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문태철,정규찬,손건호,김현표,강삼식,장현욱 영남대학교 약품개발연구소 1998 영남대학교 약품개발연구소 연구업적집 Vol.8 No.-
Tissue distributions and association of cyclooxygenase-2 (COX-2) with inflammatory have led us to search for COX-2 selective inhibitors from natural products. Conceptually, COX-2 selective inhibitors should be expected to retain anti-inflammatory efficacy by inhibition of PGs production while reducing or eliminating the gastric, renal and hemostatic side effects commonly associated with NSAIDs use. Thus, a logical approach to the treatment of inflammatory diseases should involve the inhibitors of COX-2. To develope new COX-2 inhibitors from natural products, two-hundred crude drugs were Screened by inhibiting PGD₂ generation in bone marrow derived mast cells (BMMC). Among them, 6 methanol extracts of crude drugs such as, Bletillae rhizoma, Aconiti koreani rhizoma, Belamcandae rhizoma, Nelumbinis semen, Gleniae radix, Aurantii immatri pericarpium inhibited more than 85% of BMMC COX-2 activity at a concentration 2.5 ㎍/ml.
문태철,박정옥,정광원,손건호,김현표,강삼식,장현욱,정규찬 영남대학교 약품개발연구소 1999 영남대학교 약품개발연구소 연구업적집 Vol.9 No.-
Because of the potent effects of lipid mediators such as prostaglandins (PGs). leukotriens (LTs) and platelet activating factor (PAF) on a variety of cells and tissues. they are considered as major contributors to the process leading to inflammation and allergy. To pursue the mechanism of anti-in-flammatory activity of Lonuicerα jαponicα. we tested inhibitory effects of 7 flavonoids fron Lonicerα jαponicα on arachidonic acid cascade related enzymes. such as inflammmatory phospholipase A(2), cy-cloxygenase-1 and 2, 5-lipoxygenase, in bone marrow derived mast cells (BMMC), and lyso PAF- a-cetyltransferase in rat spleen microsomes. Anti-inflammatory activities of Lenicerα jαponicα are thought to be attributed at least in part to the inhibition of arachidonic acid cascade releated enzymes by fla-vonoids such as apigenin, luteo]in and quercetin.
문태철,조천형,정성훈,이영오,정인수 한국방사성폐기물학회 2017 방사성폐기물학회지 Vol.15 No.1
국내에서 개발중인 콘크리트 저장용기는 방사성 물질의 격납 건전성을 유지하기 위하여 내부에 캐니스터를 포함하고 있다. 본 논문에서는 콘크리트 저장용기 내부 캐니스터의 뚜껑 용접시, 용접시간 저감과 이에 따른 캐니스터 용접부의 구조적 건전성을 확보하기 위한 방안으로, 정상, 비정상 및 사고조건에서 캐니스터 용접부 균열을 진전시키는 하중에 의해 발생되는균열 깊이를 분석하여, 용접부의 최대 허용결함깊이를 평가하였다. 정상, 비정상 및 사고조건에서의 구조해석은 범용 유한요소해석 프로그램인 ABAQUS를 사용하였으며, 허용결함깊이는 ASME B&PV Code Section XI에 따라 막응력과 조합하중에 대해 평가하였다. 평가결과 콘크리트 저장용기의 캐니스터 용접부의 허용결함깊이는 18.75 mm로 평가되었으며, 이는NUREG-1536에서 권고하고 있는 임계결함깊이를 만족하고 있는 것으로 나타났다. Domestically developed concrete storage casks include an internal canister to maintain the confinement integrity of radioactive materials. In this study, we analyzed the depth of flaws caused by loads that propagate canister weld cracks under normal, off-normal and accident conditions, and evaluated the maximum allowable weld flaw depth needed to secure the structural integrity of the canister weld and to reduce the welding time of the internal canister lid of the concrete storage cask. Structural analyses for normal, off-normal and accident conditions were performed using the general-purpose finite element analysis program ABAQUS; the allowable flaw depth was assessed according to ASME B&PV Code Section XI. Evaluation results revealed an allowable canister weld flaw depth of 18.75 mm for the concrete storage cask, which satisfies the critical flaw depth recommended in NUREG-1536.
문태철,백창열,윤시태,최병일,정인수,Moon, Tae-Chul,Baeg, Chang-Yeal,Yun, Si-Tae,Choi, Byung-Il,Jung, In-Su 한국방사성폐기물학회 2014 방사성폐기물학회지 Vol.12 No.4
인양장비는 원자력발전소에서 발생하는 사용후핵연료를 운반하는 운반용기를 인양하기 위해 사용된다. 본 연구는 원자력 안전위원회고시 제2013-27호와 미국 10CFR Part 71 ${\S}71.45$에서 규정하는 기술수준에 따라 이론적인 방법과 유한요소방법으로 인양장비의 구조적안전성을 평가하였다. 이론적으로 평가한 결과 모든 구성 요소에서의 응력이 응력제한치 내에 있어 운영상 발생하는 구조적 안전성을 확보하고 있는 것으로 판단하였다. 또한 유한요소해석을 통한 평가결과, 항복과 극한조건 모두에서 설계기준을 만족하는 것으로 평가되었다. 모든 구성요소에서 충분한 안전여유도(항복조건에서 3 이상의 안전율, 극한조건에서 5 이상의 안전율)를 갖는 것으로 나타나 구조적으로 안전하다고 판단하였다. A lifting device is used to deal with transport cask for the transportation of spent fuels from nuclear power plants. This study performed theoretical analysis and numerical simulation to evaluate the structural integrity of the lifting device based on Nuclear Safety and Security Commission(NSSC) Notice No.2013-27 and US 10CFR Part 71 ${\S}71.45$. The results of theoretical analysis showed that the maximum stresses of all components were below the allowable values. This result confirmed that the lifting device was structurally safe during operation. The results of finite element analysis also showed that it was evaluated to satisfy the design criteria bothyielding and ultimate condition. All components have been shown to ensure the structural safety due to sufficient safety margins. In other words, the safety factor was 3 or more for the yielding condition and was 5 or more for the ultimate condition.