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박미경,박성환,조미라,Hye-Jwa Oh,Yang-Mi Heo,Eun-Mi Park,김호연 생화학분자생물학회 2011 Experimental and molecular medicine Vol.43 No.8
Indoleamine 2,3-dioxygenase (IDO) is a key negative regulator of immune responses and has been implicated in tumor tolerance, autoimmune disease and asthma. IDO was detected in the joint synovial tissue in the inflammatory microenvironment of rheumatoid arthritis (RA), but IDO expression in joint synovial tissue is not sufficient to overcome the inflamed synovial environment. This study aimed to unravel the mechanisms involving the failure to activate tolerogenic IDO in the inflamed joint. We demonstrate that both poly (I:C) and lipopolysaccharide (LPS) induce expression of IDO in synovial fibroblasts. However, inflammatory cytokines such as IL-17, TNF-α, IL-12, IL-23 and IL-16did not induce IDO expression. Poly (I:C) appeared to induce higher IDO expression than did LPS. Surprisingly,toll-like receptor (TLR)4-mediated IDO expression was upregulated after depletion of myeloid differentiation primary response protein 88 (MyD88) in synovial fibroblasts using small interfering RNA (siRNA). IDO, TLR3 and TLR4 were highly expressed in synovial tissue of RA patients compared with that of osteoarthritis patients. In addition, RA patients with severe disease activity had higher levels of expression of IDO, TLR3 and TLR4 in the synovium than patients with mild disease activity. These data suggest that upregulation of IDO expression in synovial fibroblasts involves TLR3 and TLR4 activation by microbial constituents. We showed that the mechanisms responsible for IDO regulation primarily involve MyD88 signaling in synovial fibroblasts, as demonstrated by siRNAmediated knockdown of MyD88.
박미경,Ying Han,김미선,서은희,강수정,So-Young Park,고형종,김덕규,이혜정 대한약리학회 2012 The Korean Journal of Physiology & Pharmacology Vol.16 No.3
Fenofibrate is a selective peroxisome proliferator-activated receptor α (PPARα) activator and is prescribed to treat hyperlipidemia. The mechanism through which PPARα agonists reduce food intake, body weight, and adiposity remains unclear. One explanation for the reduction of food intake is that fenofibrate promotes fatty acid oxidation and increases the production of ketone bodies upon a standard experimental dose of the drug (100∼300 mg/kg/day). We observed that low-dose treatment of fenofibrate (30 mg/kg/day), which does not cause significant changes in ketone body synthesis, reduced food intake in Long-Evans Tokushima (LETO) rats. LETO rats are the physiologically normal controls for Otsuka Long-Evans Tokushima Fatty (OLETF) rats, which are obese and cholecystokinin (CCK)-A receptor deficient. We hypothesized that the reduced food intake by fenofibrate-treated LETO rats may be associated with CCK production. To investigate the anorexic effects of fenofibrate in vivo and to determine whether CCK production may be involved, we examined the amount of food intake and CCK production. Fenofibrate-treated OLETF rats did not significantly change their food intake while LETO rats decreased their food intake. Treatment of fenofibrate increased CCK synthesis in the duodenal epithelial cells of both LETO and OLETF rats. The absence of a change in the food intake of OLETF rats, despite the increase in CCK production, may be explained by the absence of CCK-A receptors. Contrary to the OLETF rats, LETO rats, which have normal CCK receptors, presented a decrease in food intake and an increase in CCK production. These results suggest that reduced food intake by fenofibrate treatment may be associated with CCK production.
Computed Tomography에 의한 절편영상의 추정
박미경,이의택,Park, Mi-Gyeong,Lee, Ui-Taek 한국전자통신연구원 1997 전자통신동향분석 Vol.12 No.6
CT스캔(Computed Tomography)은 다양한 분야에서 효과적으로 응용되고 있고, 특히 의학 영상에서 비침범 진단, 수술 계획 등에 커다란 영향을 끼쳤다. 이 글에서는 여러 가지 CT스캔의 종류, 그 수학적인 원리와 기본적인 평행 광선(parallel beam)을 이용한 영상의 재구축 알고리즘, 데이터의 추정과 문제점 그리고 그 개선 방향에 대해 논한다
Midazolam을 구강 점막 하로 병용 투여한 진정법의 안정성과 Houpt Scale을 이용한 진정효과에 대한 연구
박미경,김윤희,정상혁,백광우,Park, Mi-Koung,Kim, Yun-Hee,Jung, Sang-Hyuk,Beak, Kwang-Woo 대한치과마취과학회 2006 Journal of Dental Anesthesia and Pain Medicine Vol.6 No.2
Background: The purpose of this study was to compare the clinical safety and effect with and without additional submucosal midazolam to oral chloral hydrate and hydroxyzine when used for pediatric conscious sedation in a clinical dental environment. Methods: Thirty one cases of pediatric conscious sedations were performed in this study. Selection criteria included good health (ASA I), under 6 years old, 20 kg of body weight, uncooperative behavior and the need for sedation to receive dental treatment including anesthesia and restorative or surgical procedure for at least two teeth. In each visit, patients were randomly assigned into one of two groups; CH group: chloral hydrate (60 mg/kg), hydroxyzine (1 mg/kg), CH-M group: chloral hydrate (60 mg/kg). hydroxyzine (1 mg/kg) and submucoal midazolam (0.1 mg/kg). 50% nitrous oxide-oxygen was maintained during the sedation period Sedations were monitored using a pulse oximeter for estimating pulse rate (PR) and percutaneous oxygen saturation ($SpO_2$). Behavior response rated using Houpt's scale and need of restraint was assessed every 2 minutes through 30 minutes of operative procedure reviewing the videotape recording. Evaluation of overall behavior success was performed using modified overall behavior rate of Houpt's scale. Data was analyzed using t-test. Results: PR and $SpO_2$ for both groups remained within the normal values. The mean scores for sleep and movement of CH-M group were higher than those of CH group (P < 0.05). There were no significant difference in mean score for crying between two groups. The mean scores of overall behavior of CH-M group was higher than those of CH group (P < 0.01). Reinstraint of CH-M group was less required than that of CH group (P < 0.05). Conclusions: Oral chloral hydrate (60 mg/kg) and hydroxyzine (1 mg/kg) combined with submucosal injection of midazolam was safer and showed more improved sedation effect than oral chloral hydrate (60 mg/kg) and hydroxyzine (1 mg/kg) without midazolam for sedation of pediatric dental patients.
신종플루 확산(2009년) 이후 호흡기감염 아동 보호자의 감염관리 지식정도 및 수행정도
박미경,고영숙,박경임,Park, Mi-Kyung,Ko, Young-Sook,Park, Kyung-Im 한국아동간호학회 2011 Child Health Nursing Research Vol.22 No.4
Purpose: The purpose of this study was to investigate the knowledge and practice level of infection managements in child guardians with respiratory infections after H1N1 diffusion of 2009. Methods: The data were collected during February and March 2010 using a self-report questionnaire. The participants were 228 child guardians. Data were analyzed using frequency, percentage, means, SD, t-test, F-test, Pearson correlation coefficients, and Cronbach's alpha with the SPSS 17.0 program. Results: Mean age of the guardians and children were 37.8 years, 4.1 years respectively. For knowledge level of respiratory infections, hand washing method had the highest score and snuffles prevention method, the lowest. For practice level for respiratory infections, environmental hygiene management had the highest score and symptom management, the lowest. Infection management knowledge and practice level had a positively significant correlation in every area. Conclusion: The results indicate the necessity of continual education on infection management, and that the most efficient timing for the education appears be for participants during their first pregnancy or after the woman has delivered her child.
박미경,이의택,Park, M.K.,Lee, E.T. 한국전자통신연구원 1998 전자통신동향분석 Vol.13 No.3
이 논문은 음함수 곡면을 이용한 모델링의 역사와 그 응용 그리고 모델링의 여러 가지 접근 방법과 렌더링 방법을 분류, 비교하였다. 현존하는 문제점과 유효한 해결 방법 등을 평가하였고, 이 분야의 최첨단 기술에 대해서 논의하였다.