당귀음자가감방(當歸飮子加減方)과 외치법(外治法)을 병용한 소아(小兒) 건선(乾癬) 치험 1례

민들레,장성진,박은정,Min, Deul-Le,Chang, Sung-Jin,Park, Eun-Jung 대한한방소아과학회 2012 대한한방소아과학회지 Vol.26 No.3

Objectives The purpose of this case study is to report the effect of concurrent administration of Danguieumja-gagambang and external treatments on childhood psoriasis. Methods The subject is a child with psoriasis. This patient was treated with oriental herbal medicine (Danguieumjagagambang) and external treatments. The improvement of the skin condition is observed by Psoriasis Area and Severity Index (PASI) score. Results After the treatment, the symptoms of psoriasis were relieved. PASI score of this child went down from 4.7 to 0. Conclusions This study showed that concurrent administration of Danguieumja-gagambang and external treatments can be an effective choice for psoriasis.

전주지역 여고생의 체질량 지수에 따른 생활습관, 체중관리 실태 및 한방 설진(舌診)에 관한 연구

민들레,김미기,이현기,박은정,Min, Deul-Le,Kim, Mi-Ki,Lee, Hyun-Ki,Park, Eun-Jung 대한한방소아과학회 2011 대한한방소아과학회지 Vol.25 No.2

Objectives: This study is to investigate life style and weight control based on the body mass index, and tongue diagnosis in adolescent girls. Help controling unnecessary weight and establishing proper understanding of desirable body images and healthy life for adolescents are expected. Methods: The questionnaire surveys and physical examinations were conducted to examine the life style, weight-control behaviors, and the health status of 173 adolescent girls in Jeonju. Among the students surveyed, 162 answered seriously and were accepted as subjects for the study. Results: 1. The mean height was 160.4 cm and weight was 54.21 kg. The mean BMI of the girls was 21.1 kg/m2, which is normal. The percentages of the normal weight group (71.6%), overweight group (16.7%), obesity group (9.9%), underweight group (1.9%) were shown respectively. 2. The oriental medicine doctor examined the tongue diagnosis. The thin and white tongue fur was the most common (20.7%). This diagnosis showed no statistical significance to BMI. 3. The ideal height for the girls was 165 cm, and the ideal weight was 49 kg. 4. A considerable number of girls (50.6%) thought that a thin body figure was the most beautiful body shape for the women. 5. Even though the percentages of an actual overweight or obese group were 26.6%, 42.0% of the girls thought that they were plump. 6. 94.83% of the normal weight group concerned about the weight regulation. 7. Many girls were dissatisfied with their own body shape, and 86.9% of girls regarded being in a shape was important. 70.69% of the normal weight group answered that they were under stress of their body shapes. Conclusions: The findings of this study demonstrate that there are serious misconceptions on body shapes of the adolescent girls, and mostly, unnecessary and inadequate weight control behaviors were done. Therefore, establishing adequately education on their desirable body images and healthy life is needed for the adolescent girls. In this study, there is no significant relationship between BMI and tongue diagnosis. For the number of subjects is not enough, further study on the relationship between the two is expected.

甘松香 (감송향)이 아토피樣 (양) 피부염에 미치는 영향

민들레,박은정,Min, Deul-Le,Park, Eun-Jung 대한한방소아과학회 2012 대한한방소아과학회지 Vol.26 No.2

Objectives NJ is being used to treat inflammatory diseases in Korea. In this study, we attempted to evaluate the effects of NJ on atopic dermatitis (AD)-like lesions and mast cell-mediated allergy inflammation in vivo and in vitro. Methods and Results We investigated to ascertain the pharmacological effects of NJ on 2,4-dinitrofluorobenzene (DNFB)-induced allergic reactions under in vivo conditions. Additionally, to find possible explanations for the anti-inflammatory mechanisms of NJ, we evaluated the regulatory effects of NJ on the level of inflammatory mediators in phorbol 12-myristate 13-acetate plus calcium ionophore A23187 (PMACI)-stimulated human mast cells (HMC-1). Conclusions NJ inhibited the production of the inflammatory cytokines (IgE, IL-6, IL-8 and TNF-${\alpha}$) significantly in vivo and in vitro.

아토피 피부염 외용제에 관련된 국내 임상 및 실험 논문 고찰

민들레,박은정,강경하,Min, Deul Le,Park, Eun Jung,Kang, Kyung Ha 대한한방소아과학회 2013 대한한방소아과학회지 Vol.27 No.1

Objectives The goal of this review is to investigate clinical and experimental studies on external application treatment for atopic dermatitis in Korean literature and to propose for the better method of clinical studies in order to seek more effective treatment. Methods Electronic researches were performed with KTKP, OASIS, National Assembly Library, Korean Medicine Database, KISS, DBpia, and KISTI. Results and Conclusions In Twenty six studies, the numbers of clinical and experimental studies are respectively 10 (38.46%) and 16 (61.54%). The numbers of studies that used herbal complex were 20 (76.92%), and out of that, 6 studies had used a single herbal medicine (23.08%). The external application with oriental medicine for the atopic dermatitis used with Phellodendri Cortex (7), Sophorae Radix (6), Scutellariae Radix (6), Lonicerae Flos (5), Coptidis Rhizoma (5) and so on. Among the clinical studies, the 5 studies were double-blind and randomized-controlled study (50%). The numbers of studies that used Hanifin and Rajka Diagnostic Criteria (1980) were 6 (60%), and that used the Diagnostic Criteria in Korean Atopic Dermatitis (2005) were 4 (40%). Among the clinical studies, categories to evaluate of atopic dermatitis are respectively SCORAD Index (80%), Total IgE (80%), Eosinophil count (70%) and so on. All of the clinical studies (100%) showed a statistically significant decline in atopic dermatitis according to the SCORAD Index, Modified SCORAD Index, the Clinic index score. Among the experimental studies, the numbers of studies that used NC/Nga mice were 9 (56.25%), and out of that 5 studies used BALB/c mice (31.25%). Most of the studies (68.75%) used DNCB as allergy inducing materials. The scales for evaluation of atopic dermatitis were Clinical skin severity score, Histopathologic examination, Immunohematologic examination, safety test and so on. In 12 cases (75%) of experimental studies, the IgE level of experimental group showed a statistically significant decline after using external application. In 8 study cases (50%), Clinical skin severity score of experimental group showed a statistically significant decline after using external application.

영유아 아토피피부염 환자 69명의 한의학적 치료효과에 대한 후향적 연구

민들레,한명화,박건,서산,한수련,Min, Deul Le,Han, Myeong Hwa,Park, Gun,Seo, San,Han, Su Ryun 대한한방소아과학회 2014 대한한방소아과학회지 Vol.28 No.3

Objectives The purpose of this study is to report the effectiveness of Korean medicine treatment on 69 infant and young child atopic dermatitis patients. Methods 69 infants and young child atopic dermatitis patients who had visited oriental medical clinics from 2011.1.9 to 2012.1.31 were studied. All of them were continually treated for 3 to 9 months, and were analyzed by Objective SCORAD Index (OSI). A detailed analysis of OSI was done according to gender, age, using of topical steroid ointment, family history of atopic disease, treatment period, and intensity. Results 1. Male and female percentage of the study group was 56.5%: 43.5%. The average period of treatment was 6.09 months. 71.0% used topical steroid ointment, and 65.2% had family history of atopic disease. 2. The average period of treatment was significantly longer in patients who used topical steroid ointment, or who had family history of atopic disease. 3. 95.7% of total patients reported decrease in OSI score at the final visit. OSI was significantly lowered after 3, 6, and 9 months of treatment. The longer period of treatment, the lower average post-treatment OSI. 4. 85.5% of the study group had severe dermatitis, and 14.5% was moderate case based on the OSI intensity assessment at initial visit. These percentages got changed at the final visit as 34.8% of severe, 58.0% of moderate, and 7.2% of mild cases. The average treatment period of patients who were diagnosed as severe at the initial visit was 6.18 months, and their final OSI improvement rate was 39.58%. 58% of them were improved to be mild or moderate at the final visit. Conclusion The Korean medicine treatment is effective in treating infant and young child atopic dermatitis patients. There was significant decrease in OSI score after 3, 6, and 9 months of treatment. The difference increase with the treatment period.

동의보감(東醫寶鑑) 소아문(小兒門) 처방(處方)에 대한 고찰(考察)

민들레,Min, Deul Le 대한한방소아과학회 2016 대한한방소아과학회지 Vol.30 No.2

Objectives The purpose of this study is to find a way to apply current oriental pediatrics treatment guidelines based on a pediatric chapter in DongEuiBoGam. Methods I learned pediatrics prescription formula, indications of drugs, dosage regimen from DongEuiBoGam, and I classified herbs that can be used for pediatrics prescriptions based on their types, effects, tempers, flavors, toxicities, and attributive channels. Results & Conclusions I learned similarities among pediatrics prescription regimens and the herbs commonly used in pediatrics. Also, I found out physiological and pathological characteristics in pediatrics. I expect that this study would be helpful for current oriental pediatric treatments.

대시호탕(大柴胡湯)이 3T3-L1 지방전구세포와 고지방식이 유도 비만쥐에 미치는 영향

민들레,박은정,Min, Deul Le,Park, Eun Jung 대한한방소아과학회 2015 대한한방소아과학회지 Vol.29 No.1

Objectives This experimental study was designed to investigate the effects of Dai-saiko-to (DSH) on differentiation of 3T3-L1 preadipocytes and body weight, serum lipid levels in high-fat diet-induced obese mice. Materials and Methods Cells were incubated with DSH at an indicated concentration (0.01-1 mg/ml) for 24h, then the growth rate was assessed by MTS assay. 3T3-L1 preadipocytes were incubated in DMEM for 2 days with the indicated concentrations of DSH. On Day 6, the cells were fixed and the cellular lipid contents were assessed by Oil-Red-O staining. The expression of peroxisome proliferator-activated receptor ${\gamma}$ ($PPAR{\gamma}$) and cytidine-cytidine-adenosine-adenosine-thymine (CCAAT)/enhancer-binding proteins ${\alpha}$ ($C/EBP{\alpha}$) as adipocyte-specific proteins were determined by real time RT-PCR and western blotting. Four-weeks old mice (wild-type C57BL/6) were used for all experiments. Body weight gain and serum lipid levels were measured in the obesity-induced mice. Results DSH did not show toxicity even at the concentration of 1 mg/ml and DSH significantly inhibited the differentiation of 3T3-L1 preadipocytes in a dose-dependent manner. Also, DSH significantly reduced the expressions of $PPAR{\gamma}$ and $C/EBP{\alpha}$ in a dose-dependent manner. Furthermore, DSH significantly reduced body weight gain, serum glucose, total cholesterol and LDL-cholesterol contents in obesity-induced mice. Conclusions These results demonstrated that DSH inhibited 3T3-L1 preadipocyte differentiations and high-fat diet-induced obesity in mice.

교양무용 참여 대학생의 신체움직임 변화 연구

민들레(Min deul-le) 한국콘텐츠학회 2012 한국콘텐츠학회 종합학술대회 논문집 Vol.2012 No.5

규칙기반 상황인식 모듈관리에 의한 가변위치 부품창고 시스템

민들레(Deul-Le Min),전병환(Byung-Hwan Jun) 대한전자공학회 2009 電子工學會論文誌-CI (Computer and Information) Vol.46 No.4

본 논문에서는 자동차 부품과 같이 다량·다품종의 부품을 효율적으로 관리할 수 있는 ubiWarehouse 시스템을 제안한다. 먼저, 5W1H 상황표현으로 사용자 작업상황을 체계적으로 정의하고, 상황인식기를 기능별로 구분하여 관리규칙에 의해 각 모듈을 독립적으로 운영한다. 입출고 부품의 선반 적합도를 계산하여 효율적인 이동경로를 선정하고 자주 동시에 취급되는 관련 부품들이 인접할 수 있도록 한다. 이때, 다른 사용자가 현재 방문하고 있거나 바로 방문할 예정인 경우에는 충돌해결을 위해 방문순서를 변경하여 양보한다. 결과적으로, 제안한 시스템은 경쟁을 피하면서도 효율적으로 부품을 입출고할 수 있는 경로를 사용자에게 제공하고, 관련 부품들이 가까운 위치에 모이도록 선반을 배정하여 창고 공간을 효과적으로 활용한다. 또한 입출고 이력을 이용한 사용자별 성향을 파악하여 개인화된 서비스를 제공하고, 실시간적인 입출고 갱신과 경보상황 처리로 재고정보의 정확도를 향상시키는데 기여할 수 있다. In this paper, we propose ubiWarehouse system which can efficiently manages mass and many kinds of parts such as automotive parts. First, user's work situation is defined systematically as context type of 5W1H, context-aware system is separated on function, and each module operates independently. An efficient route is selected and relevant parts frequently treated at the same time are gathered by calculating the suitability of parts and racks. If other users currently are on a visit or are supposed to visit soon, the turn of visit is changed making a concession for preventing collision. As a result, the proposed system with avoiding competition can provide users with routes for inbound or outbound parts, and can effectively use spaces of a warehouse by arranging racks to gather relevant parts to near location. Also, individual service can be offered by evaluating user propensity using history of the warehouse job, and the accuracy of stock information can be improved by processing of unexpected context and real-time renewing of warehousing and delivering.

도침을 이용한 안면부 위축성 흉터의 치험례

민들레(Deul Le Min),이용호(Yong Ho Lee),고남경(Nam Gyeong Go) 대한한의학회 2015 대한한의학회지 Vol.36 No.3