당화단백질의 형서에 미치는 인삼의 효과

맹성호,배진우,전강웅 고려인삼학회 2002 Journal of Ginseng Research Vol.26 No.4

Inflammation as the Potential Basis in Depression

맹성호,홍희옥 대한배뇨장애요실금학회 2019 International Neurourology Journal Vol.23 No.S1

There is growing evidence of the association between inflammation and stress-related disorders including depression. The positive correlation between the increased levels of inflammatory cytokines observed in patients with other diseases and the byproduct of the depressive symptoms may be caused by chronic stress. Increased neuroinflammatory responses are capable of activating microglia and astrocytes, which leads to release pro-inflammatory cytokines. Moreover, elevated levels of inflammatory cytokines such as tumor necrosis factor-alpha, interleukin (IL)-1, and IL-6 are causally related to various aspects of depression such as the behavioral symptomatology. Eventually, these elevated cytokines aggravate and propagate neuroinflammation, impairing brain functions. Thus, activated astrocytes and microglia may be potential mediators in neuroinflammatory processes contributing to the development of depression.

PEMS를 이용한 대형차량 배출가스 측정 및 실시간 희석 요율 산출

맹성호(Sungho Maeng),이범호(Beomho Lee),주경석(Kyoungsuk Joo),이대엽(Daeyup Lee),박용희(Yonghee Park),권상일(Sangil Kwon),전상우(Sangwoo Jeon) 한국유체기계학회 2006 유체기계 연구개발 발표회 논문집 Vol.- No.-

Among the used vehicles, the number of heavy duty vehicles isnot so big, but the effect to environment is so high. So, it is very important to regulate emission and measure precisely in heavy duty vehicles. Chassis dynamometer for heavy duty vehicles which was introduced to the domestic research center in this year can measure exhaust emission of heavy duty vehicles(more than 3.5tons) at real road condition. Beside this measuring system has advantage forsaving time and cost. In spite of these advantages, it is impossible to adjust almost every(0.57million) used vehicles to the system. Therefore, research for measuring emission with PEMS(Portable On-board Emission Measurement System) which is portable and easy to equip, is on process. In this paper, we calculated Dilution Factor as well as analyzed density and total amount of emission to compare CVS(Constant volume sampler) system and PEMS through measured data from a same vehicle at the same time.

당화단백질의 형성에 미치는 인삼의 효과

맹성호(Sung Ho Maeng),전강웅(Kang Woong Chun),배진우(Jin-Woo Bae) 고려인삼학회 2002 Journal of Ginseng Research Vol.26 No.4

We examined effects of red ginseng on the formation of glycated protein in vivo and in vitro. The mixtures (1 : 1 : 1, v/v/v) with glucose (1.5 g/dl), hemoglobin (10 g/dl) and red ginseng extract (0.5 g/dl) in 0.067 M phosphate saline buffer were incubated for 5 days in shaking water bath (37˚C, 70 RPM). Male rats were divided into three groups with one health and two diabetes, consisting of 20 heads in each group. Diabetic rats, induced by streptozotocin<br/> injection, were treated with or without red ginseng extract (100 mg/kg/day) for 3 months. The concentration of blood glucose and the rate of glycated hemoglobin were determined by commercial kits. The rate of glycated hemoglobin was significantly decreased by the addition of ginseng extract in comparison with non-addition<br/> group in vitro (12.17± 1.01% vs 15.9± 1.95%, meansd, p<0.01). Even though the levels of blood glucose in rats were not significantly different from each other, the rate of glycated hemoglobin in ginseng treated diabetic rats was ±se significantly lower than non-treated diabetic rats after 3 months (15.1± 2.06% vs 20.1± 2.9%, mean± sd, p<0.05). Additionally, the body weight was increased, drinking water volume was decreased non-significantly by the treatment of ginseng extract. These results suggest that ginseng can also inhibit the formation of glycated protein by other mechanisms which are not related with hyoglyemic effect of ginseng.

노인의 사회경제적 지위와 운동참여도 및 만성질환 유병률의 관계

배우리,맹성호,정샘 한국발육발달학회 2020 한국발육발달학회지 Vol.28 No.1

The purpose of this study was to examine whether exercise participation of the elderly acts as a major mechanism for the socioeconomic status and the prevalence of chronic diseases in a rapid aging phenomenon. In other words, the purpose of this study is to identify the relationship between socioeconomic status, exercise participation and the prevalence of chronic diseases in the elderly, and to identify the direct and indirect roles of exercise participation in these relationships. The analysis data used in this study were 2,028 elderly people over 65 years of age from the National Health and Nutrition Examination Survey in 2017. Our findings are as follows. First, the higher the socioeconomic status of the elderly, the higher the exercise participation. Second, the higher the socioeconomic status of the elderly, the lower the prevalence of chronic diseases of circulatory system diseases, musculoskeletal disorders, and endocrine and metabolic disorders. Third, the higher the exercise participation in the elderly, the lower the prevalence of chronic disease of musculoskeletal disorders, and exercise participation serves as a parameter to amplify the negative effects between socioeconomic status and the occurrence of musculoskeletal disorders. The results of this study verified the importance of exercise in elderly and suggested the necessity of social welfare intervention measures for the prevention of chronic diseases of the elderly.

mecA 양성 메티실린 내성 포도구균의 mec 조절유전자에 대한 분자역학적 연구 및 다양성 분석

우희연,이남용,맹성호,한승훈,인경수,김상욱,성승용,김익상,최명식 대한화학요법학회 2000 대한화학요법학회지 Vol.18 No.3

목적 : 병원 감염과 지역 감염의 원인균으로서의 중요성이 증가되고 있는 MRSA와 MRCNS의 메티실린 내성 관련 유전자에 대해 분자역학적인 조사를 시행하고 mec 조절유전자의 다양성을 분석하여 분자유전학적 연구와 감염 관리에 기본적 자료를 제공하고자 연구를 시행하였다. 방법 : 본 연구에서는 국내 동일 대학병원에서 분리된 mecA 양성 MRSA 78균주와 MRCNS 36균주를 대상으로 항균제 감수성 검사와 중합효소연쇄반응을 시행하여 표현형과 유전형의 분포를 알아보고 내성 정도와 유전형의 상관성을 분석하였다. 결론 : 최소억제농도를 측정하여 oxacillin 감수성 양상을 알아본 결과 총 90개의 MRSA 임상검체 중 3균주에서 감수성을 보였고, MRCNS 36균주는 모두 내성을 보였으며, 고도 내성을 보이는 균주일수록 다제내성을 보이고 있었다. 중합효소연쇄반응으로 mecA 유전자 유무를 분석하여 mecA 양성을 보인 MRSA 78균주와 MSCNS 36균주 만을 대상으로 mec 조절유전자에 대한 중합효소연쇄반응을 시행하여 유전형의 분포를 조사하였다. 그 결과 MRSA와 MRCNS 모두에서 mecA-Pr-mecA-mecR1-mecI형, mecA-Pr-mecA-mecR1형과 mecA-Pr-mecA-mecR-1의 5′말단형의 3가지 유전형이 공통적으로 관찰되었는데, 이외에 MRSA에서는 mecA-mecR1형, mecA-mecR1의 5′말단형이, MRCNS에서는 mecA-Pr-mecA형과 mecA형이 추가로 분리되었다. 유전형의 분포를 연도별로 분석한 결과 연도별로 우세한 유전형이 서로 다른 것을 알 수 있었다. 유전형과 내성 정도의 상관성을 분석한 결과, mecA-Pr-mecA-mecR1을 보유한 MRSA의 경우 mecA 억제유전자로 생각되는 mecI 유전자 유무에 관계없이 모두 고도 내성을 나타내어 mecI의 유무는 내성 정도와는 일정한 관련이 없었으나, MRSA와 MRCNS 모두에서 mecI와 동시에 mecR1의 3′말단이 결혼된 유전형이 저도 및 중등도 내성을 보이는 균주에서 유의하게 많이 관찰되어 mecI가 결손된 균주에서는 mecR1의 3′말단부위의 유무가 내성 정도의 결정에 중요한 역할을 할 것으로 생각하였다. 결론 : 국내에서 분리되는 메티실린 내성 포도구균의 유전형의 분포가 국외 분리주와 차이를 보이는 것으로 관찰되었다. 또한 기존의 보고와는 달리 메티실린 내성 정도와 유전형 사이에 유의한 연관성이 있는 것으로 관찰되어 mec조절유전자가 내성 발현 뿐만 아니라 내성 정도의 결정에 중요한 역할을 하는 것으로 관찰되었다. MRSA가 중요한 감염균임에도 불구하고 아직까지 MRSA의 내성기전에 대해 확실하게 규명되지 않아 치료가 더욱 어려워지고 있는 실정이므로 이에 대한 더욱 종합적인 연구와 동시에 발생과 확산을 막기 위한 노력이 필요할 것으로 생각된다. Background : High prevalence of methicillin resistance has been noticed in staphylococci which also have been recognized as important nosocomial and multi-drug resistant pathogens. In this study, we investigated the distribution of mec regulator genes and the presence of the mutation in mecIgene to reveal the resistance mechanism at molecular level. Methods : The isolates included 90 clinical isolates of MRSA, 36 MRCNS of which methicillin resistance were determined by disk diffusion test and isolated in a single hospital during 1996-1999. We performed microdilution MIC test for oxacillin resistance and Kirby-Bauer test for other antibiotics. Genotypes of mecA positive (determined by PCR) isolates (78 MRSA, 36 MRCNS) were investigated by PCR amplification of mec regulator genes such as 3' end and 5' end of mecR1. mecI, and Pr-mecA. Results : In MIC assay, all MRSA strains except 3 strains and all MRCNS strains showed oxacillin resistance. The level of resistance correlated to the multi-drug resistance. Seven genotypes were observed in mecA positive MRSA and MRCNS. Differences of predominant genotypes among years isolated and among species were observed. Deletions of the 3' end of mecR1 and the mecI were more frequently observed in the low- and borderline-level resistant MRSA and MRCNS (P(0.05). So the important role of 3' end of mecRI in determining resistance level was suggested. Conclusion : This study demonstrated that genomic distribution of methicillin-resistant staphylococci isolated in Korea was different from that of strains isolated in other countries. And important role of mec regulator genes for expression of methicillin resistance was suggested.

치매 경험, 사회적 지지가 치매 태도에 미치는 영향 : 건강정보 이해능력 조절 효과를 중심으로

신혜리,김수경,이현주,조시울,맹성호,김영선 한국산학기술학회 2020 한국산학기술학회논문지 Vol.21 No.11

The current study examines whether the dementia experience and social support is associated with dementia attitude and whether health literacy moderates the relationship between these variables. We used data from the 2016 Dementia Literacy Survey collected by K University. We conducted our analysis with 522 community-dwelling older Koreans aged 60 to 79. Findings of the multivariate regression analyses showed belows. First, dementia experience and dementia attitude were related in cognitive and behavioral aspects. Second, social support was also related negatively with dementia attitude in cognitive part. However, social support was also related positively with dementia attitude in behavior part. Third, health literacy was positively related with dementia attitude in cognitive part. However, health literacy was negatively related with dementia attitude in behavior part. Lastly, health literacy had significant moderating effects with social support and dementia attitude in cognitive part. Our findings suggest that health literacy plays an important role in fostering a positive dementia attitude.

치매 서비스 경험과 인지기능 간의 관계 연구: 건강정보이해능력 집단 비교를 중심으로

신혜리,김영선,이상화,최은영,맹성호 한국디지털정책학회 2020 디지털융복합연구 Vol.18 No.11

The current study aims to examine whether dementia service utilization is associated with cognitive function and whether health literacy moderates the relationship between dementia service utilization and cognitive function. Data were drawn from the 2016 Dementia Literacy Survey collected by K University. The final analytic sample included 522 community-dwelling older Koreans aged 60 to 79. Results from multivariate regression analyses showed that both dementia service use and higher levels of health literacy were related to better cognitive function and that health literacy had significant moderating effects. When older adults used dementia service, those with higher levels of health literacy reported higher levels of cognitive function than those with lower levels of health literacy. Our findings suggest that health literacy plays an important role in determining the cognitive health benefits arising from dementia service utilization. 본 연구는 한국 성인 및 노인들을 대상으로 치매 서비스 이용 여부와 인지기능의 관계를 살펴보고, 건강정보이해능력이 두 변수 간의 관계에서 조절효과를 나타내는지 검증하고자 하였다. 이를 위해 K대학교에서 전국 60~79세 지역사회 거주자를 대상으로 직접면접조사를 통해 수집한 2016년 치매이해능력 설문조사 자료를 활용하였으며, 최종분석대상자로는 522명이 선정되었다. 다중회귀분석을 실시한 결과, 첫째, 치매 서비스 경험이 있는 노인일수록 인지기능이 높게 나타났다. 둘째, 건강정보이해능력이 높을수록 인지기능이 높게 나타났다. 셋째, 치매 서비스 경험과 인지기능의 관계에서 건강정보이해능력이 조절효과를 보이는 것으로 나타났다. 본 연구는 건강정보이해능력이 치매서비스 이용에 있어 중요한 역할을 하고 있음을 실증적으로 발견하여 고령자의 치매 및 건강 관련 정책에 주요 시사점을 제시한다.

6-Hydroxydopamine을 이용한 파킨슨병 흰쥐 모델의 도파민 운반체의 변화

김상윤,정재민,장영수,주완석,맹성호,하충건,김종민,김용식,이명철 대한신경과학회 1998 대한신경과학회지 Vol.16 No.4

노인의 사회경제적 지위와 운동참여도 및 성공적 노화의 관계

심지은,정샘,이윤표,유민수,윤홍식,한가을,맹성호 한국노년학회 2018 한국노년학회 학술발표논문집 Vol.2018 No.춘계