s mother was implemented to facilitate the effect of the play therapy. Observed outcomes of therapy reported decreased anxiety, heighten self-esteem, improved socialization skills, and reduced her level of stress. This study supports play therapy as effective intervention for children who have school refusal.
박연주,남영란,전병록,오남순,인만진 한국응용생명화학회 2003 Applied Biological Chemistry (Appl Biol Chem) Vol.46 No.4
마늘이 함유되어 있는 기능성 두부를 제조함에 있어 마늘의 첨가량이 두부의 품질과 저장성에 미치는 영향을 조사하였다. 건조 대두를 기준으로 마늘을 5-20% 첨가하여 제조한 두부의 수율, 물성 및 저장성을 마늘을 첨가하지 않고 제조한 일반두부와 비교하였다. 두부의 수율은 마늘의 첨가량에 비례하여 다소 감소하였으나 그 영향은 미미하였다. 마늘의 첨가량이 5∼10%인 경우 두부의 물성 중 견고성이 통계적으로 유의하게 증가하였으며, 마늘을 20%사용한 두부는 견고성, 부착성, 응집성, 탄성, 씹힘성이 통계적으로 유의하게 감소하였다. 제조한 두부를 15℃로 보관하면서 pH와 총균수의 변화를 측정한 결과 마늘의 첨가량에 비례하여 두부와 두부 침지액에서 pH 하락과 미생물 생육이 효율적으로 지연되었다. 두부 제조시 마늘의 첨가량은 5∼10%가 적당하였다. The effect of garlic addition on quality and shelf-life of soybean curd was investigated. The yield of garlic soybean curd slightly decreased in proportion to amount of garlic added. In the case of texture, hardness of the garlic, soybean curd increased when 5~10% garlic wat added, whereas hardness, adhesiveness, cohesiveness, springiness and chewiness significantly decreased in the case of 20% garlic added. Microbial counts of soybean curd stored in sterilized distilled water as tofu-immersion solution increased, whereas pH decreased during storage at 15℃. During all storage periods, microbial counts of the soybean curds containing garlic were always lower than that of the ordinary soybean curd. These results imply that garlic is a useful additive in suppressing the proliferation of aerobic microorganism and has a potential use in extending the shelf-life of soybean curd. According to yield, textural properties and shelf-life data, the suitable concentration of garlic was around 5~10%.
박연주,김은경 대한초음파의학회 2015 ULTRASONOGRAPHY Vol.34 No.2
Purpose: To evaluate the upgrade rate of ultrasonography (US)-guided core-needle biopsy(CNB) of the breast for a pure mucocele-like lesion (MLL), to evaluate the clinical and radiologicfeatures, and to correlate the image-pathologic features further on to guide the management ofMLL. Methods: Between January 2003 and February 2013, 14-gauge US-guided CNB was performedin 18,111 cases. Thirty-two cases associated with MLL were identified, and five cases of MLLsassociated with breast carcinoma or with other high-risk breast lesions (i.e., atypical ductalhyperplasia [ADH], papillary lesions, lobular carcinoma in situ , and radial scar complex) wereexcluded. Among these 27 pure MLLs, 21 cases with surgical or vacuum-assisted excision (VAE)pathology were included in our study. Medical records, mammograms, and ultrasonograms werereviewed for the clinical and radiologic features of the cases. Results: Among the 21 cases with pure MLLs at CNB, the final pathology showed a 0%proportion of cases upgraded to malignancy. All the 21 cases with either surgical or VAEpathology were benign MLLs including three cases of focal involvement of ADH (14.3%). Thecommon features were mammographic features of microcalcifications that were round in shapeand had a grouped distribution. The US features included oval shape, circumscribed margin,parallel orientation, complex solid and cystic echo pattern, no posterior feature, and complexsolid and cystic echoic masses. The predominant Breast Imaging Reporting and Data System (BIRADS)category was 4A. All the lesions showed image-pathologic concordance. Conclusion: For pure MLL on US-guided CNB with image-pathologic concordance, close imagingfollow-up might be considered instead of surgical excision.