악하부에 발생한 Progressive Transformation of Germinal Centers: 증례보고

박수원,장수미,김동율,손장호,조영철,성일용,Park, Su-Won,Jang, Soo-Mi,Kim, Dong-Yul,Son, Jang-Ho,Cho, Yeong-Cheol,Sung, Iel-Yong 대한악안면성형재건외과학회 2011 Maxillofacial Plastic Reconstructive Surgery Vol.33 No.4

Progressive transformation of germinal centers (PTGC) is mostly a disease of young adults and it presents as unexplained, asymptomatic, localized or generalized lymphadenopathy that is usually persistent or recurrent over a period of many years. PTGCs are larger than regular germinal centers and they contain a variable proportion of small mantle zone lymphocytes and so they become progressively transformed and they may result in the loss of clear demarcation between them and the mantle zone. PTGC may resemble the nodules of nodular lymphocyte predominant Hodgkin's disease (NLPHD) and it may be mistaken for NLPHD. Histological and immunohistochemical studies are helpful in differentiating these diseases. Because of the relatively frequent recurrences of PTGC, follow-up and repeat biopsy are indicated. Although PTGC is not considered to be a premalignant condition, PTGC may occur prior to, concurrent with or following NLPHD. This emphasizes the need for ongoing follow-up and repeat biopsy. Although PTGC is reported in 3.5% to 10% of the cases of chronic nonspecific lymphadenopathy, oral & maxillofacial surgeons are not widely aware of this condition and its clinical implications. Herein, we present a case of PTGC. A 24-year-old male without any history of immunodeficiency or autoimmune disease was admitted to the Department of Oral & Maxillofacial surgery at Ulsan University Hospital for evaluation of a right submandibular swelling. He had another mass on the right thigh that was noticed about 1 year ago. The submandibular lesion was completely resected and biopsied. The histological findings and immunohistochemical stains (CD3, CD15, CD20, CD30, CD57, BCL-2, EMA) were consistent with PTGC. He was followed up without any other complaints for 9 months.

전자코를 사용하여 할랄식품 적용을 위한 고추장 중 에탄올 분석

박수원(Su Won Park),심유신(You Sin Sim),최진영(Jin Young Choi),박은영(Eun Young Park),노봉수(Bong Soo Noh) 한국식품과학회 2016 한국식품과학회지 Vol.48 No.3

본 연구에서는 할랄 인증을 위한 고추장 중 에탄올 분석 시 1차 스크리닝 절차로서 전자코가 적용 가능한지를 알아보고자 하였다. 먼저 공인된 알코올 분석법인 GC-FID를 사용하여 25개의 재래식 고추장을 분석한 결과 모든 고추장에서 에탄올이 검출되었으며 그 함량은 0.14-2.7%이었다. 이 중 8개 고추장을 선별하여 전자코 분석한 결과, 에탄올 함량이 비슷한 고추장끼리 유사한 패턴을 나타내는 것을 확인하였다. 또한 시판 고추장 2개를 대상으로 전자코 분석을 통해 할랄 인증기관이 요구하는 에탄올 기준을 준수하는지를 1차적으로 신속하게 스크리닝이 가능함을 확인하였다. The purpose of this study was to investigate whether the electronic nose can be applied as a primary screening procedure to detect ethanol in gochujang for halal certification. First, ethanol content in 25 traditional gochujang was measured by gas chromatography with flame ion detector, widely accepted as the conventional method of alcohol detection. The content ranged from 0.14 to 2.7%. Then, 8 gochujangs selected from among the initial 25 samples were analyzed by electronic nose. Similar ethanol content patterns were observed between the two detection methods. In addition, commercial gochujang products were examined by electronic nose to ensure that they complied with the required ethanol standard of the halal certification authority. Consequently, it was confirmed that electronic nose analysis can be applied as a primary screening method for halal certification.

임플란트 식립 부위의 골밀도 평가에 관한 연구

박수원(Su-Won Park),장수미(Soo-Mi Jang),최병환(Byoung-Hwan Choi),손한나(Han-Na Son),박봉찬(Bong-chan Park),김창환(Chang-Hwan Kim),손장호(Jang-Ho Son),성일용(Iel-Yong Sung),이지호(Ji-Ho Lee),조영철(Yeong-Cheol Cho) 대한구강악안면외과학회 2010 대한구강악안면외과학회지 Vol.36 No.5

Introduction: Bone density is one of the important factors for the long term success of endosseous implants. The bone density varies from site to site and from patient to patient. A preoperative evaluation of the bone density is quite useful to oral surgeons for planning dental implantation. More accurate information on the bone density will help surgeons identify suitable implant sites, thereby increase the success rate of dental implantation. This study examined the correlation between the bone density measured preoperatively by computed tomography (CT) and the implant primary stability measured by resonance frequency analysis. Furthermore, the effects of the implant sites, gender, age and generalized systemic disorder patients on the bone density and primary implant stability were examined. Materials and Methods: One hundred and fourteen patients were selected. None of the patients had undergone a tooth extraction or bone graft history in the previous year. Preoperatively, the patients underwent CT scanning to evaluate the Hounsfield unit (HU), and resonance frequency analysis(RFA) was used to evaluate the implant primary stability at the time of implant installation. All implants were 4.0 mm diameter and 11.5 mm length US II. All patients were recorded and the HU and implant stability quotient (ISQ) value were evaluated according to the sites, gender and age. Results: The highest HU values were found in the mandibular anterior site (827.6±151.4), followed by the mandibular molar site (797±135.1), mandibular premolar site (753.8±171.2), maxillary anterior site (726.3±154.4), maxillary premolar site (656.7±173.8) and maxillary molar site (621.5±164.9). The ISQ value was the highest in the mandibular premolar site (81.5±2.4) followed by the mandibular molar site (80.0±5.7), maxillary anterior site (77.4±4.1), mandibular anterior site (76.4±11.9), maxillary premolar site (74.2±14.3) and maxillary molar site (73.7±7.4). The mean HU and ISQ value were similar in females and males. (HU: P=0.331, ISQ: P=0.595) No significant difference was also found in the age group respectively. However, the correlation coefficients between the variables showed a closed correlation between the HU and ISQ value. Conclusion: These results showed close correlation between the bone density (HU) and primary stability value (ISQ) at the time of implant installation(Correlation coefficients=0.497, P<0.01). These results strengthen the hypothesis that it might be possible to predict and quantify the initial implant stability and bone density from a presurgical CT diagnosis.

하악골 양측 하악지 시상분할 골절단술 후 흡수성 고정의 안정성에 관한 연구

최병환,박수원,장수미,손한나,박봉찬,손장호,조영철,성일용,Choi, Byoung-Hwan,Park, Su-Won,Jang, Soo-Mi,Son, Han-Na,Park, Bong-Chan,Son, Jang-Ho,Cho, Yeong-Cheol,Sung, Iel-Yong 대한구강악안면외과학회 2010 대한구강악안면외과학회지 Vol.36 No.4

Introduction: To evaluate the skeletal stability after a bilateral sagittal split osteotomy (BSSO) setback of the mandible fixed with a biodegradable internal fixation device or metal internal fixation device. Materials and Methods: Thirty consecutive patients underwent mandibular setback via BSSO. Fifteen patients were fixed with a biodegradable internal fixation device or metal internal fixation device respectively. Posteroanterior (PA) and lateral cephalograms were taken preoperatively and at two days, 5.5 months and 14.5 months postoperatively. The relevant skeletal points were traced and digitized to evaluate the skeletal changes postoperatively. The relapse rates were analyzed and compared statistically. Results: There was no statistically significant differences in postoperative stability between the two groups.(P<0.05) Conclusion: The biodegradable internal fixation device may make an effective device alternative to a metal internal fixation device for setback BSSO.

구강 내에 발생한 원발성 점막관련 림프양 림프종의 치험례

손장호,박수원,최병환,조영철,성일용,변기정,Son, Jang-Ho,Park, Su-Won,Choi, Byoung-Hwan,Cho, Yeong-Cheol,Sung, Iel-Young,Byun, Ki-Jeong 대한악안면성형재건외과학회 2009 Maxillofacial Plastic Reconstructive Surgery Vol.31 No.1

Mucosa-associated lymphoid tissue(MALT) lymphoma is thought to originate from marginal zone B-cells. In the WHO classification, Extranodal marginal zone lymphoma of MALT is classified B-cell Non-Hodgkin lymphoma. Common sites of MALT lymphoma include stomach, lung and the ocular-adnexa. Although less common in other sites, it is the most common low-grade lymphoma of the breast, thyroid, bowel skin and soft tissue. No strong age or gender predominance exists in MALT lymphoma. Dissemination to other sites can occur. In the oral cavity, MALT lymphoma is rare. Herein, we present a case of intra-oral MALT lymphoma. 66 year-old woman without any background of immunodeficiency or autoimmune disease admitted department of oral & maxillofacial surgery in Ulsan university hospital for evaluation of long-standing mild upper lip swelling. The lesion was completely resected and biopsied. Histological and immunohistochemical stains(CD3, CD5, CD20, CD21, CK) findings were used to confirm the lesion. Bone marrow biopsy was done and no bone marrow involvement was found. She did not receive chemotherapy and radiotherapy after surgery. No recurrence has been noted in the 22 months to date.

SolvencyⅡ를 적용한 생명보험 상품의 수익성 측정에 관한 연구

오창수 ( Chang Su Ouh ),박수원 ( Soo Won Park ) 한국계리학회 2012 계리학연구 Vol.4 No.2

최근 보험업감독규정의 개정으로 보험료 산출 방식은 기존의 3이원방식에서 현금흐름 방식(CFP;Cash-Flow Pricing)으로 전환되고 있다. 현금흐름방식에서는 이자율, 사업비율, 위험률이외에도 투자수익률, 해지율, 지급여력 등의 계리적 요인과 계약자구성(성별, 연령별), 판매규모 등의 마케팅 요인 등 다양한 기초율을 최적기초율로 적용하고 있다. 최적기초율로 장래 현금흐름을 생성하여 보험료를 산출하고, 장래 현금흐름을 기초로 상품의 수익성 분석을 통해 회사가 원하는 목표 달성 가능 여부를 판단하여 보험료를 결정하는 프로세스를 거치고 있다. 본 연구에서는 수익성 분석을 위한 측정지표로 Profit Margin을 적용하였고, 수익성 측정시 자본비용의 적용 방법을 한국의 기존 EU식 지급여력제도인 SolvencyⅠ, RBC제도, 현재 EU에서 논의중인 SolvencyⅡ를 적용하여 수익성이 어떻게 변하는지 비교 분석해보았다. 이 연구의 분석결과를 정리해 보면, 첫째 종신보험, 건강보험의 수익성은 자본비용을 기존 EU식 지급여력제도인 SolvencyⅠ을 적용할 경우 보다 RBC제도로 적용할 경우 다소 줄어드는 것으로 나타나고, 현재 EU에서 논의중인 SolvencyⅡ 방식을 적용할 경우에는 수익성이 크게 줄어드는 것을 알 수 있었다. 두 번째로 SolvencyⅡ 방식을 적용한 수익성은 건강보험(암보험) 상품이 종신보험 상품보다 좀더 줄어듬을 알 수 있었다. 이는 건강보험의 보험금지급률이 높아 종신보험 보다 수익성이 낮은 상태에서 SolvencyⅡ에서는 생명보험 언더라이팅 리스크 측정시 장해/질병리스크가 추가되는 등 세부적으로 다양하게 측정하고 보다 강화된 요건으로 측정하기 때문이다.현재 우리나라에서는 RBC제도를 지급여력제도로 적용하고 있어 수익성 측정시 RBC 제도 기준으로 자본비용을 반영하고 있으나, 우리나라에서도 국제적 기준의 자본비용을 반영한 수익성을 측정해볼 필요가 있으며 이러한 값이 회사에서 상품개발시 장기적으로 고려해야 하는 실질 수익성으로 볼 수 있을 것이다. 지급여력제도는 EU에서 논의중인 SolvencyⅡ제도 수준으로 점차 강화될 가능성이 있으므로 수익성 측정요건을 현 수준에서 보다 강화할 필요가 있다. 또한 상품판매를 위한 상품 포트폴리오 정책 수립시 규제자본의 변화를 고려하여 수익성을 제고하는 전략을 마련하는 것이 필요하다고 하겠다. Recently pricing method is being switched to CFP(Cash Flow Pricing) under revision of insurance supervision regulation. Under CFP, other than interest rate, expense ratio and mortality/morbidity rate, various assumptions are applied as best estimate assumption, for example marketing factors such as policy holders`portfolio(sex, age), sum insured and volume, as well as actuarial factors such as investment return rate, lapse rate and solvency capital requirement. Setting premium goes through the process of calculating premium by generating future cash flow using best estimate assumption and considering feasibility of the business target through profit margin analysis of the products, based on future cash flow. For the studies, profit margin was used as a measurement for profitability analysis. And to measure profitability, profitability changes were compared in each case using SolvencyⅠ which is previous Korean EU method, RBC, and SolvencyⅡ which is under discussion at EU at the moment. To sum up the results of the studies, first of all, applying RBC lowers profitability for wholelife insurance and health insurance compared to applying SolvencyⅠ which is previous EU method. Also, when applied SolvencyⅡ which is under EU discussion at the moment, it shows profitability gets worse. Secondly, under solvencyⅡ profitability for health insurance(cancer insurance) products are a little lessen compared to profitability for wholelife insurance products. This is because the ratio of claim paid is higher for health insurance, which leads lower profit compared to the wholelife insurance product, and furthermore, it is more detailed and strict when measuring life underwriting risk under SolvencyⅡ, for example considering disability/morbidity risk as well. In Korea, RBC method is used at the moment and capital cost under RBC criteria is considered for profit measure. However, we need to measure profits which reflectscapital cost under international standard and these numbers could be real profits which might be taken into account in the long term in developing products. Also, since solvency margin regulation tends to be getting stricter to SolvencyⅡ which is under EU discussion, it might be needed to reinforce the current profit measure conditions. Additionally, the strategies for raising profits considering changes in capital regulation might be necessary when making product portfolio policy for sales.

수배관 시스템에서의 여과식 수처리기의 효용성 평가

경도현(Do Hyun Kyung),박수원(Su Won Park),김은태(Eun Tae Kim) 대한설비공학회 2017 대한설비공학회 학술발표대회논문집 Vol.2017 No.6

MS-전자코를 사용한 페트(polyethylene terephthalate) 생수병과 뚜껑의 이취 이행 분석

한현정(Hyun Jung Han),박수원(Su Won Park),정효연(Hyo Yeon Jung),김정선(Jung Sun Kim),동혜민(Hyemin Dong),노봉수(Bong Soo Noh) 한국식품과학회 2015 한국식품과학회지 Vol.47 No.4

원료인 생수와 포장 용기인 페트병과 뚜껑에서 야기되는 이취성분의 존재여부를 MS-전자코를 통하여 분석해 보았다. 이취가 나는 생수는 농도별로 DF2 양의 방향으로 이동하는 것을 확인할 수 있었고, 이취의 원인이 페트병 혹은 페트병의 뚜껑이라고 가정하여 분석을 진행한 결과 뚜껑에서 휘발 성분이 페트병 보다 많이 검출되는 것으로 나타났다. 이는 물에서 나는 이취가 페트병보다는 뚜껑에 영향을 더 많이 받았을 것이라고 볼 수 있었다. 또한 이온 분획의 결과로 보아 이취의 원인이 되는 물질인 2,4-di-tert-butylphenol, 노난올과 데칸올이 페트병과 뚜껑에 포함되어 있다고 추측되었다. The objective of the study was to investigate the off-flavor generated from PET water bottles and their caps by using a mass spectrometry-based electronic nose. The ion fragment data obtained from the electronic nose were used for discriminant function analysis (DFA). In the case of increased concentrations of the contamination of water, the off-flavor pattern depended on the discriminant function second score instead of the discriminant function first score. To identify the cause of off-flavor in polyethylene terephthalate (PET) bottled water, the PET bottle and its cap were analyzed by DFA. The results showed that the cap generated more volatile compounds than the bottle or mineral water did. The substances causing the off-flavor were predicted to be 2,4-di-tert-butylphenol (2,4-DTBP), nonanal, and decanal when the main peak of the mass spectrum was compared with the major ion fragments of the electronic nose. Thus, using this method, we could determine whether the PET water bottle was contaminated and whether the off-flavor resulted from contamination of the bottle cap.

다발성 유아기 흑색 신경외배엽성 종양의 치험례

최병환(Byoung-Hwan Choi),박수원(Su-Won Park),장수미(Soo-Mi Jang),박봉찬(Bong-Chan Park),손한나(Han-Na Son),손장호(Jang-Ho Son),성일용(Iel-Yong Sung),김종렬(Jong-Ryoul Kim),조영철(Yeong-Cheol Cho) 대한구강악안면외과학회 2010 대한구강악안면외과학회지 Vol.36 No.5

A melanotic neuroectodermal tumor of infancy (MNTI) is a uncommon osteolytic pigmented neoplasm that primarily affects the jaws of newborn infants. Most patients (> 90%) present with the tumor in the first year of life. Approximately 65% form in the maxilla, 11% in the mandible, 5% in the brain and elsewhere. MNTI is normally benign, but up to 15% may recur and a few have metastasized. Approximately 200 cases of MNTI have been reported but only 2 of them presented as multifocal. A case of MNTI in a 7 month old boy was encountered. The chief complaint was maxillary anterior ridge swelling. The incisional biopsy findings were MNTI. Two months after the first operation, mild swelling of another site was observed. The infant was examined periodically since undergoing two procedures with no recurrence. This case demonstrates the possibility of a multicentric MNTI. We report a multicentric MNTI with a review of the relevant literature

소규모 창업자를 위한 효율적인 ERP 시스템 구현

이상명 ( Lee Sang Myung ),김대훈 ( Park Su Won ),박수원 ( Kim Dae Hun ),야마모토마사노리 ( Yamamoto Masanori ),조규남 ( Jo Gyu Nam ),정동준 ( Jung Dong Jun ),정성원 ( Jung Sung Won ),정영애 ( Jung Young-ae ) 한국정보처리학회 2014 한국정보처리학회 학술대회논문집 Vol.21 No.2

본 논문에서는 소규모 창업자를 위해 기업내부의 통합정보시스템을 구축하여 물류,창고,자재관리에 초점을 맞춘 웹 ERP시스템을 구축하였다. 본 논문에서 제안한 시스템은 모듈로 분리되어 쉽게 수정 및 추가가 가능하고 이동성 확장을 위해 모바일 인터페이스도 구축하였다. 본 논문에서 구축한 ERP시스템 ShopE.R는 기업의 업무 프로세스 변화에 따라 유연하게 변화할 수 있도록 구성된 솔루션이다. In this paper, we build a web ERP system that is focused on the logistics, storage, materials management to establish internal enterprise informantion system for small business. This system is possible to be transformed to separated modules so it is possible to be modified and added easily. And it is also implemented to provide mobile interface ofr mobility extension. The ShopE.R ERP system is a solution that can be reorganized flexibly according to variable changes in the corporate business processes.