Benzo(a)pyrene의 산화에 대한 분자 궤도함수론적 해석

도성탁 대구보건대학 1996 대구보건대학 論文集 Vol.16 No.-

Molecular orbital calculation was carried out to analyze the reactivity of benzo(a)pyrene. Choozing the HOMO electron density to investigate the one electron oxidation reactivity, the values of 1, 3, 6 carbon atom are greater than the other atoms. This is coincident with one electron oxidation expriment. Choosing the density matrix which represents bond oxidation reactivty, the values of 4C-5C and 7C-8C bond are greater than other regions. This is also agreement with the expriment of the addition of oxygen atom to bezo(a)pyrene. Bond reactivity at 4, 5-positon is greater than at 7, 8-positon but 7, 8-epoxide benzo(a)pyrene is well known as proximate carcinogen. In 7, 8-epoxide B(a)P, the reactity of 9, 10-position is increased. Accordingly, oxyganation is the porocess to polarize benzo(a)pyrene. Most polarized and electron deficient benzo(a)pyrene-7, 8-dihydrodiol-9, 10-epoxide is potent carcinogen.

학점은행제 도입을 위한 소고

도성탁,박재원 대구보건대학 2003 대구보건대학 論文集 Vol.23 No.-

The Credit Bank System (CBS) is an open educational system which recognizes diverse learning experiences gained not only in-school but also out-of-school. When the learner accumulates the necessary CBS-approved credits, he/she can be awarded a degree. The Credit Bank, a central agency for continuing education, aims to provide all citizens with greater access to a variety of educational opportunities and to foster a lifelong learning society. Between May and December 1997, the accreditation system and standardized curriculum were developed and the first proposal for accreditation of educational institutes and curricula were evaluated. In March 1998, with effective of Enforcement Decree and Regulations of the Act on the Credit Recognition, the first stage of implementation was begun. There was a considerable increase in the number of students who took a degree from CBS year after year. Therefore it is desirable to introduce credit bank system into Daegu Health College(DHC). To operate CBS in DHC, we must get certification for standardized studying subjects from Ministry of Education & Human Resources Development. DHC can manage only 15 subjects in the first year of running CBS. So, cultural subjects is thought to have advantage over major subject. It is desirable to determine the major subjects according to students desires.

입학전형에 따른 임상병리과 학생의 학습적응도

도성탁,신두만,권순일 대구보건전문대학교 2006 대구보건대학 論文集 Vol.26 No.-

This study on the correlation between academic achievement and admission process was performed on a group of students who are majoring clinical pathology at Daegu Health College, Academic achievement of a group of students was evaluated on the basis of their average GPA of whole semesters enrolled at the college, In terms of admission type, Bachelor (Dae-Jol) group showed the best GPA among all groups, followed by General (Il-Ban), Rural(Nong-Oe-Chon) and Special (Teuk-Byul) group in a row. From the view point of admission time, Regular Admission (Joeng-Si) group showed a little bit higher GPA than Early Admission (Soo-Shi) group. When classified by the graduated-high schools, the GPA of the students who are from General high school (In-Moon-Kye) was higher than that of those who graduated Technical high school (Shil-Up-Kye). By the gender, female students exceeded male students in GPA in the first (freshman) and the second (junior) year of the college. However, in the third (senior) year, male students exceeded female students. In a conclusion, in order to select the applicants with better academic capability it may be needed to put more importance on General (Il-Ban) admission by type and Regular Admission (Joeng-Si) by time during the new students admission assessment. In addition it is also recommended to give some preferential treatment to the applicants from General high school (In-Moon-Kye).

Benzo(a)pyrene 과 Cytochrome P-450의 상호작용에 대한 이론적 연구

도성탁 THE KOREAN SOCIETY FOR BIOMEDICAL LABORATORY SCINE 1995 Journal of biomedical laboratory sciences Vol.1 No.1

요약 B(a)P와 cytochrome P-450의 heme부분은 구조가 평면이므로 겹침상호작용이 가능하다. 가능성이 큰 겹침상호작용모형을 결정하기 위해 이들 분자에 대해 MO계산을 행하였다. 이 경우 궤도함수 상호작용이 가장중요하므로, 프론티어궤도함수의 eigen vetor값이 크며 상호 결합성을 보여야 한다. 이를 바탕으로 다섯가지 가능성이 있는 모형을 선택한 후 MN2와 MO방법을 실행하였다. 이중 B(a)P의 4, 5, 6번 위치와 heme group의 y탄소와 III pyrrole환이 포개어지는 형태가 가장 안정하였다. Considering the planar structure and nonpolar properity of benzo(a)pyrene(B(a)p) and the planar heme part of cytochrome P-450, stacking interaction is probable. MO calculation on B(a)P and heme part of cytochrome P-450 were carried out to dertermine probable stacking interaction models. In this case, orbital interaction is most important. Accordingly, the stacking positions have high eigen vector in frontier orbital and boning type between two molecules. In this way, five probale models were selected and examined by MN2 and MO method. The most probable stacking interaction model which is the 4, 5, 6 positions of B(a)P overlap y carbon atom and III pyrrole ring of heme group was determine.

소중한 사람에게 샘톡 하세요

도성탁,양수영,김수환 샘터사 2017 월간 샘터 Vol.573 No.-

The Effect of Antioxidant-complex on Oxygen Free Radical Generating and Scavenging System in Rats

도성탁,이상일 대한의생명과학회 2006 Biomedical Science Letters Vol.12 No.1

4,5-Diarylpyrroles의 구조와 활성의 상관관계

도성탁 대구보건대학 2001 대구보건대학 論文集 Vol.21 No.-

The antiinflammatory activity of a series of 2-substituted- and 2,3-disubstituted -4-(4-flurorophenyl)-5-[4-(methylsulfonyl)phenyl]-1H-pyrroles was shown by structure-activity relationship studies to be correlated with the molar refractivity of the 1-substituent and size effect and electronic effect of the 2-substituent. Other molecular descriptors such as ovality, molecular weight and charge contributed to antiinflammatory activity. Much of the anti-inflammatory activity of these pyrroles could be correlated with the inhibition of the isoform of cyclooxygenase(COX2). Additional structure-activity relationship studies have been used to identify the molecular parameters necessary for maximizing COX2 inhibition while simultaneously minimizing the inhibition of constitutively expressed cyclooxygenase-1. Such an effort should facilitate the discovery and development of selective COX inhibitors that should lead to safer nonsteroidal antiinflammatory drugs.

고려시대 전염병에 대한 사료적 고찰

도성탁 대구보건대학 2013 대구보건대학 論文集 Vol.33 No.-

This study was to review epidemics prevalent in Goryeo Dynasty and health care policies in the above period. 36 cases were studied by using Goryeosa(高麗史), Goryeosajeolyo(高麗史節要), the inscriptions of tombs and the anthologies of the literti in the Goryeo dynasty. First, the epidemics of the Goryeo breakouts with famine and war. From the 12th century, Northern nomads invaded Goryeo frequently. They might bring new zoonosis, such as anthracnose. Second, Che-Ui-Po(濟危寶), Tong-Seo-Tae-Pi-Won(東西大悲院) were established in order to save people stricken with epidemics. The policies to amnesty prisoners, to reduce taxes or pray on heaven ect. - not directly related in epidemics was practiced. Third, Jang-yeok(瘴疫: miasma epidemic) which was specified plague that broke out in the Goryeo dynasty was recognized that the disease came from the contact of toxic fog or miasma of forest(山林瘴氣) in spring and autumn at the southern part of China. The sympton of Jang-yeok in Dong-eui-bo-gam(東醫寶鑑) was similar to Relapsing fever.

Benzo(a)pyrene과 Cytochrome P-450의 상호작용에 대한 이론적 연구

도성탁(Seong-Tak Doh) 대한의생명과학회 1995 Biomedical Science Letters Vol.1 No.1

요약 B(a)P와 cytochrome P-450의 heme부분은 구조가 평면이므로 겹침상호작용이 가능하다. 가능성이 큰 겹침상호작용모형을 결정하기 위해 이들 분자에 대해 MO계산을 행하였다. 이 경우 궤도함수 상호작용이 가장 중요하므로, 프론티어궤도함수의 eigen vetor값이 크며 상호 결합성을 보여야 한다. 이를 바탕으로 다섯가지 가능성이 있는 모형을 선택한 후 MN2와 MO방법을 실행하였다. 이중 B(a)P의 4, 5, 6번 위치와 heme group의 ?탄소와 Ⅲ pyrrole환이 포개어지는 형태가 가장 안정하였다. Considering the planar structure and nonpolar properity of benzo(a)pyrene(B(a)p) and the planar heme part of cytochrome P-450, stacking interaction is probable. MO calculation on B(a)P and heme part of cytochrome P-450 were carried out to dertermine probable stacking interaction models. In this case, orbital interaction is most important. Accordingly, the stacking positions have high eigen vector in frontier orbital and boning type between two molecules. In this way, five probale models were selected and examined by MN2 and MO method. The most probable stacking interaction model which is the 4, 5, 6 positions of B(a)P overlap ?carbon atom and Ⅲ pyrrole ring of heme group was determined.

임상병리과 임상실습에 대한 병원실습지도자 및 학생의 의식조사

도성탁 ( Seong-tak Doh ),권순일 ( Sun-il Kwon ),안승주 ( Seung-ju Ahn ) 한국고등직업교육학회 2008 한국고등직업교육학회논문집 Vol.9 No.4

임상병리과의 임상실습에 대한 의식조사로서 병원관계자 36명 및 대구보건대학 임상병리과 3학년 재학생 중 임상실습을 마친 148명을 대상으로 하여 2007년 5월부터 2007년 6월까지 설문지를 배부하여 조사한 결과는 다음과 같다. 임상실습기간에 대해 병원관계자의 경우 80.6%, 학생은 65.8%가 적절하다고 응답하였으나, 늘려야 한다는 의견도 각각 19.4%, 21.2%가 되었다. 실습 내용면에서 학생들의 34.5%가 실제업무위주로 이루어졌다고 한 반면, 60.8%가 단순한 보조업무였다고 답하였다. 병원 측의 30.6%가 체계적인 실습프로그램이 없다고 응답하였다. 실습지도자의 성의에 만족하는가하는 질문에 보통이상이라고 답한 학생 90.5%, 불만족이라는 학생 9.5%이었는데, 이는 성심성의껏 지도하였다는 병원 측의 94.1%와 그렇지 않다 5.9%와 대체적으로 일치하였다. 임상실습 후 실습에 대한 만족도 조사에서 91.7%가 보통이상이라고 답하였고, 실습 후 자신감을 얻었다고 75.7%가 응답하였다. 위에서 보는바와 같이 학생들은 임상실습을 통해 자신감을 쌓아가는 긍정적인 반응을 보였다. 그러나 체계적인 계획에 의거한 교육가 평가가 병원마다 차이를 보이고 있어 구체적인 실습지침의 필요하다 하겠다. Hospital practice program (HPP, Im-Sang-Sil-Seup) is an important part of current curriculum of various health- related academic majors of Korean health science colleges. This survey aims to study the satisfaction level of students who have completed HPP. The respondents to the questionnaire consist of 148 senior students who did HPP and 36 hospital staffs who actually led HPP for the students. As for the length of HPP, the 65.8% of students and 80.6% of hospital staffs said current 8 week period was appropriate to achieve the educational goal of HPP. In contrast, 21.2% of students and 19.4% of hospital staffs thought longer period was needed to learn various important topics during HPP. While 34.5% of students said their HPP in hospital was focused on valuable practical works, as much as 60.8% of students thought their role was merely simple temporary assisting work forces in hospitals. The 30.6% of respondent hospital staffs admitted that they did not have any well organized training program for HPP. With regard to satisfaction level to the sincerity of trainer of HPP in the hospitals, 90.5% of students were positioned in the middle or satisfied scale, and 9.5% of students were in dissatisfied scale. These figures are in good accordance with the answer of hospital staffs that they taught the students in all sincerity by 61.8%, and in the middle by 32.4%. The 91.7% of students were in the middle or satisfied scale in terms of the satisfaction level on whole HPP implementation. The 76.8% of students said they gained self-confidence after completing HPP. The overall assessment on HPP by students was rather positive. HPP provided with a good chance for students to learn practical clinical works and to build self-confidence for their vocational tasks. However, depending on hospital condition, training program and evaluation system was quite variable. A detailed and standardized training guide for HPP is recommended to be prepared to assure a guaranteed quality education.