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위장관 ( 胃腸管 ) : 진행성 위암에 대한 5 - FU , Adriamycin , Cisplatin 및 OK - 432를 이용한 병용 화학 면역요법의 치료 효과
구자영(Ja Young Koo),이상욱(Sang Uk Lee),최영식(Young Sik Choi),박병채(Byung Chea Park) 대한소화기학회 1991 대한소화기학회지 Vol.23 No.1
N/A Twenty-two evaluable patients with advanced stomach cancer were treated with a combination of Adriamycin (40 mg,/m2, IV, day 1), Cisplatin (40 mg/m, IV, day 2) and 5-FU (500 mg/m, IV, day 3-5) every 3 weeks, OK-432 was administrated 1M twice areekly with a dose of 5 K.E. Tumor responses and survival of treated patients were compared to the untreated control patients (32 cases) who had similar tumor burden and performance status. There were one objective pa'rtial response, giving a response rate of 6%. Seven patients (43%) achieved disease stabilization and eight cases (50%) had tumor progression. No complete response was observed. Treatment group showed significantly superior overall survival compared to control. One year survival rate of FAC OK-432 regimen was 3096 compared to 10% for the control and median survival time were 6.4 months versus 4.6 onths. respectively. Toxicity was moderate and consisted of nausea, vomiting, hair loss and fever. In conclusion, FAC-OK 432 regimen appears to be not so satisfactory in tumor reponse in patients with advanced stomach cancer, but it is helpful for prolongation of survival time as compared to the untreated control patients.