외상성 중뇌막동맥-판간정맥누

문석배,김국기,이봉암,이영근 中央醫學社 1977 中央醫學 Vol.33 No.5

Extravasation of contrast material from a branch-of the middle meningeal artery during cerebral angiography following head injury has been regarded by some to be diagnostic evidence of extradural or subdural hematoma. Furthermore, the two varieties of blood collections may coexist, thus showing on the angiog-raphic films atypical blood vessel displacements which are difficult to interpret. Authors reported a case of subdural hematoma with extravasation of contrast material from a torn middle meningeal artery into the diploi, It was seen near the crossing of a branch of the middle meningeal artery and a fracture line.

새로운 플라스틱 광자결정 광섬유의 제작과 도파특성

문석배,최재호,신인희,육영춘,김덕영,백운출 한국통신학회 2001 한국통신학회 기타 간행물 Vol.2001 No.10

Effects of black garlic on the pacemaker potentials of interstitial cells of Cajal in murine small intestine in vitro and on gastrointestinal motility in vivo

문석배,최나리,김정남,권민지,김보성,하기태,임은영,김윤태,김병주 한국통합생물학회 2022 Animal cells and systems Vol.26 No.1

Black garlic (BG) is a newly explored food stuff obtained via fermentation of raw, healthy garlic, especially in Asian countries. Interstitial cells of Cajal (ICC) are the pacemaker cells of gastrointestinal (GI) motility. The purpose of this study was to investigate the effects of BG extract on the pacemaker potentials of the ICC in the small intestines of mice and the possibility of controlling GI motility. The antioxidant activity of BG extract was also investigated. The whole-cell electrophysiological method was used to measure pacemaker potentials of the ICC in vitro, whereas GI motility was measured using the intestinal transit rate (ITR) in vivo. BG extract depolarized the pacemaker potentials of the ICC. Y25130 and RS39604 5-HT receptor antagonists could not inhibit the effect of BG extract on the pacemaker potentials of the ICC, whereas the 5- HT receptor antagonist SB269970 could. Pre-treatment with external Na+ (5 mM) or Ca2+-free solution inhibited the BG extract-induced depolarization of the ICC. With SB203580, PD98059, or c-jun NH2-terminal kinase II inhibitor pre-treatment, BG extract did not induce pacemaker potential depolarization. Moreover, the ITR values were increased by BG extract. Elevation of the ITR due to BG extract was related with increased protein expression of the 5-HT7 receptors. In addition, BG extract showed antioxidant activity. Collectively, these results highlight the ability of BG extract to regulate GI motility and the possibility of using it to develop GI motility modulators in the future. Moreover, BG showed immense potential as an antioxidant.

1.55㎛ 이득 스위칭 반도체 레이저와 EDFA를 이용한 Supercontinuum 생성

문석배,오철웅,김덕영 한국통신학회 2004 한국통신학회 기타 간행물 Vol.2004 No.11

Falciform Ligament Abscess after Omphalitis: Report of a Case

문석배,이해원,박귀원,정성은 대한의학회 2010 Journal of Korean medical science Vol.25 No.7

A falciform ligament abscess is a rare type of intra-abdominal abscess. A 2-yr-old male,who had omphalitis two months previously, presented with a fever and right upper quadrant abdominal pain. The ultrasound and CT scan showed an abdominal wall abscess located anterior to the liver, which was refractory to conservative management with percutaneous draninage and antibiotics. On the third recurrence, surgical exploration was performed and revealed an abscess arising from the falciform ligament; the falciform ligament was excised. A follow up ultrasound confirmed complete resolution of the abscess with no further recurrence.

심한 고혈압과 심부전을 동반한 신경절신경모세포종 1예

문석배,김혜은,이석구,서정민,Moon, Suk-Bae,Kim, Hae-Eun,Lee, Suk-Koo,Seo, Jeong-Meen 대한소아외과학회 2009 소아외과 Vol.15 No.1

Neuroblastoma is the most common extracranial solid tumor in children, and accompanies various clinical symptoms including hypertension. Hypertension is associated with catecholamines secreted from the tumor, and is usually not severe. We report one case of malignant hypertension with cardiac failure in a patient with adrenal neuroblastoma, successfully treated with adrenalectomy. A 3 year-old boy complained of protrusion of the chest wall. Physical examination revealed severe hypertension with cardiac failure. The levels of metabolites of catecholamine were increased in blood (norepinephrine >2000 pg/mL) and urine (norepinephrine 1350.5 ug/day). Abdominal CT showed a 7 cm-sized solid mass arising from the right adrenal gland. After stabilizing the hemodynamics with oral phenoxybenzamine, right adrenalectomy was performed. Pathological diagnosis was a ganglioneuroblastoma. The hypertension and cardiac failure were resolved after tumor removal.

소아 I 흔한 소아외과 진단과 치료: 최신 동향을 중심으로

문석배 대한외과학회 2022 대한외과학회 학술대회 초록집 Vol.2022 No.5

신경모세포종: 20년 치료 경험의 분석

문석배,이성철,박귀원,정성은,Moon, Suk-Bae,Lee, Seong-Cheol,Park, Kwi-Won,Jung, Sung-Eun 대한소아외과학회 2009 소아외과 Vol.15 No.1

Neuroblastoma is the most common extracranial solid tumor in children. We retrospectively analyzed the results of neuroblastoma treatment of 191 patients (116 males and 75 females) treated between January 1986 and December 2005 at the Department of Pediatric Surgery and the Department of Pediatrics, Seoul National University Children's Hospital. The mean age at diagnosis was 3.1 years (0.1 yrs - 13.5 yrs). Forty-seven patients were under 1 year of age. The mean follow-up period was 57.3 months (24 days - 19.1 yrs). Patients were classified into two groups according to the completeness of resection of the primary tumor; (1) gross total resection (GTR) and (2) incomplete resection (IR). The number of patients in stages I, II, III, IV, IV-S were 17 (8.9 %), 12 (6.3 %), 43 (22.5 %), 114 (59.7 %), 4 (2.1 %), respectively. GTR was achieved in 120 patients and IR in 71 (22 stage III, 47 stage IV, 1 stage IV-S, 1 brain). Overall survival (OS) was 65.2 % and event-free survival (EFS) was 48.6 %. EFS were 100 %, 75 %, 66.8 %, 31.3 %, 75 % at stage I, II, III, IV, IV-S, respectively. There was no significant difference in EFS according to the completeness of resection. EFS was improved in GTR group (p=ns) of stage III, but by contrast, stage IV patients showed worse EFS in GTR group. EFS was improved significantly after the introduction of autologous stem cell transplantation (ASCT) (58.1% vs. 40.6%, p=.029). The EFS improved significantly after the introduction of ASCT in IR group (p=.009) rather than GTR group (p=ns). The EFS of the patients under 1 year of age (N=47) was better than the patients over 1 year of age (N=144) significantly (75.5 % vs. 39.4 %, p=.0034). The prognosis of neuroblastoma was related to the INSS stage and age at diagnosis. The survival of IR group significantly improved after ASCT.

회절위상현미경을 이용한 광섬유의 굴절률 프로파일 측정

문석배,Moon, Sucbei 한국광학회 2012 한국광학회지 Vol.23 No.4

본 연구에서는 공동경로간섭계(common-path interferometer)에 기반한 회절위상현미경(diffraction phase microscopy)을 이용한 광섬유의 굴절률 프로파일(refractive index profile) 측정기술을 개발하였다. 투과형 회절격자를 이용하여 광섬유 시료를 통과한 빛으로부터 핀홀을 이용하여 영의 공간주파수 성분만을 갖는 기준광을 생성하고, 기준광을 다시 시료의 위상정보를 갖는 시료광과 간섭시키는 방법을 통해 시료의 위상정보를 가진 간섭무늬를 형성시켰다. 이렇게 얻어진 간섭 이미지로부터 수치적 처리과정을 거쳐 공간적 위상정보 곧, 위상 이미지를 획득하고 이 데이터를 역아벨변환(inverse Abel transform)을 통해 굴절률 프로파일로 변환할 수 있었다. 이때 클래딩과 광섬유 주변의 매질 사이의 굴절률차로 인해 발생하는 배경위상을 이론적으로 얻어진 함수형태에 맞춰 예측하고 이를 측정된 위상에서 제거하는 배경위상제거 방법을 개발하여 사용하였다. 이를 통해 광섬유 코어 부근의 위상정보만으로도 굴절률 프로파일을 성공적으로 이뤄질 수 있음이 입증되었다. 본 연구를 통하여 회절위상현미경 특유의 측정 안정성과 편의성을 가진 광섬유 굴절률 프로파일 측정장치를 개발하였고 광섬유 및 도파로의 굴절률 분포를 비파괴적으로 분석할 수 있어 광섬유 및 광섬유소자 개발에 활용될 수 있을 것으로 기대된다. We have developed a measurement method of the refractive index profile of an optical fiber by using diffraction phase microscopy. In the microscope system, the reference light was extracted directly from the probe light that passed through the sample by means of pinhole filtering with a diffraction grating. The spatial interference pattern produced by the probe light and the reference light was processed to generate the phase image of the sample fiber. The index profile was obtained by the inverse Abel transform of the phase profile. In order to remove the background phase that originated from the index difference between the cladding and the surrounding medium, the background phase was calculated from the phase data of the cladding to make a core phase profile that can be directly transformed to the index profile of the core without the full phase image that includes the entire cladding part.

Desmoplastic small round cell tumor of the stomach mimicking a gastric cancer in a child

문석배,허정민,구홍회,서연림,신현백,서정민,이석구 대한외과학회 2011 Annals of Surgical Treatment and Research(ASRT) Vol.80 No.6

Intra-abdominal desmoplastic small round cell tumor (DSRCT) is a highly malignant tumor of uncertain histogenesis. Here we report a case of DSRCT involving the stomach, initially misdiagnosed as gastric cancer. A 12-year-old boy presented with upper abdominal pain developed 1 month prior. On gastroscopy, a 7-cm mass was noted involving the esophago-gastric junction to the fundus, and positron emission tomography showed multiple hot uptakes suggesting distant metastasis. Gastroscopic biopsy showed poorly differentiated malignant cells. We diagnosed as stage IV gastric cancer and treated with 6 cycles of chemotherapy. Laparotomy revealed a huge gastric mass along with peritoneal disseminations. Palliative proximal gastrectomy was performed. Pathological examination revealed transmural involvement of DSRCT, and t(11;22)(p12;q12) was demonstrated on fluorescence in situ hybridization test. The chemotherapeutic regimen was changed and the patient underwent 8 additional cycles of post-operative chemotherapy. The patient is now alive and the residual tumor shows no significant changes after chemotherapy.