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N-치환 5-Hydroxyanthranilic acid의 합성
문정술(Jung Sul Moon),이강노(Kang Ro Lee),임중기(Joong Ki Lim),우원식(Won Sick Woo),박상우(Sang Woo Park) 대한약학회 1993 약학회지 Vol.37 No.3
Six N-substituted-5-hydroxyanthranilic acids were synthesized by the coupling reaction of 5-tosyloxyanthranilic acid ethyl ester with corresponding acid chlorides. The structure of the obtained compounds was proved by NMR and IR. These compounds did not inhibit the growth of micro-organisms while suppressed HSV-1 replication in vero cell at 100mcg/ml.