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문우남(Woo Nam Moon),윤재범(Jae Bum Yoon),양광문(Kwang Moon Yang),양재혁(Jae Hyug Yang) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.2
목적 : 임산부의 증상유발 골반 이완증의 증상 및 유의한 이학적 검사 방법을 알아보고, 증상의 심한 정도, 동통의 정도, 이학적 검사 방법 및 초음파로 측정한 치골관절 간격 사이의 연관성이 있는가를 확인하기 위하여 전향적 연구를 시행하였다. 방법 및 재료 : 골반통 산모 465명을 대상으로 설문지 및 동통 그림표를 이용한 조사를 하여 96명의 골반이완증 환자를 진단하였다. 이들을 대상으로 이학적 검사 및 치골관절의 초음파 검사를 시행하였다. 임상증상, 동통의 정도(Visual analog scale: VAS), 이학적 검사의 양성 유무 및 초음파 검사상의 관절 간격을 비교 분석하여 연관성을 확인하였다. 결과 : 가장 흔한 환자의 불편은 돌아눕기 였다 (100%). 후방 관절통 유발 검사가 가장 유의하였다(85.4%). VAS와 임상증상사이에는 유의한 상관관계가 있었으나 (r=0.340, P=0.001), VAS 혹은 증상과 이학적 검사와의 사이에는 관계가 없었다 (P>0.05). 결론 : 이상의 결과로 임신시의 증상유발 골반이완증을 진단하는데 다른 이학적 검사 방법과 더불어 후방관절 동통 유발 검사를 시행하여 객관적인 진단이 가능 할 것으로 사료 된다. Objective : This prospective study was done to find out common symptoms and beneficial physical examinations, and to evaluate relations among symptom, pain severity, physical examination method and width of symphysis pubis of symptom-giving pelvic girdle relaxation (PGR) in pregnant women. Methods : Four hundreds sixty-five pregnant women who complained pelvic pain were asked to fill out a questionnaire. Ninety-six pregnant women were diagnosed as PGR and were examined physically and took the sonogram. Statistical correlation was evaluated among symptoms, pain severity (visual analog scale: VAS), physical examination method and sonogram. Results : The most common complain was difficulty of rolling in bed (100%). The most frequent positive diagnostic physical method was posterior pelvic pain provocative test (PPPT) (85.4%). There was correlation between VAS and symptoms (r= 0.340, P=0.001) but no correlations between VAS or symptoms and numbers of positive physical examination (P>0.05). Conclusion : It is suggested that PPPT was most beneficial diagnostic methods of PGR in pregnancy.
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최명진,문우범,최진호,Choi, Myung-Jin,Moon, Woo-Bum,Choi, Jin-Ho The Korea Institute of Military Science and Techno 2011 한국군사과학기술학회지 Vol.14 No.3
In war time, minimizing the logistics response time for supporting military operations is strongly needed. In this paper, i propose the mathematical formulation for minimizing the maximal acquisition completion time in wartime or during a state of emergency. The main structure of this formulation is based on the traveling purchaser problem (TPP), which is a generalized form of the well-known traveling salesman problem (TSP). In the case of the general TPP, an objective function is to minimize the sum of the traveling cost and the purchase cost. However, in this study, the objective function is to minimize the traveling cost only. That's why it's more important to minimize the traveling cost (time or distance) than the purchase cost in wartime or in a state of emergency. I generate a specific instance and find out the optimal solution of this instance by using ILOG OPL STUDIO (CPLEX version 11.1).
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김태진,문우남,오한진,윤재범 대한산부인과학회 2000 Obstetrics & Gynecology Science Vol.43 No.3
목적: 임산부의 증상유발 골반 이완증의 유병율 및 유발 인자의 확인을 위해 본 연구를 하였다. 방법 및 재료: 본원에서 출산 한 산모 332명을 대상으로 설문지 및 동통 그림표를 이용한 조사를 하고 이를 분석하였다. 증상유발 골반이완증의 진단 기준은 스칸디나비안 의학협회에서 정한 것과 Larsen등의 기준을 따랐다. 산모의 나이, 분만력(parity), BMI(Kg/m2), 임신중 체중증가의 정도, 신생아의 무게, 이전 임신중의 증상유발 골반이완증의 유무, 임신전 및 임신중의 운동 및 직업의 유무 등을 위험인자로 잡았으며, 이에 대해 student t-test 및 logistic regression으로 통계학적인 분석을 하였다. 유의점은 p$lt;0.05로 하였다. 결과: 임신중의 증상유발 골반이완증의 유병율은18.9% 였으며, 이전 임신시의 증상유발 골반이완증, 다산 및 임신전에 운동을 않한 경우가 유의한 유발인자로 확인 되었다. 결론: 이상의 결과로 임신시의 증상유발 골반이완증의 빈도를 줄이기 위하여 이전 임신시 증상유발 골반이완증이 있었던 임신 예정 여성에 대하여는 운동 요법을 통한 치료를 선행 하여야 하며, 임신중에도 지속적인 운동 및 체중조절을 하여야 할 것으로 사료 된다. Objective: This study was done to evaluate the risk factors and prevalence of symptom-giving pelvic girdle relaxation in pregnant women. Methods: Three hundreds thirty-two postpartum women were asked to fill out a questionnaire within one week after their parturition. The diagnostic criteria of this lesion were adopted from the Norwegian Medical Association's and Larsen's criteria. The questionnaire were included age, parity, BMI(kg/cm2), weight gain during the pregnancy, history of symptom giving pelvic girdle relaxation in previous pregnancy, level of exercise and vocational status during and before the pregnancy and baby's birth weight. The answers were evaluated to determine the risk factors. The correlation was tested by student t-test and logistic regression. Results: The prevalence of symptom-giving pelvic girdle relaxation during pregnancy was 18.9%. The history of symptom-giving pelvic girdle relaxation in previous pregnancy, multiparity and the absence of regular exercise before and during pregnancy showed correlation with symptom-giving pelvic girdle relaxation in pregnancy (p$lt;0.05). Conclusion: It is suggested that women who experienced symptom-giving pelvic girdle relaxation in previous pregnancy should be checked for this lesion before pregnancy. Regular exercise is required to lower the incidence and lessen the severity of this lesion in pregnancy.
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Identification of Two Novel NPM1 Mutations in Patients with Acute Myeloid Leukemia
전용범,서상원,박선양,박승만,김소연,라은경,박성섭,성문우 대한진단검사의학회 2013 Annals of Laboratory Medicine Vol.33 No.1
Background: Genetic abnormalities in adult AML are caused most frequently by somatic mutations in exon 12 of the NPM1 gene, which is observed in approximately 35% of AML patients and up to 60% of patients with cytogenetically normal AML (CN-AML). Methods: We performed mutational analysis, including fragment analysis and direct sequencing of exon 12 of the NPM1 gene, on 83 AML patients to characterize the NPM1 mutations completely. Results: In this study, NPM1 mutations were identified in 19 (22.9%) of the 83 AML patients and in 12 (42.9%) of the 28 CN-AML patients. Among the 19 patients with NPM1 mutations, type A NPM1 mutations were identified in 16 (84.2%) patients, whereas non-A type NPM1 mutations were observed in 3 (15.8%) patients. Two of the 3 non-A type NPM1 mutations were novel: c.867_868insAAAC and c.869_873indelCTTTAGCCC. These 2 novel mutant proteins display a nuclear export signal motif (L-xxx-L-xx-V-x-L) less frequently and exhibit a mutation at tryptophan 290 that disrupts the nucleolar localization signal. Conclusions: This study suggests that novel NPM1 mutations may be non-rare and that supplementary sequence analysis is needed along with conventional targeted mutational analysis to detect non-A types of NPM1 mutations.
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박승만,박준은,조성임,전용범,박성섭,성문우 대한진단검사의학회 2012 Annals of Laboratory Medicine Vol.32 No.1
Hereditary hemolytic anemia comprises a group of disorders in which red blood cells are destroyed faster than they are produced in the bone marrow; various hereditary factors can cause this condition, including production of defective Hb and erythrocyte membrane. Recently, we identified Hb Koriyama, a rare Hb variant that was undetectable in Hb electrophoresis and stability tests, in a patient with severe hemolytic anemia. This is the first study to show the nucleotide-level sequence variations in Hb Koriyama. On the basis of our results, we conclude that unstable Hb may not be detectable by conventional Hb electrophoresis or stability tests. Thus, we suggest further genetic workup in cases of unexplained hereditary hemolytic anemia.
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