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박동진,육연수,박대균,이상화,오희목,김창진,Park, Dong-Jin,Yuk, Youn-Su,Park, Dae-Gyun,Lee, Sang-Hwa,Oh, Hee-Mock,Kim, Chang-Jin 한국미생물학회 1998 미생물학회지 Vol.34 No.4
대청호 퇴적층에 부존하는 미생물들의 분포 양상을 알아보기 위해 대전광역시 동구 추동 대전 취수탑(정체수역) 부근과 충청북도 보은군 회남면 어성리 회남교(본류수역) 부근의 두 지점으로부터 0.5~2 cm와 19~21 cm의 두 깊이에서 장마 전(1998년 5월)과 후(1998년 8월)에 각각 퇴적토를 채집하여 세균, 방선균, 진균의 분포 밀도를 측정하였다. 조사된 모든 미생물군들은 정체수역 보다 본류수역에서 평균 3.9배 더 높게 분포하였으며, 또한 각 수역에서 세균은 장마 전후에 큰 차이가 없었으나 방선균은 장마 후에, 진균은 장마 전에 더 높게 나타났다. 그리고 미생물들의 분포 밀도는 퇴적층의 길이가 깊어짐에 따라 큰 감소를 나타내지 않았으며 오히려 일부 심층에서는 표층보다 더 높게 나타났다. 대청호 인근의 초지 지역과 비교하였을 때, 세균, 방선균, 진균의 분포 밀도는 각각 52.9%, 35%, 7%로 나타났다. 또한 대청호 접경 지점과 비교하였을 때, 세균과 방선균은 각각 1.89배 및 3.63배 더 높았으나 진균은 71.2%의 낮은 분포 수준을 나타내었다. In order to characterize the microbial distribution at sediments of Lake Daechung, soil samples were collected at two depths of 0.5~2 cm and 19~21 cm of Chudong(static) and Hoenam(streaming) site on May 18th(before rainy season) and on August 24th in 1998(after rainy season), and then the density(CFU/g soil) of microorganisms including bacteria, actinomycetes, and fungi was investigated by the viable cell counting method. Microbial density at streaming site was on the whole 3.9-fold higher than that at static site. Bacterial densities examined before and after rainy season was revealed to be similar, whereas actinomycetes and fungi exhibited higher distribution after and before rainy season, respectively. The microbial distribution was not generally reduced with the increase of depth and was rather higher at some deep sites. On comparing with the microbial densities of grass land around the lake, bacteria, actinomycetes, and fungi at lake sediments on the average showed the distribution of 52.9%, 35%, and 7%, respectively. However, their distribution except for fungi which exhibited 71.2% was mostly found to be somewhat higher than at the shore of lake.
생쥐의 B 세포에서 anti-CD40과 rIL-4로 유도된 싸이토카인 생산에 대한 자초의 효과
박대원 ( Park Dae Won ),이용섭 ( Lee Yong Seob ),서영배 ( Seo Yeong Bae ),안덕균 ( An Deog Gyun ),최호영 ( Choe Ho Yeong ) 대한본초학회 2003 大韓本草學會誌 Vol.18 No.4
N/A Objectives : In order to study the anti-allegy effect of water extract of Lithospermi Radix on the B-cells from healthy Balb mice. Methods : The cytotoxicity of Lithospermi Radix was measured with the murine normal lung fibroblast cells by modified SRB assay. And the murine splenic B-cells was stimulated with anti-CD40 mAb and r U . The various cytokines related with allergy were measured by flow cytometry and by RT-PCR. Results : The anti-allegy effects to Lithospermi Radix were identified and observed. The cytotoxicity of Lithosptmni Radix on mouse lung fibroblast cells showed no significant activities. Lithospenni Radix had inhibitory effect on CD23, CD69 and IgE expression by Lithospenni Radix with anti-CD40 mAb plus rIL-4-stimdated murine splenic B-cells. Lithospermi Radix had inhibitory effect on cytokines (IL-1 a, IL-4, IL-5, IL-6, TNF-a) by Lithospermi Radix with anti-CM mAb plus rIL-stimulated murine splenic B-cells. Conclusion : We concluded that Lithospermi Radix showed anti-allegy effect on murine splenic B-cells.
증례 : 순환기 ; 뇌경색의 색전 원인 병소로서 상행대동맥의 유동성 혈전 1예
이상호 ( Sang Ho Lee ),박대균 ( Dae Gyun Park ),김민관 ( Min Kwan Kim ),김성은 ( Sung Eun Kim ),이준희 ( Jun Hee Lee ),한규록 ( Kyoo Rok Han ),오동진 ( Dong Jin Oh ) 대한내과학회 2011 대한내과학회지 Vol.80 No.2S
폐암(소세포암)으로 항암치료 시행 후 외래 추적관찰 중인 환자가 내원 3시간 전 시작된 우하지의 무기력함으로 응급실에 내원하여 뇌 자기공명영상을 통하여 급성 뇌경색을 진단하였다. 뇌 자기공명혈관조영술과 경흉부 심초음파에서 특이 소견이 없었고, 경식도 심초음파를 통하여 대동맥궁 근처의 상행대동맥에 실형태의 유동성 혈전을 가진 1.3 × 0.9cm 크기의 둥근 종괴를 확인하였다. 스타틴과 함께 항응고 치료를 시행하였고, 20일 후에 재시행한 경식도 심초음파에서 실 형태의 종괴는 보이지 않았으며 둥근 종괴의 크기는 감소하였다. 퇴원 후 항응고 치료를 항혈소판 치료로 변경하였고, 외래 추적 과정에서 재발 소견은 관찰되지 않았다. 흉부 대동맥 경화반이 관찰되는 환자들 중에서 상행대동맥에 위치한 복합죽종은 그 빈도가 매우 드물기에 문헌고찰과 함께 보고하는 바이다. Plaque in the ascending aorta can be an important embolic source of stroke. Diagnostic tests for identifying embolic sources are critical for preventing the occurrence of other devastating complications before the initiation of treatment. Here, we report the case of a patient with mobile thrombi attached to the distal ascending aortic wall that were identified by transesophageal echocardiography (TEE). The mobile thrombi in the ascending aorta were treated with anticoagulants and statins. The TEE images we obtained for this case were noteworthy because complex atheromas of the ascending aorta are very rare. (Korean J Med 2011;80:S152-S156)
문한국 ( Han Kook Moon ),박대균 ( Dae Gyun Park ),김성은 ( Sung Eun Kim ),윤덕형 ( Duk Hyung Yoon ),이준희 ( Jun Hee Lee ),한규록 ( Kyoo Rok Han ),오동진 ( Dong Jin Oh ) 대한내과학회 2008 대한내과학회지 Vol.74 No.4
전격성 심근염은 급성기에 높은 사망률을 보이나 약물치료나 기계적 순환 보조장치로 회복되기만 하면 급성 심근염 환자에 비해 장기 생존률은 좋은 것으로 알려져 있다. 현재까지 국내에서 기생충 질환에 의한 과민반응에 기인하여 양호한 경과를 보였던 호산구성 심질환은 보고 되었으나 폐 흡충증과 연관되어 호산구수가 증가하고 증상 시작 2일만에 혈압저하, 호흡곤란등 울혈성 심부전 경과를 보이는 급성 호산구성 전격성 심근염을 국내에서는 처음으로 경험하여 문헌고찰과 함께 보고하는 바이다. Fulminant myocarditis is characterized by critical illness at presentation. However, if affected patients recover with pharmacologic therapy and mechanical circulatory support, they may have a better long-term prognosis than patients with other forms of myocarditis. A 31-year-old man was admitted due to chest pain associated with dyspnea. Electrocardiogram showed ST-segment elevation in all leads except for aVR and aVL. Non-sustained ventricular tachycardia developed 12 hours after admission. The echocardiography showed diffuse hypokinesia, concentric edematous thickening of the left ventricular wall, and pericardial effusion. Serum cardiac enzymes and absolute eosinophil count were elevated. Since the ELISA (Enzyme-Linked Immunosorbent Assay) against Paragonimus westermani was positive, the patient was treated with praziquantel for 2 days. Eosinophil count normalized after 10 days, with conversion to negativity on ELISA after 4 weeks. We concluded that his myocarditis was probably caused by allergic reaction secondary to Paragonimus westermani infection.(Korean J Med 74:451-456, 2008)
김성은 ( Sung Eun Kim ),박대균 ( Dae Gyun Park ) 대한내과학회 2012 대한내과학회지 Vol.82 No.2
Background/Aims: Unlike pleural effusions or ascites, few studies have examined the role of chemical and cell-count parameters in the etiologic diagnosis of pericardial effusion. We determined the cut-off points of chemical parameters that can differentiate the causes of pericardial effusion. Methods: This study included 45 patients who underwent pericardiocentesis from 2003 to 2010. We examined the cell count and chemistry of blood and pericardial fluid, and divided the patients into a systemic group (the pericardium and myocardium were not invaded directly, such as in uremia and hypothyroidism) and a local inflammation group (the pericardium or myocardium was involved directly, such as in malignancy, tuberculosis, infection, and connective tissue disease). Results: Common causes of pericardial effusion requiring pericardiocentesis were malignancy (42.8%), iatrogenic (11.9%), and tuberculosis (9.5%). The pericardial lactate dehydrogenase (LDH) level and pericardial/serum (P/S) LDH ratio were higher in the local inflammation group than the systemic group (288.33±143.9 vs. 2,372.07±3,916.00 IU/L, p=0.002, and 5.7 vs. 0.6, p=0.007, respectively). The discrimination accuracy of the P/S LDH ratio (1.12) and pericardial fluid LDH level (435 IU/L) for predicting local inflammation was significant, as evidenced by the respective areas under the receiver operating characteristic curves of 0.84 (sensitivity 81.4%, specificity 81.5%) and 0.88 (sensitivity 83.3%, specificity 81.5%). Conclusions: The LDH level (435 IU/L) of pericardial fluid and P/S LDH ratio (1.12) in patients with a pericardial effusion can help to differentiate between systemic causes and other diseases directly involving the pericardium. (Korean J Med 2012;82:194-199)
증례 : 순환기 ; 갑상선기능항진증 환자에서 발현한 우심부전과 변이형 협심증 1예
박혜원 ( Hye Won Park ),박대균 ( Dae Gyun Park ),박철민 ( Chul Min Park ),김성은 ( Sung Eun Kim ),이준희 ( Jun Hee Lee ),한규록 ( Kyoo Rok Han ),오동진 ( Dong Jin Oh ) 대한내과학회 2009 대한내과학회지 Vol.76 No.5
저자들은 갑상선기능항진증 환자에서 중증의 삼첨판 역류 및 폐고혈압을 동반한 우심부전증과 심실세동으로 발현한 변이형 협심증을 진단하였으며, 갑상선치료 시작 이후 삼첨판 역류 및 우심부전, 폐고혈압이 회복되는 것을 경험하여 문헌고찰과 함께 보고하는 바이다. Thyroid hormone has many effects on the heart and vascular system. Cardiovascular manifestations of excess thyroid hormone are variable, and include enhanced cardiac contractility, enhanced oxygen myocardial consumption, and reduced systemic vascular resistance. Sinus tachycardia, atrial fibrillation, heart failure, and angina pectoris are common clinical manifestations, while right heart failure without severe left heart failure is rare in patients with hyperthyroidism. In addition, ventricular fibrillation may occur in thyrotoxic patients due to myocardial ischemia, such as in variant angina. This case report describes a young woman who presented with right heart failure and variant angina, whose only concurrent illness was hyperthyroidism. The symptoms and sign of right heart failure improved on treating the hyperthyroidism. (Korean J Med 76:584-588, 2009)