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위암 환자의 혈액에서 Telomerase 활성도 검출의 의의
박기호,정순재,유용운,박성환,이한일,주대현,박기혁,최동락,전창호,Park Ki Ho,Jung Soon Jai,Yu Young Woon,Park Sung Hwan,Lee Han Il,Joo Dae Hyun,Park Ki Hyuk,Choi Dong Rak,Jeon Chang Ho 대한위암학회 2003 대한위암학회지 Vol.3 No.4
Purpose: Telomerase activity is generally absent in primary cell cultures and normal tissues. Telomerase is known to be induced upon immortalization or malignant transformation of human cells. Telomerase activity can be increased in immature lymphocytes and activated lymphocytes, but it is not detected in the peripheral blood of normal persons. The authors analyzed peripheral blood telomerase from patients of gastric cancer to evaluate the possibility of using it for diagnosis and as a prognostic factor. Materials and Methods: We obtained blood samples from 11 inflammatory patients and 64 gastric cancer patients. The telomerase activity was measured using the [PCR-ELISA] method. The results were correlated with the T, N, M stage, cell differentiation, vascular, neural, and lymphatic invasion, tumor size, and tumor location. Results: In the 11 inflammatory patients, telomerase activity was not detected while in the gastric cancer patients, a positive rate of $28.1\%$ was noted. The peripheral telomerase activity was not related with tumor size, tumor site, lymphatic and vascular invasion, stage, or histologic differentiation. Conclusion: The peripheral blood telomerase activity for patients of gastric cancer can be utilized as a marker for the diagnosis of not only advanced gastric cancer, but also relatively early stage gastric cancer, but not as a prognostic factor.
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박기호,박상혁,Park, Ki-Ho,Park, Sang-Hyeok The Society of Digital Policy and Management 2011 디지털융복합연구 Vol.9 No.4
최근 셀프리더십과 관련된 연구들은 주로 경영학, 심리학, 상담학 등의 다양한 분야에서 많은 관심을 보이는 연구 분야다. 오랜 기간 동안 리더십은 조직 내 경영진이나 팀리더 등의 조직책임자들에게 강조되는 개념이었다. 그러나 최근에는 개인의 자유의지를 스스로 통제 혹은 관리하여 자신의 행동을 바람직한 방향으로 이끌고자 하는 셀프리더십(self-leadership)관련 연구에 학계, 산업계의 관심이 모아지고 있다. 본 연구는 정보기술(information technology) 및 엔지니어링 과목을 수강한 학부재학생들의 셀프리더십 전략(독립변수)이 수강태도에 영향을 미치는지 수강태도가 매개변인의 역할을 하여 학업성과(종속변수)에 어떤 영향을 미치는 지를 연구하였다. 한국(116명)과 인도학생(36명)을 대상으로 국가간 차이를 비교 연구하였다. 분석결과 한국학생들의 경우 건설적 사고유형의 학생일수록 자기노력을 많이 하며, 결과적으로 학업성과에 긍정적 영향을 미쳤다. 인도학생들의 경우는 행위중심유형의 학생일수록 학업성과가 높은 것으로 나타났다. 연구 결과는 조직 구성원 혹은 학생들의 셀프리더십을 고양함으로써 과업에 임하는 태도나 수업에 임하는 바람직한 태도를 제시하여 학업성과를 촉진할 수 있는 방안수립에 시사점을 줄 수 있을 것이다. 나아가 글로벌 환경의 기업 생산성 제고를 위한 셀프리더십 프로그램 마련에 도움을 줄 것이다. A number of organizations have had big interests in studies concerning leadership and not only academia but also psychological areas do also. Until now, leadership has been accentuated by managers or team leaders especially. Recently, however, the concept of self-leadership directing one's own activities through self-control or self-management is being focused on in practices and in academia. This study is to investigate the influence between self-leadership strategies as predictors and learning performance in IT classes as dependents variables mediated by attitude of attendance focused on the social science students in two universities (Korea(116 samples) and India(36 samples)). And this research tried to compare difference between two university students. As a result of empirical analysis, Korean learners making an effort by themselves show a tendency to think constructively. Namely, even though the level of difficulty may be high, by positive self-talk, respondents usually make an effort to get high academic performance. In case of Indian respondents, students who are in behavior-oriented show higher academic performance. Research results can give us direction of task-taking attitudes in firms or learning attitudes in teaching organizations and implications to human resource managers who are in charge of improving learning performance or productivity.
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박기호,정순재,Park, Ki-Ho,Jung, Soon-Jai 대한위암학회 2004 대한위암학회지 Vol.4 No.2
Purpose: Esophagojejunal anastomotic complications after a total gastrectomy include leakage, stenosis, bleeding, and abscess formation. Especially, the mortality rate for esophagojejunal anastomotic leakage is $80\%$. Although these complications hare been reduced by the usage of the EEA stapler, they are still serious and depend on various factors: the surgeon's experience, the stage of disease, the extent of surgical intervention, the method of operation, and the patient. Some local factors, such as vascularization of the graft, traction on the anastomosis suture line, and local infections, have been implicated as contributing to these complications. Materials and Methods: During the period $1995\∼2003$, of the 850 gastrectomies for gastric carcinomas, 171 were intra-abdominal total gastrectomies. All of these 171 operations were performed by one surgeon using a routine D2 lymph-node dissection and a 25-mm EEA stapler on an antecolic end-to-side esophagojejunostomy. In the 77 cases a seromuscular reinforced suture at the esophagojejunostomy site was performed, and in 94 cases, a whole layer reinforced suture with absorbible materials was used. We evaluated the incidence of complications according to age, sex, stage of patients, and combined resection. Also, we compared the incidences of complications for seromuscular and whole layer reinforced sutures. Results: The complications are major leaks ($2.9\%$), minor leaks ($3.5\%$), stenosis, bleeding ($1.8\%$), and abscess formation formation ($1.8\%$). In the five cases of major leaks, there were four mortalities with operative methods. The other patients with stenosis, bleeding, and abscess formation were treated conservatively with success. The incidences of complications were not related with age, sex, stages, and combined resection. The incidences of complications for the whole layer reinforced suture group ($2.9\%$) were less than those for the seromuscular reinforced group ($8.8\%$, P=0.04). Conclusion: The most serious complication of esophagojejunal anastomosis is major leakage with an $80\%$ mortality. The other complications are stenosis, bleeding, and abscess formation, for which no mortalities occurred during this study. Whole layer suture of the esophagojejunal anastomotic site is an important method for preventing leakage.
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인터넷 관문사업자와 디지털 콘텐츠사업자간 상생정책 방안에 관한 탐색적 연구
박기호,Park, Ki-Ho 한국디지털정책학회 2008 디지털융복합연구 Vol.6 No.1
This study explored which policies can be win-win strategies among internet portals and digital content providers. With taking the professional advise by interview and descriptive Questionnaires, the study suggested which governmental policies may be the mutual and proper winning strategies in internet industry, specifically between internet portal sites and content providers. Researcher kept in contact with five opinion leaders in this field and proposed thirteen candidate policies, which can give implications to the related governmental agencies, internet portals and contents providers. Some of these suggested policies may have been done and are being done conservatively in some area. But, in order to positively activate and develop the domestic digital contents industry, this study emphasized that the related agencies should perform the progressive policies and assign the financial supports to internet industry.
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박기호,정재곤,Park, Ki-Ho,Jeong, Jae-Gon 한국공간정보학회 1999 개방형지리정보시스템학회 논문지 = Journal of the Korea Open Geogr Vol.1 No.2
지금까지 지리공간 데이터에 대한 접근과 처리에 있어서 상호운용성 보장을 위해 $OpenGIS^{TM}$ 명세에 준하는 다양한 프로토타입 시스템들이 설계되어 왔다. 그러나, 오브젝트 웹 GIS의 관점에서 보았을 때 실질적인 상호운용성을 보장할 수 있는 운영 시스템이 되기까지는 많은 걸림돌들이 존재한다. 특히, 새로운 아키텍쳐 설계에 있어 핵심 기반 기술 중의 하나라고 할 수 있는 매핑 라이브러리의 상호운용성 측면에서 진행되는 연구는 거의 없는 실정이다. 본 논문은 타 $OpenGIS^{TM}$ 기반 데이터 제공자들과 상호운용될 수 있는 매핑 커널인 OpenViews를 개발하는 데 초점을 두고, 이를 기반으로 한 새로운 차원의 개방형 GIS 시스템 설계를 제시한다. 이를 위해 향후 등장하게 될 여러 시스템들을 ORB를 통해 통합하기 위한 기본적 시스템 요구 사항들을 추출하였으며, 특히 심볼 객체를 분산시킬 수 있는 표준 인터페이스를 제시하였다. 개발된 매핑 커널은 확장성과 유연성을 보장할 수 있도록 100% 순수 자바를 기반으로 하였으며, 잘 알려진 디자인 패턴과 UML을 설계 과정에 도입하였다. OpenViews를 내장한 GIS 애플리케이션 서버는 OpenBroker를 이용하는 데이터 제공자와 함께 서블릿과 EJB기반의 웹 전자지도 출판을 쉽고 빠르게 처리할 수 있도록 하는 개방형 GIS 시스템 아키텍쳐의 핵심 구성 요소이다. To meet the interoperability requirements associated with geospatial data access and geoprocessing, much efforts to design prototypical systems conforming to $OpenGIS^{TM}$ specification has been made. With respect to Object Web GIS, however, current internet mapping technology mainly focuses on either developing mapping libraries or client applications regardless of the future needs for interoperability such as an integration of $OpenGIS^{TM}$ standard for CORBA. In this paper, we propose an $OpenGIS^{TM}$ compliant mapping kernel. OpenViews, which is designed to meet those requirements. The kernel of OpenViews encapsulates the process of acquiring geospatial data in the format of $OpenGIS^{TM}$ Geometry through ORB(Object Request Broker). OpenViews, being designed based on well-known design patterns, is a highly extensible in that programmers can easily customize it on the object oriented architecture. The components implemented in OpenViews are CORBA/Java objects, and as such are portable and scalable in a networked environment. A companion package, OpenBroker, is also developed as a portable geoprocessing application server to facilitate the implementation and configuration of server side CORBA objects. It can be used for implementing objects for spatial analysis service which would be independent of legacy spatial database systems in many cases. OpenViews, together with OpenBroker, has been successfully prototyped using the technologies including EJB and servlet as the core components of an Open GIS compliant internet mapping.
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Diisocyanate 및 Chain Extender의 화학적 구조가 폴리우레탄의 열적 특성에 미치는 영향
박기호,김광복,이한섭,Park, Ki-Ho,Jin, Gangfu,Lee, Han-Sup 한국섬유공학회 2008 한국섬유공학회지 Vol.45 No.2
Polyurethane(PU), a type of thermoplastic elastomer, consists of two different segments (hard and soft segments) that are incompatible at room temperature. Depending on the chemical and physical structure of those two segments, polyurethane shows various internal structures. In this study, a series of polyurethane were synthesized using PPDI (l,4-phenylene diisocyanate), TODI(3,3'-dimethyl diphenyl 4,4'-diisocyanate), MDI(4,4'-diphenylmethane diisocyanate) as disocyanate, 1,4 BD and HQEE(hydroxyquinone-di-(beta-hydroxyethyl)ether) as chain extender in order to test the effect of chemical structure of hard segment on the phase separation behavior and thermal stability of polyurethane. The effect of diisocyanate and chain extender on the thermal stability of polyurethane was measured with DSC, POM, SAXS and FTIR methods. Compared with PU based on the asymmetric and aliphatic component, PUs based on the symmetric and aromatic chemical structures were found to form phase separated structure showing enhanced thermal stability. The good thermal properties were also explained in terms of the good packing behavior between hard segments in the PPDI-based polyurethane.
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IT프로젝트 감리 사례 비교 연구 : 컴포넌트 기반 개발법(CBD Method)
박기호(Ki ho Park) 호서대학교 사회과학연구소 2016 社會科學硏究 Vol.35 No.1
Different from traditional development methodology like waterfall model, the CBD (component-based development) uses a building block approach to the design and development of information system. The audit procedure and checklist for the traditional IS development methodology should also be modified for suitable use of the CBD. This research analyzed IS audit guidelines for the existing developing process and case projects applying component-based development process in order to explore possible ways of improving audit criteria. For purpose of the study, the governmental public project and the next-generation IS project of financial agency were employed as case projects. By comparing the existing IS audit checklist and the audited items of case projects, this study identified newly addable and proper check items for the CBD-centric audit program. As a result of the analysis, the study proposed new items to be added such as project control in management phase, usage case and conceptual model establishment, etc. in analysis design phase, and component evaluation and design, etc. in implementation phase, and so forth. The result of the research provides new items and guidelines suitable for the CBD projects and clues for increasing the efficiency and quality of application software development projects. 전통적 프로그램 개발방법론인 폭포수 모델 개발생명주기와 달리, 부품 형태의 컴포넌트를 조립하여 개발하는 방법론이 확산되고 있다. 컴포넌트 기반 개발(Component Based Development)의 감리에는 전통적 개발방법에 근간을 둔 감리기준이 아닌 컴포넌트 기반 개발방법에 적합한 감리가 실시되어야 한다. 본 연구에서는 전통적 개발방법론 근간의 감리기준과 CBD적용 프로젝트 사례 분석을 통하여 감리기준의 개선점여부를 탐색하고자 하였다. 연구 사례로는 정부 공공프로젝트와 금융기관의 차세대정보시스템 구축 프로젝트를 선정하였다. 기존의 정보시스템감리 기본점검표와 사례에서 의 감리검토항목을 비교 분석한 결과 감리검토항목의 개선점을 발견할 수 있었다. 사례분석의 결과로 CBD 프로젝트에 적합한 감리검토항목을 제시하였으며, 연구결과는 소프트웨어 제품 개발의 효율성 제고 및 품질향상에 이바지 할 것이다.
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