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Biosensors based on graphene oxide for diagnostics and drug discovery
민달희 한국공업화학회 2016 한국공업화학회 연구논문 초록집 Vol.2016 No.0
In this talk, I will introduce recent studies which harness graphene derivatives for developing bioanalytical platforms to quantitatively analyze various enzyme activities and biomarkers including helicase and microRNA. The systems rely on attractive interaction between graphene oxide and nucleic acids and fluorescence quenching by graphene oxide. Quantitative microRNA sensing was successfully demonstrated in living cells. Recently, we employed one of the graphene-based bioassay systems to anti-viral drug screening and identified potent hit compounds to treat hepatitis C. This study shows that a new nanobio-technology can be routinely implemented in drug discovery with high-throughput capability, providing many advantages over conventional methods.
민달희 한국공업화학회 2014 한국공업화학회 연구논문 초록집 Vol.2014 No.1
For the development of practically useful bioanalytical systems using new nanomaterials, one should be able to understand and fully utilize chemical/physical properties to detect molecular changes during certain biochemical transformations in a biological system. New bioanalytical platforms should overcome limitations of conventional assay methods-detection limits, cost issues, labors, efficiencies, quantitativeness, reproducibility, etc. In this talk, I will introduce recent studies which harness graphene derivatives for developing bioanalytical platforms to quantitatively analyze various enzyme activities and biomarkers including helicase and microRNA. The systems rely on attractive interaction between graphene oxide and nucleic acids and fluorescence quenching by graphene oxide. Quantitative microRNA sensing was successfully demonstrated in living cells. Recently, we employed one of the graphene-based bioassay systems to anti-viral drug screening and identified potent hit compounds to treat hepatitis C. This study shows that a new nanobio-technology can be routinely implemented in drug discovery with high-throughput capability, providing many advantages over conventional methods.
A New Helicase Assay Based on Graphene Oxide for Anti-Viral Drug Development
장홍제,민달희,유수윤,이민재,한상우 한국분자세포생물학회 2013 Molecules and cells Vol.35 No.4
Recently, graphene oxide (GO), one of the carbon nanomaterials, has received much attention due to its unique physical and chemical properties and high poten-tial in many research areas, including applications as a biosensor and drug delivery vehicle. Various GO-based biosensors have been developed, largely based on its surface adsorption properties for detecting biomolecules, such as nucleotides and peptides, and real-time monitor-ing of enzymatic reactions. In this review, we discuss recent advances in GO-based biosensors focusing on a novel assay platform for helicase activity, which was also employed in high-throughput screening to discover selective helicase inhibitors.