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문승환,Woo Hee Choi,유이령,Soo Jin Lee,팽진철,Shin Young Jeong,Sang-Woo Lee,Kihyun Kim,최준영 대한영상의학회 2018 Korean Journal of Radiology Vol.19 No.3
Objective: We investigated the prognostic value of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) in patients with multiple myeloma (MM). Materials and Methods: Subjects were 76 patients with newly diagnosed myeloma and pretreatment with18F-FDG PET/CT from four hospitals. The PET/CT features were evaluated and the clinical characteristics were reviewed. Prognostic factors related to poor progression-free survival (PFS) and overall survival (OS) were identified using a Cox proportional hazards regression model and a prediction scale was developed based on the identified factors. Results: Multivariate analysis showed that the presence of 18F-FDG-avid focal bone lesions (≥ 3) was a significant and independent predictor of PFS (hazard ratio [HR] = 3.28, p = 0.007) and OS (HR = 11.78, p = 0.001). The presence of extramedullary disease on PET/CT scan was also a significant predictor of poor PFS (HR = 2.79, p = 0.006) and OS (HR = 3.89, p = 0.003). A prognostic scale was developed using these two predictors. An increase in score on the scale corresponded to a significantly increased risk of poor OS (p = 0.005). In addition, Kaplan-Meier analysis demonstrated that patient survival varied significantly according to the scale (p < 0.001 for OS and p = 0.001 for PFS). Conclusion: 18F-FDG-avid focal lesions and the presence of extramedullary disease on PET/CT scan are significantly associated with poor OS in MM patients. The scale developed according to these predictors represents a potential prognostic tool for evaluation of patients with MM.
Reality Check: Rethinking the Global Software Piracy Problem
문승환 정보통신정책학회 2013 정보통신정책연구 Vol.20 No.2
This study examines the complex dynamics of the international software piracy problem by focusing on the size of revenue losses made from pirated software. Although a considerable number of cross-national studies have focused on software piracy, there is a widespread but incorrect perception in the policy and academic landscape that ineffective copyright protection of computer software is prevalent mostly in less developed countries with low-income, ineffective legal systems and collectivist culture. By using the estimated value of revenues lost to software piracy as an alternative indicator, this study empirically disproves the conventional understanding of the piracy problem. Our empirical investigation of the impact of various national factors on the per capita value of pirated software confirmed that the present piracy phenomenon in the international market is complex and multi-faceted, involving multiple factors within a nation’s economic, technological and industry-specific capabilities.
Prognostic Significance of Volume-Based PET Parameters in Cancer Patients
문승환,현승협,최준영 대한영상의학회 2013 Korean Journal of Radiology Vol.14 No.1
Accurate prediction of cancer prognosis before the start of treatment is important since these predictions often affect the choice of treatment. Prognosis is usually based on anatomical staging and other clinical factors. However, the conventional system is not sufficient to accurately and reliably determine prognosis. Metabolic parameters measured by 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) have the potential to provide valuable information regarding prognosis and treatment response evaluation in cancer patients. Among these parameters, volume-based PET parameters such as metabolic tumor volume and total lesion glycolysis are especially promising. However, the measurement of these parameters is significantly affected by the imaging methodology and specific image characteristics, and a standard method for these parameters has not been established. This review introduces volume-based PET parameters as potential prognostic indicators, and highlights methodological considerations for measurement, potential implications, and prospects for further studies.
문승환,최준영,이환주,손영익,백정환,안용찬,안명주,박근칠,김병태 대한이비인후과학회 2015 Clinical and Experimental Otorhinolaryngology Vol.8 No.2
Objectives. The aim of this study was to evaluate the prognostic value of volume-based metabolic parameters measured by18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) in patients with nasopharyngeal carcinoma(NPC). Methods. Forty-four NPC patients who underwent 18F-FDG PET/CT for initial staging work-up before concurrent chemoradiotherapy(CCRT) were retrospectively evaluated. Maximum standardized uptake value (SUV), mean SUV, metabolictumor volume (MTV), and total lesion glycolysis (TLG) of the primary tumors were measured. The prognosticsignificance and predictive performance of these parameters were assessed by Cox proportional hazards regressionanalysis and time-dependent receiver operating characteristics (ROC) curve analysis. Results. Multivariate analysis showed that American Joint Committee on Cancer stage 7th edition (hazard ratio [HR],1.525; 95% confidence interval [CI], 1.062 to 2.188; P=0.022), and TLG (HR, 7.799; 95% CI, 2.622 to 23.198; P≤0.001) were independent predictive factors associated with decreased disease-free survival (DFS). Time-dependentROC curve analysis indicated that TLG was a better predictor of DFS than MTV (P=0.008). Conclusion. The TLG of the primary tumor was a significant independent metabolic prognostic factor of DFS in patientswith NPC treated with CCRT.