http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : 단기순 (검색결과 5 건)
- 무료
- 기관 내 무료
- 유료
-
-
-
-
-
Proteomic Profiling of Serum from Patients with Tuberculosis
송상훈,한민제,최양선,단기순,양만길,송정한,박성섭,이재호 대한진단검사의학회 2014 Annals of Laboratory Medicine Vol.34 No.5
Background: Effective treatment and monitoring of tuberculosis (TB) requires biomarkers that can be easily evaluated in blood samples. The aim of this study was to analyze the serum proteome of patients with TB and to identify protein biomarkers for TB. Methods: Serum samples from 26 TB patients and 31 controls were analyzed by using nano-flow ultra-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry in data-independent mode, and protein and peptide amounts were calculated by using a label-free quantitative approach. The generated data were analyzed by using principal component analysis and partial least squares discriminant analysis, a multivariate statistical method. Results: Of more than 500 proteins identified, alpha-1-antitrypsin was the most discrimina- tive, which was 4.4 times higher in TB patients than in controls. Peptides from alpha-1-an- titrypsin and antithrombin III increased in TB patients and showed a high variable impor- tance in the projection scores and coefficient in partial least square discriminant analysis. Conclusions: Sera from patients with TB had higher alpha-1-antitrypsin levels than sera from control participants. Alpha-1-antitrypsin levels may aid in the diagnosis of TB.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
