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박귀영,박미경,김은주,이미경,서성준 대한의학회 2011 Journal of Korean medical science Vol.26 No.7
IgE-dependent activation of mast cells and basophils through the high-affinity IgE receptor (FcεRI) is involved in the pathogenesis of allergen-induced immune responsiveness in atopic diseases like atopic dermatitis (AD). We sought to determine FcεRI gene polymorphisms are associated with AD in Korean patients, and analyzed the relevance of FcεRI gene polymorphisms and serum IgE levels. We conducted a case-control association analysis (175 patients and 56 controls) of Korean subjects. Genotyping was performed using the TaqMan fluorogenic 5´ nuclease assay, and serum levels of IgE were measured using a fluorescence enzyme immunoassay. We found that there were no significant relationships between FcεRI and AD, although there were trends towards an association between the 66T>C (rs2251746) polymorphism and total serum IgE levels in the Korean AD patients. In conclusion, while the 66T>C (rs2251746) of the FcεRIα polymorphism may be linked to AD and higher serum IgE levels, polymorphisms in the FcεRIβ gene did not confer susceptibility to AD in our patient sample.
A Study on the Correlation of Skin Types with Genetic Factors and Environmental Factors in Koreans
박귀영,홍준기,신선혜,고영규,한혜성,문남주,안건영,서성준 대한피부과학회 2022 대한피부과학회지 Vol.60 No.4
Background: The Baumann skin type (BST) classification provides a new approach for clinical care of dermatologic patients. Objective: To investigate the correlation of skin types with genetic factors and environmental factors that have an important influence on Korean skin by comparing and analyzing the correlation between phenotype and genotype. Methods: From July to October 2016, 774 adults who visited the one online shopping mall were subjected to skin BST questionnaire and gene single-nucleotide polymorphism (SNP) tests. Oral epithelial cells of the subjects were collected using a Genoplan DNA analysis kit, and 14 genes were analyzed by a genetic analysis agency (Genoplan Inc., Fukuoka, Japan). Results: The most abundant skin type was OSNT (oily, sensitive, non-pigmented, tight) observed in 205 participants (26.5%). Of the filaggrin (FLG) SNPs, 143 participants (18.5%) had the GG (good) SNP; 391 (50.5%), GA (normal) SNP; and 240 (31.0%), AA (poor) SNP. Among those whose FLG SNP was GG (good), 121 (84.6%) were sensitive and 22 (15.4%) were resistant. Of those whose filaggrin (FLG) SNP was GA (normal), 337 (86.2%) were sensitive and 54 (13.8%) were resistant. Of those whose FLG SNP was AA (poor), 213 (88.8%) were sensitive and 27 (11.3%) were resistant. There was also a statistically significant difference in the fruit-vegetable consumption and use of a sunbathing bed between sensitive and resistant type in the groups that classified the FLG SNP as GA. Conclusion: This is the first study to investigate the association of BST with genetic factors and environmental factors.
박귀영 한국군사회복지학회 2013 한국군사회복지학 Vol.6 No.2
본연구의 목적은 군 사회복지사 자격제도와 양성방안에 대한 세부 교육과정을 통한 양성방안을 제 시하는 것이다. 이에 본 연구는 군에 적합한 군 사회복지의 실행과, 국가가 인증하는 전문적인 군 사회복지사의 양 성이시급히 이루어져야 될 것으로 사료되어 군에서의 사회복지를 재조명하고 현행 한국에서 시행되 고 있는 전문 사회복지와 미국의 군 사회복지에 대한 연구를 통해 군사회복지사 자격제도와 양성을 위한 세부교육과정을 검토하였다. 군 복무 중에 있는 개인과 가족, 군 환경이 개선됨을 통해 염려와 고충을 해결하고 전투력 손실을 사 전에 예방하여 전장에서 승리하는데 필요로 하는 강한 군대 조성을 위해서는 전문적인 군사회복지 사 자격을위한 법제화가 추진되어야 할 것이며 군사회복지사의 활동과 배치 등을 위한 계속적인 노 력이 필요하며 군사회복지를 담당하는 전문 군사회복지사의 양성이 시급히 요구되고 있다. 따라서 본 연구는 군의 목표인 전장에서 승리하는데 필요로 하는 강한 군대를 육성하는데 꼭 필요로 하는 군 사회복지사 자격제도와 양성방안을 제시였다.
Safety Evaluation of Stamp Type Digital Microneedle Devices in Hairless Mice
박귀영,김범준,장우선,임윤영,안주희,김명남,이상진,김찬웅,김성은 대한피부과학회 2013 Annals of Dermatology Vol.25 No.1
Background: Microneedles provide a minimally invasive means to transport molecules into the skin. A number of specific strategies have been employed to use microneedles for transdermal delivery. Objective: The purpose of this study was to investigate the safety of two new digital microneedle devices (Digital HandⓇ and Digital ProⓇ; Bomtech Electronics Co., Ltd., Seoul, Korea) for the perforation of skin in skin-hairless-1 mice. This device replaces conventional needles and is designed specifically for intradermal delivery. Methods: We used two newly developed digital microneedle devices to perforate the skin of skin-hairless-1 mice. We conducted a comparative study of the two digital microneedle devices and DTSⓇ (Disk type-microneedle Therapy System; DTS lab., Seoul, Korea). To evaluate skin stability, we performed visual and dermatoscopic inspections, measurements of transepidermal water loss, and biopsies. Results: The two novel digital microneedle devices did not induce significant abnormalities of the skin on visual or dermatoscopic inspection, regardless of needle size (0.25∼2.0 mm). No significant histopathological changes, such as inflammatory cell infiltration, desquamation of the stratum corneum, or disruption of the basal layer, were observed. The digital microneedle devices and microneedle therapy system produced similar results on measures of skin stability. Conclusion: These two novel digital microneedle devices are safe transdermal drug delivery systems.
박귀영,김동하,정미숙,이갑석,서성준 대한의학회 2010 Journal of Korean medical science Vol.25 No.5
Increased transepidermal water loss (TEWL) and downregulated antimicrobial peptides (AMPs) are observed in patients with atopic dermatitis (AD). Tacrolimus and ceramide-dominant emollients are effective in the treatment of AD by preventing the production of inflammatory cytokines and by correcting skin barrier dysfunctions,respectively. Present study was designed to investigate the relationship between antimicrobial and barrier factors by measuring the changes of AMPs and TEWL after topical application of tacrolimus and ceramide-dominant emollient in the patients with AD. A total of three patients with AD were treated with tacrolimus in one lesion and ceramide-dominant emollient in another lesion for 4 weeks. RT-PCR and western blotting revealed that the mRNA and protein expression levels of hBD-2 and LL-37 were increased on the both study sites. Immunohistochemical analysis showed significant increase of AMPs and IL-1a, while, IL-4 was decreased on the both study sites. The mean changes of TEWL and AMPs showed no statistical difference between both sites. Tacrolimus and ceramide-dominant emollient influence on both TEWL and AMPs expression in patients with AD, namely they have similar effects on both of the two. This study shows that restoration of permeability barrier function is accompanied by the concomitant improvement of antimicrobial defense in patients with AD.