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목단피(牧丹皮)가 손상된 성상신경세포의 CD81 및 GFAP의 발현에 미치는 영향
문성진,성기문,임진영,송봉근,Moon, Sung-Jin,Seon, Ki-Moon,Lim, Jin-Young,Song, Bong-Keun 대한한방내과학회 2009 大韓韓方內科學會誌 Vol.30 No.1
Object : In conditions of brain infarction, irreversible axon damage occurs in the central nerve system (CNS), because gliosis makes physical and mechanical barriers. If gliosis formation could be suppressed, irreversible axon damage would be reduced. This could mean that an injured CNS could be regenerated. CD81 and GFAP have close relationships to gliosis. The increase in glial cells at CNS injury gives rise to the expression of CD81 and GFAP. CD81 was postulated to play a central role in the process of CNS scar formation. Method : In this study, the author investigated the effect of the water extract of the Moutan Radicis Cortex on regulation of CD81 and GFAP expression in injured CNS cells. MTT assay was used to examine cell viability, while RT-PCR and ELISA methods were carried out to measure the expression of CD81 and GFAP in the astrocyte. Results : We observed that water extract of the Moutan Radicis Cortex increased cell viability under hypoxia induced by $CoCl_2$ and suppressed the expression of CD81 and GFAP up-regulated by hypoxia. Conclusion : These results suggest that the Moutan Redicis Cortex could promote neural regeneration as a consequence of protecting CNS cells from hypoxia and suppressing the reactive gliosis following CNS injury.
Mycophenolate Mofetil과 Cyclophosphamide의 증식성 루푸스 신염 치료 효과 비교
문성진 ( Sung Jin Moon ),김동기 ( Dong Ki Kim ),박선영 ( Sun Young Park ),장제현 ( Jae Hyun Chang ),김현욱 ( Hyun Wook Kim ),이정은 ( Jung Eun Lee ),한승혁 ( Seung Hyeok Han ),고광일 ( Kwang Il Ko ),김동현 ( Dong Hyun Kim ),김찬호 대한내과학회 2008 대한내과학회지 Vol.74 No.6
목적: 루푸스 신염은 루푸스 환자에서 사망의 주된 원인 중의 하나로 고용량 cyclophosphamide 충격 요법이 그 표준 치료로 알려져 있다. 그러나 이러한 치료법은 부작용이 심하여, 좀 더 부작용이 적고 효과적인 치료방법에 대한 연구가 필요하였다. MMF는 상대적으로 선택적인 림프구증식 억제제로, 최근 신이식 후의 면역조절, 루푸스 신염, 다른 자가면역 질환의 치료에 널리 사용되고 있다. 증식성 루푸스성 신염의 치료에 있어서 MMF 사용에 따른 효과는 국외에서는 다양한 보고가 있었으나 국외에서는 연구가 드문 실정이다. 이에 본 연구자들은 증식성 루푸스 신염 환자의 관해 요법에 있어서 고용량 cyclophosphamide 충격 요법과 MMF 치료의 효과를 비교해 보고자 하였다. 방법: 2000년 1월부터 2006년 12월까지 연세대학교 의과대학 세브란스 병원에서 증식성 루푸스 신염으로 진단 받은 43명의 환자를 대상으로 고용량 cyclophosphamide 충격 요법을 받은 환자군(CP군)과 MMF 치료를 받은 환자군(MMF군)으로 나누어 양군 간에 관해 정도, 합병증의 발생빈도와 치료 시작 후 6개월간의 혈액, 면역, 생화학 검사 결과의 변화를 후향적으로 조사하였다. 결과: 대상 환자는 MMF군 19명, CP군 24명이었다. 완전 관해는 MMF군에서 8명(33.3%), CP군에서 7명(36.8%)이었으며(p>0.05), 불완전 관해는 MMF군에서 10명(52.6%), CP군에서 11명((45.8%))로 양 군 사이에 통계적으로 의미있는 차이를 보이지 않았다. 헤모글로빈, 크레아티닌, C-reactive protein, ESR, C3, C4, 일일 단백뇨량으로 살펴본 혈액, 면역, 생화학, 소변 검사 결과의 변화는 양 군 사이에 유의한 차이가 없었다. 또한 백혈구 감소증, 감염 등과 같은 합병증의 발생 빈도에 있어서도 의의있는 차이가 없었다. 결론: 결론적으로 증식성 루푸스 신염의 관해 유도 치료에 있어 MMF는 cyclophosphamide 치료와 비교하여 관해율 및 부작용의 차이가 없었다. 이번 연구는 비록 후향적 연구라는 단점이 있지만, 우리나라에서 루푸스 신염의 치료에 있어서 MMF 치료가 cyclophosphamide 치료를 대체할 수 있는 가능성을 보여주는 연구라 할 수 있겠다. Background/Aims: Our study aimed to evaluate the efficacy of MMF as compared with intravenous cyclophosphamide as induction therapy for proliferative lupus nephritis in Koreans. Methods: Forty-three patients who were diagnosed with proliferative lupus nephritis (WHO Class III and IV) between Jan 2000 and Dec 2006 were included in this study. Nineteen patients were treated with oral MMF (initial dose: 1.0 g/day and then it was increased to 2.0 g/day) and 24 patients were treated with 0.75-1.0 g/m2 of monthly intravenous cyclophosphamide (CP) followed by subsequent treatment with oral corticosteroid (initial dose 1 mg/kg/day and then it was slowly tapered down) for 6 months. The demographic and laboratory findings, the response rate and the adverse events were reviewed retrospectively and these were compared between the two groups. Results: A complete response occurred in 7 out of the 19 patients (36.8%) treated with MMF and in 8 out of the 24 patients (33.3%) treated with CP, and the difference was not significantly different between the two groups (p=0.66). A partial response was achieved in 52.6% and 45.8%, respectively. There were no significant differences of the laboratory findings such as serum albumin, C3, C4, the urine protein/creatinine ratio and serum creatinine after treatment for 6 months. In addition, both groups had similar rates of adverse events. Conclusions: Our study showed that for the treatment of lupus nephritis, MMF was as effective as IV cyclophosphamide with similar adverse events. This finding suggests that MMF could be an alternative treatment for active lupus nephritis as induction therapy.(Korean J Med 74:640-647, 2008)
고립성 현미경적 혈뇨 환자에서 신장 조직검사 시행 여부의 결정을 위한 요중 βig-h3의 유용성
문성진 ( Sung Jin Moon ),한승혁 ( Seung Hyeok Han ),김진주 ( Jin Ju Kim ),이금희 ( Jin Ji Li ),정동섭 ( Dong Sub Jeong ),곽승재 ( Seung Jae Kwak ),이정은 ( Jung Eun Lee ),김동기 ( Dong Ki Kim ),김현욱 ( Hyun Wook Kim ),장제현 ( Ja 대한신장학회 2007 Kidney Research and Clinical Practice Vol.26 No.6
Purpose : This study was undertaken to elucidate the usefulness of urinary βig-h3 concentrations in differential diagnosis of isolated microscopic hematuria patients. Methods : Seventy-seven patients, in whom renal biopsy was performed due to microscopic hematuria without proteinuria, were enrolled. The patients were divided into two groups, IgAN group (patients with IgA nephropathy, N=37) and NM group (patients with normal or minor change on renal biopsy, N=40), and the clinical characteristics and laboratory findings were compared between the two groups. TGF-β and βig-h3 concentrations in urine were determined by ELISA and were compared between the two groups. To establish the optimal cut-off value of βig-h3/creatinine (Cr) ratio for the diagnosis of IgA nephropathy, a receiver operating characteristic curve was constructed and the sensitivity and specificity were calculated. Results : A comparative analysis revealed no significant differences in age and sex ratio between the two groups. There were no differences in serum IgG, IgA, IgM, C3, and C4 levels between the two groups. The urinary βig-h3/Cr ratio was significantly higher in the IgAN group compared to the NM group (6.632.6 vs. 4.462.6 ng/mg, p<0.05), whereas there was no significant difference in the urinary TGF-/Cr ratio between the two groups (14.82.1 vs. 13.75.1 pg/mg, p>0.05). A cut-off βig-h3/Cr ratio 4.5 has a sensitivity of 85.0% and a specificity of 77.8%. Conclusion : The urinary βig-h3/Cr ratio was a good predictor for the diagnosis of IgA nephropathy. Therefore, renal biopsy should be considered in isolated microscopic hematuria patients with high urinary βig-h3/Cr ratio.
증례 : 복강경으로 성공적으로 절제한 후복막 점액성 낭선종 1예
문성진 ( Sung Jin Moon ),윤영훈 ( Young Hoon Yoon ),전태주 ( Tae Joo Jeon ),정재복 ( Jae Bock Chung ),이우정 ( Woo Jung Lee ),신은아 ( Eun Ah Shin ),김호근 ( Ho Geun Kim ) 대한내과학회 2005 대한내과학회지 Vol.69 No.-
저자 등은 28세 여자 환자에서 발생한 후복막 점액성 낭선종 1예를 복강경을 이용하여 성공적으로 치료한 예를 경험하였기에 문헌 고찰과 함께 보고하는 바이다. Primary retroperitoneal mucinous cystadenoma is a extremely rare tumor, reported exclusively in women. There have been about 30 cases of reports in worldwide literature, and only 3 reported cases in Korea to date. Because this tumor is histologically heterogenous and may have metastatic potential, a careful surgical excision with a thorough histopathological examination is needed, and close follow-up is mandatory. While transabdominal laparotomy and complete surgical excision is a standard of treatment, there had been a case-report of laparoscopic resection in 1998. Herein we report a case of primary retroperitoneal mucinous cystadenoma, which was successfully resected by laparoscopy, in 28-year-old woman. (Korean J Med 69:S741-S745, 2005)