반복 발작성 긴장성 두통을 호소하는 소양인(少陽人) 태음인(太陰人) 치험 2례

박병주,신현상,강미정,이지원,장현수,이준희,이의주,고병희,Park, Byung-Joo,Shin, Hyun-Sang,Kang, Mi-Jeong,Lee, Ji-Won,Jang, Hyun-Su,Lee, Jun-Hee,Lee, Eui-Ju,Koh, Byeong-Hee 사상체질의학회 2010 사상체질의학회지 Vol.22 No.2

1. Objectives: This study reports two cases of repetitive episodic tension-type headache patients who were each constitutionally typed as the Taeeum type and the Soyang type and respectively treated with Yanggyeoksanhwa-tang and Galgeunhaegi-tang. 2. Methods: The patients' subjective and objective symptoms were observed daily, and the VAS scores for the main symptoms were recorded daily throughout hospitalization period. When deemed necessary, other assessment tools were engaged (Migraine-Specific Quality of Life questionnaire, Migraine Disablity Assessment questionnaire, Headache Impact Test-6, etc.). 3. Results: The Soyang Type patient's headache improved by the end of hospitalization, with a dramatic drop in the VAS score from VAS 10 to VAS 2. The Taeeum Type patient's headache also showed improvement, with an equally dramatic decrease in the VAS score from VAS 10 to VAS 2. 4. Conclusion: Although the two patients were experiencing the same symptoms of repetitive episodic tension-type headache, they were each given different medicinal interventions in accordance to their respective constitutional types. This series of cases is notable in that the two widely different medications (Yanggyeoksanhwa-tang and Galgeunhaegi-tang) were applied to specifically conforming pathologies (the Sogal symptomatology and the Ganyeol symptomatology, respectively) to produce equally dramatic improvements.

양격산화탕(凉膈散火湯)의 기원(基源), 변천과정(變遷過程) 및 구성원리(構成原理)

박병주,이준희,이의주,고병희,Park, Byung-Joo,Lee, Jun-Hee,Lee, Eui-Ju,Koh, Byung-Hee 사상체질의학회 2011 사상체질의학회지 Vol.23 No.2

1. Objectives: This paper investigates the origin, the progressive changes and the constructive principles of Yangkyuksanhwa-tang (凉膈散火湯). 2. Methods: Yangkyuksanhwa-tang and other related prescriptions were analyzed in terms of their pathological indications, based on previous literature including "Donguisusebowon Chobongwon (東醫壽世保元 草本卷)", "Donguisusebowon Gabobon (東醫壽世保元 甲午本)", "Donguisusebowon Sinchukbon (東醫壽世保元 辛丑本)" and "Dongmuyugo (東武遺稿)". 3. Results and Conclusion: 1) The Yangkyuksanhwa-tang most likely originates from Sodokeum, Yangkyuksan, Baekho-tang and Indongdeung. 2) Sodoksanhwa-tang introduced in "Donguisusebowon Chobongwon (東醫壽世保元 草本卷)" progressively transformed into Chungyangsanghwa-tang ("Donguisusebowon Gabobon (東醫壽世保元 甲午本)") and ultimately into Yangkyuksanhwa-tang ("Donguisusebowon Sinchukbon (東醫壽世保元 辛丑本)"), a prescription appropriate for usage in the Sangso symptomatology (上消證). 3) Yangkyuksanhwa-tang is composed of 9 herbs. Of these, Schixonepetae herba(荊芥), Ledebouriellae Radix(防風), Forsythiae fructus(連翹), Menthae Herba(薄荷), Gardeniae fructus(梔子) scatter the Hwa-qi(火氣), and Rehmanniae Radix(生地黃), Gypsum fibrosum(石膏), Anemarrhenae(知母) put off the Stomach-heat(胃熱), whereas Lonicerae caulis(忍冬藤) support the prevention of carbunculosis(癰疽).

팔물군자탕(八物君子湯)의 기원(基源), 변천과정(變遷過程) 및 구성원리(構成原理)

박병주,권진혁,이준희,이의주,고병희,Park, Byung-Joo,Kwon, Jin-Hyuk,Lee, Jun-Hee,Lee, Eui-Ju,Koh, Byung-Hee 사상체질의학회 2010 사상체질의학회지 Vol.22 No.4

1. Objectives This paper investigates the origin, the progressive changes and the constructive principles of Palmulgunja-tang (八物君子湯). 2. Methods Palmulgunja-tang and other related prescriptions were analyzed in terms of their pathological indications, based on previous literature including "Donguisusebowon Chobongwon (東醫壽世保元 草本卷)", "Donguisusebowon Gabobon (東醫壽世保元 甲午本)", "Donguisusebowon Sinchukbon (東醫壽世保元 辛丑本)" and "Dongmuyugo (東武遺稿)". 3. Results and Conclusions 1) The Palmulgunja-tang most likely originates from Paljin-tang introduced in "Donguisusebowon Chobongwon (東醫壽世保元 草本卷)". Paljin-tang progressively transformed into Seungyangpalmul-tang ("Donguisusebowon Gabobon (東醫壽世保元 甲午本)") and ultimately into Palmulgunja-tang ("Donguisusebowon Sinchukbon (東醫壽世保元 辛丑本)"), a prescription appropriate for usage in the Ulgwang symptomatology (鬱狂證). Also, Seungyangikgi-tang in "Donguisusebowon Sinchukbon (東醫壽世保元 辛丑本)" can be presumed to have been affected by Seungyangpalmul-tang. 2) The variational prescriptions (變方) of Palmulgunja-tang shows increasing Seungyang (升陽) effect in order of Baekhaogunja-tang, Sipjeondaebo-tang, Palmulgunja-tang, and Doksampalmul-tang. 3) Palmulgunja-tang is composed of 8 herbs. Of these, Paeoniae Radix Alba (白芍藥), Glycyrrhizae Radix(甘草), Angelicae gigantis Radix (當歸), and Cnidii Rhizoma (川芎) fortify the Soeumin Spleen Element (脾元). Ginseng Radix (人蔘) and Astragali Radix (黃?) support the ascension of Yang, whereas Atractlodis Rhizoma White (白朮) and Citrus unshiu (陳皮) encourage the descension of Yin.

사상체질(四象體質)에 따른 주관적(主觀的) 식욕(食慾) 비교(比較) 연구(硏究)

박병주,이의주,고병희,이준희,Park, Byung-Joo,Lee, Eui-Ju,Koh, Byung-Hee,Lee, Jun-Hee 사상체질의학회 2012 사상체질의학회지 Vol.24 No.1

1. Objectives : This investigation compares the subjective appetite ratings across male groups of different Sasang constitutional types. 2. Methods : We recruited 36 male participants aged 20-36 with BMI 18.5-30. The subjective appetite ratings was assessed using VAS before and after standard meal.(6 time points : 30 Minutes Pre-prandial, Immediately before Meal, 15, 30, 60, 120 Minutes Post-prandial) 3. Results : In comparison of subjective appetite ratings between Sasang constitutional types, Soyang-type showed a pattern like high appetite, high hunger, low satiety, high 'how much I can eat', Soeum-type showed a pattern like low appetite, low hunger, high satiety, low 'how much I can eat', and Taeeum-type showed a pattern like low appetite, low hunger. 4. Conclusions : The results of this study suggest that the subjective appetite ratings could be different across different Sasang constitutional types.

한국 여성에서의 자궁경부암 발생률

박병주,이무송,안윤옥,최영민,주영수,유근영,김헌,유하성,박태수,Park, Byung-Joo,Lee, Moo-Song,Ahn, Yoon-Ok,Choi, Young-Min,Ju, Yeong-Su,Yoo, Keun-Young,Kim, Hun,Yew, Ha-Seung,Park, Tae-Soo 대한예방의학회 1996 Journal of Preventive Medicine and Public Health Vol.29 No.4

To estimate the incidence of uterine cervix cancer among Korean women, we have conducted a study using the claim data on the beneficiaries of Korea Medical Insurance Corporation (KMIC). All medical records of the potential cases with diagnosis of ICD-9 180, 181, 182, 199, 219, 233 in the claims sent by medical care institutions in the whole country to the KMIC from January 1988 to December 1989, were abstracted and Gynecology specialist reviewed the records to identify the new cases of uterine cervix cancer among the potential cases during the corresponding period. Using these data, the incidence of uterine cervix cancer among Korean women was estimated as of July 1, 1988 to June 30, 1989. The crude rate was estimated to be 17.34(95% CI: $16.76\sim17.92$) per 100,000 and the cumulative rates for the ages $0\sim64\;and\;0\sim74$ were 1.7% and 2.2%, respectively. The age-adjusted rate for the world population was 19.93 per 100,000 which was higher than those of other Asian countries including China and Japan in $1983\sim1987$. The truncated rate for ages $35\sim64$ was 52.05 per 100,000 which was one of the highest in the world. With increasing age, the incidence rate increased to 78.11 per 100,000 in women aged $55\sim59$ years, then it decreased in the older groups. This finding suggests that detecting rate of uterine cervix cancer may decrease in women aged 60 years or older due to inadequate medical care seeking behavior. In the geographical area, the SIR of Jeju province was significantly low but it might be due to statistical unstability by small case numbers.

원조, 제도 및 사회적 자본 그리고 성장: 동태패널분석

박병주 ( Byung Ju Park ) 한양대학교 경제연구소 2009 경제연구 Vol.30 No.1

DNA 앱타머를 이용한 Streptococcus mutans의 부착 억제

박병주(Byung-Ju Park),옥승호(Seung-Ho Ohk) 한국산학기술학회 2018 한국산학기술학회논문지 Vol.19 No.3

본 연구는 치아우식증의 주 원인균으로 작용하는 S. mutans에 특이적인 앱타머 및 그 작용 기전에 관한 것으로 더욱 상세하게는 SELEX방법을 이용하여 S. mutans에 특이적인 앱타머를 선별하고, 앱타머와 결합하는 단백질 분자를 정제 및 동정함으로써 S. mutans의 부착에 관련된 기전을 보다 더 명확하게 규명하고자 하였다. 표적분자에 높은 친화도와 선택성으로 결합할 수 있는 특성을 가지는 앱타머는 3차원적인 특이적 구조에 의해 표적물질에 대해 수 nM ~ 수 pM 수준의 높은 결합력과 선택성을 지니고 있으며, 항체와 유사한 특성을 가지는 핵산으로 여겨지고 있다. 또한, 항체에 비해 안정성이 매우 높아 실온 보관이나 운반이 가능하고, 장시간이나 반복사용이 요구되는 진단용으로의 응용이 매우 용이하다. 또한 생체 내면역거부반응이 거의 일어나지 않는 점 등을 바탕으로 보다 저렴한 앱타머로 대체하려는 시도가 이루어지고 있으며, 이는 치료용으로의 개발연구에 매우 중요한 장점이 될 수 있다. 이를 위하여 39개의 random sequence를 갖는 DNA library를 제조하고, S. mutans를 앱타머 선별의 대상물질로 하여, SELEX 방법을 통하여 선별하고 pCR2.1 cloning vector에 cloning하고, 그 염기서열을 분석하였다. 그 결과 6종의 서로 다른 염기서열을 갖는 앱타머를 선별하였으며, 선별된 앱타머 중 SM-2를 이용하여 앱타머와 직접 결합하는 단백질을 분리, 동정하였다. 위의 결과로부터 선별된 앱타머들은 S. mutans에 선택적으로 결합함을 확인하였고, 이 앱타머는 세균의 당 대사 및 단백질 합성 관련 단백질에 결합함으로서 세균의 부착을 억제 할 수 있음을 확인하였다. In this study, the SELEX method was used to screen for and select aptamers with high selectivity and affinity for Streptococcus mutans, which is the causative agent of dental caries. Aptamers are single stranded oligonucleotides of DNA or RNA with high selectivity and affinity for target molecules because of their specific three-dimensional structures that are used to collect biometric information. When compared to antibodies in vitro, aptamers are more advantageous because of their ease of use in the screening process, low cost, chemical stability, and lack of restrictions on the target molecules. We sorted DNA aptamers, which contain 44 bp or 38 bp primer sequences in 5" and 3", 39 bp random sequences in the middle.We then analyzed the character and affinity to S. mutans. Aptamers of specific oligonucleotides that combine with S. mutans were selected and these results are selectively fused to S. mutans. The results confirmed that DNA aptamers can be used for rapid diagnosis and treatment of dental caries caused by bacteria of the oral cavity, namely S. mutans.

하수처리 : ZVI(Zero-Valent Iron)를 조합한 SBR 공정의 색도 및 유기물 제거 특성

박병주 ( Byung Ju Park ),최영균 ( Young Gyun Choi ),공영호 ( Young Ho Kong ) 대한상하수도학회 2007 공동추계 학술발표회 논문집 Vol.2007 No.-

하수처리 : Zero-Valent Iron을 조합한 MLE 공정의 염색폐수에 대한 색도 및 인 제거 특성

박병주 ( Byung Ju Park ),최영균 ( Young Gyun Choi ),송창수 ( Chang Soo Song ),오영기 ( Young Khee Oh ),이상도 ( Sang Do Lee ) 대한상하수도학회 2006 공동추계 학술발표회 논문집 Vol.2006 No.-

트레이닝방법의 차이가 태권도 선수의 하지 근 기능에 미치는 영향

박병주 ( Byung Ju Park ),주동욱 ( Dong Wook Joo ) 대한무도학회 2011 대한무도학회지 Vol.13 No.1

본 연구는 고등학교 태권도 선수들에게 웨이트 트레이닝, 써킷 웨이트 트레이닝, 플라이오메트릭 트레이닝을 각각 실시하여 각 훈련 방법의 특성이 태권도 선수의 하지의 근 파워, 근력, 근지구력, 동측·양측 근력비율의 증가에 어떠한 반응으로 나타나는지를 비교해 봄으로서 태권도 선수들의 경기력 향상에 필요한 운동 형태를 제시하고자 하였다. 본 연구의 대상자는 무선표집법을 사용하여 웨이트 트레이닝 집단 8명, 써킷 웨이트 트레이닝 집단 8명, 플라이오메트릭 트레이닝 집단 8명으로 각각 구분하여 각각 12주간 훈련을 실시하였으며, 슬관절의 최대우력, 근지구력, 동측근력비율, 양측근력비율을 측정하였다. 자료처리는 반복측정에 의한 이원변량분석을 실시하였으며, 집단과 시점별 상호작용효과가 있을 경우 시점별 대응표본 t-검증을 실시하였고, 집단 간 일원변량 분석(one-way ANOVA)을 실시하여 유의차가 나타날 경우 SNK로 사후검증을 실시하였다. 유의수준은 P<.05로 하였다. 본연구의 결과로서 최대우력은 좌·우측 신·굴근 모두에서 세집단이 유의하게 증가한 것으로 나타났으며, 우측 신근에서는 플라이오메트릭 집단이 서킷웨이트트레이닝 집단에 비하여 유의하게 높은 결과를 나타내었다. 근지구력은 좌·우측 신·굴근 모두에서 세집단이 유의하게 증가한 것으로 나타났으며, 좌·우측굴근 및 좌측신근에서는 운동 후 서킷트레이닝 집단이 플라이오메트릭 집단 보다 높은 근지구력을 나타내었고, 우측신근에서는 서킷웨이트 트레이닝 집단이 웨이트 트레이닝집단과 플라이오메트릭 집단 보다 높은 근지구력을 나타내었다. 동측근력비율, 양측근력비율은 운동전·후와 세 집단 간에 유의한 차이가 나타나지 않았다. The purpose of this study was to investigate the effect of weight Training and circuit training and Plyometric Training to Knee joint Isokinetic muscle function in the high-school Taekwondo athlete. This subjects were randomly assigned to three groups; a weight Training group(n=8), circuit Training group(n=8), Plyometric Training group(n=8). Taekwondo athlete shares each, 12 weeks between executes a motion. peak torque, H/Q ratio, bilateral muscler ratio muscler endurance of knee joint measured, This study training subjects were analyzed using two-way ANOVA with repeated measure. The result of this study presents between groups was not plain difference expressed H/Q ratio, bilateral muscular ratio, muscular endurance was plain difference expressed after 12week point of time (p>.05)and, peak torque was plain difference expressed(p<.05). Conclusion each group did appear peak torque, and muscular endurance, but point of view exercise was effect H/Q ratio, bilateral muscler ratio.