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Oxytocin 이 Succinylcholine 의 근이완 작용에 미치는 영향
민경신,서재현 대한마취과학회 1983 Korean Journal of Anesthesiology Vol.16 No.3
Oxytocin has a stimulant effect on the smooth muscle of the uterus and mammary gland. Infusion or bolus injection of oxytocin followed later by the administration of succinylcholine is a fairly frequent sequence of events in our practice of obstetrical anesthesia. There were few reports and conflicting results about the effect of oxytocin on the response to a muscle relaxant. To assess the effect of oxytocin on the response to succinylcholine, we studied pregnant women(20 cases) compared with non pregnant women(20 cases). All patients were free of hepatic, renal, endocrine or neuromuscular disease. The ulnar nerve was stimulated at elbow using surface electrodes with square wave, supramaximal stimuli of 0.2 ms duration at a frequency of 1 Hz(Emerson peripheral nerve stimulator, U.S.A). The isometric twitch tension of indirectly stimulated adductor muscle was recorded by biophysiograph(San Ei, Japan). The effect of single bolus injection of oxytocin 10 I.U at the 50% recovery of succinylcholine induced neuromuscular blockade was compared in the pregnant and non pregnant patients. The results were as follows: 1) In the pregnant patients group: Twitch height was unaffected in 50% of patients while 10% of the patients were observed with 100% twitch height depression. Mean maximal twitch height depression was 61.2±28.58% and the duration of twitch depression was 95.2±43.45 sec. The effect of oxytocin on serum potassium change was not significant statistically(p$lt;0.05). 2) In the non-pregnant patients group: Twitch height was unaffected in 25% of patients and 100% twitch height depreesion was not observed. Mean maximal twitch height depression was 41.5±31.0% and the duration of twitch height depression was 65.1±39.26 sec. A change of serum potassium before and after oxytocin injection was not significant statistically(p$gt;0.05).
Bieomycin 과 Captopril 의 병용투여가 흰쥐 폐에 미치는 효과
민경신,손태익,권학덕 대한마취과학회 1993 Korean Journal of Anesthesiology Vol.26 No.4
Bleomycin is well recognized as an antineoplastic agent. Pulmonary toxicity is the most significant complication of bleomycin administration. The purpose of this study was to determine whether Captopril(an angiotensin converting enzyme inhibitor) can ameliorate pulmonary toxicity induced by bleomycin. Eighty mice were divided into two groups. The control group(n=40) received only bleomycin, and the other experimental group(n=40) received bleomycin in combination with captopril. Bleomycin was administered intraperitoneally to the mice, 8 mg/kg twice a week for 5 weeks. Captopril was administered in the feed at a regimen of 50 mg/kg everyday for 5 weeks. The animals were sacrified at 6 weeks later. Morphometric analysis with light microscopy was performed to the following parameters: the number of total pulmonary: cell count, percentage of consolidation of lung parenchyma and degree of fibrosis of lung parenchyma. The results were as follows; 1) In the control group, the number of total pulmonary cell count were 23.30±4.35/10(-8) ㎡ and the percentage of consolidation was 13.9±7.l%(P$lt;0.01). 2) In the experimental group, the number of total pulmonary cell count were 18.39±3.48/10(-5) ㎡ and the percentage of consolidation was 9.8±4.8%(P$lt;0.01). 3) There were no typical findings of pulmonary fibrosis in Massons trichrome stain, but early fibrotic change in the portion of severe consolidation and alveolar septal thickening in some control group. In conclusion, this study demonstrated that captopril ameliorates the pulmonary toxicity by bleomycin in the mice.
Sodium nitroprusside 에 의한 유도저혈압시 혈장 catecholamine 치의 변화
김승록,문세호,정동석,정운혁,문정현,민경신 대한마취과학회 1991 Korean Journal of Anesthesiology Vol.24 No.1
Sodium nitroprusside is used to induce hypotension to decrease bleeding in operation site. Sodium nitroprusside decrease vascular resistance by directly relax arteriolar and venous smooth muscle, to a lesser extent. Hypotension stimulate baroreceptors and increase sympatho-adrenal activity. The function of sympatho-adrenal mdullary system may be monitored by the changes of plasma cancentrations of epinephrine and norepinephrine. To study the relationship between induced hypotension and the catecholamine release, the plasma epinephrine and norepinephrine concentration were measured before, during and after infusion of aodium nitropruaside to rabbits. The results were as follows: 1) The mean arterial blood pressure decreased significantly after SNP infusion (5.0 ug/kg/minute) from the control value of 98.1±11.9 mmHg to 66.3±16.2, 57.9±17.9 mmHg in 10 and 20 minutes after SNP infusion (P$lt;0.01) and 78.8±12.5 mmHg after discontinuation of SNP infusion. 2) The heart rate increased significantly after SNP infusioom the control value of 149.8±12.8 beat/minute to 166.5±10.8, 190.4±17.6 beats/minute in 10 and 20 minutes after SNP infusion (P$lt;0.05, P$lt;0.01) and the heart rate increased after discontinuation of SNP infusion. 3) The plasma epinephrine concentration increased significantly after SNP infusion from the control value of 181.2±91.9 pg/ml to 547.5±163.2, 837.5±253.6 pg/ml in 10 and 20 minutes after SNP infusion and continued to increase of epinephrine after discontinuation of SNP infusion. 4) The plasma norepinephrine concentration increased significantly after SNP infusion from the control value of 566.2±92.6 pg/ml to 1131.3±424.7, 1432.5±479.2 pg/ml 10 and 20 minutes after SNP infusion and continued to increase after discontinuation of SNP infusion. There was a highly significant correlation between decrease in mean arterial pressure and increase in plasma epinephrine and norepinephrine concentrations.
좌측 흉부 Zoster Sine Herpete 후 반대측 흉부에 재발한 대상포진 환자의 치험
김수미(Soo Mi Kim),한경림(Kyung Ream Han),민경신(K 대한통증학회 1999 The Korean Journal of Pain Vol.12 No.1
This report is a case of 62-year-old man with anterior chest pain and pin pricking pain with allodynia affecting left T5 sensory dermatome for 3 months without history of vesicular skin eruption. He had a history of diabetes mellitus for 10 years and insulin therapy for recent 1 year. EKG, chest PA and rib series wen normal. Serologic evaluation of IgG antibody to varicella-zoster virus was positive and was diagnosed as post herpetic neuralgia after zoster sine herpete. He was treated with left T nerve root block followed by thoracic epidural blockade and intercostal nerve block for 2 weeks. His VAS score decreased from 10 to 2 after 2 weeks of treatment. After 3 months, he revisited our clinic com- plaining right side chest pain followed by vesicular skin eruption 8 days after the onset of pain. He was treated as herpes zoster and tolerates well after 4 months.