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文濬典,崔達永,朴元煥,尹相柱 대한동의병리학회 1993 동의생리병리학회지 Vol.8 No.-
연구배경 : 최근 우리나라에 있어서도 생활 양식의 서구화로 말미암아 다발하고 있는 각종 현대병의 하나인 고지혈증을 한의학적으로 치료하기 위한 방법론의 개발을 연구목적으로 하여, 한의학의 전통적 병인 개념인 담음이론을 통해 고지혈증의 한의학적 개념을 설명하고, 〈의학입문〉처방인 소조중탕을 통해 치료 약재의 개발 가능성을 실험적으로 규명하고자 한다. 방법 : 실험동물에 cholesterol현탁액을 투여하여 고지혈증을 유발시키면서, 〈의학입문〉에 수재된 소조중탕을 투여하여 혈청지질에 포함되어 있는 total-cholesterol, H. D. L-cholesterol, triglyceride, phospholipid 등의 함량변화를 관찰한다. 결과 : 血淸中 total-cholesterol과 triglyceride含量에 미치는 影響은 對照群에 比하여 매우 顯著한 有意性있는 減少가 나타났으며, 血淸中 H.D.L.-cholesterol과 phospholipid含量에 미치는 影響은 對照群에 比하여 有意性있는 減少가 나타났으며, 血淸中 total cholesterol과 HDL cholesterol의 比率은 對照群에 比하여 有意性이 認定되지 않지만 total cholesterol과 phospholipid의 比率은 對照群에 比하여 有意性이 認定된다. 결론 : 祛痰之劑인 小調中湯은 高脂血症의 改善에 有意性있는 成績을 나타내므로 高脂血症과 痰飮은 相關性이 있으며 脂質代謝異常에 따른 動脈硬化症에도 活用될 수 있는 것으로 思慮된다. In order to study the effects of Xiaotiaozhongtang on hyperlipidemia, white rats were induced by lipid metabolism disorder by the oral-injection of cholesterol. The effects of Xiaotiaozhongtang on lipid in serum were measured by the quantity of total-cholesterol and of H.D.L-cholesterol and of triglyceride and of phospholipid, by the rate of total-cholesterol vs H.D.L-cholesterol and of total-cholesterol vs phospholipid in serum. As a result, we can conclude as follows: 1. Effects of Xiaotiaozhongtang on total-cholesterol and triglyceride levels in serum of cholesterol treated rats were very noticeable. 2. Effects of Xiaotiaozhongtang on H. D. L-cholesterol and phospholipid levels in serum of cholesterol treated rats were noticeable. 3. Effect of Xiaotiaozhogtang on the rate of total-cholesterol vs H. D. L-cholesterol in serum of cholesterol treated rats was unnoticed, but on the rate of total-cholesterol vs phospholipid was noticeable. Thus,as the above-mentioned, on hyperlipidemia, the effects of Xiaotiaozhongtang can be recognized. Secondly, both hyperlipidemia and "phlegm-retention" have correlation each other. In the last place,Xiaotiaozhongtang may be used to artherosclerosis induced by, lipid metabolism disorder, hyperlipidemia.
血栓症과 高粘度血症에 미치는 황기, 桂枝 및 紅花의 效能에 關한 實驗的 硏究
文濬典,安圭錫,鄭燦吉 대한동의병리학회 1989 동의생리병리학회지 Vol.4 No.-
In order to investigate the effects of Astragali Radix, Cinnamomi Ramulus and Carthami Flos on thrombosis and elevated blood viscosity, Sprague-Dawley rats injected endotoxin into the caudal vein to make experimental thrombosis model were oral administrated solid extract of Astragali Radix 38.4㎎/200g (Sample A), Cinnamomi Ramulus 9.0㎎/200g (Sample B) and Carthami Flos 107.5㎎/200g (Sample C), and then observed platelet, prothrombin time, fibrinogen and FDP. Another group injected hydroortisone acetate into the muscular rump to make experimental elevated blood viscosity model were oral administrated Sample A, B and C, thereafter measured body weight, body temperature, whole blood viscosity, plasma viscosity, hematocrit, RBC, WBC, hemoglobin, glucose, albumin, total protein, cholesterol and triglyceride. The results were summarized as follows: 1. Platelet was increased significantly in Sample C compared with the control group. 2. Prothrombin time was shortened significantly in the trial groups compared with the control group. 3. Fibrinogen was increased significantly in Sample C compared with the control group. 4. FDP was decreased significantly in Sample A and C compared with the control group. 5. Body weight was increased significantly in Sample A after 7 days, and body temperature revealed a significance in Sample B after 3 days. 6. Whole blood viscosity and plasma viscosity were highly decreased in the trial groups compared with the control group, especially Sample A and B were more significantly decreased at lower shear rates than Sample C. 7. The increase of WBC and decrease of hematocrit, RBC and Hemoglobin were showed in the trial groups, especially Sample B revealed a significance on the decrease of RBC and WBC was increased significantly in Sample C. 8. The decrease of hemoglobin, glucose, albumin, total protein, cholesterol and triglyceride was showed in the trial groups, especially Sample C revealed a significance on the decrease of albumin and cholesterol, total protein was significantly decreased in Sample A, and triglyceride was significantly decreased in Sample A, B and C. According to tje above results, it was considered that Carthami Flos was curative for thrombosis and Astragali Radix and Cinnamomi Ramulus had curative effects for elevated blood viscosity.
甘草湯의 Human Immunodeficiency Virus-1 抑制能에 관한 硏究
이태균,文濬典 東國大學校韓醫學硏究所 1992 東國韓醫學硏究所論文集 Vol.1 No.-
The microculture XTT antiviral assay method is used quantitate HIV-1 induced cytopathic effects as modulated by test substances. This relatively simple assay facilitated the safe and rapid determination of in vitro antiviral activity of selected chemicals as well as direct cytotoxicity. This experiment also confirmed that this system measures infection and subsequent viral replica-tion in target cells and XTT formazan formations correlated with the accumulation of extracellular virions, as measured by quantitative HIV-1 induced syncytium formation. The present results with Glycyrrhizin using this in vitro culture system demonstrated that effective dose EC50(the concentration at which increase XTT formazan production in infected culture to 50% of that in untreated, uninfected controls) was 250g/ml. As comparison, AZT was included in this experiment and demonstrated that EC50 AZT of was 0.05g/ml, approximately 5,000 times more potent than Glycyrrhizin based on EC50 ratio's alone. However, this potency is limited by severe cytotoxicity of AZT, while Glycyrrhizin is approxima-tely 16 times less toxic(IC50 of Glycyrrhizzn 800 and AZT 51g/ml). While AZT's anti-HIV-1 viral activity os mediated by inhibition of reverse transcriptase. Further study is necessary in order to understand the precise mechanisms of Glycyrrhizin action against HIV-1 viruses. Althouth Glycyrrhizin is less effective antiviral agent than AZT. much less toxicity of Glycyrrhizin is desirable in terms of chronic treatment. Combination treatment of AZT and Glycyrrhizin may be therapeutically beneficial. Clinical effectiveness of two drug combination treatment of AZT patient is unknown at this time. However, this experimental investigation presents the scientific rational basis for such therapeutic approach.